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Conserved domains on  [gi|296434227|ref|NP_001171783|]
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kelch domain-containing protein 4 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
38-285 1.53e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 105.24  E-value: 1.53e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227  38 NELYVYNTRKDTWTKVDiPSPPPRRCAHQAVVVpqgGGQLWVFGGEFASPNGEQFyhYKDLWVLHLATKTWEQVKSTggP 117
Cdd:COG3055   38 NSFEVYDPATNTWSELA-PLPGPPRHHAAAVAQ---DGKLYVFGGFTGANPSSTP--LNDVYVYDPATNTWTKLAPM--P 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 118 SGRSGHRMVAWKRQLILFGGFHESTrdyiYYNDVYAFNLDTFTWSKLSPSgtgPTPRSGCQMSVTPQGGIVVYGGyskqr 197
Cdd:COG3055  110 TPRGGATALLLDGKIYVVGGWDDGG----NVAWVEVYDPATGTWTQLAPL---PTPRDHLAAAVLPDGKILVIGG----- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 198 vkkdvdkgtRHSDMFLLKpedgredkwvWTRMNPSgvkPTPRSGFSVAmAPNHQTLFFGGvcdeeeeeslSGEFFNDLYF 277
Cdd:COG3055  178 ---------RNGSGFSNT----------WTTLAPL---PTARAGHAAA-VLGGKILVFGG----------ESGFSDEVEA 224


                 ....*...
gi 296434227 278 YDATRNRW 285
Cdd:COG3055  225 YDPATNTW 232
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
38-285 1.53e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 105.24  E-value: 1.53e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227  38 NELYVYNTRKDTWTKVDiPSPPPRRCAHQAVVVpqgGGQLWVFGGEFASPNGEQFyhYKDLWVLHLATKTWEQVKSTggP 117
Cdd:COG3055   38 NSFEVYDPATNTWSELA-PLPGPPRHHAAAVAQ---DGKLYVFGGFTGANPSSTP--LNDVYVYDPATNTWTKLAPM--P 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 118 SGRSGHRMVAWKRQLILFGGFHESTrdyiYYNDVYAFNLDTFTWSKLSPSgtgPTPRSGCQMSVTPQGGIVVYGGyskqr 197
Cdd:COG3055  110 TPRGGATALLLDGKIYVVGGWDDGG----NVAWVEVYDPATGTWTQLAPL---PTPRDHLAAAVLPDGKILVIGG----- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 198 vkkdvdkgtRHSDMFLLKpedgredkwvWTRMNPSgvkPTPRSGFSVAmAPNHQTLFFGGvcdeeeeeslSGEFFNDLYF 277
Cdd:COG3055  178 ---------RNGSGFSNT----------WTTLAPL---PTARAGHAAA-VLGGKILVFGG----------ESGFSDEVEA 224


                 ....*...
gi 296434227 278 YDATRNRW 285
Cdd:COG3055  225 YDPATNTW 232
PLN02193 PLN02193
nitrile-specifier protein
 50-256 9.50e-17

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 82.31  E-value: 9.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227  50 WTKVDIPSPPP-RRCAHQavvVPQGGGQLWVFGGEFaSPNGEQFYHykdLWVLHLATKTWEQVKSTGGPSGRS--GHRMV 126
Cdd:PLN02193 153 WIKVEQKGEGPgLRCSHG---IAQVGNKIYSFGGEF-TPNQPIDKH---LYVFDLETRTWSISPATGDVPHLSclGVRMV 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 127 AWKRQLILFGGFHESTRdyiyYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQgGIVVYGGYS-KQRVK-----K 200
Cdd:PLN02193 226 SIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEE-NVYVFGGVSaTARLKtldsyN 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 201 DVDKGTRH----SDMFLLKPEDGRE----DKWV---------------------WTRMNPSGVKPTPRSGFSVAMAPNHQ 251
Cdd:PLN02193 301 IVDKKWFHcstpGDSFSIRGGAGLEvvqgKVWVvygfngcevddvhyydpvqdkWTQVETFGVRPSERSVFASAAVGKHI 380


                 ....*
gi 296434227 252 TLFFG 256
Cdd:PLN02193 381 VIFGG 385
Kelch_3 pfam13415
Galactose oxidase, central domain;
129-181 2.76e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.20  E-value: 2.76e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 296434227  129 KRQLILFGGFHESTRDYiyYNDVYAFNLDTFTWSKLspsGTGPTPRSGCQMSV 181
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR--LNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
38-285 1.53e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 105.24  E-value: 1.53e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227  38 NELYVYNTRKDTWTKVDiPSPPPRRCAHQAVVVpqgGGQLWVFGGEFASPNGEQFyhYKDLWVLHLATKTWEQVKSTggP 117
Cdd:COG3055   38 NSFEVYDPATNTWSELA-PLPGPPRHHAAAVAQ---DGKLYVFGGFTGANPSSTP--LNDVYVYDPATNTWTKLAPM--P 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 118 SGRSGHRMVAWKRQLILFGGFHESTrdyiYYNDVYAFNLDTFTWSKLSPSgtgPTPRSGCQMSVTPQGGIVVYGGyskqr 197
Cdd:COG3055  110 TPRGGATALLLDGKIYVVGGWDDGG----NVAWVEVYDPATGTWTQLAPL---PTPRDHLAAAVLPDGKILVIGG----- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 198 vkkdvdkgtRHSDMFLLKpedgredkwvWTRMNPSgvkPTPRSGFSVAmAPNHQTLFFGGvcdeeeeeslSGEFFNDLYF 277
Cdd:COG3055  178 ---------RNGSGFSNT----------WTTLAPL---PTARAGHAAA-VLGGKILVFGG----------ESGFSDEVEA 224


                 ....*...
gi 296434227 278 YDATRNRW 285
Cdd:COG3055  225 YDPATNTW 232
PLN02193 PLN02193
nitrile-specifier protein
 50-256 9.50e-17

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 82.31  E-value: 9.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227  50 WTKVDIPSPPP-RRCAHQavvVPQGGGQLWVFGGEFaSPNGEQFYHykdLWVLHLATKTWEQVKSTGGPSGRS--GHRMV 126
Cdd:PLN02193 153 WIKVEQKGEGPgLRCSHG---IAQVGNKIYSFGGEF-TPNQPIDKH---LYVFDLETRTWSISPATGDVPHLSclGVRMV 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 127 AWKRQLILFGGFHESTRdyiyYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQgGIVVYGGYS-KQRVK-----K 200
Cdd:PLN02193 226 SIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEE-NVYVFGGVSaTARLKtldsyN 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 201 DVDKGTRH----SDMFLLKPEDGRE----DKWV---------------------WTRMNPSGVKPTPRSGFSVAMAPNHQ 251
Cdd:PLN02193 301 IVDKKWFHcstpGDSFSIRGGAGLEvvqgKVWVvygfngcevddvhyydpvqdkWTQVETFGVRPSERSVFASAAVGKHI 380


                 ....*
gi 296434227 252 TLFFG 256
Cdd:PLN02193 381 VIFGG 385
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
29-196 7.29e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 74.81  E-value: 7.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227  29 SRKEETFLYNELYVYNTRKDTWTKvdIPSPPPRRCAHQAVVVpqgGGQLWVFGGEFASPngeqfyHYKDLWVLHLATKTW 108
Cdd:COG3055   81 GANPSSTPLNDVYVYDPATNTWTK--LAPMPTPRGGATALLL---DGKIYVVGGWDDGG------NVAWVEVYDPATGTW 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 109 EQVKS--------------------TGG----------------PSGRSGHRMVAWKRQLILFGGFHEstrdyiYYNDVY 152
Cdd:COG3055  150 TQLAPlptprdhlaaavlpdgkilvIGGrngsgfsntwttlaplPTARAGHAAAVLGGKILVFGGESG------FSDEVE 223

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 296434227 153 AFNLDTFTWSKLspsGTGPTPRSGcQMSVTPQGGIVVYGGYSKQ 196
Cdd:COG3055  224 AYDPATNTWTAL---GELPTPRHG-HAAVLTDGKVYVIGGETKP 263
PLN02153 PLN02153
epithiospecifier protein
 39-285 3.94e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 64.24  E-value: 3.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227  39 ELYVYNTRKDTWTKVDIPSPPPRrCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLwvlhlaTKTWE---QVKSTG 115
Cdd:PLN02153  51 DLYVFDFNTHTWSIAPANGDVPR-ISCLGVRMVAVGTKLYIFGGRDEKREFSDFYSYDTV------KNEWTfltKLDEEG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 116 GPSGRSGHRMVAWKRQLILFGGFHES--TRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTpQGGIVVYGGY 193
Cdd:PLN02153 124 GPEARTFHSMASDENHVYVFGGVSKGglMKTPERFRTIEAYNIADGKWVQLPDPGENFEKRGGAGFAVV-QGKIWVVYGF 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 194 SKQRVKKDVDKGTRHSDMFLlKPEDGRedkwvWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFN 273
Cdd:PLN02153 203 ATSILPGGKSDYESNAVQFF-DPASGK-----WTEVETTGAKPSARSVFAHAVVGKYIIIFGGEVWPDLKGHLGPGTLSN 276

                        250
                 ....*....|..
gi 296434227 274 DLYFYDATRNRW 285
Cdd:PLN02153 277 EGYALDTETLVW 288
PLN02153 PLN02153
epithiospecifier protein
 45-294 3.62e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 58.07  E-value: 3.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227  45 TRKDTWTKVDIP--SPPPRRCAHQAVVVpqgGGQLWVFGGEFaSPNgeqFYHYKDLWVLHLATKTWEQVKSTGGPSGRS- 121
Cdd:PLN02153   4 TLQGGWIKVEQKggKGPGPRCSHGIAVV---GDKLYSFGGEL-KPN---EHIDKDLYVFDFNTHTWSIAPANGDVPRISc 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 122 -GHRMVAWKRQLILFGGFHESTRdyiyYNDVYAFNLDTFTW---SKLSPSGtGPTPRSGCQMSvTPQGGIVVYGGYSKQR 197
Cdd:PLN02153  77 lGVRMVAVGTKLYIFGGRDEKRE----FSDFYSYDTVKNEWtflTKLDEEG-GPEARTFHSMA-SDENHVYVFGGVSKGG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 198 VKKdvdKGTRHSDMFLLKPEDGRedkwvWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEfFNDLYF 277
Cdd:PLN02153 151 LMK---TPERFRTIEAYNIADGK-----WVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFATSILPGGKSDYE-SNAVQF 221

                        250
                 ....*....|....*..
gi 296434227 278 YDATRNRWFEGQLKGPK 294
Cdd:PLN02153 222 FDPASGKWTEVETTGAK 238
Kelch_3 pfam13415
Galactose oxidase, central domain;
129-181 2.76e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.20  E-value: 2.76e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 296434227  129 KRQLILFGGFHESTRDYiyYNDVYAFNLDTFTWSKLspsGTGPTPRSGCQMSV 181
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR--LNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
PLN02153 PLN02153
epithiospecifier protein
 25-192 4.85e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 48.44  E-value: 4.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227  25 VSKRSRKEETFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGggQLWVFGGeFAS---PNGEQFYHYKDLWVL 101
Cdd:PLN02153 146 VSKGGLMKTPERFRTIEAYNIADGKWVQLPDPGENFEKRGGAGFAVVQG--KIWVVYG-FATsilPGGKSDYESNAVQFF 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 102 HLATKTWEQVKSTGG-PSGRSGHRMVAWKRQLILFGGfhESTRDY-------IYYNDVYAFNLDTFTWSKLSPSGTGPTP 173
Cdd:PLN02153 223 DPASGKWTEVETTGAkPSARSVFAHAVVGKYIIIFGG--EVWPDLkghlgpgTLSNEGYALDTETLVWEKLGECGEPAMP 300

                        170       180
                 ....*....|....*....|..
gi 296434227 174 R---SGCQMSVTPQGGIVVYGG 192
Cdd:PLN02153 301 RgwtAYTTATVYGKNGLLMHGG 322
Kelch_3 pfam13415
Galactose oxidase, central domain;
74-127 6.67e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.05  E-value: 6.67e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 296434227   74 GGQLWVFGGEFASPNGeqfyHYKDLWVLHLATKTWEQVKSTggPSGRSGHRMVA 127
Cdd:pfam13415   1 GDKLYIFGGLGFDGQT----RLNDLYVYDLDTNTWTQIGDL--PPPRSGHSATY 48
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 117-159 8.55e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 42.55  E-value: 8.55e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 296434227  117 PSGRSGHRMVAWKRQLILFGGFheSTRDYIYYNDVYAFNLDTF 159
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGY--TGGEGQPSDDVYVLSLPTF 41
Kelch_4 pfam13418
Galactose oxidase, central domain;
119-169 1.59e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 42.21  E-value: 1.59e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 296434227  119 GRSGHRMVAW-KRQLILFGGFhesTRDYIYYNDVYAFNLDTFTWSKLSPSGT 169
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGE---GEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
160-288 4.54e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 45.15  E-value: 4.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 160 TWSKLSPSgtgPTPRSGCQMsVTPQGGIVVYGGYSKqrvkkdvdkGTRHSDMFLLKPEDGRedkwvWTRMNPsgvKPTPR 239
Cdd:COG3055    2 TWSSLPDL---PTPRSEAAA-ALLDGKVYVAGGLSG---------GSASNSFEVYDPATNT-----WSELAP---LPGPP 60

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 296434227 240 SGFSVAMAPNHQTLFFGGvcdeEEEESLSGEFFNDLYFYDATRNRWFEG 288
Cdd:COG3055   61 RHHAAAVAQDGKLYVFGG----FTGANPSSTPLNDVYVYDPATNTWTKL 105
PRK14131 PRK14131
N-acetylneuraminate epimerase;
106-256 9.84e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.62  E-value: 9.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 106 KTWEQVKS-TGGPsgRSGHRMVAWKRQLILFGGFHESTRD--YIYYNDVYAFNLDTFTWSKL---SPSGTgptprSGcQM 179
Cdd:PRK14131  62 KGWTKIAAfPGGP--REQAVAAFIDGKLYVFGGIGKTNSEgsPQVFDDVYKYDPKTNSWQKLdtrSPVGL-----AG-HV 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 180 SVTPQGG-IVVYGGYSKQ----------RVKKDVDKGTR-HSDMFLLKPEDgredkWVWTR----MNPS-------GVKP 236
Cdd:PRK14131 134 AVSLHNGkAYITGGVNKNifdgyfedlaAAGKDKTPKDKiNDAYFDKKPED-----YFFNKevlsYDPStnqwknaGESP 208

                        170       180
                 ....*....|....*....|.
gi 296434227 237 -TPRSGFSVAMAPNHQTLFFG 256
Cdd:PRK14131 209 fLGTAGSAVVIKGNKLWLING 229
Kelch_4 pfam13418
Galactose oxidase, central domain;
60-113 2.35e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.75  E-value: 2.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 296434227   60 PRRCaHQAVVVPqgGGQLWVFGGEfaSPNGEQfyhYKDLWVLHLATKTWEQVKS 113
Cdd:pfam13418   1 PRAY-HTSTSIP--DDTIYLFGGE--GEDGTL---LSDLWVFDLSTNEWTRLGS 46
Kelch_6 pfam13964
Kelch motif;
62-111 3.69e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 3.69e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 296434227   62 RCAHQAVVVpqgGGQLWVFGGefaspNGEQFYHYKDLWVLHLATKTWEQV 111
Cdd:pfam13964   2 RTFHSVVSV---GGYIYVFGG-----YTNASPALNKLEVYNPLTKSWEEL 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 120-166 6.53e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 6.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 296434227  120 RSGHRMVAWKRQLILFGGFHESTRDyiyyNDVYAFNLDTFTWSKLSP 166
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSL----NSVEVYDPETNTWSKLPS 44
PRK14131 PRK14131
N-acetylneuraminate epimerase;
25-195 1.38e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.77  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227  25 VSKRSRKEETFLYNELYVYNTRKDTWTKVDipSPPPRRCAHQAVVVPQgGGQLWVFGGEfaspNGEQFYHYkdlwvlhla 104
Cdd:PRK14131  93 IGKTNSEGSPQVFDDVYKYDPKTNSWQKLD--TRSPVGLAGHVAVSLH-NGKAYITGGV----NKNIFDGY--------- 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227 105 tktWEQVKSTGGPSGrsghrmvawKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLspsgtGPTPRSG-CQMSVTP 183
Cdd:PRK14131 157 ---FEDLAAAGKDKT---------PKDKINDAYFDKKPEDYFFNKEVLSYDPSTNQWKNA-----GESPFLGtAGSAVVI 219

                        170
                 ....*....|...
gi 296434227 184 QGG-IVVYGGYSK 195
Cdd:PRK14131 220 KGNkLWLINGEIK 232
Kelch_4 pfam13418
Galactose oxidase, central domain;
173-229 1.79e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.44  E-value: 1.79e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 296434227  173 PRSGCQMSVTPQGGIVVYGGYSkqrvkkdvDKGTRHSDMFLLKPEDGRedkwvWTRM 229
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEG--------EDGTLLSDLWVFDLSTNE-----WTRL 44
Kelch_3 pfam13415
Galactose oxidase, central domain;
37-70 1.80e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 1.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 296434227   37 YNELYVYNTRKDTWTKVDiPSPPPRRCaHQAVVV 70
Cdd:pfam13415  18 LNDLYVYDLDTNTWTQIG-DLPPPRSG-HSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
50-153 5.52e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 38.84  E-value: 5.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434227  50 WTKV-DIPSPPpRRCAHQAVVvpqgGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKsTGGPSGRSGHRMVAW 128
Cdd:PRK14131  64 WTKIaAFPGGP-REQAVAAFI----DGKLYVFGGIGKTNSEGSPQVFDDVYKYDPKTNSWQKLD-TRSPVGLAGHVAVSL 137

                         90       100
                 ....*....|....*....|....*.
gi 296434227 129 -KRQLILFGGFHESTRDYiYYNDVYA 153
Cdd:PRK14131 138 hNGKAYITGGVNKNIFDG-YFEDLAA 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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