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Conserved domains on  [gi|296011057|ref|NP_001171618|]
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granulocyte colony-stimulating factor isoform d precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL6 super family cl02473
Interleukin-6/G-CSF/MGF family;
51-163 1.56e-60

Interleukin-6/G-CSF/MGF family;


The actual alignment was detected with superfamily member pfam16647:

Pssm-ID: 413331  Cd Length: 149  Bit Score: 184.43  E-value: 1.56e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296011057   51 VRKIQGDGAALQEKL------------------------------------AGCLSQLHSGLFLYQGLLQALEGISPELG 94
Cdd:pfam16647   1 VRKIQADGAVLQEQLcatyklchpeelvllghslgipkaplsscssqalqlTGCLSQLHSGLFLYQGLLQALSGISPELA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 296011057   95 PTLDTLQLDVADFATTIWQQMEELGMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLR 163
Cdd:pfam16647  81 PTLDTLQLDVADFATTIWQQMENLGVAPAVQPTQGAMPAFTSAFQRRAGGVLVASYLQGFLETAYRALR 149
 
Name Accession Description Interval E-value
GCSF pfam16647
Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte ...
 51-163 1.56e-60

Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte colony-stimulating factor proteins. Granulocyte colony-stimulating factors are cytokines that are involved in haematopoeisis. They control the production, differentiation and function of white blood cell granulocytes. GCSF binds to the extracellular Ig-like and CRH domain of its receptor GCSFR, thereby triggering the receptor to homodimerize. Homodimerization result in activation of Janus tyrosine kinase-signal transducers and other activators of transcription (JAK-STAT)-type signalling cascades.


Pssm-ID: 406939  Cd Length: 149  Bit Score: 184.43  E-value: 1.56e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296011057   51 VRKIQGDGAALQEKL------------------------------------AGCLSQLHSGLFLYQGLLQALEGISPELG 94
Cdd:pfam16647   1 VRKIQADGAVLQEQLcatyklchpeelvllghslgipkaplsscssqalqlTGCLSQLHSGLFLYQGLLQALSGISPELA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 296011057   95 PTLDTLQLDVADFATTIWQQMEELGMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLR 163
Cdd:pfam16647  81 PTLDTLQLDVADFATTIWQQMENLGVAPAVQPTQGAMPAFTSAFQRRAGGVLVASYLQGFLETAYRALR 149
IL6 smart00126
Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and ...
 65-163 6.33e-31

Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and myelomonocytic growth factor (MGF). IL-6 is also known as B-cell stimulatory factor 2.


Pssm-ID: 128431  Cd Length: 154  Bit Score: 109.41  E-value: 6.33e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296011057    65 LAGCLSQLHSGLFLYQGLLQALEGISPELGPTLDTLQLDVADFATTIWQQMEELGM--APALQPTQGAMPAFASAFQ--R 140
Cdd:smart00126  52 QEICLVKITAGLLEYQVYLEYLQNEFPENKENVDTLQLDTKTLIQIIQQEMKDLGKitYPTPTANRGLLPKLQSQNQwvR 131

                           90       100
                   ....*....|....*....|...
gi 296011057   141 RAGGVLVASHLQSFLEVSYRVLR 163
Cdd:smart00126 132 NATGFLILSSLERFLQFALRALR 154
 
Name Accession Description Interval E-value
GCSF pfam16647
Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte ...
 51-163 1.56e-60

Granulocyte colony-stimulating factor; GCSF is a family of higher eukaryotic granulocyte colony-stimulating factor proteins. Granulocyte colony-stimulating factors are cytokines that are involved in haematopoeisis. They control the production, differentiation and function of white blood cell granulocytes. GCSF binds to the extracellular Ig-like and CRH domain of its receptor GCSFR, thereby triggering the receptor to homodimerize. Homodimerization result in activation of Janus tyrosine kinase-signal transducers and other activators of transcription (JAK-STAT)-type signalling cascades.


Pssm-ID: 406939  Cd Length: 149  Bit Score: 184.43  E-value: 1.56e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296011057   51 VRKIQGDGAALQEKL------------------------------------AGCLSQLHSGLFLYQGLLQALEGISPELG 94
Cdd:pfam16647   1 VRKIQADGAVLQEQLcatyklchpeelvllghslgipkaplsscssqalqlTGCLSQLHSGLFLYQGLLQALSGISPELA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 296011057   95 PTLDTLQLDVADFATTIWQQMEELGMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLR 163
Cdd:pfam16647  81 PTLDTLQLDVADFATTIWQQMENLGVAPAVQPTQGAMPAFTSAFQRRAGGVLVASYLQGFLETAYRALR 149
IL6 smart00126
Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and ...
 65-163 6.33e-31

Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and myelomonocytic growth factor (MGF). IL-6 is also known as B-cell stimulatory factor 2.


Pssm-ID: 128431  Cd Length: 154  Bit Score: 109.41  E-value: 6.33e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296011057    65 LAGCLSQLHSGLFLYQGLLQALEGISPELGPTLDTLQLDVADFATTIWQQMEELGM--APALQPTQGAMPAFASAFQ--R 140
Cdd:smart00126  52 QEICLVKITAGLLEYQVYLEYLQNEFPENKENVDTLQLDTKTLIQIIQQEMKDLGKitYPTPTANRGLLPKLQSQNQwvR 131

                           90       100
                   ....*....|....*....|...
gi 296011057   141 RAGGVLVASHLQSFLEVSYRVLR 163
Cdd:smart00126 132 NATGFLILSSLERFLQFALRALR 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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