|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
10-417 |
0e+00 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 664.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 10 RTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 90 VNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTL 169
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 170 ALSGALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGK-KGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKkKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 249 FFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSNYGNPRHGLLLFMMAGMTVSMYLFRVTVTSDSPK 328
Cdd:cd17343 241 LFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSSE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 329 LWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAAST 408
Cdd:cd17343 321 LFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEILCAITV 400
|
....*....
gi 256219483 409 AAFFLLRNI 417
Cdd:cd17343 401 VILFLLRNI 409
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
18-397 |
8.25e-150 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 430.26 E-value: 8.25e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 18 FGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWS 97
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 98 STVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGP-ILATILAQSYSWRSTLALSGALC 176
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 177 VVVSFLCLLLIHNEPADVGLRNLDPMPSEG--------KKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNEEpdgdaekkEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 249 FFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsNYGNPRHGLLLFMMAGMTVSMYLFRVTVTSDspK 328
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDK--------LFNGRRGPLAVFFMALIIVSLLVYWLNPAAN--P 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256219483 329 LWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAF 397
Cdd:TIGR00881 311 LMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
10-415 |
5.19e-123 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 361.21 E-value: 5.19e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 10 RTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 90 VNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTL 169
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 170 ALSGALCVVVSFLCLLLIHNEPadvglrnldpmpsegkkgslkeestlqelllsPYLWVLSTGYLVVFGVKTCCTDWGQF 249
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP--------------------------------PYVWVLSLAYAFVYIVRYACLDWGPL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 250 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnYGNPRHGLLLFMMAGMTVSMYLFRVTVtsdSPKL 329
Cdd:cd17312 209 YLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL--------FGGRRAPIAVIYMLLMTLSLALFWFFP---HNKL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 330 WILVLGAVFGFSSYGPIALFGVIANESAPP-NLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAAST 408
Cdd:cd17312 278 LSIVLLFLIGFFVGGPINLIGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSV 357
|
....*..
gi 256219483 409 AAFFLLR 415
Cdd:cd17312 358 LLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
4-413 |
5.94e-77 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 245.78 E-value: 5.94e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 4 QGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSG 83
Cdd:PRK11663 15 ARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 84 LLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSY 163
Cdd:PRK11663 95 LIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHY 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 164 SWRSTLALSGALCVVVSFLCLLLIHNEPADVGL------RNlDPMP----SEGKKGSLKEESTlQELLLSPYLWVLSTGY 233
Cdd:PRK11663 175 GWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLpsvgewRH-DALElaqqQEGAGLSRKEILT-KYVLLNPYIWLLSFSY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 234 LVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnYGNPRHGLLLFMMAGMtv 313
Cdd:PRK11663 253 VLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKL--------FNGNRGPMNLIFAAGI-- 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 314 smyLFRVTVTSDSPKLWILVLGAVF---GFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKH 390
Cdd:PRK11663 323 ---LLSVGSLWLMPFASYVMQAACFftiGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEI 399
|
410 420
....*....|....*....|...
gi 256219483 391 YSWsTAFWVAEVICAASTAAFFL 413
Cdd:PRK11663 400 WHW-TGFFVVISIAAGISALLLL 421
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
10-414 |
6.82e-70 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 225.36 E-value: 6.82e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 10 RTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 90 VNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTL 169
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 170 ALSGALCVVVSFLCLLLIHNEPadvglrnldpmpsegkkgslkeestlqelllsPYLWVLSTGYLVVFGVKTCCTDWGQF 249
Cdd:cd17488 161 YVPGIIAILMGIVLCWRLRDRP--------------------------------PYIWLLAFCYVLVYVVRTAINDWGNL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 250 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAkaglsnyGNPRHGLLLFMMAGM--TVSMYLFRVTvtsdsp 327
Cdd:cd17488 209 YLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFK-------GNRGPMNLIFALGLLvsVGALWLVPVH------ 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 328 KLWIL-VLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWStAFWVAEVICAA 406
Cdd:cd17488 276 SYWLLaTCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWS-GFFIVISIAAA 354
|
....*...
gi 256219483 407 STAAFFLL 414
Cdd:cd17488 355 ISGLLLLP 362
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
10-415 |
1.86e-64 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 212.49 E-value: 1.86e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 10 RTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 90 VNIFFA----WSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQ---S 162
Cdd:cd17345 81 INILIGfvpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAifgD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 163 YSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDPM----PSEGKKGSLKEESTLQELLL-----SPYLWVLSTG- 232
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYkgdyPEEADGEEEEQELSAWEIFVkyvlkNKLLWYIAIAn 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 233 ---YLVVFGVktccTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnYGNPRHGLLLFMMA 309
Cdd:cd17345 241 vfvYLVRYGI----LDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKL--------FKGRRAPTGIIFMI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 310 GMTVSMylfrVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGG-FLAGLPFSTIA 388
Cdd:cd17345 309 LVIVAL----IVYWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGsVLATALIGIIV 384
|
410 420
....*....|....*....|....*..
gi 256219483 389 KHYSWSTAFWVAEVICAASTAAFFLLR 415
Cdd:cd17345 385 DHFGWNGGFIVLLASCILAIIFLALVA 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-415 |
7.94e-57 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 191.24 E-value: 7.94e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 3 AQGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSS 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 83 GLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQS 162
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 163 YSWRSTLALSGALCVVVSFLclllihnepadvglrnldpmpsegkkgslkeestlqelllspYLWVLSTGYLVVFGVKTC 242
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL------------------------------------------RFWLLALAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 243 CTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRHGLLLFMMAGMTVSMYLFRVTv 322
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---------LGRRRKLVLAIGLLLAALALLLLALL- 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 323 tsdSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEV 402
Cdd:COG2271 269 ---PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAA 345
|
410
....*....|...
gi 256219483 403 ICAASTAAFFLLR 415
Cdd:COG2271 346 LALLAALLALLLL 358
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
6-399 |
3.90e-47 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 167.71 E-value: 3.90e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 6 YGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEiPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLL 85
Cdd:TIGR00712 21 YKRLRWQVFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSKGELGFALSAISIAYGFSKFIMGSVSDRSNPRVFLPAGLI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 86 LVGLVNIFFA---W-SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATI-LA 160
Cdd:TIGR00712 100 LSAAVMLLMGfvpWaTSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWNCAHNIGGGIPPLLVLLgMA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 161 QSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDP----MPSEGKKGSLKEEST----LQELLLSPYLWVLSTG 232
Cdd:TIGR00712 180 WFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIEEyrndYPDDYNEKAEQELTAkeifMQYVLPNKLLWYIAIA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 233 YLVVFGVKTCCTDWGQFFLIQEKGqSALVGSSYMSAL-EVGGLVGSIAAGYLSDRAM-AKAGLSNYgnprhglllFMMAG 310
Cdd:TIGR00712 260 NVFVYLLRYGVLDWSPTYLKEVKH-FALDKSSWAYFLyEYAGIPGTLLCGWMSDKVFkGNRGATGV---------FFMTL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 311 MTVSMYLFRVTVTSDSpkLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFL-AGLPFSTIAK 389
Cdd:TIGR00712 330 VTIAVIVYWMNPAGNP--LVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVD 407
|
410
....*....|
gi 256219483 390 HYSWSTAFWV 399
Cdd:TIGR00712 408 FFGWDGGFMV 417
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
6-414 |
2.62e-36 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 138.30 E-value: 2.62e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 6 YGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEiPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLL 85
Cdd:PRK11273 23 YRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 86 LVGLVNIFFAW----SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGL-GPILATILA 160
Cdd:PRK11273 102 LAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLpPLLFLLGMA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 161 QSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGL------RNLDPmpsEGKKGSLKEESTLQEL-----LLSPYLWVL 229
Cdd:PRK11273 182 WFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLppieeyKNDYP---DDYNEKHEQELTAKQIfmqyvLPNKLLWYI 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 230 STGYLVVFGVKTCCTDWGQFFLiQEKGQSALVGSSYMSAL-EVGGLVGSIAAGYLSDRAMAkaglsnyGNpRHGLLLFMM 308
Cdd:PRK11273 259 AIANVFVYLLRYGILDWSPTYL-KEVKHFALDKSSWAYFLyEYAGIPGTLLCGWMSDKVFR-------GN-RGATGVFFM 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 309 AGMTVSMYLFRVTvTSDSPKLWILVLGAVfGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGlpfSTI- 387
Cdd:PRK11273 330 TLVTIATIVYWLN-PAGNPTVDMACMIVI-GFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA---SAIv 404
|
410 420 430
....*....|....*....|....*....|
gi 256219483 388 ---AKHYSWSTAFWVaeVICAASTAAFFLL 414
Cdd:PRK11273 405 gytVDFFGWDGGFMV--MIGGSILAVILLI 432
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-415 |
3.08e-36 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 136.93 E-value: 3.08e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 9 YRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVG 88
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 89 LVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRST 168
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 169 LALSGALCVVVSFLCLLLIHNEPADvglrnldpmPSEGKKGSLKeesTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAG---------AAAAAKASLR---DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 249 FFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFrvTVTSDSPK 328
Cdd:COG2223 230 PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-----------GGRRVLLIVFALMALGLLLL--ALALGSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 329 LWILVLGAVFGFSSYGPIALFGVIAnESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVICAAS 407
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVP-DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVA 375
|
....*...
gi 256219483 408 TAAFFLLR 415
Cdd:COG2223 376 LVLTLLLY 383
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-414 |
2.63e-31 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 122.68 E-value: 2.63e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 10 RTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 90 VNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTL 169
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 170 ALSGALCVVVSFLCLLLIhnePADVGLrnldpmpsegkkgslkeesTLQELLLSPYLWVLSTgylvvfgvktcctdWGQF 249
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL---RQVWGL-------------------ALGYFGINYALYGLLT--------------WLPT 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 250 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAglsnygnpRHGLLLFMMAGMTVSMYLFrvtVTSDSPKL 329
Cdd:cd17319 205 YLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA--------RRLVIIIGLLLAAVGLLLA---YLTTSPVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 330 WILVLGAVFGFsSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKH-YSWSTAFWVAEVICAAST 408
Cdd:cd17319 274 AVILLSLAGFG-IGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAA 352
|
....*.
gi 256219483 409 AAFFLL 414
Cdd:cd17319 353 LLVLLL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-380 |
5.02e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 121.62 E-value: 5.02e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 8 YYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLV 87
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 88 GLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRS 167
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 168 TLALSGALCVVVSFLCLLLihnepadvglrnldpMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWG 247
Cdd:COG2814 166 VFLVNAVLALLALLLLLRL---------------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 248 QFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFRVTVTSdsp 327
Cdd:COG2814 231 PLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----------GRRRLLLIGLLLLALGLLLLALAGSL--- 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 256219483 328 kLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 380
Cdd:COG2814 297 -WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-380 |
1.32e-30 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 120.60 E-value: 1.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 17 MFGGYSLYYFNRKTFSFVMPS-LVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFA 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 96 WSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGAL 175
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 176 CVVVSFLCLLLIHNEPADVglrnldpmPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTdwGQFFLIQEK 255
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKR--------PKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 256 GQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSnygnprhgLLLFMMAGMTVSMYLFRVTVTSdspkLWILVLG 335
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL--------LALLLLILAALGLLLLSLTLSS----LWLLLAL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 256219483 336 AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 380
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-413 |
2.20e-28 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 115.22 E-value: 2.20e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 17 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 97 SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQ--SYSWRSTLALSGA 174
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 175 LCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGslkeestLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQE 254
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKL-------LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 255 KGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnyGNPRHGLLLFMMAGMTVSMYLFRVTvtsdSPKLWILVL 334
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR----------LIGRKPLLLIGLLLMALGLALLLLA----PSLLLLLLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256219483 335 GAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFL 413
Cdd:cd06174 300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-411 |
2.33e-25 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 106.55 E-value: 2.33e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 36 PSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQG 115
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 116 LGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAdvg 195
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA--- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 196 lrnldpmPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLV 275
Cdd:cd17475 177 -------ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 276 GSIAAGYLSDRamakaglsNYGNPRHGLLLFMMAgmTVSMYLFRVTVTSDSPKLWILVLG-AVFGFSSYGPIALFGVIAN 354
Cdd:cd17475 250 GRIGLGRVSDR--------VFGGRRRPVLVITAA--IAAAALLVLSLLSPGTPLWLLVLLlILLGLFAIGWNGLYLTLVA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 256219483 355 ESAPPNLCGTSHAIVGLMANVGGFLAGLPF-STIAKHYSWSTAFWVAEVICAASTAAF 411
Cdd:cd17475 320 ESAGPEQAGTALGLANTINFIGIAIGPPLFgLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
34-415 |
2.62e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 100.73 E-value: 2.62e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 34 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 113
Cdd:cd17325 18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 114 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPad 193
Cdd:cd17325 98 SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 194 vglrnldPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGG 273
Cdd:cd17325 176 -------PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLAS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 274 LVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFRVtvtsdSPKLWILVLGAVF---GFSSYGPiALFG 350
Cdd:cd17325 249 ALSQPPAGKLSDRI-----------GRKPLILIGLLLSAVALLLLPL-----ATSFWLLLLLLALlglGLGLVFP-ATLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256219483 351 VIAnESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLR 415
Cdd:cd17325 312 LLA-DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
14-419 |
7.56e-21 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 94.34 E-value: 7.56e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 14 FSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIF 93
Cdd:PRK09556 31 YLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 94 F-----AWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRST 168
Cdd:PRK09556 111 FgaslgSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 169 LAL---SGALCVVVSFLCLLLIHNEPADVGLRN--------LDPMPSEGKKGSL-KEESTLQELLLSPYLWVLSTGYLVV 236
Cdd:PRK09556 191 IGMfifPSIIALIIGFIGLRYGSDSPEELGWGKaeeifgepISEEDKETESTDMtKWQIFVEYVLKNPVIWLLCFANIFL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 237 FGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygNPRHGLLLFMMAGMTVSMY 316
Cdd:PRK09556 271 YIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA----------NGRRALVACIALALIIFTL 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 317 LFRVTVTSDspklwILVLGAVF--GFSSYGPIALFGVIANESAPPN--------------LCGTSHAIVGLMANVGGFLA 380
Cdd:PRK09556 341 GVYQHATSE-----YMYLASLFalGFLVFGPQLLIGVAAVGFVPKKaigvangikgtfayLFGDSFAKVGLGMIADPTKN 415
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 256219483 381 GLPFSTIAKHySWS---TAFWVAEVICAASTA--AFFLLRNIRT 419
Cdd:PRK09556 416 GTPIFGYTLT-GWAgtfAALDIAAIGCICLMAivAVMEERKIRR 458
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
28-412 |
4.90e-19 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 88.10 E-value: 4.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 28 RKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALW 107
Cdd:cd17355 19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 108 FLNGLAQ--GLGWPPCGKVLRKWFEPSQfGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLL 185
Cdd:cd17355 99 GLLGGGGagTLAAVAFATVAAWWFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 186 LIHNEPADVGLRNLDPMPSEGkkgslkEESTLQELLLSPYLWVLSTGYLVVfGVKTCCTDWGQFFLIQEKGQSALVGSSY 265
Cdd:cd17355 178 LLRRRPADLALRAYDDASPAS------PGSTLKEALRSASFWLLALAFFLC-GFAVVGLIVHLVPYLADRGISPAAAAVA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 266 MSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRHGLLLFMMAGMTVSMYLFrvtvtSDSPKLWILVLGAVFGFSSYGP 345
Cdd:cd17355 251 LALIGLFNIVGRLLSGWLGDR---------YSPRRLLAASYALRALGLALLLL-----LPFPPLALLLFAALFGLGWGAT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256219483 346 IALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVICAASTAAFF 412
Cdd:cd17355 317 VPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-412 |
8.69e-18 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 84.14 E-value: 8.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 34 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 113
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 114 QGLGWPPCGKVLRKwFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHnepad 193
Cdd:cd17478 98 SAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 194 vglRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTdwgqfFLIQEKGQSALVGSSYMSALEVGG 273
Cdd:cd17478 172 ---LKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLFLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 274 LVGSIAAGYLSDRAMAKAglsnygnprhgLLLFMMAGMTVSMYLFRVTvtsdsPKLWILVLGAVFGFSSYGPIALFGVIA 353
Cdd:cd17478 244 AIGTLIGGPLSDRFGRRR-----------VIIASLLLAAPFLLLFLLT-----PGIWSYILLVLAGFLLFASFPVTVVLA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 256219483 354 NESAPPNLcGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFF 412
Cdd:cd17478 308 QELLPGNV-GLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-414 |
1.19e-17 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 84.15 E-value: 1.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 34 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 113
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 114 QGLGWPPCGKVLRKWFePSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAD 193
Cdd:COG2807 120 IAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 194 vglrnldpmpsegkKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLiQEKGQSALVGSSYMSALEVGG 273
Cdd:COG2807 199 --------------AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 274 LVGSIAAGYLSDRAmakaglsnygNPRHGLLLFMMAGMTVSMYLFrVTVTSDSPKLWILVLGAVFGFSsygPIALFGVIA 353
Cdd:COG2807 264 IPGSLLVPLLADRL----------GDRRPLLLLLGLLGLAGLLGL-LLAPGSLPWLWAVLLGLGQGGL---FPLALTLIG 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256219483 354 NESAPPN----LCGTSHAIVGLMANVGGFLAGLPFSTIAkhySWSTAFWVAEVICAASTAAFFLL 414
Cdd:COG2807 330 LRARTPAeaaaLSGMAQSVGYLLAALGPLLVGALHDATG---SWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-412 |
9.39e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 75.28 E-value: 9.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 50 GFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWF 129
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 130 EPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAdvglrnldpmpseGKKG 209
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPP-------------KKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 210 SLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMA 289
Cdd:cd17324 184 SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 290 KAglsnygnprhglLLFMMAGMTVSMYLFrvTVTSDSPKLWILVLgAVFGFSSYGPIALFGVIANESAPPNLcGTSHAIV 369
Cdd:cd17324 264 RA------------LLIALLLLAAALLLL--TLLGPSPLLLLVGL-VLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLY 327
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 256219483 370 GLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFF 412
Cdd:cd17324 328 LAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
32-382 |
3.53e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 73.54 E-value: 3.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 32 SFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNG 111
Cdd:TIGR00895 37 GFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 112 LAQGLGWPPCgKVLRKWFEPSQF-GTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGA-----LCVVVSFL--- 182
Cdd:TIGR00895 117 LGLGGLMPNL-NALVSEYAPKRFrGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIaplllLLLLMRFLpes 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 183 ----------CLLLIHNEPADVGLRNLDPMPSE------GKKGSLKEESTLQELLLSPYLWVL-STGYLVVFGVktccTD 245
Cdd:TIGR00895 196 idflvskrpeTVRRIVNAIAPQMQAEAQSALPEqkstqgTKRSVFKALFQGKTARITVLLWLLyFMLLVGVYFL----TN 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 246 WGQfFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygNPRHGLLLFMMAGMTVSMYLFRVTvtsd 325
Cdd:TIGR00895 272 WLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL----------GPRVTALLLLLGAVFAVLVGSTLF---- 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 256219483 326 SPKLwILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTShaiVGLMANVGGFLAGL 382
Cdd:TIGR00895 337 SPTL-LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATG---VGWAIGIGRLGAII 389
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-414 |
1.44e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 71.83 E-value: 1.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 34 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 113
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 114 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAqSYSWRSTLALSGALCVVvSFLCLLLIHNEPad 193
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPV-AFLAILFLLPEP-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 194 vglrnldpmPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGG 273
Cdd:cd17474 177 ---------KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 274 LVGSIAAGYLSDRAmakaglsnygNPRHGLLLFMMAGMTVSMYLFRVTvtsdsPKLWILVLG-AVFGFSSYGPIALFGVI 352
Cdd:cd17474 248 ALGSLFVGRLLKKR----------FGARRILVIGLLLYALSLLLLGFV-----PSLALLLIAiVLFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 256219483 353 ANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLL 414
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
17-412 |
7.46e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 69.57 E-value: 7.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 17 MFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAW 96
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 97 SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQS-YSWRSTLALSGAL 175
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 176 CVVVSFLCLLLIHNEPadvgLRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLI--- 252
Cdd:cd17328 164 GVLLAILLLLFVREPP----RGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRafg 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 253 QEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKaglsnygNPRHGLLL--FMMAGMTVSMYLFRVTVTSDSPKLW 330
Cdd:cd17328 240 VGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRK-------TPRADPLVcaVGLLAAAPFLFLALVLALSNLLLAW 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 331 ILV-LGAVFGFSSYGPIAlfgVIANESAPPNLCGTSHAIVGLMAN-----VGGFLAGLPFSTIAKHY--------SWSTA 396
Cdd:cd17328 313 VLLfLGEFLLSLNWAPVF---AILLYVVIPTRRSTASAIQILLSHllgdaGSPYLIGLISDLLRQNKdsplaeaaSLQYA 389
|
410
....*....|....*.
gi 256219483 397 FWVAEVICAASTAAFF 412
Cdd:cd17328 390 LLLCSFVLVLGGFFFL 405
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
34-420 |
1.82e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.34 E-value: 1.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 34 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 113
Cdd:COG0738 30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 114 QGLGWPPCGKVLRkWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQ---SYSWRSTLALSGALCVVVSFLCLLLIHne 190
Cdd:COG0738 110 LGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRSKL-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 191 padvglrnldPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALE 270
Cdd:COG0738 187 ----------PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 271 VGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFRVTvtsdsPKLWILVLGAV---FGFSSYGPIA 347
Cdd:COG0738 257 GGMTIGRFLGGFLLKRF-----------GPVRLLRLSALLAAVGLLLALLA-----PGPWLALIGLAlvgLGLSLMFPTI 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256219483 348 LfgVIANESAPPNLCGTShAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTK 420
Cdd:COG0738 321 F--SLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-414 |
2.45e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 68.03 E-value: 2.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 14 FSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWL-----FSSGLLLVG 88
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 89 LVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRST 168
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 169 LALSgALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGslkeestLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:cd06173 161 FAIN-ALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG-------LRYLRRSPLLRLLLLALALFALLGGALTVLLP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 249 FFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnygNPRHGLLLFMMAGMTVSMYLFRVtvtsdSPK 328
Cdd:cd06173 233 LLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR-----------RRRGRLLLIGALLLGLALLVLGL-----SPS 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 329 LWILVLGAVFGFSSYGPI-ALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAAS 407
Cdd:cd06173 297 LWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLA 376
|
....*..
gi 256219483 408 TAAFFLL 414
Cdd:cd06173 377 ALLLLLL 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-412 |
6.72e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.47 E-value: 6.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 14 FSAMFGGYSLYYFNRKTFSFVMPSLVEEIP--LDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVN 91
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 92 IFFAWSSTVPVFAALWFLNGLAQGlGWPPCGKVLRKWFEPSQF-GTWWAILSTSMN----LAGGLGPILATILAQSYSWR 166
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIG-GEYPGASTYVAEFAPSKRrGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 167 STLALSGALCVVVsflclllihnepadvglrnldpmpsegkkgslkeestlqeLLLSPYLWVLSTGYLVVFGVKTCCTDW 246
Cdd:cd17316 160 ILFLIGALPALLA----------------------------------------LLLRRRTLLLILLWFFISFGYYGLTTF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 247 GQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFrvTVTSDS 326
Cdd:cd17316 200 LPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-----------GRKKTLVIGLILSGILALPL--FYLLSG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 327 PKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMAN-VGGFLAGLPFSTIAKHYSWSTAFWVAEVICA 405
Cdd:cd17316 267 SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRlGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
....*..
gi 256219483 406 ASTAAFF 412
Cdd:cd17316 347 VALIVAL 353
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
10-413 |
6.77e-12 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 66.57 E-value: 6.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 10 RTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEI-------------------PL--DKDD----LGFITSSQSAAYAISK 64
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWtpsnsntsielheetwnanPLfpSQDDaalfLGVLDTIFLFSYAIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 65 FVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSS------TVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWW 138
Cdd:cd17342 81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 139 AILSTSmnlaGGLGPILATILAQsyswrSTLALSGALCVVVSFLCLLLIhnepADVGLRNLDPMPSEGKKGSLKeestlq 218
Cdd:cd17342 161 GLWSAC----ASVGNIIGALLAS-----SVLDYGYEYAFLVTSSLLFAG----AIVVFFGLLSSPPGVIPYSLA------ 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 219 elllspYLWVLSTGYLVVFgvktcctdWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRaMAKaglsnygn 298
Cdd:cd17342 222 ------YACLKLVNYSFFF--------WLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDR-MGS-------- 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 299 pRHGLLLFMMAGMTVSMYLFRvtvTSDSPKLWILVLGAVFGFSSYGPIALF--GVIANESAPPNLCGTSHAivglMANVG 376
Cdd:cd17342 279 -RSPVVVVMLLLAIPSLFVYS---HSPSDKVLNAFVMTITGFFIGGPANLIssAISADLGRQPQLRGSSEA----LATVT 350
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 256219483 377 GFLAG----------LPFSTIAKHYSWSTAFWVAeVICAASTAAFFL 413
Cdd:cd17342 351 GIIDGtgsigaaigqVLVPLIQNRLGWMWVFYFF-IIMTILTIVCIL 396
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-186 |
6.87e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.91 E-value: 6.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 10 RTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 90 VNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTL 169
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170
....*....|....*..
gi 256219483 170 ALSGALCVVVSFLCLLL 186
Cdd:COG0477 172 LINAPLGLLALVLRLRL 188
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-414 |
3.91e-10 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 61.16 E-value: 3.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 14 FSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIF 93
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 94 FAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQ----SYSWRSTL 169
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 170 ALSGALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGSLKEESTLQELLLSPylwVLSTG-YLVVFGVKTcctdWGQ 248
Cdd:cd17371 161 LLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLAS---LLATGaLGGYYGITT----WLP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 249 FFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRHGLLLFMMAGMTVSMYLFrvtvTSDSPK 328
Cdd:cd17371 234 SYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFALGSAISILLYFF----LPLSPT 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 329 LwILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTShaiVGLMANVGGFLAGL-PFST--IAKHYSWSTAF-WVAEVIC 404
Cdd:cd17371 301 L-ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATA---QGFCYNVGRIIGALfPFLVgfLATSGSLGTAIaVFAAVYY 376
|
410
....*....|
gi 256219483 405 AASTAAFFLL 414
Cdd:cd17371 377 IAGLVLALLL 386
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
35-405 |
6.97e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 60.41 E-value: 6.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 35 MPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQ 114
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 115 GLGwPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILAT-ILAQSYSWRSTLALSGALCVVVsFLCLLLIHNEPad 193
Cdd:cd17333 99 GIL-DTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLL-AILILLTLFPE-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 194 vglrnlDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGG 273
Cdd:cd17333 175 ------LPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 274 LVGSIAAGYLSDRAMAKAglsnygnprhglllFMMAGMTVSMYLFRVTVTSDSPkLWILVLGAVFGFSSYGPIALFGVIA 353
Cdd:cd17333 249 TIGRLLGGPISRRIKPHT--------------LLVLSGSGALLGLLILLLAPTL-VVGLVATALLGLFMAALFPTILSLG 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 256219483 354 NESAP-PNLCGTSHAIVglMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICA 405
Cdd:cd17333 314 ISNLPyAKGKGTSVLLA--AGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYA 364
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
31-413 |
9.14e-10 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 59.96 E-value: 9.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 31 FSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVP-VFAALWFL 109
Cdd:cd17341 18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYwGLLVLGFL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 110 NGLAqGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQS-------YSWRSTLALSGALCVVVSFL 182
Cdd:cd17341 98 LGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAivfdggfVGWRNAFFVPGILLAIAAVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 183 CLLLIHNEPadvglrnldpmpsEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVG 262
Cdd:cd17341 177 VLLFGDDLP-------------TGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 263 SSYMSALEVGGLVGSIAAGYLSDRAMAKaglsnygnprhGLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLGAVFGFSS 342
Cdd:cd17341 244 GILAALFPLAGALARPAGGWLSDRFGGR-----------RRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256219483 343 YGPI--ALFGVIANESapPNLCGTSHAIVGLMANVGGFLAGLPFSTIAK-HYSWSTAFWVAEVICAASTAAFFL 413
Cdd:cd17341 313 AGAGngSVFRMVPFIF--RRELGAVTGLVGAIGGLGGFFLPLLFGSSALmTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
43-415 |
1.10e-09 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 60.02 E-value: 1.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 43 PLDKDD----LGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWS-----STVPVFAALWFLNGLA 113
Cdd:cd17344 54 PFDGKNgtelLGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGyywniHSLWYFVVVQILAGLF 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 114 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAqSYSWRSTLALSGALCVVVSFLCLLLIHNEPAD 193
Cdd:cd17344 134 QSTGWPSVVACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFV-SSAWGLSFIVPGIIIAAMGVLVFLFLVEHPPG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 194 VglrnldpmpsegkkgslkeestlqelllSPYLWVLSTGYLVVFGVKTcctdWGQFFLIQEKGQSALVGSSYMSALEVGG 273
Cdd:cd17344 213 V----------------------------IEFSLCLFFAKLVSYTFLY----WLPLYISNTAILSAKKAGDLSTLFDVGG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 274 LVGSIAAGYLSDRAMAKAGLSnygnprhGLLLFMMAGMtvsMYLFRvTVTSDSPKLWILVLgAVFGFSSYGPIALF--GV 351
Cdd:cd17344 261 IVGGILAGYISDYTGGRATTC-------AAMLILAAPM---LFIYN-YFGQVSMTTNIVLL-IVCGLLVNGPYALIttAV 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 256219483 352 IANESAPPNLCGTSHAI------------VGlmANVGGFLAGLPFStiakhYSWSTAFWVaeVICAASTAAFFLLR 415
Cdd:cd17344 329 SADLGTHKSLKGNARALatvtaiidgtgsIG--AALGPLLAGLISS-----RGWNNVFYM--LIAADVCAGLLLTR 395
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
26-186 |
4.39e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.01 E-value: 4.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 26 FNRKTFSFVMPS----LVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVP 101
Cdd:cd17329 10 LNRLGFFMVWPFmaiyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 102 VFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSwrSTLALSGALCVVVSF 181
Cdd:cd17329 90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF--RLLFLAAAVLFLLAA 167
|
....*
gi 256219483 182 LCLLL 186
Cdd:cd17329 168 LVLLF 172
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
32-415 |
1.29e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 56.44 E-value: 1.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 32 SFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNG 111
Cdd:cd17365 19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 112 LAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALsGALCVVVSFLCLLlihnep 191
Cdd:cd17365 99 LGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL-GGVPPLILLPLLR------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 192 advglrnldpmpsegkkGSLKeestlqelllspyLWVLS-TGYLVVFGVKTcctdWGQfFLIQEKGQSALVGSSYMSALE 270
Cdd:cd17365 172 -----------------GTLL-------------LWVTFfMGLLLVYLLNS----WLP-KLMVEAGYSLSQALTITLLLN 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 271 VGGLVGSIAAGYLSDRamakaglsnyGNPRHGLLLFMMAGMtVSMYLFrvtVTSDSPKLWILVLGAVFGFSSYGPIALFG 350
Cdd:cd17365 217 IGGVIGSLLLGWLADR----------FGPKRVLALFFALGA-VSLALL---GVSPASLVLLYVLVFLAGACVNGAQVGLY 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256219483 351 VIANESAPPNLCGT----SHAIVGLMANVGGFLAGLpfsTIAKHYSWSTAFWVAEVICAASTAAFFLLR 415
Cdd:cd17365 283 ALAARFYPTEVRATgvgwALGVGRLGAILGPLLGGL---LLAAGLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
35-415 |
1.53e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.03 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 35 MPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQ 114
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 115 GLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVsflclllihnepadv 194
Cdd:cd17321 99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA--------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 195 glrnldpmpsegkkgslkeestlqeLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGL 274
Cdd:cd17321 164 -------------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAML 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 275 VGSIAAGYLSDRAMAKAglsnygnprhgLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLgAVFGFSSYGPIALFGVIAN 354
Cdd:cd17321 219 VAAPLAGRLADRFGPRL-----------VLVAGLLLTAVGLLLLALLGADSSVWLLLPGL-VLLGLGLGLFATPLTNAAL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 355 ESAPPNLCGTSHAIVGLMANVGGFL-----------------------AGLPFSTIAKHYSWSTAFWVAEVICAASTAAF 411
Cdd:cd17321 287 SSVPKEKAGAASGILNTARQLGGALgvallgalltaglsanlgdsgvaALLSAAAAAFAAGFHLAFLVAAALALLAALLA 366
|
....
gi 256219483 412 FLLR 415
Cdd:cd17321 367 LLLP 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-415 |
3.05e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 3.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 13 IFSAMFGGYSLYYFnrktFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNI 92
Cdd:cd17489 1 ILLANFFFFLSFYL----LLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 93 FFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRStLALS 172
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV-LFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 173 GALCVVVSFLCLLLIHNEPAdvglrnldPMPSEGKKGSLKEESTLQELLLSPYLWVLSTG--------YLVVFGVKTCCT 244
Cdd:cd17489 156 AAVLALLALLLVFLVKDPPP--------VAAEEAEAGTRAFRRLVEKKVLPPALILFLASiaygaistFLPLYAAERGIS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 245 DWGQFFLIQekgQSALVGSSYMSalevgglvgsiaaGYLSDramakaglsnygnpRHGLLLFMMAGMTVsmYLFRVTVTS 324
Cdd:cd17489 228 NAGLFFTVY---AIALLLSRPFS-------------GKLSD--------------RKGPKTVIIPGLLL--LALGLLLLS 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 325 DSPKLWILVLGAVF---GFSSYGPIalFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAE 401
Cdd:cd17489 276 FAGSPWMLLLAAVLyglGFGLLFPA--LQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAA 353
|
410
....*....|....
gi 256219483 402 VICAASTAAFFLLR 415
Cdd:cd17489 354 VVVLLALVLYIFLL 367
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
30-414 |
3.31e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 55.31 E-value: 3.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 30 TFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWS-STVPVFAALWF 108
Cdd:cd17353 21 AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAiSLPLLFLGYGV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 109 LNGLAQGLGWPPCGKVLRKWFePSQFGtwwaiLSTSMNLAG-GLGPI----LATILAQSYSWRSTLALSGALCVVVSFLC 183
Cdd:cd17353 101 LGGIGAGIGYITPVSTAVKWF-PDKRG-----LATGIVIAGfGLGSLifspLIAYLINTVGVPTTFLILGIIFLIIIVIG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 184 LLLIHNEPADVGlrNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLstgYLVVFgvktCCTDWGQF-------FLIQEKG 256
Cdd:cd17353 175 AFLIRDPPKGWV--PPGVDPLANNAENSPRDYTPREMLRTPTFWLL---WLMFF----LNATAGLMligqakpIGQEFAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 257 QSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGnpRHGLLLFMMAGMTVSMYLFrvtVTSDSPKLWILVLGA 336
Cdd:cd17353 246 LDAGIAALAVSILSIFNGGGRPFWGWLSDK---------IG--RKNTLSIAFLIQGVAMFLL---PFIGSVAVLFVLGVA 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256219483 337 VFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAevICAASTAAFFLL 414
Cdd:cd17353 312 LIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIA--AALSLVALALAL 387
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
45-187 |
2.58e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 52.24 E-value: 2.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 45 DKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIF---FAWSSTVPVFAaLWFLNGLAQGLGWPPC 121
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLtplAARGGYGALIV-LRILQGLAQGVTFPAM 132
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 122 GKVLRKWFEPSQFGTwwaiLSTSMNLAGGLGPI----LATILAQSYSWRSTLALSGALCVVVSFLCLLLI 187
Cdd:cd17318 133 HALWAKWAPPLERSR----LTSIAYSGSQFGTViampLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
58-381 |
1.02e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 50.65 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 58 AAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTW 137
Cdd:cd17320 45 LGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 138 WAILSTSMNLAGGLGPILATILAQSYSWRS---TLALSGALCVVVSFLCLllihnepadvglrnldPMPSEGKKGSLKEE 214
Cdd:cd17320 125 FSLLMMILAIAPALAPLLGGLLLLFFGWRAifvFLALLGLLLLLLVLLFL----------------PETLPEEKRKPLLS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 215 STLQ---ELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKA 291
Cdd:cd17320 189 SLLRaykRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRR 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 292 GLsnygnpRHGLLLFMMAGMTVSmyLFRVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIaneSAPPNLCGTSHAIVGL 371
Cdd:cd17320 269 LL------RLGLLLLLAAALVLL--LAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAL---EPFPHVAGTASALLGF 337
|
330
....*....|
gi 256219483 372 MANVGGFLAG 381
Cdd:cd17320 338 LQFLIGALAG 347
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
15-178 |
1.24e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 50.25 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 15 SAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFF 94
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 95 AW--SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALS 172
Cdd:cd17380 82 PLlaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFF 161
|
....*.
gi 256219483 173 GALCVV 178
Cdd:cd17380 162 GLLGLL 167
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
29-415 |
1.35e-06 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 50.24 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 29 KTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVF-AALW 107
Cdd:cd17352 20 NSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLyLTYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 108 FLNGLAQGLGWPPCGKVLRKWFEPsqfgtwWAILSTSMNLAG-GLG----PILATILAQSYSWRSTLALSGALCVVVSFL 182
Cdd:cd17352 100 VLGGLGLGLIYSPAIVIVGQYFEK------KRGLATGIAVAGsGVGtfvfPPLLRYLLDNYGWRGALLILGGLCLNLCVC 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 183 CLLLIhnepadvglrnldpmpsegkkgslkeestlqeLLLSP-YLWVLSTGYLVVFGVKTCCTdwGQFFLIQEKGQSALV 261
Cdd:cd17352 174 GLLLR--------------------------------LLKDPtFVLLALGVSFAMLGFFVPFV--YLPSYAKSLGIDESD 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 262 GSSYMSALEVGGLVGSIAAGYLSDRamakaglsnygnPRHGLLLFMMAGMTVS-MYLFRVTVTSDSPKLWilVLGAVFGF 340
Cdd:cd17352 220 AAFLLSIIGISDIVGRILLGLLADK------------PRIGRLYLYIFTLLILgLSLLAFPLATTYVGLI--VFSVLFGF 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 256219483 341 SSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGfLAGLPFS--TIAKHYSWSTAFWVAEVICAASTAAFFLLR 415
Cdd:cd17352 286 CSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAA-LVGPPIAglLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-381 |
1.64e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 49.94 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 12 VIFSAMFGGYSLYYFNRKTFS--FVMpSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:cd17327 5 FILPLLCILYFLQYLDKSNISnaAVM-GMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 90 VNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQS------Y 163
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 164 SWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRN-------LDPMPSEGKKGSLKEE--STLQELLLSPYLWVLStgyL 234
Cdd:cd17327 164 GWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTeeekelaVERLRANQTGKGDQKFkwKQIKEAFKDPRTWLLF---L 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 235 VVFGVKTCCTDWGQF-FLIQEKGQSALVGSSYMS-ALEVGGLVGSIAAGYLSDRAmakaglsnygnprHGLLLFMMAGMT 312
Cdd:cd17327 241 FFFCSQITNNGISNFlPLILKSLGFYSLQTNLLSvPIGALGAVSLLIAALLSDRF-------------KKRGLFAIFACV 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256219483 313 VSMYLFRVTVTSDSPklWILVLGAVF--GFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAG 381
Cdd:cd17327 308 LALVGSIILLAAPNP--PGAYFAAYIlgGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
58-188 |
2.45e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.87 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 58 AAYAISKFV----SGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQ 133
Cdd:TIGR00880 5 AGYALGQLIysplSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 256219483 134 FGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIH 188
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
9-175 |
1.32e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.19 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 9 YRTVIFSAMFGGYSLYyfnrkTFSFVMPSLVEEI-PLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLV 87
Cdd:cd17503 180 FTLGLLLSFLLGLGLF-----GAMFLLPLYLQNVlGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLL 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 88 GLVNIFFAW---SSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYS 164
Cdd:cd17503 255 ALGTLLLAFltpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRT 334
|
170
....*....|.
gi 256219483 165 WRSTLALSGAL 175
Cdd:cd17503 335 QFHHSRLSELL 345
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-186 |
1.57e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 46.78 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 13 IFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQ--MSARWLFSSGLLLVGLV 90
Cdd:cd17352 184 TFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 91 NIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLG-PILATILAQSYSWRSTL 169
Cdd:cd17352 264 LLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGpPIAGLLRDYTGDYDAAF 343
|
170
....*....|....*..
gi 256219483 170 ALSGALCVVVSFLCLLL 186
Cdd:cd17352 344 YFCGACLLLSGVLLFLL 360
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
49-412 |
2.00e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.38 E-value: 2.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 49 LGFITSSQSAAYAISKFVSGVLSDQMSARWLF-SSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPP------- 120
Cdd:cd17370 36 VGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLvILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPrdallad 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 121 -CGKVLRKWfepsQFGtwwaiLSTSMNLAGG-LGPILATIL--AQSYSWRSTLALSgALCVVVSFLCLLLIHNEPadvgl 196
Cdd:cd17370 116 aTPPSGRGK----AFG-----LHRALDTLGAvLGPLLAALLlyLLGGNYRTIFLLA-AIPALLALLILLFVVKEY----- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 197 rnldpmpsEGKKGSLKEESTLQELLLSPYLWVlstgYLVVFGVKTCCTDWGQFFLI--QEKGQSALVGSSYMSALEVGGL 274
Cdd:cd17370 181 --------PRPPKLRKKSKKTSLKKLPKAFWL----YLLAVALFALGNFSFAFLILraQELGLSAALIPLLYALFNLVYA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 275 VGSIAAGYLSDRamakaglsnygNPRHGLLLFmmagmTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYGPI-ALFGVIA 353
Cdd:cd17370 249 LAAYPAGRLSDR-----------IGRKKLLIL-----GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAV 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256219483 354 NESAPPNLCGTS----HAIVGLMANVGGFLAGLpfstIAKHYSWSTAFWVAEVICAASTAAFF 412
Cdd:cd17370 313 ADLVPAELRGTAyglfNTVVGIGWLLASLIAGY----LWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
47-193 |
4.96e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 45.50 E-value: 4.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 47 DDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVfaALWFLNGLAQGLGWPPC----G 122
Cdd:TIGR00894 76 ALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGI--ALVVFCRVIQGLAQGSVspatH 153
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 256219483 123 KVLRKWFEPSQFGTWwailsTSMNLAGGL------GPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAD 193
Cdd:TIGR00894 154 KIIVKWAPPKERSRL-----LGMSTSGFQlgtfifLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSI 225
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
6-186 |
6.18e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.87 E-value: 6.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 6 YGYYRTVIfsAMFGGYSLYYFNRKTFSFVMPS-LVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMS--ARWLFSS 82
Cdd:cd17319 175 WFYLRQVW--GLALGYFGINYALYGLLTWLPTyLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgARRLVII 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 83 GLLLVGLVNIFFAWSSTVPVFAALW-----FLNGLAQGLGWPPCGKVLRkwfePSQFGTWWAILSTSMNLAGGLGPILAT 157
Cdd:cd17319 253 IGLLLAAVGLLLAYLTTSPVVAVILlslagFGIGAASPVFWSLPADLLP----GEAAATAGGLINSGGNLGGFVAPLLIG 328
|
170 180 190
....*....|....*....|....*....|
gi 256219483 158 ILAQ-SYSWRSTLALSGALCVVVSFLCLLL 186
Cdd:cd17319 329 YLVDaTGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
61-415 |
6.67e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 6.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 61 AISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAI 140
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 141 LSTSMNLAGGLGPILATILAqSYSWRSTLALSGalcvvVSFLCLLLihnepADVGLRNLDPMPSEGKKGSLKEESTLQEL 220
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYL-----LALPVLIL-----VLLFLPEPARKSKSAASPGAATAAALPWK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 221 LLSPYLWVLSTGYLVVFGVKTcctdWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPR 300
Cdd:cd17473 198 RVLPIYFLAFLAMLLFYVIPI----QLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRL-----------GK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 301 HGLLLFMMAGMTVSMYLFrvtvtSDSPKLWILVLGAV---FGFSSYGPIALfgVIANESAPPNLCGTSHAIVGLMANVGG 377
Cdd:cd17473 263 RRLLAIGFALMALGFLLL-----ALASGLWVVLLGAIlagLGFGLLLPTLN--SWAMSLVPPELRGRAMGIVTSAFFLGQ 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 256219483 378 FLAGLPFSTIAKHY-SWSTAFWVAEVICAASTAAFFLLR 415
Cdd:cd17473 336 FLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
12-186 |
6.89e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.83 E-value: 6.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 12 VIFSAMFGGYSLYYFnrkTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVN 91
Cdd:cd17369 232 LAIGLRLAENVLFYL---FTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFA 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 92 IFFAW----SSTVPVFAALWFLNGLAQGLGWPPCGKVLrkwfePSQFGTwwAI----LSTSMN----LAGGLGPILATIL 159
Cdd:cd17369 309 FPFFWlldtGSTWLIVLAAVVVLGVLHGMMYGPQAAFL-----AELFPT--RVrytgASLGYQlgaiLGGGFAPLIATAL 381
|
170 180
....*....|....*....|....*...
gi 256219483 160 -AQSYSWRSTLALSGALCvVVSFLCLLL 186
Cdd:cd17369 382 vAATGSWWPVALYLAALA-VISLVAALF 408
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
61-429 |
7.19e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 7.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 61 AISKFVSGVLSDQMSARW-------LFSSGLLLVGLVNIFFA--WSSTVPV--FAALWFLNGLAQGLGWPPCGKVLRKWF 129
Cdd:COG2211 60 AITDPLIGALSDRTRTRWgrrrpwiLIGAIPLALSFVLLFTApdLSPTGKLiyALVTYLLLGLAYTLVNIPYSALGAELT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 130 EPSQ-----FGTWWAILSTSMNLAGGLGPILATILA--QSYSWRSTLALSGALCVVVSFLCLLLIHnepadvglrnlDPM 202
Cdd:COG2211 140 PDYEertrlSSWRFAFAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLAFLLTFFGTK-----------ERP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 203 PSEGKKGSLKEesTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGY 282
Cdd:COG2211 209 VPEEEKVSLKE--SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPR 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 283 LSDRamakaglsnYGnpRHGLLLFMMAGMTVSMYLFRVTVTSDSPklWILVLGAVFGFSSYGPIALFGVIANESAPPNLC 362
Cdd:COG2211 287 LAKR---------FG--KKKAFIIGLLLAALGLLLLFFLGPGNLW--LLLVLAALAGIGLGAILVLPWAMLADVVDYDEW 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 363 GTSH----------------------AIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTK 420
Cdd:COG2211 354 KTGRrreglyfgiftfaiklgqalagALAGLLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRER 433
|
....*....
gi 256219483 421 MGRVSKKAE 429
Cdd:COG2211 434 HAEIRAELA 442
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
59-344 |
7.70e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.49 E-value: 7.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 59 AYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWW 138
Cdd:cd17323 46 GFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAM 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 139 AILSTSMNLAGGLGPILATILAQSYSWRST---LALSGALCVVVSFLCLLLIhnepadvglrnldpmpsegkkgslkees 215
Cdd:cd17323 126 GVYSLGPLLGPALGPIIGGFITQSLGWRWIfwfLAIISGFCLILIFLFLPIV---------------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 216 tlqeLLLSPY-------LWVLSTGYLVVFGVKTCCTDWGqffliqekgqsalVGSSYMSALeVGGLVGSIAAGYLSDRAM 288
Cdd:cd17323 178 ----LLLGLYvglvyaiLYLFLTAFPYVFGEVYGFSPGE-------------VGLMYLPIG-IGALIGSIIGGRLSDYYY 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 289 AKAGLSNYGNPR-HGLLLFMMAG---MTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYG 344
Cdd:cd17323 240 RRLKKKNGGKPEpEARLPPAFIGaflFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLML 299
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
250-414 |
9.26e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.19 E-value: 9.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 250 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFrvtVTSDSPkL 329
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-----------GRRRVLLLGLLLFALGSLLC---ALAPSL-W 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 330 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTA 409
Cdd:COG2814 100 LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALL 179
|
....*
gi 256219483 410 AFFLL 414
Cdd:COG2814 180 LLLRL 184
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
35-167 |
1.17e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.10 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 35 MPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLF--SSGLLLVGLVNIFFAWSSTVPVFAALwfLNGL 112
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFltALALFTLGSLLCGLAPNLASLIIFRI--LQGF 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 256219483 113 AQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRS 167
Cdd:cd17503 97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRW 151
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
45-175 |
1.43e-04 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 43.87 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 45 DKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVP--VFAALWFLNGLAQGLGWPPCG 122
Cdd:cd17382 47 TPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHygCVIFVRILQGLVEGVTYPACH 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 256219483 123 KVLRKWFEPSQfGTWWAILSTSMNLAGG-LGPILATILAQSYSWRSTLALSGAL 175
Cdd:cd17382 127 GIWRKWAPPLE-RSRLATTAFCGSYAGAvVGMPLSGILVQYVGWSSPFYVYGVF 179
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-411 |
1.49e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 34 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 113
Cdd:cd17477 18 LLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 114 QGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILatiLAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPAD 193
Cdd:cd17477 98 LAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL---LALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 194 vglrnldpmpsegkkgsLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQeKGQSALVGSSYMSALEVGG 273
Cdd:cd17477 175 -----------------IEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLR-LGLSVAQAALLLAAFVLGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 274 LVGSIAAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLFRVTVTSDspkLWILVLGAVFGFSSYGPIALFGVIA 353
Cdd:cd17477 237 LLLQWPLGWLADRF-----------DRRRVLLGCALLGALAALLLPLVPGLP---LALLVLLFLWGGAAGPLYTLALALA 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 256219483 354 NESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAF 411
Cdd:cd17477 303 GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
256-414 |
4.39e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.15 E-value: 4.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 256 GQSALVGSSYMSALEVGGLVgsiaAGYLSDRAmakaglsnygnPRHGLLLFMMAGMTVSMYLfrvtvTSDSPKLWILVLG 335
Cdd:cd17324 34 AQAGLLVSAYALGYALGALL----LGPLSDRI-----------ERRRLLLVLLLLFILGNLL-----AALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 336 -AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVgLMANVGGFLAGLPFST-IAKHYSWSTAFWVAEVICAASTAAFFL 413
Cdd:cd17324 94 rALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGlLGQLLGWRAAFLAIAVLALLAALLLWR 172
|
.
gi 256219483 414 L 414
Cdd:cd17324 173 L 173
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
256-414 |
1.24e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 40.64 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 256 GQSALVGSSYMSALEVgglVGSIAAGYLSDRAMakaglsnygnpRHGLLLFMMAGMTVSMYL---FRVTVTSDSPKLWIL 332
Cdd:cd17315 213 GTASILASIIVGVVNL---LATLVAIRLVDKVG-----------RRPLLLIGFAGMAASLLLlaiAFLLPALAKAAGWLA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 333 VLGA---VFGFS-SYGPIalFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAAST 408
Cdd:cd17315 279 LLGIllyIAAFAmGAGPV--PWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLAL 356
|
....*.
gi 256219483 409 AAFFLL 414
Cdd:cd17315 357 VFVFFF 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
250-429 |
1.41e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 250 FLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRhgLLLFMMAGMTVSMYLFRVTVTSdspkL 329
Cdd:pfam07690 22 LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---------FGRRR--VLLIGLLLFALGLLLLLFASSL----W 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 330 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTA 409
Cdd:pfam07690 87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170 180
....*....|....*....|
gi 256219483 410 AFFLLRNIRTKMGRVSKKAE 429
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEA 186
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
99-407 |
3.00e-03 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 39.59 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 99 TVPVFAALWFLNG--LAQGLGWPPC---GKVLRK-WFEPSQFGTWWAILSTsMNLAGG-----LGPILatilaqsyswrs 167
Cdd:cd17397 89 PVPNHLATWLIHIgqFLNGLAGPVAmaaAPFLSAtWFPPNQRATATAIASI-FNYLGGaasflIGPLV------------ 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 168 TLALSGALCVVVsFLCLLLIhnepadvgLRNLDPMP----SEGKKGSLKeeSTLQELLLSPYLWVLSTGYLVVFGVKTCc 243
Cdd:cd17397 156 LMYLEFGWSALI-FLAMLIY--------FPSKPPTPpsvsASTQRLSYK--SGILSLLKNKRFWLIALAYGIPTGVYAG- 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 244 tdWGQFFLIQEKGQ------SALVGssYMSAleVGGLVGSIAAGYLSDRAMAKAGLsnygnprhgLLLFMMAGMTVSMYL 317
Cdd:cd17397 224 --WSGVLDVNLTPFgvsqveAGWIG--FYST--VAGCVGGIIVGRFADRFGGRMKL---------ILLLLFSGATGSFLW 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 318 FRVTVTSDSP--KLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGG--FLAGLPFSTIAKhySW 393
Cdd:cd17397 289 FTLICLKLLPfsTVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGlvFLLILIIPNIGT--SW 366
|
330
....*....|....
gi 256219483 394 STafWVAEVICAAS 407
Cdd:cd17397 367 MN--WCLLGSCLLS 378
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
26-195 |
3.38e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.59 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 26 FNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAA 105
Cdd:cd06180 13 IGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 106 LWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILstsmnLAG-GLGPILAT-----ILAQSYSWRSTLALSGALCVVV 179
Cdd:cd06180 93 LRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLL-----FAGvGLGIALSGllvpaGLGGGLSWRAGWLALALLSAVL 167
|
170
....*....|....*.
gi 256219483 180 SFLCLLLIHNEPADVG 195
Cdd:cd06180 168 LLLSFLLLRRGPSAPT 183
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
33-411 |
3.59e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.16 E-value: 3.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 33 FVMPSLVEEIP-------LDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAA 105
Cdd:cd17393 13 ILMASWATRIPaikdrlgLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 106 LWFLNGLAQGLG---WPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGpiLATILAQSYSWRSTLALSGALCVVVSFL 182
Cdd:cd17393 93 ALFLFGAANGALdvaMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLG--AAAIGAGVSPGVHLLAAAVLLLLAALVA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 183 CLLLihnePADVGLRNLDPMPSEGKKGSLkeestlqelLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVG 262
Cdd:cd17393 171 IRAL----LPGTGEAAEDRPDGAGKPGFL---------LPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 263 SSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSnygnprhglllfmmAGMTVSMYLFRVTVTSDSPklWILVLGAV---FG 339
Cdd:cd17393 238 ALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLR--------------AGALLAALGLLLALLAPSV--WVALAGFAlmgLG 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256219483 340 FSSYGPIALFGVIANESAPPNLCGTSHAIVGLmanvGGFLAGLP-FSTIAKHYSWSTAFWVAeVICAASTAAF 411
Cdd:cd17393 302 LSVVVPLAFSAAGALPGLAAGIAVARVATLGY----LGFLVGPPlIGFLADATGLRTAFLVV-ALLALLVALL 369
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
34-188 |
4.30e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.10 E-value: 4.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 34 VMPSLVEEIPLDKDD---LGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLN 110
Cdd:cd17330 18 VLPFYVREFNKLGASgyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLD 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256219483 111 GLAQGlGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSwrstLALSGALCVVVSFLCLLLIH 188
Cdd:cd17330 98 GLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG----YALPFLVAAALALLNLVLVL 170
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
33-377 |
4.93e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.82 E-value: 4.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 33 FVMPSLVEEIP-----LDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSsGLLLVGLVNIFFAWSSTVP--VFAA 105
Cdd:TIGR00886 18 FAFSPLAVFLIkddlgLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTA-LSLLLLAIPCLWAGLAVQSysVLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 106 LWFLNGLAqGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLAL---SGALCVVVSFL 182
Cdd:TIGR00886 97 IRLFIGIA-GGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGGGQPAhlaWGWAFVIVPAG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 183 CLLLIHNEPADVGLRNLDPMPSEGKkgsLKEESTLQeLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVG 262
Cdd:TIGR00886 176 ILLLPALLIFFVGADTPPGKPATGK---LSFKEALK-VFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 263 SSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGNPRHGLLLFMMAGMtVSMYLFRVTVTSDSPKLWILVLGAVFGFSS 342
Cdd:TIGR00886 252 GAYASLGGFLGSLARPAGGAISDR---------LGGARKLLMNFLGVAM-GAFLVVLGLVSDGSLAAFIVLFVALFFFAG 321
|
330 340 350
....*....|....*....|....*....|....*
gi 256219483 343 YGPIALFGVIANESAPPNlcGTSHAIVGLMANVGG 377
Cdd:TIGR00886 322 AGNGSTFALVPHIFRRAT--GAVSGLIGAIGNLGG 354
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
34-415 |
5.10e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.71 E-value: 5.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 34 VMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLA 113
Cdd:cd17504 18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 114 QGLgWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLlihnepad 193
Cdd:cd17504 98 GAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPL-------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 194 VGLRnldpmpsegkkgslkeestlqeLLLSPYLWVLSTGYLvVFGVKTCCTDWGQFFLIQEK-----GQSALVGSSYMSA 268
Cdd:cd17504 169 IDLR----------------------LLRRRNVLLANITAL-LAGFGMFMVFQLLPQLLQLPtptgfGLGITEAGLLLLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 269 LEVGGLVGSIAAGYLSDRAMAKAglsnygnprhgLLLFMMAGMTVSMYLFRVTVTSdspkLWILVLGAVFGFSSYG--PI 346
Cdd:cd17504 226 GALVMLIAGPLAGRLIARVGPRR-----------VLLIGLVISAVGLLLLALLHSS----LWALVVALLLIGIGLGlaFA 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 347 ALFGVIAnESAPPNLCGTSHAIVGLMANVGG-------------FLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFL 413
Cdd:cd17504 291 SLPNIVV-ESVPPDRTGIATGMNTVLRTIGSaigpaiagailttYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLL 369
|
..
gi 256219483 414 LR 415
Cdd:cd17504 370 IP 371
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
8-403 |
5.77e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.55 E-value: 5.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 8 YYRTVIFSAMFGGYSLyyfnrkTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSAR--WLFSSGLL 85
Cdd:cd17314 5 LYVSFLLSAMSTGFIL------SWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRplMALAGIMV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 86 LVGLVNIFFAWSStVPVFAALWFLNGLAQGLGWPPCGKVLRKWFePSQFGTWWAILSTSMNLAGGLGPILATILAQSYSW 165
Cdd:cd17314 79 LAGYTYLSYVFNS-FPLSYACFVFIGAGTGILYGSAVLVTTQYF-PDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 166 RSTLALSGALCVVVSFLCLLLIHNEPADVGLRnldpmpsegKKGSLKEESTLQELLLSPYLWVLSTGYLVVFgvktccTD 245
Cdd:cd17314 157 ALVYTILGILAAIVLSVVSLLGFKEPPDNQAR---------LHVQKKKTQTMGEIFRDKVFWILFIAIFLVL------IG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 246 WGQFFLIQE------KGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSNygnprhglLLFMMAGMTVSMYLFR 319
Cdd:cd17314 222 GFLFIANMAslvrslQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLS--------ILLTILGLGLCAFLFL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 320 VTVTSdspkLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAI----VGLMANVGGFLAGLPFSTiakHYSWST 395
Cdd:cd17314 294 LKMTP----VGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGIllfaPAIGSILGPMLGAKFYDR---TPSYIS 366
|
....*...
gi 256219483 396 AFWVAEVI 403
Cdd:cd17314 367 AVYIYAVI 374
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
247-414 |
5.78e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.78 E-value: 5.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 247 GQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRamakaglsnYGnpRHGLLLFMMAGMTVSMYLFRVTVTSDS 326
Cdd:cd17357 36 DRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANR---------FG--RKNGLLISNALLVVSSLLMFLSKSAKS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 327 PKLWIL--VLGAVFGFSSYGPIALFgviANESAPPNLCGTSHAIVGLMANVG---GFLAGLPFsTIAKHYSWSTAFWVAE 401
Cdd:cd17357 105 PELLIFgrFLVGIACGLSTGFVPMY---LQEISPSELRGALGSLTQIGVTLGillGQVFGLPS-VLGTETLWPYLLFFPG 180
|
170
....*....|...
gi 256219483 402 VICAASTAAFFLL 414
Cdd:cd17357 181 IPALLQLAALPFF 193
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
152-415 |
6.45e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 39.14 E-value: 6.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 152 GPILATILAQSY------SWRSTLALSGALCVVVSFLCLLLihnepadvgLRNLDPMPSEGKKGSLKEES--------TL 217
Cdd:PRK08633 155 GTALFSFLFESVngntpsEILGRIAPAGLVLLAVAVLGLIF---------AYRLPKVPAAAPEVFDKKKYlfpkllwrNL 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 218 QELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGL-VGSIAAGYLSDRAMAkaglsny 296
Cdd:PRK08633 226 KLLRSDRVLWLAIIGLSYFWFISQLAQANFPAYAKEVLGLDNTFQVQYLLAASAIGIgIGSLLAGRLSGRHIE------- 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 297 gnprHGLLLFMMAGMTVSMYLFrvtVTSDSPkLWILVLGAVFGFSSygpiALFGVIANE----SAPPNLCGTSHAIVGLM 372
Cdd:PRK08633 299 ----LGLVPLGALGLALSLFLL---PTAPSL-ASVLVLFFLFGFSA----GLFIVPLNAliqfRAPEKELGKVLAANNFL 366
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 256219483 373 ANVGGFLAgLPFSTIAKHYSWSTA--FWVAEVICAASTAA------FFLLR 415
Cdd:PRK08633 367 QNVGMLLF-LALTTLFSGLGLSPAglFYLIALVTLIGTLYtllllpDSLLR 416
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-185 |
6.56e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 6.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 9 YRTVIFSAMFGGYSLYYFnrkTFSFVMPS-LVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLL- 86
Cdd:cd17316 177 RRTLLLILLWFFISFGYY---GLTTFLPTyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILs 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 87 -VGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSW 165
Cdd:cd17316 254 gILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
|
170 180
....*....|....*....|
gi 256219483 166 RSTLALSGALCVVVSFLCLL 185
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
57-394 |
7.06e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 38.54 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 57 SAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWF--------LNGLAQG--LGWPPcgKVLR 126
Cdd:cd17334 45 SLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNALGSVLKCIPLGQQPKFallvlgqvLNALAQVlvLSLPP--LIAA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 127 KWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQS-----YSWRSTLALSGALCVVVSFLCLLLIHNEPAdvglrnldP 201
Cdd:cd17334 123 VWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPpkgtkKEFGAVFYGEFGFACLLLALVLALFPPKPK--------Y 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 202 MPSEGKKGSLKEESTLQELLLSPYLWVLSTGY---LVVFGVKT-CCTDWGQFF-LIQEKGQSALVGSSYMSALE-VGGLV 275
Cdd:cd17334 195 PPSAASARQQNSEHVILELQKSISELLRNEPFvllAVAFSIMMgVFAGFSSVLaQILLPFGVSQTSAGWLGFFGiVAGMV 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 276 GSIAAGYLSDRA-MAKaglsnygnpRHGLLLFMMAgmTVSMYLFRVTVTSDSPKLWILVLGAVFGF-----SSYGPIALf 349
Cdd:cd17334 275 GGLLLGLFVDRTrMFK---------LIGLIILALG--TVVCTFFMLLVDRYGLPYVTLAFYLLCGLlgffqNSMVPIMF- 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 256219483 350 gVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWS 394
Cdd:cd17334 343 -ELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTE 386
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
32-183 |
8.14e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 38.28 E-value: 8.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 32 SFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMsARWlfsSGLLLVGLVNIFFAW-SSTVPVFAALWFLN 110
Cdd:cd17372 19 SFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKY-GRR---KGLIISALWTFYAGFlSAFAPNYMWLIILR 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 256219483 111 GLAQ-GLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPI-LATILAQSYSWRSTLALSGALCVVVSFLC 183
Cdd:cd17372 95 CLVGlGLGGGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEAsLAWLVMPRLGWRWLLAFSSVPSSLLLVFY 169
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
139-412 |
8.82e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 8.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 139 AILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRnldpmpsegkkgslKEESTLQ 218
Cdd:cd17471 128 SVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKA--------------TPASSLV 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 219 ELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSA-LVGS--SYMSALEVgglVGSIAAGYLSDRAmakaglsn 295
Cdd:cd17471 194 KAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSEsWVGLlfGLAAALEI---PIMLLAGLLAKRF-------- 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256219483 296 ygnprhGLLLFMMAGMTVSMYLFRVTVTSDSPklWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANV 375
Cdd:cd17471 263 ------GKRRLLLAGFLAGVLFYLGLALATSL--WQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRI 334
|
250 260 270
....*....|....*....|....*....|....*..
gi 256219483 376 GGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFF 412
Cdd:cd17471 335 GSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| |
