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Conserved domains on  [gi|268840382|ref|NP_001161403|]
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interleukin-1 receptor accessory protein isoform 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig3_IL1RAP cd20931
Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members ...
 243-349 4.14e-77

Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members here are composed of the third immunoglobulin Ig interleukin-1 receptor accessory protein (IL1RAP). The interleukin 1 receptor accessory protein (IL-1RAP), also known as IL-1R3, is a coreceptor of type 1 interleukin 1 receptor (IL-1R1) and is required for transmission of IL-1 signaling. The activated IL-1 receptor complex, which consists of IL-1R1 and IL-1RAP, induces multiple cellular responses including NF-kappa-B activation, IL-2 secretion, and IL-2 promoter activation. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective Toll/IL-1 receptor (TIR) domains of the receptor/coreceptor subunits. Moreover, IL1RAP is known to be the accessory co-receptor that activates signal transduction upon IL-36 binding to IL-36R. IL-36 cytokines, which are a subfamily of the IL-1 superfamily, bind to the IL-36 receptor (IL-36R) and use IL1RAP as a co-receptor.


:

Pssm-ID: 409525  Cd Length: 107  Bit Score: 241.85  E-value: 4.14e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 243 PVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVT 322
Cdd:cd20931    1 PQIYSPNDRVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDVTIDVTINESISYSSTEDETRTQILSIKKVT 80

                         90       100
                 ....*....|....*....|....*..
gi 268840382 323 SEDLKRSYVCHARSAKGEVAKAAKVKQ 349
Cdd:cd20931   81 PEDLKRNYVCHARNAKGEVEKAAKVKQ 107
Ig1_IL1R_like cd20992
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 25-132 1.44e-73

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


:

Pssm-ID: 409584  Cd Length: 108  Bit Score: 232.51  E-value: 1.44e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382  25 DDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPT 104
Cdd:cd20992    1 DDWGLDTMRQIQVFEGEPARIKCPLFEHFLKYNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPDNRISKEKDVLWFRPT 80

                         90       100
                 ....*....|....*....|....*...
gi 268840382 105 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 132
Cdd:cd20992   81 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 108
Ig2_IL-1RAP_like cd20993
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 143-235 1.47e-53

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


:

Pssm-ID: 409585  Cd Length: 93  Bit Score: 178.94  E-value: 1.47e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 143 KLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRT 222
Cdd:cd20993    1 KPTPVIAYIEYGGRTITCPDLDGIKPPSVSPTVTWYHECNAFGNFNDRVPKGDKLVIHVMLEHYQGNYTCVVTYETKGRT 80

                         90
                 ....*....|...
gi 268840382 223 FHLTRTLTVKVVG 235
Cdd:cd20993   81 IKLTRTVNVKVVG 93
TIR smart00255
Toll - interleukin 1 - resistance;
404-547 1.22e-21

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 91.23  E-value: 1.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382   404 EYDIYVSYARNaeeEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVLSPDYVtEKSISMLEF 483
Cdd:smart00255   1 EYDVFISYSGK---EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYA-ESEWCLDEL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268840382   484 KLGVMCQNSI-ATKLIVVEYRPLE---HPHPGILQLKESVSFVSWKGEKSKhsgsKFWKALRLALPLR 547
Cdd:smart00255  77 VAALENALEEgGLRVIPIFYEVIPsdvRKQPGKFRKVFKKNYLKWPEDEKE----QFWKKALYAVPSK 140
 
Name Accession Description Interval E-value
Ig3_IL1RAP cd20931
Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members ...
 243-349 4.14e-77

Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members here are composed of the third immunoglobulin Ig interleukin-1 receptor accessory protein (IL1RAP). The interleukin 1 receptor accessory protein (IL-1RAP), also known as IL-1R3, is a coreceptor of type 1 interleukin 1 receptor (IL-1R1) and is required for transmission of IL-1 signaling. The activated IL-1 receptor complex, which consists of IL-1R1 and IL-1RAP, induces multiple cellular responses including NF-kappa-B activation, IL-2 secretion, and IL-2 promoter activation. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective Toll/IL-1 receptor (TIR) domains of the receptor/coreceptor subunits. Moreover, IL1RAP is known to be the accessory co-receptor that activates signal transduction upon IL-36 binding to IL-36R. IL-36 cytokines, which are a subfamily of the IL-1 superfamily, bind to the IL-36 receptor (IL-36R) and use IL1RAP as a co-receptor.


Pssm-ID: 409525  Cd Length: 107  Bit Score: 241.85  E-value: 4.14e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 243 PVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVT 322
Cdd:cd20931    1 PQIYSPNDRVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDVTIDVTINESISYSSTEDETRTQILSIKKVT 80

                         90       100
                 ....*....|....*....|....*..
gi 268840382 323 SEDLKRSYVCHARSAKGEVAKAAKVKQ 349
Cdd:cd20931   81 PEDLKRNYVCHARNAKGEVEKAAKVKQ 107
Ig1_IL1R_like cd20992
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 25-132 1.44e-73

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409584  Cd Length: 108  Bit Score: 232.51  E-value: 1.44e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382  25 DDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPT 104
Cdd:cd20992    1 DDWGLDTMRQIQVFEGEPARIKCPLFEHFLKYNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPDNRISKEKDVLWFRPT 80

                         90       100
                 ....*....|....*....|....*...
gi 268840382 105 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 132
Cdd:cd20992   81 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 108
Ig2_IL-1RAP_like cd20993
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 143-235 1.47e-53

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409585  Cd Length: 93  Bit Score: 178.94  E-value: 1.47e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 143 KLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRT 222
Cdd:cd20993    1 KPTPVIAYIEYGGRTITCPDLDGIKPPSVSPTVTWYHECNAFGNFNDRVPKGDKLVIHVMLEHYQGNYTCVVTYETKGRT 80

                         90
                 ....*....|...
gi 268840382 223 FHLTRTLTVKVVG 235
Cdd:cd20993   81 IKLTRTVNVKVVG 93
TIR smart00255
Toll - interleukin 1 - resistance;
404-547 1.22e-21

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 91.23  E-value: 1.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382   404 EYDIYVSYARNaeeEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVLSPDYVtEKSISMLEF 483
Cdd:smart00255   1 EYDVFISYSGK---EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYA-ESEWCLDEL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268840382   484 KLGVMCQNSI-ATKLIVVEYRPLE---HPHPGILQLKESVSFVSWKGEKSKhsgsKFWKALRLALPLR 547
Cdd:smart00255  77 VAALENALEEgGLRVIPIFYEVIPsdvRKQPGKFRKVFKKNYLKWPEDEKE----QFWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 405-541 2.89e-21

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 91.27  E-value: 2.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382  405 YDIYVSYARNAEEEEFVLLTLRGVleNEFGYKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVLSPDYVTEKSiSMLEFK 484
Cdd:pfam01582   1 YDVFLSFRGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGW-CLDELV 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268840382  485 LGVMCQNSIATKLIVVEYRPLEHP-----------HPGILQLKESVSFVSWKGE----------KSKHSGSKFWKALR 541
Cdd:pfam01582  78 KILECALDLGQKVIPIFYEVDPSDvrkqtgsfgkaFKKHKKVLTEEKVLKWRGAlnevaniwhsKSVSDESKFWKKIA 155
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 8-334 5.95e-12

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 67.35  E-value: 5.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382   8 VSLYFYG-ILQSDASERCDDWGLdTMRQIQVFEDEPARIKCPlfehflKFNYSTAHSAGLTLIWYWTRQDRDLEEPINfr 86
Cdd:PHA02785   9 LPIFFYSsFVQTFNAPECIDKGQ-YFASFMELENEPVILPCP------QINTLSSGYNILDILWEKRGADNDRIIPID-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382  87 lpenrisKEKDVLWFRPTLlNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPvhKLYIEYGIQRITCPNVDGY 166
Cdd:PHA02785  80 -------NGSNMLILNPTQ-SDSGIYICITKNETYCDMMSLNLTIVSVSESNIDLISYP--QIVNERSTGEMVCPNINAF 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 167 FPSSVKPTITWyMGCYKIQNFN-NVIPEGMnlsFLIALISNN--GNYTCVVTYPENGRTFHLTRTLTVKVvgsPKNAVPP 243
Cdd:PHA02785 150 IASNVNADIIW-SGHRRLRNKRlKQRTPGI---ITIEDVRKNdaGYYTCVLKYIYGDKTYNVTRIVKLEV---RDRIIPP 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 244 VIHSPNDHVVyekEPGEELLIPCTVYFSfLMDSRNEVWWTIDGKKPDDITIDVTINESISHS-RTEDETR--TQILSIKK 320
Cdd:PHA02785 223 TMQLPEGVVT---SIGSNLTIACRVSLR-PPTTDADVFWISNGMYYEEDDEDGDGRISVANKiYTTDKRRviTSRLNINP 298

                        330
                 ....*....|....
gi 268840382 321 VTSEDlKRSYVCHA 334
Cdd:PHA02785 299 VKEED-ATTFTCMA 311
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 70-140 3.82e-06

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 46.64  E-value: 3.82e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268840382   70 WYWTRQDRDLEEPINFRLPEnrISKEKDVLWFRPTLLNDTGNYTCMLRNTTY-----CSKVAfpLEVVQKD--SCFNS 140
Cdd:pfam18452  48 WYWQPKNGDPLEAITESSPH--IIQEGNALWFLPVGVNDSGSYICRPRIRSPqdeacCLKII--LEVQPKTnaSCSGS 121
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 168-233 1.84e-05

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 43.15  E-value: 1.84e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 268840382  168 PSSVKPTITWYMGcykiqnfNNVIPEGMNLSFLIALISNNGNYTCVVTypeNGRTFHLTRTLTVKV 233
Cdd:pfam13895  24 PGNPPPSYTWYKD-------GSAISSSPNFFTLSVSAEDSGTYTCVAR---NGRGGKVSNPVELTV 79
 
Name Accession Description Interval E-value
Ig3_IL1RAP cd20931
Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members ...
 243-349 4.14e-77

Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP); The members here are composed of the third immunoglobulin Ig interleukin-1 receptor accessory protein (IL1RAP). The interleukin 1 receptor accessory protein (IL-1RAP), also known as IL-1R3, is a coreceptor of type 1 interleukin 1 receptor (IL-1R1) and is required for transmission of IL-1 signaling. The activated IL-1 receptor complex, which consists of IL-1R1 and IL-1RAP, induces multiple cellular responses including NF-kappa-B activation, IL-2 secretion, and IL-2 promoter activation. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective Toll/IL-1 receptor (TIR) domains of the receptor/coreceptor subunits. Moreover, IL1RAP is known to be the accessory co-receptor that activates signal transduction upon IL-36 binding to IL-36R. IL-36 cytokines, which are a subfamily of the IL-1 superfamily, bind to the IL-36 receptor (IL-36R) and use IL1RAP as a co-receptor.


Pssm-ID: 409525  Cd Length: 107  Bit Score: 241.85  E-value: 4.14e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 243 PVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVT 322
Cdd:cd20931    1 PQIYSPNDRVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDVTIDVTINESISYSSTEDETRTQILSIKKVT 80

                         90       100
                 ....*....|....*....|....*..
gi 268840382 323 SEDLKRSYVCHARSAKGEVAKAAKVKQ 349
Cdd:cd20931   81 PEDLKRNYVCHARNAKGEVEKAAKVKQ 107
Ig1_IL1R_like cd20992
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 25-132 1.44e-73

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409584  Cd Length: 108  Bit Score: 232.51  E-value: 1.44e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382  25 DDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPT 104
Cdd:cd20992    1 DDWGLDTMRQIQVFEGEPARIKCPLFEHFLKYNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPDNRISKEKDVLWFRPT 80

                         90       100
                 ....*....|....*....|....*...
gi 268840382 105 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 132
Cdd:cd20992   81 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 108
Ig2_IL-1RAP_like cd20993
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 143-235 1.47e-53

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409585  Cd Length: 93  Bit Score: 178.94  E-value: 1.47e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 143 KLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRT 222
Cdd:cd20993    1 KPTPVIAYIEYGGRTITCPDLDGIKPPSVSPTVTWYHECNAFGNFNDRVPKGDKLVIHVMLEHYQGNYTCVVTYETKGRT 80

                         90
                 ....*....|...
gi 268840382 223 FHLTRTLTVKVVG 235
Cdd:cd20993   81 IKLTRTVNVKVVG 93
Ig1_IL1R_like cd05756
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 25-132 2.87e-44

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409414  Cd Length: 96  Bit Score: 153.73  E-value: 2.87e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382  25 DDWGLDtMRQIQVFEDEPARIKCPLFEHFLkfnystAHSAGLTLIWYWTrqdrDLEEPINFRlPENRISKEKDVLWFRPT 104
Cdd:cd05756    1 DEWGED-IKILVVLEGEPDVIKCPLFPNFL------AQSAGLNLTWYKN----DSETPISFE-PDSRIHQEKDKLWFVPA 68

                         90       100
                 ....*....|....*....|....*...
gi 268840382 105 LLNDTGNYTCMLRNTTYCSKVAFPLEVV 132
Cdd:cd05756   69 LLEDSGNYYCVVRNSTYCSKVSISLEVV 96
Ig1_IL1RAPL-1_like cd05896
First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory ...
 26-131 1.10e-32

First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. IL1RAPL is encoded by a gene on the X-chromosome, this gene is wholly or partially deleted in multiple cases of non-syndromic intellectual disability. This group also contains IL1RAPL-2 which is also encoded by a gene on the X-chromosome and is a candidate for another non-syndromic intellectual disability loci.


Pssm-ID: 409477  Cd Length: 105  Bit Score: 121.59  E-value: 1.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382  26 DWGLDtMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFrlPENRISKEKDVLWFRPTL 105
Cdd:cd05896    2 DWSVD-LKKYMVLAGEPVRIKCALFYGYIRTNYSMAQSAGLSLMWYKSSGPGDFEEPIIF--DGVRMSKEEDSIWFRPAE 78

                         90       100
                 ....*....|....*....|....*.
gi 268840382 106 LNDTGNYTCMLRNTTYCSKVAFPLEV 131
Cdd:cd05896   79 LQDSGLYTCVLRNSTYCMKVSMSLTV 104
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 143-235 2.13e-31

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 117.43  E-value: 2.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 143 KLPVHKLYIEYGiQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRT 222
Cdd:cd05757    1 PRYKQKLPITKG-GKITCPDLDDYKNENVLPPIQWYKDCKPLQGDKRFIPKGSKLLIQNVTEEDAGNYTCKFTYTHNGKQ 79

                         90
                 ....*....|...
gi 268840382 223 FHLTRTLTVKVVG 235
Cdd:cd05757   80 YNVTRTISLTVTE 92
TIR smart00255
Toll - interleukin 1 - resistance;
404-547 1.22e-21

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 91.23  E-value: 1.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382   404 EYDIYVSYARNaeeEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVLSPDYVtEKSISMLEF 483
Cdd:smart00255   1 EYDVFISYSGK---EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYA-ESEWCLDEL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268840382   484 KLGVMCQNSI-ATKLIVVEYRPLE---HPHPGILQLKESVSFVSWKGEKSKhsgsKFWKALRLALPLR 547
Cdd:smart00255  77 VAALENALEEgGLRVIPIFYEVIPsdvRKQPGKFRKVFKKNYLKWPEDEKE----QFWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 405-541 2.89e-21

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 91.27  E-value: 2.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382  405 YDIYVSYARNAEEEEFVLLTLRGVleNEFGYKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVLSPDYVTEKSiSMLEFK 484
Cdd:pfam01582   1 YDVFLSFRGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGW-CLDELV 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268840382  485 LGVMCQNSIATKLIVVEYRPLEHP-----------HPGILQLKESVSFVSWKGE----------KSKHSGSKFWKALR 541
Cdd:pfam01582  78 KILECALDLGQKVIPIFYEVDPSDvrkqtgsfgkaFKKHKKVLTEEKVLKWRGAlnevaniwhsKSVSDESKFWKKIA 155
PHA02785 PHA02785
IL-beta-binding protein; Provisional
 8-334 5.95e-12

IL-beta-binding protein; Provisional


Pssm-ID: 165149 [Multi-domain]  Cd Length: 326  Bit Score: 67.35  E-value: 5.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382   8 VSLYFYG-ILQSDASERCDDWGLdTMRQIQVFEDEPARIKCPlfehflKFNYSTAHSAGLTLIWYWTRQDRDLEEPINfr 86
Cdd:PHA02785   9 LPIFFYSsFVQTFNAPECIDKGQ-YFASFMELENEPVILPCP------QINTLSSGYNILDILWEKRGADNDRIIPID-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382  87 lpenrisKEKDVLWFRPTLlNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPvhKLYIEYGIQRITCPNVDGY 166
Cdd:PHA02785  80 -------NGSNMLILNPTQ-SDSGIYICITKNETYCDMMSLNLTIVSVSESNIDLISYP--QIVNERSTGEMVCPNINAF 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 167 FPSSVKPTITWyMGCYKIQNFN-NVIPEGMnlsFLIALISNN--GNYTCVVTYPENGRTFHLTRTLTVKVvgsPKNAVPP 243
Cdd:PHA02785 150 IASNVNADIIW-SGHRRLRNKRlKQRTPGI---ITIEDVRKNdaGYYTCVLKYIYGDKTYNVTRIVKLEV---RDRIIPP 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 244 VIHSPNDHVVyekEPGEELLIPCTVYFSfLMDSRNEVWWTIDGKKPDDITIDVTINESISHS-RTEDETR--TQILSIKK 320
Cdd:PHA02785 223 TMQLPEGVVT---SIGSNLTIACRVSLR-PPTTDADVFWISNGMYYEEDDEDGDGRISVANKiYTTDKRRviTSRLNINP 298

                        330
                 ....*....|....
gi 268840382 321 VTSEDlKRSYVCHA 334
Cdd:PHA02785 299 VKEED-ATTFTCMA 311
Ig1_IL1R_like cd20991
First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 67-132 5.64e-10

First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three Ig-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. IL-1 receptor antagonist (IL-1RA), a naturally occurring cytokine, is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.


Pssm-ID: 409583  Cd Length: 91  Bit Score: 56.53  E-value: 5.64e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 268840382  67 TLIWYwtrqDRDLEEPINFRlPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVV 132
Cdd:cd20991   31 TITWY----KNDSKTPISME-QDSRIHQYKEKLWFVPAKVEDSGHYYCVVRNSTYCLKIKITAKFV 91
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 407-473 8.37e-09

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 53.86  E-value: 8.37e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 268840382  407 IYVSYARnaEEEEFVLlTLRGVLENEfGYKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVLSPDYV 473
Cdd:pfam13676   1 VFISYAG--EDRAWAE-WLADALEAA-GYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYL 63
Ig_6 pfam18452
Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 ...
 70-140 3.82e-06

Immunoglobulin domain; This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra). IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.


Pssm-ID: 465773  Cd Length: 128  Bit Score: 46.64  E-value: 3.82e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 268840382   70 WYWTRQDRDLEEPINFRLPEnrISKEKDVLWFRPTLLNDTGNYTCMLRNTTY-----CSKVAfpLEVVQKD--SCFNS 140
Cdd:pfam18452  48 WYWQPKNGDPLEAITESSPH--IIQEGNALWFLPVGVNDSGSYICRPRIRSPqdeacCLKII--LEVQPKTnaSCSGS 121
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 168-233 1.84e-05

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 43.15  E-value: 1.84e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 268840382  168 PSSVKPTITWYMGcykiqnfNNVIPEGMNLSFLIALISNNGNYTCVVTypeNGRTFHLTRTLTVKV 233
Cdd:pfam13895  24 PGNPPPSYTWYKD-------GSAISSSPNFFTLSVSAEDSGTYTCVAR---NGRGGKVSNPVELTV 79
PHA02826 PHA02826
IL-1 receptor-like protein; Provisional
 8-234 4.31e-04

IL-1 receptor-like protein; Provisional


Pssm-ID: 165173 [Multi-domain]  Cd Length: 227  Bit Score: 42.21  E-value: 4.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382   8 VSLYFYGILQ---SDASERCDDWGLDTMRQIQVFEDePARIKCPLfEHFLK---FNYSTAHSAGLTliwyWTRQD----- 76
Cdd:PHA02826   3 VIIFFIIILQfisAFLCLYCKYRGGDLTPVYAKFGD-PMVLLCTG-KHYKKsifFDKTFITSYNVT----WSKTDslafv 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382  77 RDLEEPINFR-LPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEV------VQKDSCFNSpmklpvhkl 149
Cdd:PHA02826  77 RDSGARTKIKkITHNEIGDRSENLWIGNVINIDEGIYICTISSGNICEESTIRLTFdsgtinYQFNSGKDS--------- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 150 yieygiqRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLI--ALISNNGNYTCVVTYPENGRTFHLTR 227
Cdd:PHA02826 148 -------KLHCYGTDGISSTFKDYTLTWYKNGNIVLYTDRIQLRNNNSTLVIksATHDDSGIYTCNLRFNKNSNNYNITK 220


                 ....*..
gi 268840382 228 TLTVKVV 234
Cdd:PHA02826 221 EYKVTII 227
Ig2_IL1R_like cd20994
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 157-235 8.74e-03

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409586  Cd Length: 94  Bit Score: 36.29  E-value: 8.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268840382 157 RITCPNVDgYF--PSSVKPTITWYMGCyKIQNFNNVIPEGMNLSFLI--ALISNNGNYTCVVTYPENGRTFHLTRTLTVK 232
Cdd:cd20994   14 RIVCPHLD-FFkdENNNLPKVQWYKDC-KPLLLDDKRFAGLESDLLIfnVTVQDQGNYTCHTSYTYMGKQYNISRTISLI 91


                 ...
gi 268840382 233 VVG 235
Cdd:cd20994   92 VLE 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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