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Conserved domains on  [gi|308818206|ref|NP_001184225|]
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extracellular matrix protein 2 isoform 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
294-621 2.35e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 2.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 294 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 373
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 374 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 451
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 452 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 529
Cdd:COG4886  192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 530 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 607
Cdd:COG4886  245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                        330
                 ....*....|....
gi 308818206 608 MKALHFLRLNNNKI 621
Cdd:COG4886  321 TTLLLLLLLLKGLL 334
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 9.73e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 68.99  E-value: 9.73e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 308818206  103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
294-621 2.35e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 2.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 294 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 373
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 374 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 451
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 452 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 529
Cdd:COG4886  192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 530 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 607
Cdd:COG4886  245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                        330
                 ....*....|....
gi 308818206 608 MKALHFLRLNNNKI 621
Cdd:COG4886  321 TTLLLLLLLLKGLL 334
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
298-550 9.75e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 9.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 298 CSLSYRTISCINAM-LTQIPPLTAPQITSLELTGNSIASIPDeafNGLPNLERLDLSKNNITSSgigPKAfkLLKKLMRL 376
Cdd:PRK15370 175 CLKNNKTELRLKILgLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSI---PAT--LPDTIQEM 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 377 NMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDlnQLVTLELEGNNLS-----------EANV--NPLAFKPLK- 442
Cdd:PRK15370 247 ELSINRITELPERLPSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRtlpahlpsgitHLNVqsNSLTALPETl 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 443 --SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEIcfnhtrkinvivlrynkieenrIAPlawinqeNLESIDL 520
Cdd:PRK15370 324 ppGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPET----------------------LPP-------TITTLDV 374

                        250       260       270
                 ....*....|....*....|....*....|
gi 308818206 521 SYNKLYHVPSYLPKSLLHLVLLGNQIERIP 550
Cdd:PRK15370 375 SRNALTNLPENLPAALQIMQASRNNLVRLP 404
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 9.73e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 68.99  E-value: 9.73e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 308818206  103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
LRR_8 pfam13855
Leucine rich repeat;
321-383 4.45e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 4.45e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308818206  321 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMDGNNL 383
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-157 2.96e-12

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 61.76  E-value: 2.96e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 308818206   103 CLVKGITMYNKAVWSPEPCTTCLCSDGR-VLCDETMCHP-QRCPQ--TVIPEGECCPVC 157
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNpeRVKPPGECCPRC 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 312-482 1.03e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 312 LTQIPPL-TAPQITSLELTGNSIASIpdEAFNGLPNLERLDLSKNNITSsgigpkafklLKKLMRLNMdgnnliqipsql 390
Cdd:cd21340   36 ITKIENLeFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISV----------VEGLENLTN------------ 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 391 pstLEELKVNENNLQ-----AIDEESLSDL-NQLVTLELEGNNLSEanvnplafkpLKSLAYLRlgknkfriipqglpgS 464
Cdd:cd21340   92 ---LEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDS----------LEPLAPLR---------------N 143

                        170
                 ....*....|....*...
gi 308818206 465 IEELYLENNQIEEITEIC 482
Cdd:cd21340  144 LEQLDASNNQISDLEELL 161
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
294-621 2.35e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 2.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 294 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 373
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 374 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 451
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 452 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 529
Cdd:COG4886  192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 530 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 607
Cdd:COG4886  245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                        330
                 ....*....|....
gi 308818206 608 MKALHFLRLNNNKI 621
Cdd:COG4886  321 TTLLLLLLLLKGLL 334
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
315-601 3.30e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 3.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 315 IPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTL 394
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 395 EELKvNENNLQAIDEESLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGKNKFRIIPQGLPG--SIEELYLEN 472
Cdd:COG4886   93 GDLT-NLTELDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 473 NQIEEITEICFNHTrKINVIVLRYNKIEEnriAPLAWINQENLESIDLSYNKLYHVPSYLP--KSLLHLVLLGNQIERIP 550
Cdd:COG4886  169 NQLTDLPEELGNLT-NLKELDLSNNQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 308818206 551 GyvFGHMePGLEYLYLSFNKLADdgmdrVSFYGAYHSLRELFLDHNDLKSI 601
Cdd:COG4886  245 E--LGNL-TNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-602 6.12e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 6.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 303 RTISCINAMLTQIPPLTA--PQITSLELTGNSIASIPDEaFNGLPNLERLDLSKNNITSsgIgPKAFKLLKKLMRLNMDG 380
Cdd:COG4886  116 ESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTD--L-PEELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 381 NNLIQIPSQL--PSTLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEANvnplAFKPLKSLAYLRLGKNKFRIIP 458
Cdd:COG4886  192 NQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLP 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 459 QGLP-GSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLL 537
Cdd:COG4886  267 PLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 308818206 538 HLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIP 602
Cdd:COG4886  347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
350-622 6.26e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 6.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 350 LDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLS 429
Cdd:COG4886    4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 430 EANVNPLAFKPLKSLAYLRLGKNKfriiPQGLPGSIEELYLENNQIEEITEicfnhtrkinvivlrynkieenRIAPLaw 509
Cdd:COG4886   84 LLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPE----------------------ELANL-- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 510 inqENLESIDLSYNKLYHVPSYLP--KSLLHLVLLGNQIERIPGyVFGHMePGLEYLYLSFNKLADDGMdrvSFYGAyHS 587
Cdd:COG4886  136 ---TNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNL-TNLKELDLSNNQITDLPE---PLGNL-TN 206

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 308818206 588 LRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIR 622
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
298-550 9.75e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 9.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 298 CSLSYRTISCINAM-LTQIPPLTAPQITSLELTGNSIASIPDeafNGLPNLERLDLSKNNITSSgigPKAfkLLKKLMRL 376
Cdd:PRK15370 175 CLKNNKTELRLKILgLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSI---PAT--LPDTIQEM 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 377 NMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDlnQLVTLELEGNNLS-----------EANV--NPLAFKPLK- 442
Cdd:PRK15370 247 ELSINRITELPERLPSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRtlpahlpsgitHLNVqsNSLTALPETl 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 443 --SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEIcfnhtrkinvivlrynkieenrIAPlawinqeNLESIDL 520
Cdd:PRK15370 324 ppGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPET----------------------LPP-------TITTLDV 374

                        250       260       270
                 ....*....|....*....|....*....|
gi 308818206 521 SYNKLYHVPSYLPKSLLHLVLLGNQIERIP 550
Cdd:PRK15370 375 SRNALTNLPENLPAALQIMQASRNNLVRLP 404
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
292-549 7.35e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.20  E-value: 7.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 292 LRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEafngLPN-LERLDLSKNNITSSgigPKafKLL 370
Cdd:PRK15370 212 KSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPER----LPSaLQSLDLFHNKISCL---PE--NLP 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 371 KKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNqlvTLELEGNNLSEAnvnPLAFKPlkSLAYLRLG 450
Cdd:PRK15370 283 EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLK---TLEAGENALTSL---PASLPP--ELQVLDVS 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 451 KNKFRIIPQGLPGSIEELYLENNQIEEITEicfnhtrkiNVivlrynkieenriaPLAwinqenLESIDLSYNKLyhvpS 530
Cdd:PRK15370 355 KNQITVLPETLPPTITTLDVSRNALTNLPE---------NL--------------PAA------LQIMQASRNNL----V 401

                        250
                 ....*....|....*....
gi 308818206 531 YLPKSLLHLVLLGNQIERI 549
Cdd:PRK15370 402 RLPESLPHFRGEGPQPTRI 420
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 9.73e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 68.99  E-value: 9.73e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 308818206  103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
371-611 2.08e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 76.66  E-value: 2.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 371 KKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDLNQLvtLELEGNNLSEANVN-PLAFKPL-------- 441
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPDTIQE--MELSINRITELPERlPSALQSLdlfhnkis 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 442 -------KSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEicfnhTRKINVIVLrynKIEENRIAPLAWINQEN 514
Cdd:PRK15370 276 clpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE-----TLPPGLKTL---EAGENALTSLPASLPPE 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 515 LESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPgyvfGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLD 594
Cdd:PRK15370 348 LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLP----ENLPAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVE 423

                        250
                 ....*....|....*..
gi 308818206 595 HNDLKSipPGIQEMKAL 611
Cdd:PRK15370 424 YNPFSE--RTIQNMQRL 438
LRR_8 pfam13855
Leucine rich repeat;
321-383 4.45e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 4.45e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308818206  321 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMDGNNL 383
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-157 2.96e-12

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 61.76  E-value: 2.96e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 308818206   103 CLVKGITMYNKAVWSPEPCTTCLCSDGR-VLCDETMCHP-QRCPQ--TVIPEGECCPVC 157
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNpeRVKPPGECCPRC 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
369-621 3.97e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.79  E-value: 3.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 369 LLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEeslsdlnqlvtlELEGNnlseanvnplafkpLKSLaYLR 448
Cdd:PRK15370 176 LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPE------------NLQGN--------------IKTL-YAN 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 449 lgKNKFRIIPQGLPGSIEELYLENNQIEEITEicfNHTRKINVIVLRYNKieenrIAPLAWINQENLESIDLSYNKLYHV 528
Cdd:PRK15370 229 --SNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNK-----ISCLPENLPEELRYLSVYDNSIRTL 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 529 PSYLPKSLLHLVLLGNQIERIPGYvfghMEPGLEYLYLSFNKLA-------------DDGMDRVSFYGAY--HSLRELFL 593
Cdd:PRK15370 299 PAHLPSGITHLNVQSNSLTALPET----LPPGLKTLEAGENALTslpaslppelqvlDVSKNQITVLPETlpPTITTLDV 374

                        250       260
                 ....*....|....*....|....*...
gi 308818206 594 DHNDLKSIPPGIQemKALHFLRLNNNKI 621
Cdd:PRK15370 375 SRNALTNLPENLP--AALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 312-482 1.03e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 312 LTQIPPL-TAPQITSLELTGNSIASIpdEAFNGLPNLERLDLSKNNITSsgigpkafklLKKLMRLNMdgnnliqipsql 390
Cdd:cd21340   36 ITKIENLeFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISV----------VEGLENLTN------------ 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 391 pstLEELKVNENNLQ-----AIDEESLSDL-NQLVTLELEGNNLSEanvnplafkpLKSLAYLRlgknkfriipqglpgS 464
Cdd:cd21340   92 ---LEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDS----------LEPLAPLR---------------N 143

                        170
                 ....*....|....*...
gi 308818206 465 IEELYLENNQIEEITEIC 482
Cdd:cd21340  144 LEQLDASNNQISDLEELL 161
LRR_8 pfam13855
Leucine rich repeat;
345-428 1.21e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206  345 PNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMdgnnliqipsqlpstleelkvNENNLQAIDEESLSDLNQLVTLELE 424
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDL---------------------SNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 308818206  425 GNNL 428
Cdd:pfam13855  58 GNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
290-550 2.82e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.18  E-value: 2.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 290 GTLRLPSGCSLSYRTISCINAMLTQIPPLtAPQITSLELTGNSIASIPDEAfnglPNLERLDLSKNNITSSGIGPKAfkl 369
Cdd:PRK15387 212 GLTTLPDCLPAHITTLVIPDNNLTSLPAL-PPELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHLPALPSG--- 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 370 lkkLMRLNMDGNNLIQIPSqLPSTLEELKVNENNLQaideeSLSDL-NQLVTLELEGNNLSEANVNPlafkplKSLAYLR 448
Cdd:PRK15387 284 ---LCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLA-----SLPALpSELCKLWAYNNQLTSLPTLP------SGLQELS 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 449 LGKNKFRIIPQgLPGSIEELYLENNQIEEITEICFNHTRKInvivlrynkIEENRIAPLAWINQEnLESIDLSYNKLYHV 528
Cdd:PRK15387 349 VSDNQLASLPT-LPSELYKLWAYNNRLTSLPALPSGLKELI---------VSGNRLTSLPVLPSE-LKELMVSGNRLTSL 417

                        250       260
                 ....*....|....*....|..
gi 308818206 529 PsYLPKSLLHLVLLGNQIERIP 550
Cdd:PRK15387 418 P-MLPSGLLSLSVYRNQLTRLP 438
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 321-525 4.06e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 59.03  E-value: 4.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 321 PQITSLELTGNSI----ASIPDEAFNGLPNLERLDLSKNNITSSGIGP--KAFKLLKKLMRLNMDGNNL-----IQIPSQ 389
Cdd:COG5238  208 TTVTTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGNQIgaegaIALAKA 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 390 L--PSTLEELKVNENNLQaiDE------ESLSDLNQLVTLELEGNNLSEANVNPL--AFKPLKSLAYLRLGKNKfrIIPQ 459
Cdd:COG5238  288 LqgNTTLTSLDLSVNRIG--DEgaialaEGLQGNKTLHTLNLAYNGIGAQGAIALakALQENTTLHSLDLSDNQ--IGDE 363

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 308818206 460 GLPGSIEelYLENNQieeiteicfnHTRKINvivLRYNKI-EENRIAPLAWINQENLESIDLSYNKL 525
Cdd:COG5238  364 GAIALAK--YLEGNT----------TLRELN---LGKNNIgKQGAEALIDALQTNRLHTLILDGNLI 415
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 322-621 1.57e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 322 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNItSSGIGPKAFKLLKKLMRLNMDGNNLI-QIPSQLPSTLEELKVN 400
Cdd:PLN00113  70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLS 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 401 ENNLQAIDEESLSDLNQLVTLELEGNNLSeaNVNPLAFKPLKSLAYLRLGKNKFriiPQGLPGSIEELylennqieeite 480
Cdd:PLN00113 149 NNMLSGEIPNDIGSFSSLKVLDLGGNVLV--GKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQM------------ 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 481 icfnhtRKINVIVLRYNKIE---ENRIAPLAWINQenlesIDLSYNKLY-HVPSYLP--KSLLHLVLLGNQIE-RIPGYV 553
Cdd:PLN00113 212 ------KSLKWIYLGYNNLSgeiPYEIGGLTSLNH-----LDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSgPIPPSI 280

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 308818206 554 FGHMEpgLEYLYLSFNKLADDGMDRVSfygAYHSLRELFLDHNDLK-SIPPGIQEMKALHFLRLNNNKI 621
Cdd:PLN00113 281 FSLQK--LISLDLSDNSLSGEIPELVI---QLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKF 344
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
447-633 2.48e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 2.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 447 LRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEicfNHTRKINVIVLRYNK-----------IEE-----NRIAPLAWI 510
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQltsipatlpdtIQEmelsiNRITELPER 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 511 NQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPgyvfGHMEPGLEYLYLSFNKLaddgmdrvSFYGAY--HSL 588
Cdd:PRK15370 260 LPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLP----AHLPSGITHLNVQSNSL--------TALPETlpPGL 327

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 308818206 589 RELFLDHNDLKSIPPGIQemKALHFLRLNNNKIRCVSDAVLETVT 633
Cdd:PRK15370 328 KTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLPPTIT 370
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
294-433 1.44e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 294 LPSGCSlsyrTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAfngLPNLERLDLSKNNITssgIGPKAfkLLKKL 373
Cdd:PRK15370 302 LPSGIT----HLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQIT---VLPET--LPPTI 369

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308818206 374 MRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDE---ESLSDLNQLVTLELEGNNLSEANV 433
Cdd:PRK15370 370 TTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPEslpHFRGEGPQPTRIIVEYNPFSERTI 432
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 308-530 9.54e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.16  E-value: 9.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 308 INAMLTQIPPLTAPQITSLELTGnsiaSIPDEaFNGLPNLERLDLSKNNIT--------SSGigpKAFKLLkkLMRLNMD 379
Cdd:PLN00113 324 IPVALTSLPRLQVLQLWSNKFSG----EIPKN-LGKHNNLTVLDLSTNNLTgeipeglcSSG---NLFKLI--LFSNSLE 393

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 380 GnnliQIPSQLP--STLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSeANVNPLAFKpLKSLAYLRLGKNKFRii 457
Cdd:PLN00113 394 G----EIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ-GRINSRKWD-MPSLQMLSLARNKFF-- 465

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 308818206 458 pQGLPGS-----IEELYLENNQIEEITEICFNHTRKINVIVLRYNKIeeNRIAPLAWINQENLESIDLSYNKLY-HVPS 530
Cdd:PLN00113 466 -GGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL--SGEIPDELSSCKKLVSLDLSHNQLSgQIPA 541
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 321-468 1.26e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 321 PQITSLELTGNSI-ASIPDeaFNGLPNLERLDLSKNNItsSGIGPKAFKLLKKLMRLNMDGNNLI-QIPSQLpstleelk 398
Cdd:PLN00113 452 PSLQMLSLARNKFfGGLPD--SFGSKRLENLDLSRNQF--SGAVPRKLGSLSELMQLKLSENKLSgEIPDEL-------- 519

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308818206 399 vnennlqaideeslSDLNQLVTLELEGNNLSeaNVNPLAFKPLKSLAYLRLGKNKFR-IIPQGLpGSIEEL 468
Cdd:PLN00113 520 --------------SSCKKLVSLDLSHNQLS--GQIPASFSEMPVLSQLDLSQNQLSgEIPKNL-GNVESL 573
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
376-602 1.79e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 51.32  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 376 LNMDGNNLIQIPSQLPSTLEELKVNENNLQaideeSLSDL-NQLVTLELEGNNLSEANV------------NPLAFKPL- 441
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLT-----SLPALpPELRTLEVSGNQLTSLPVlppgllelsifsNPLTHLPAl 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 442 -KSLAYLRLGKNKFRIIPQgLPGSIEELYLENNQIEEI----TEICfnhtrkinvIVLRYNkieeNRIAPLAWInQENLE 516
Cdd:PRK15387 281 pSGLCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLASLpalpSELC---------KLWAYN----NQLTSLPTL-PSGLQ 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 517 SIDLSYNKLYHVPSyLPKSLLHLVLLGNQIERIPGyvfghMEPGLEYLYLSFNKLaddgmdrVSFYGAYHSLRELFLDHN 596
Cdd:PRK15387 346 ELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLPA-----LPSGLKELIVSGNRL-------TSLPVLPSELKELMVSGN 412


                 ....*.
gi 308818206 597 DLKSIP 602
Cdd:PRK15387 413 RLTSLP 418
LRR_8 pfam13855
Leucine rich repeat;
514-571 2.42e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.42e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308818206  514 NLESIDLSYNKLYHVPSYLPKSLLHLVLL---GNQIERIPGYVFGHMePGLEYLYLSFNKL 571
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLdlsNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
561-628 2.50e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 2.50e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 308818206 561 LEYLYLSFNKLADDGMDRVSFygayHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRCVSDAV 628
Cdd:COG4886  115 LESLDLSGNQLTDLPEELANL----TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL 178
LRR_8 pfam13855
Leucine rich repeat;
392-454 3.35e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 3.35e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308818206  392 STLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEanVNPLAFKPLKSLAYLRLGKNKF 454
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
294-436 3.37e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.16  E-value: 3.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 294 LPSGcslsYRTISCINAMLTQIPPLTApQITSLELTGNSIASIPdeafnGLPN-LERLDLSKNNITSSGIGPKAfklLKK 372
Cdd:PRK15387 340 LPSG----LQELSVSDNQLASLPTLPS-ELYKLWAYNNRLTSLP-----ALPSgLKELIVSGNRLTSLPVLPSE---LKE 406

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 308818206 373 LMrlnMDGNNLIQIPsQLPSTLEELKVNENNLQAIdEESLSDLNQLVTLELEGNNLSEANVNPL 436
Cdd:PRK15387 407 LM---VSGNRLTSLP-MLPSGLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPLSERTLQAL 465
LRR_8 pfam13855
Leucine rich repeat;
535-598 3.73e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 3.73e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 308818206  535 SLLHLVLLGNQIERIPGYVFGHMePGLEYLYLSFNKLadDGMDRVSFYGaYHSLRELFLDHNDL 598
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLL--TTLSPGAFSG-LPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 317-621 5.32e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 5.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 317 PLTAPQITSLE----LTGNSIASIPdEAFNGLPNLERLDLSKNNITSSgIGPKAFKLlKKLMRLNMDGNNLI-QIPS--- 388
Cdd:PLN00113 229 PYEIGGLTSLNhldlVYNNLTGPIP-SSLGNLKNLQYLFLYQNKLSGP-IPPSIFSL-QKLISLDLSDNSLSgEIPElvi 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 389 QLpSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEAnvNPLAFKPLKSLAYLRLGKNKFR-IIPQGL--PGSI 465
Cdd:PLN00113 306 QL-QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGE--IPKNLGKHNNLTVLDLSTNNLTgEIPEGLcsSGNL 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 466 EELYLENNQIEEITEICFNHTRKINVIVLRYNK-------------------IEEN----RIAPLAWiNQENLESIDLSY 522
Cdd:PLN00113 383 FKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSfsgelpseftklplvyfldISNNnlqgRINSRKW-DMPSLQMLSLAR 461

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 523 NKLY-HVP-SYLPKSLLHLVLLGNQIERIPGYVFGHMePGLEYLYLSFNKLADDGMDRVSfygAYHSLRELFLDHNDLK- 599
Cdd:PLN00113 462 NKFFgGLPdSFGSKRLENLDLSRNQFSGAVPRKLGSL-SELMQLKLSENKLSGEIPDELS---SCKKLVSLDLSHNQLSg 537

                        330       340
                 ....*....|....*....|..
gi 308818206 600 SIPPGIQEMKALHFLRLNNNKI 621
Cdd:PLN00113 538 QIPASFSEMPVLSQLDLSQNQL 559
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 296-525 5.46e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 5.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 296 SGCSLSYRTISCINAMLTQIPPLTapqitSLELTGNSIASIPD------EAFNGLPNLERLDLSKNNITSSGIGPkaFKL 369
Cdd:cd00116   31 EGNTLGEEAAKALASALRPQPSLK-----ELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGV--LES 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 370 LkklmrlnmdgnnliqipsQLPSTLEELKVNENNLQ----AIDEESLSDLN-QLVTLELEGNNLSEANVNPLA--FKPLK 442
Cdd:cd00116  104 L------------------LRSSSLQELKLNNNGLGdrglRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAkaLRANR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 443 SLAYLRLGKNK-----FRIIPQGLPGS--IEELYLENNQIEE----ITEICFNHTRKINVIVLRYNKIEENRIAPLAWIN 511
Cdd:cd00116  166 DLKELNLANNGigdagIRALAEGLKANcnLEVLDLNNNGLTDegasALAETLASLKSLEVLNLGDNNLTDAGAAALASAL 245

                        250
                 ....*....|....*..
gi 308818206 512 QEN---LESIDLSYNKL 525
Cdd:cd00116  246 LSPnisLLTLSLSCNDI 262
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 320-635 6.95e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.02  E-value: 6.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 320 APQITSLELTGNSI-----ASIPDEAFNGLPNLERLDLSKNNITSSGIgpkafKLLKKLMRLNmdgnnliqipsqlpSTL 394
Cdd:COG5238  150 PLGGNAVHLLGLAArlgllAAISMAKALQNNSVETVYLGCNQIGDEGI-----EELAEALTQN--------------TTV 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 395 EELKVNENNlqaIDEES-------LSDLNQLVTLELEGNNLSEANVNPLAfkplkslAYLRLGKNkfriipqglpgsIEE 467
Cdd:COG5238  211 TTLWLKRNP---IGDEGaeilaeaLKGNKSLTTLDLSNNQIGDEGVIALA-------EALKNNTT------------VET 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 468 LYLENNQIEEITEICFNHTRKINvIVLRYNKIEENRIAPLAWIN-----QEN--LESIDLSYNKLyhvpsylpksllhlv 540
Cdd:COG5238  269 LYLSGNQIGAEGAIALAKALQGN-TTLTSLDLSVNRIGDEGAIAlaeglQGNktLHTLNLAYNGI--------------- 332

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 541 llGNQ-IERIpgyvFGHMEPG--LEYLYLSFNKLADDGMDRVSFYGAYH-SLRELFLDHNDL-----KSIPPGIQEMKaL 611
Cdd:COG5238  333 --GAQgAIAL----AKALQENttLHSLDLSDNQIGDEGAIALAKYLEGNtTLRELNLGKNNIgkqgaEALIDALQTNR-L 405

                        330       340
                 ....*....|....*....|....
gi 308818206 612 HFLRLNNNKIRCVSDAVLETVTNR 635
Cdd:COG5238  406 HTLILDGNLIGAEAQQRLEQLLER 429
LRR_8 pfam13855
Leucine rich repeat;
559-621 1.43e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.43e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 308818206  559 PGLEYLYLSFNKLadDGMDRVSFYGAyHSLRELFLDHNDLKSIPPG-IQEMKALHFLRLNNNKI 621
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKGL-SNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 312-622 1.45e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.86  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 312 LTQIPPLTAPQITSLEltGNSIASIPDEAFNGLPNLERldlSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQlp 391
Cdd:COG5238   15 LLSANPATTEQSELTK--RATIVNLRSYHLHGGAILLA---RYLQSRSSITQYLRFEGQGDPGLNPVALEKAAEAFPT-- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 392 stlEELKVNENNLQAIDEESLSDLNQLVT-----LELEGNNLSEANVNPLA-----------FKPLKSLAYLRLGKNKFR 455
Cdd:COG5238   88 ---QLLVVDWEGAEEVSPVALAETATAVAtpppdLRRIMAKTLEDSLILYLalprrinliqvLKDPLGGNAVHLLGLAAR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 456 I--------IPQGLPGSIEELYLENNQIEE--ITEICfNHTRK---INVIVLRYNKIEENRIAPLAWINQEN--LESIDL 520
Cdd:COG5238  165 LgllaaismAKALQNNSVETVYLGCNQIGDegIEELA-EALTQnttVTTLWLKRNPIGDEGAEILAEALKGNksLTTLDL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 521 SYNK-----LYHVPSYL--PKSLLHLVLLGNQIEripgyvfghmEPGLEYL--YLSFNKladdgmdrvsfygayhSLREL 591
Cdd:COG5238  244 SNNQigdegVIALAEALknNTTVETLYLSGNQIG----------AEGAIALakALQGNT----------------TLTSL 297

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 308818206 592 FLDHNDL-----KSIPPGIQEMKALHFLRLNNNKIR 622
Cdd:COG5238  298 DLSVNRIgdegaIALAEGLQGNKTLHTLNLAYNGIG 333
LRR_8 pfam13855
Leucine rich repeat;
464-525 2.71e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.71e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 308818206  464 SIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIeeNRIAPLAWINQENLESIDLSYNKL 525
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 468-626 3.62e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 3.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 468 LYLENNQIEEITEicFNHTRKINVIVLRYNKIEenRIaplawinqENLESidlsynklyhvpsyLPKsLLHLVLLGNQIE 547
Cdd:cd21340    7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT--KI--------ENLEF--------------LTN-LTHLYLQNNQIE 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 548 RIPGyvFGHMePGLEYLYLSFNKLAddgmdRVSFYGAYHSLRELFLDHNDLksiPPGiQEM-----------KALHFLRL 616
Cdd:cd21340   60 KIEN--LENL-VNLKKLYLGGNRIS-----VVEGLENLTNLEELHIENQRL---PPG-EKLtfdprslaalsNSLRVLNI 127

                        170
                 ....*....|
gi 308818206 617 NNNKIRCVSD 626
Cdd:cd21340  128 SGNNIDSLEP 137
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 320-454 1.35e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 320 APQITSLELTGNSIASIPDE----AFNGLPNLERLDLSKNNITSSGIGP--KAFKLLKKLMRLNMDGNN--------LIQ 385
Cdd:cd00116  136 PPALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNLEVLDLNNNGltdegasaLAE 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 308818206 386 IPSQLPStLEELKVNENNL-----QAIDEESLSDLNQLVTLELEGNNLSEANVNPLA--FKPLKSLAYLRLGKNKF 454
Cdd:cd00116  216 TLASLKS-LEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAevLAEKESLLELDLRGNKF 290
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 320-428 1.57e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 320 APQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNItsSGIGPKAFKLLKKLMRLNMDGNNLI-QIP---SQLPsTLE 395
Cdd:PLN00113 474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL--SGEIPDELSSCKKLVSLDLSHNQLSgQIPasfSEMP-VLS 550

                         90       100       110
                 ....*....|....*....|....*....|...
gi 308818206 396 ELKVNENNLQAIDEESLSDLNQLVTLELEGNNL 428
Cdd:PLN00113 551 QLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 470-630 1.62e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 470 LENNQIEEITEICFNHTRKINVIVlrynkieenRIAPLAWINQENLESIDLSYNKLYH-----VPSYLPKSLL-HLVL-- 541
Cdd:cd00116   47 LRPQPSLKELCLSLNETGRIPRGL---------QSLLQGLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLqELKLnn 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 542 --LGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVS-FYGAYHSLRELFLDHNDLKsiPPGI----QEMKA---L 611
Cdd:cd00116  118 ngLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAkALRANRDLKELNLANNGIG--DAGIralaEGLKAncnL 195

                        170
                 ....*....|....*....
gi 308818206 612 HFLRLNNNKIRCVSDAVLE 630
Cdd:cd00116  196 EVLDLNNNGLTDEGASALA 214
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
103-143 2.37e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 39.85  E-value: 2.37e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 308818206   103 CLVKGITMYNKAVWSpEPCTTCLCSDGRVLCDETMCHPQRC 143
Cdd:smart00215   1 CWNNGSYYPPGAKWD-DDCNRCTCLNGRVSCTKVWCGPKPC 40
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 321-360 9.18e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 9.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 308818206  321 PQITSLELTGNSIASIPdeAFNGLPNLERLDLSKNNITSS 360
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITD 38
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 394-621 1.10e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 394 LEELKVNENNLqaiDEESLSDL-------NQLVTLELEGNNLSEANVN----PLAFKPLKSLAYLRLGKNKFRIIPQGL- 461
Cdd:cd00116   25 LQVLRLEGNTL---GEEAAKALasalrpqPSLKELCLSLNETGRIPRGlqslLQGLTKGCGLQELDLSDNALGPDGCGVl 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 462 -----PGSIEELYLENNQIEE-----ITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQEN--LESIDLSYNKLYH-- 527
Cdd:cd00116  102 esllrSSSLQELKLNNNGLGDrglrlLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANrdLKELNLANNGIGDag 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 528 VPSYLP-----KSLLHLVLLGNQIERIPGYVFGHM---EPGLEYLYLSFNKLADDGMDRV--SFYGAYHSLRELFLDHND 597
Cdd:cd00116  182 IRALAEglkanCNLEVLDLNNNGLTDEGASALAETlasLKSLEVLNLGDNNLTDAGAAALasALLSPNISLLTLSLSCND 261

                        250       260
                 ....*....|....*....|....*....
gi 308818206 598 L-----KSIPPGIQEMKALHFLRLNNNKI 621
Cdd:cd00116  262 ItddgaKDLAEVLAEKESLLELDLRGNKF 290
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 321-398 1.26e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 321 PQITSLELTGNSI----ASIPDEAFNGLPNLERLDLSKNNITSSGigpkAFKLLK-----KLMRLNMDGNNL-IQIPSQL 390
Cdd:COG5238  348 TTLHSLDLSDNQIgdegAIALAKYLEGNTTLRELNLGKNNIGKQG----AEALIDalqtnRLHTLILDGNLIgAEAQQRL 423


                 ....*...
gi 308818206 391 PSTLEELK 398
Cdd:COG5238  424 EQLLERIK 431
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 339-431 2.10e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 339 EAFNGLPNLERLDLSKNNITSSGIG--PKAFKLLKKLMRLNMDGNNLIQIP-----SQLPS---TLEELKVNENNLQAID 408
Cdd:cd00116  187 EGLKANCNLEVLDLNNNGLTDEGASalAETLASLKSLEVLNLGDNNLTDAGaaalaSALLSpniSLLTLSLSCNDITDDG 266

                         90       100
                 ....*....|....*....|....*..
gi 308818206 409 EESLS----DLNQLVTLELEGNNLSEA 431
Cdd:cd00116  267 AKDLAevlaEKESLLELDLRGNKFGEE 293
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 345-392 2.91e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 308818206  345 PNLERLDLSKNNITSSGigpkAFKLLKKLMRLNMDGNNLIQIPSQLPS 392
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP----PLAKLPNLETLDLSGNNKITDLSDLAN 44
PLN03150 PLN03150
hypothetical protein; Provisional
 325-394 3.43e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 3.43e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206 325 SLELTGNSIASIPDEAFNGLPNLERLDLSKNNItsSGIGPKAFKLLKKLMRLNMDGNNLiqiPSQLPSTL 394
Cdd:PLN03150 446 SINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF--NGSIPESLGQLTSLRILNLNGNSL---SGRVPAAL 510
IGFBP pfam00219
Insulin-like growth factor binding protein;
133-161 5.33e-03

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 35.38  E-value: 5.33e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 308818206  133 CDETMC--HPQRCPQTVIPEG-ECCPVCSATE 161
Cdd:pfam00219   5 CDPERCppPPPGCPAGVVLDGcGCCKVCARQE 36
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 587-626 6.72e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 6.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 308818206  587 SLRELFLDHNDLKSIPPgIQEMKALHFLRL-NNNKIRCVSD 626
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP-LAKLPNLETLDLsGNNKITDLSD 41
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 116-189 6.96e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 39.29  E-value: 6.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308818206  116 WSPEPC---TTCLCSDGRVLcdETMCH--PQRCPQT-----VIPEGECCPVCSAT----------EQREPTNLLHKQLPP 175
Cdd:pfam14828 186 VGPEACsdpSGCGCGNDENL--ERICAnvLQRCPPPhclspLRPEGHCCDVCGAIvsldysscfdLQTYRARLRHLFLAL 263

                          90
                  ....*....|....*....
gi 308818206  176 P-----QVGMDRIVRKEAL 189
Cdd:pfam14828 264 PkykgvQLAVSKVGKDQRL 282
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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