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Conserved domains on  [gi|258614033|ref|NP_001158253|]
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ataxin-3 isoform y [Homo sapiens]

Protein Classification

ataxin-3 family protein( domain architecture ID 11128249)

ataxin-3 (ATXN3) family protein similar to Homo sapiens ataxin-3 and ataxin-3-like protein

Gene Ontology:  GO:0004843|GO:0016579
PubMed:  34813758

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Josephin pfam02099
Josephin;
5-93 6.84e-43

Josephin;


:

Pssm-ID: 460444  Cd Length: 154  Bit Score: 143.90  E-value: 6.84e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614033    5 FHEKVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQ 84
Cdd:pfam02099  66 FSIQVLEKALEVWGLELVPWRSPEMQDAKDDPETEVGFICNLSQHWFTIRKFGGQWYNLNSLLKAPELISDTYLSAFLDQ 145


                  ....*....
gi 258614033   85 LQQEGYSIF 93
Cdd:pfam02099 146 LEAEGYSIF 154
SUIM_assoc pfam16619
Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on ...
 193-259 2.92e-23

Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on Ataxin 3 proteins that lies immediately C-terminal to the second UIM domain linking it to a third when present. The function is not known. It is rich in glutamine residues.


:

Pssm-ID: 465203  Cd Length: 60  Bit Score: 89.94  E-value: 2.92e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 258614033  193 NISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQqqqqqqgDLSGQSSHPCERPATSSGALGSD 259
Cdd:pfam16619   1 NISQDVPQTSGTSLTSEELRKRREAYFEKQQQQQQQL-------DQPGQSSHPHERPTTSSGALGSD 60
 
Name Accession Description Interval E-value
Josephin pfam02099
Josephin;
5-93 6.84e-43

Josephin;


Pssm-ID: 460444  Cd Length: 154  Bit Score: 143.90  E-value: 6.84e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614033    5 FHEKVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQ 84
Cdd:pfam02099  66 FSIQVLEKALEVWGLELVPWRSPEMQDAKDDPETEVGFICNLSQHWFTIRKFGGQWYNLNSLLKAPELISDTYLSAFLDQ 145


                  ....*....
gi 258614033   85 LQQEGYSIF 93
Cdd:pfam02099 146 LEAEGYSIF 154
SUIM_assoc pfam16619
Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on ...
 193-259 2.92e-23

Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on Ataxin 3 proteins that lies immediately C-terminal to the second UIM domain linking it to a third when present. The function is not known. It is rich in glutamine residues.


Pssm-ID: 465203  Cd Length: 60  Bit Score: 89.94  E-value: 2.92e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 258614033  193 NISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQqqqqqqgDLSGQSSHPCERPATSSGALGSD 259
Cdd:pfam16619   1 NISQDVPQTSGTSLTSEELRKRREAYFEKQQQQQQQL-------DQPGQSSHPHERPTTSSGALGSD 60
 
Name Accession Description Interval E-value
Josephin pfam02099
Josephin;
5-93 6.84e-43

Josephin;


Pssm-ID: 460444  Cd Length: 154  Bit Score: 143.90  E-value: 6.84e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614033    5 FHEKVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQ 84
Cdd:pfam02099  66 FSIQVLEKALEVWGLELVPWRSPEMQDAKDDPETEVGFICNLSQHWFTIRKFGGQWYNLNSLLKAPELISDTYLSAFLDQ 145


                  ....*....
gi 258614033   85 LQQEGYSIF 93
Cdd:pfam02099 146 LEAEGYSIF 154
SUIM_assoc pfam16619
Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on ...
 193-259 2.92e-23

Unstructured region C-term to UIM in Ataxin3; SUIM_assoc is a natively unstructured region on Ataxin 3 proteins that lies immediately C-terminal to the second UIM domain linking it to a third when present. The function is not known. It is rich in glutamine residues.


Pssm-ID: 465203  Cd Length: 60  Bit Score: 89.94  E-value: 2.92e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 258614033  193 NISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQqqqqqqgDLSGQSSHPCERPATSSGALGSD 259
Cdd:pfam16619   1 NISQDVPQTSGTSLTSEELRKRREAYFEKQQQQQQQL-------DQPGQSSHPHERPTTSSGALGSD 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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