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Conserved domains on  [gi|223556008|ref|NP_001138638|]
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protein arginine N-methyltransferase 3 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
168-331 1.72e-36

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 134.39  E-value: 1.72e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 168 HEEMLKDKIRTESYRDFIYQnpHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQ-AMDIIRLNKLEDTITL 246
Cdd:COG4076   12 HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAvARRIIAANGLSDRITV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 247 IKGKIEEVHLPvEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTislVAVSDVNKHADRIAFWDD-VY 325
Cdd:COG4076   90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERIT---NAAQPVESPVDAEGFEDWqFD 165


                 ....*.
gi 223556008 326 GFKMSC 331
Cdd:COG4076  166 GFDFRL 171
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
168-331 1.72e-36

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 134.39  E-value: 1.72e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 168 HEEMLKDKIRTESYRDFIYQnpHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQ-AMDIIRLNKLEDTITL 246
Cdd:COG4076   12 HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAvARRIIAANGLSDRITV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 247 IKGKIEEVHLPvEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTislVAVSDVNKHADRIAFWDD-VY 325
Cdd:COG4076   90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERIT---NAAQPVESPVDAEGFEDWqFD 165


                 ....*.
gi 223556008 326 GFKMSC 331
Cdd:COG4076  166 GFDFRL 171
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 197-297 3.51e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 74.00  E-value: 3.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 197 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHL-PVEKVDVIISEWMGYFL-- 273
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHLve 81

                         90       100
                 ....*....|....*....|....
gi 223556008 274 LFESMLDSVLyaknKYLAKGGSVY 297
Cdd:cd02440   82 DLARFLEEAR----RLLKPGGVLV 101
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
190-265 1.51e-13

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 70.18  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 190 HIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDI----IRLNKLEDTITLIKGKieevhlpvEKVDVII 265
Cdd:PRK00517 116 LVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD---IDPQAVEAarenAELNGVELNVYLPQGD--------LKADVIV 184
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 197-266 1.20e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 60.66  E-value: 1.20e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223556008  197 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEI-LYQAMDiiRLNKLEDTITLIKGKIEEVHLPVEKVDVIIS 266
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARE--RAAEAGLNVEFVQGDAEDLPFPDGSFDLVVS 69
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 193-265 9.18e-09

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 56.38  E-value: 9.18e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223556008  193 KDKVVLDVGCGTGILSMFAAKAGAKKVLGVD-QSEILYQAMDIIRLNKLEDTITLIKGKIEEvhlPVE-KVDVII 265
Cdd:TIGR00406 159 KDKNVIDVGCGSGILSIAALKLGAAKVVGIDiDPLAVESARKNAELNQVSDRLQVKLIYLEQ---PIEgKADVIV 230
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
168-331 1.72e-36

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 134.39  E-value: 1.72e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 168 HEEMLKDKIRTESYRDFIYQnpHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQ-AMDIIRLNKLEDTITL 246
Cdd:COG4076   12 HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAvARRIIAANGLSDRITV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 247 IKGKIEEVHLPvEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTislVAVSDVNKHADRIAFWDD-VY 325
Cdd:COG4076   90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERIT---NAAQPVESPVDAEGFEDWqFD 165


                 ....*.
gi 223556008 326 GFKMSC 331
Cdd:COG4076  166 GFDFRL 171
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 197-297 3.51e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 74.00  E-value: 3.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 197 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHL-PVEKVDVIISEWMGYFL-- 273
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHLve 81

                         90       100
                 ....*....|....*....|....
gi 223556008 274 LFESMLDSVLyaknKYLAKGGSVY 297
Cdd:cd02440   82 DLARFLEEAR----RLLKPGGVLV 101
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
190-265 4.44e-16

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 78.29  E-value: 4.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 190 HIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEilyQAMDI----IRLNKLEDTITLIKGKIeevhLPVEKVDVII 265
Cdd:COG2264  145 LLKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVDIDP---VAVEAarenAELNGVEDRIEVVLGDL----LEDGPYDLVV 217
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
190-265 1.51e-13

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 70.18  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 190 HIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDI----IRLNKLEDTITLIKGKieevhlpvEKVDVII 265
Cdd:PRK00517 116 LVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD---IDPQAVEAarenAELNGVELNVYLPQGD--------LKADVIV 184
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 188-266 9.00e-13

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 65.04  E-value: 9.00e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223556008 188 NPHIFKDKVVLDVGCGTGILSMFAAKAGAkKVLGVDQSEilyQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIIS 266
Cdd:COG2227   19 ARLLPAGGRVLDVGCGTGRLALALARRGA-DVTGVDISP---EALEIARERAAELNVDFVQGDLEDLPLEDGSFDLVIC 93
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 197-266 1.20e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 60.66  E-value: 1.20e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223556008  197 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEI-LYQAMDiiRLNKLEDTITLIKGKIEEVHLPVEKVDVIIS 266
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARE--RAAEAGLNVEFVQGDAEDLPFPDGSFDLVVS 69
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 193-265 2.95e-11

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 64.21  E-value: 2.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008  193 KDKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDI----IRLNKLEDTItlikgkieEVHL----PVEKVDVI 264
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGAKKVVGVD---IDPVAVRAakenAELNGVEARL--------EVYLpgdlPKEKADVV 229


                  .
gi 223556008  265 I 265
Cdd:pfam06325 230 V 230
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
192-266 3.87e-11

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 62.23  E-value: 3.87e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223556008 192 FKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDIIRLN--KLEDTITLIKGKIEEVHLpVEKVDVIIS 266
Cdd:COG2263   44 IEGKTVLDLGCGTGMLAIGAALLGAKKVVGVD---IDPEALEIARENaeRLGVRVDFIRADVTRIPL-GGSVDTVVM 116
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 197-266 1.21e-10

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 61.31  E-value: 1.21e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 223556008 197 VLDVGCGTGILS-MFAAKAGAKKVLGVDQSEILY-QAMDIIRLNKLEDTITLIKGKIEEV--HLPVEKVDVIIS 266
Cdd:COG4123   41 VLDLGTGTGVIAlMLAQRSPGARITGVEIQPEAAeLARRNVALNGLEDRITVIHGDLKEFaaELPPGSFDLVVS 114
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 193-266 9.16e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 56.93  E-value: 9.16e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223556008 193 KDKVVLDVGCGTGILSMFAAKAGAkKVLGVDQS-EILYQAMDiiRLNKLEDTITLIKGKIEEVHLPVEKVDVIIS 266
Cdd:COG2226   22 PGARVLDLGCGTGRLALALAERGA-RVTGVDISpEMLELARE--RAAEAGLNVEFVVGDAEDLPFPDGSFDLVIS 93
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 162-371 1.19e-09

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 59.34  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008  162 YGHYGIHeemlkdkIRTESYRDFIYQN--PHI--FKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEI-LYQAMDIIR 236
Cdd:pfam08003  87 FHLFGVH-------IDTEWRSDWKWDRvlPHLspLKGRTILDVGCGNGYHMWRMLGEGAAMVVGIDPSELfLCQFEAVRK 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008  237 LNKLEDTITLIKGKIEevHLP-VEKVDVIISewMGYFLLFESMLDSVLYAKNKyLAKGGSVYPDictiSLVAVSDVNK-- 313
Cdd:pfam08003 160 LLGNDQRAHLLPLGIE--QLPaLAAFDTVFS--MGVLYHRRSPLDHLLQLKDQ-LVKGGELVLE----TLVIDGDENTvl 230

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223556008  314 -HADRIAFWDDVYgfkmscmkkaVIPEAvvevldpKTLIS--EPCGIKHIDCHTTSISDLE 371
Cdd:pfam08003 231 vPGDRYAQMRNVY----------FIPSA-------AALINwlEKCGFVDVRIVDVSVTTLE 274
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 193-265 9.18e-09

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 56.38  E-value: 9.18e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223556008  193 KDKVVLDVGCGTGILSMFAAKAGAKKVLGVD-QSEILYQAMDIIRLNKLEDTITLIKGKIEEvhlPVE-KVDVII 265
Cdd:TIGR00406 159 KDKNVIDVGCGSGILSIAALKLGAAKVVGIDiDPLAVESARKNAELNQVSDRLQVKLIYLEQ---PIEgKADVIV 230
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
165-284 1.66e-08

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 56.02  E-value: 1.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 165 YGIHeemlkdkIRTESYRDFIYQN--PHIF--KDKVVLDVGCGTGiLSMF-AAKAGAKKVLGVDQSEI-LYQAMDIIRLN 238
Cdd:PRK15068  97 FGIH-------IDTEWRSDWKWDRvlPHLSplKGRTVLDVGCGNG-YHMWrMLGAGAKLVVGIDPSQLfLCQFEAVRKLL 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 223556008 239 KLEDTITLIKGKIEEVHlPVEKVDVIISewMGyfllfesmldsVLY 284
Cdd:PRK15068 169 GNDQRAHLLPLGIEQLP-ALKAFDTVFS--MG-----------VLY 200
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 198-269 4.23e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 50.74  E-value: 4.23e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223556008  198 LDVGCGTGILSMFAAKAGAkKVLGVDQSEilyQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWM 269
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVDISP---EMLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEV 68
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 183-297 5.16e-08

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 53.35  E-value: 5.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 183 DFIYQNPHIfKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDIIRLNKLE--DTITLIKGKIEEVHlPVEK 260
Cdd:COG3897   61 RYLLDHPEV-AGKRVLELGCGLGLVGIAAAKAGAADVTATD---YDPEALAALRLNAALngVAITTRLGDWRDPP-AAGG 135

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 223556008 261 VDVII-SEwmgyfLLFE-SMLDSVLYAKNKYLAKGGSVY 297
Cdd:COG3897  136 FDLILgGD-----VLYErDLAEPLLPFLDRLAAPGGEVL 169
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 197-294 5.95e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 51.85  E-value: 5.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 197 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQ-AMDIIRLNKLEDTITLIKGKIEEVHLPvEKVDVIIS----EWMG- 270
Cdd:COG2230   55 VLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEyARERAAEAGLADRVEVRLADYRDLPAD-GQFDAIVSigmfEHVGp 133

                         90       100
                 ....*....|....*....|....*.
gi 223556008 271 --YFLLFESMLDSvlyaknkyLAKGG 294
Cdd:COG2230  134 enYPAYFAKVARL--------LKPGG 151
PRK14968 PRK14968
putative methyltransferase; Provisional
 193-297 8.59e-08

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 52.21  E-value: 8.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 193 KDKVVLDVGCGTGILSMFAAKAGaKKVLGVDQSEI-LYQAMDIIRLNKLE---------DTITLIKGKIEEV------HL 256
Cdd:PRK14968  23 KGDRVLEVGTGSGIVAIVAAKNG-KKVVGVDINPYaVECAKCNAKLNNIRnngvevirsDLFEPFRGDKFDVilfnppYL 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 223556008 257 PVEKvDVIISEWMGYFL--------LFESMLDSVlyakNKYLAKGGSVY 297
Cdd:PRK14968 102 PTEE-EEEWDDWLNYALsggkdgreVIDRFLDEV----GRYLKPGGRIL 145
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 193-265 4.63e-07

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 51.72  E-value: 4.63e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223556008 193 KDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSE-ILYQAMDIIRLNKLEDTITLIKGK----IEEVHLPVEKVDVII 265
Cdd:COG1092  216 KGKRVLNLFSYTGGFSVHAAAGGAKSVTSVDLSAtALEWAKENAALNGLDDRHEFVQADafdwLRELAREGERFDLII 293
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 197-297 9.41e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 49.53  E-value: 9.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 197 VLDVGCGTGILSMFAAKAGAKKVLGVDQS-EILYQAMDIIRLNKLeDTITLIKGKIEEVH-LPVEKVDVIISewMGYF-L 273
Cdd:COG0500   30 VLDLGCGTGRNLLALAARFGGRVIGIDLSpEAIALARARAAKAGL-GNVEFLVADLAELDpLPAESFDLVVA--FGVLhH 106

                         90       100
                 ....*....|....*....|....
gi 223556008 274 LFESMLDSVLYAKNKYLAKGGSVY 297
Cdd:COG0500  107 LPPEEREALLRELARALKPGGVLL 130
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 191-266 1.08e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 48.18  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008  191 IFKDKVVLDVGCGTGILSMFAAK--AGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEE--VHLPVEKVDVIIS 266
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEelGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEElpELLEDDKFDVVIS 80
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
179-266 4.57e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 46.92  E-value: 4.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 179 ESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGaKKVLGVDQSEilyqAM-DIIRLNKLEDtiTLIKGKIEEVHLP 257
Cdd:COG4976   32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG-YRLTGVDLSE----EMlAKAREKGVYD--RLLVADLADLAEP 104


                 ....*....
gi 223556008 258 VEKVDVIIS 266
Cdd:COG4976  105 DGRFDLIVA 113
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
197-266 1.08e-05

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 44.04  E-value: 1.08e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223556008 197 VLDVGCGTGILS-MFAAKAGAKKVLGVDQSEilyqAMdIIRLNKLEDTITLIKGKIEEVHLPvEKVDVIIS 266
Cdd:COG4106    5 VLDLGCGTGRLTaLLAERFPGARVTGVDLSP----EM-LARARARLPNVRFVVADLRDLDPP-EPFDLVVS 69
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 193-267 1.58e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 45.32  E-value: 1.58e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 223556008 193 KDKVVLDVGCGTGILSMFAAKAGAkKVLGVD-QSEILYQAMDIIRLNKLEDtITLIKGKIEEVHLPVEKVDVIISE 267
Cdd:COG1041   26 EGDTVLDPFCGTGTILIEAGLLGR-RVIGSDiDPKMVEGARENLEHYGYED-ADVIRGDARDLPLADESVDAIVTD 99
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 187-266 1.94e-05

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 45.74  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008  187 QNPHIFKDKVVLDVGCGTGILSMFAAKAGAK-KVLGVDQSEI-LYQAMDIIRLNkledtITLIKGKIEEVHLPVEKVDVI 264
Cdd:TIGR02072  28 KEKGIFIPASVLDIGCGTGYLTRALLKRFPQaEFIALDISAGmLAQAKTKLSEN-----VQFICGDAEKLPLEDSSFDLI 102


                  ..
gi 223556008  265 IS 266
Cdd:TIGR02072 103 VS 104
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 191-313 2.63e-05

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 45.17  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 191 IFKDKVVLDVGCGTGILSMFAAK-AGAK-KVLGVDQSEilyQAMDIIRLN----KLEDTITLIKGKIEEVhlpvekVDVI 264
Cdd:PRK00377  38 LRKGDMILDIGCGTGSVTVEASLlVGETgKVYAVDKDE---KAINLTRRNaekfGVLNNIVLIKGEAPEI------LFTI 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 223556008 265 ISEWMGYFLLFESM-LDSVLYAKNKYLAKGGSVYPDICTISLV--AVSDVNK 313
Cdd:PRK00377 109 NEKFDRIFIGGGSEkLKEIISASWEIIKKGGRIVIDAILLETVnnALSALEN 160
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 193-296 4.28e-05

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 44.12  E-value: 4.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008  193 KDKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDIIRLNkleDTITLIKGKI--EEVHLPVE-----KVDVII 265
Cdd:pfam01728  21 PGKTVLDLGAAPGGWSQVALQRGAGKVVGVD---LGPMQLWKPRND---PGVTFIQGDIrdPETLDLLEellgrKVDLVL 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 223556008  266 SEwMGYFLLFESMLD---------SVLYAKNKYLAKGGSV 296
Cdd:pfam01728  95 SD-GSPFISGNKVLDhlrsldlvkAALEVALELLRKGGNF 133
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 190-297 4.84e-05

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 43.92  E-value: 4.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 190 HIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSeilYQAMDIIRLN----KLEDTITLIKGKIEEV--HLPVEKVDV 263
Cdd:COG0742   38 PDIEGARVLDLFAGSGALGLEALSRGAASVVFVEKD---RKAAAVIRKNleklGLEDRARVIRGDALRFlkRLAGEPFDL 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 223556008 264 IisewmgyFL-------LFESMLDSVlyAKNKYLAKGGSVY 297
Cdd:COG0742  115 V-------FLdppyakgLLEKALELL--AENGLLAPGGLIV 146
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 174-321 6.78e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 43.19  E-value: 6.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008  174 DKIRTESYRDFI-YQNPHIFKDKVVLDVGCGTGILSMFAAKAGAkKVLGVDQSEILYQAMDIIRLNKLEDtitlikgkIE 252
Cdd:pfam13489   2 AHQRERLLADLLlRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGF-SVTGVDPSPIAIERALLNVRFDQFD--------EQ 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223556008  253 EVHLPVEKVDVIISewmgyFLLFESMLDSVLYAKN--KYLAKGGSVYpdictISLVAVSDvnKHADRIAFW 321
Cdd:pfam13489  73 EAAVPAGKFDVIVA-----REVLEHVPDPPALLRQiaALLKPGGLLL-----LSTPLASD--EADRLLLEW 131
arsM PRK11873
arsenite methyltransferase;
196-266 6.95e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 44.55  E-value: 6.95e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223556008 196 VVLDVGCGTGILSMFAAKA-GAK-KVLGVDQSEilyqAM-DIIRLNKLE---DTITLIKGKIEEVHLPVEKVDVIIS 266
Cdd:PRK11873  80 TVLDLGSGGGFDCFLAARRvGPTgKVIGVDMTP----EMlAKARANARKagyTNVEFRLGEIEALPVADNSVDVIIS 152
PRK14967 PRK14967
putative methyltransferase; Provisional
 197-266 3.23e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 41.96  E-value: 3.23e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223556008 197 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEilyQAMDIIRLNKLED--TITLIKGKIEEvHLPVEKVDVIIS 266
Cdd:PRK14967  40 VLDLCTGSGALAVAAAAAGAGSVTAVDISR---RAVRSARLNALLAgvDVDVRRGDWAR-AVEFRPFDVVVS 107
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 198-294 3.31e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 39.66  E-value: 3.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008  198 LDVGCGTG-ILSMFAAKAGAKKVLGVDQSEilyQAMDII--RLNKLE----DTITLIKGKIEEVHLPveKVDVIIsewMG 270
Cdd:pfam08242   1 LEIGCGTGtLLRALLEALPGLEYTGLDISP---AALEAAreRLAALGllnaVRVELFQLDLGELDPG--SFDVVV---AS 72

                          90       100
                  ....*....|....*....|....
gi 223556008  271 YFLLFESMLDSVLYAKNKYLAKGG 294
Cdd:pfam08242  73 NVLHHLADPRAVLRNIRRLLKPGG 96
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 193-226 5.68e-04

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 41.36  E-value: 5.68e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 223556008 193 KDKVVLDVGCGTGILSMFAAKAGAkKVLGVDQSE 226
Cdd:PRK07580  63 TGLRILDAGCGVGSLSIPLARRGA-KVVASDISP 95
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 197-266 6.52e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 40.56  E-value: 6.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 197 VLDVGCGTGILSMFAAKAGAK-KVLGVDQSEilyQAMDI----IRLNKLEDTitlikgkieEVH-------LPVEKVDVI 264
Cdd:COG2813   53 VLDLGCGYGVIGLALAKRNPEaRVTLVDVNA---RAVELaranAAANGLENV---------EVLwsdglsgVPDGSFDLI 120


                 ..
gi 223556008 265 IS 266
Cdd:COG2813  121 LS 122
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 191-265 6.60e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 41.30  E-value: 6.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 191 IFKDKVVLDVGCGTGILSMFAAKA-GAK-KVLGVDQSEilyQAMDIIRLN----KLEDTITLIKGKIEEVhLPVEKVDVI 264
Cdd:COG2519   89 IFPGARVLEAGTGSGALTLALARAvGPEgKVYSYERRE---DFAEIARKNlerfGLPDNVELKLGDIREG-IDEGDVDAV 164


                 .
gi 223556008 265 I 265
Cdd:COG2519  165 F 165
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 193-265 9.24e-04

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 41.32  E-value: 9.24e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223556008 193 KDKVVLDVGCGTGILSMFAAKAgAKKVLGVDQSE--ILyQAMDIIRLNKLEDtITLIKGKIEEV---HLPVEKVDVII 265
Cdd:COG2265  233 GGERVLDLYCGVGTFALPLARR-AKKVIGVEIVPeaVE-DARENARLNGLKN-VEFVAGDLEEVlpeLLWGGRPDVVV 307
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 196-266 1.21e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 40.52  E-value: 1.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223556008 196 VVLDVGCGTGI--LSMFAAKAGAkKVLGVDQSEilyQAMDI----IRLNKLEDTITLIKGKIEEVHLPVEKVDVIIS 266
Cdd:COG2890  115 RVLDLGTGSGAiaLALAKERPDA-RVTAVDISP---DALAVarrnAERLGLEDRVRFLQGDLFEPLPGDGRFDLIVS 187
PRK08317 PRK08317
hypothetical protein; Provisional
 179-267 1.64e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.92  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 179 ESYRDFIYQNPHIFKDKVVLDVGCGTGILSM-FAAKAGAK-KVLGVDQSEILYqAMDIIRLNKLEDTITLIKGKIEEVHL 256
Cdd:PRK08317   5 RRYRARTFELLAVQPGDRVLDVGCGPGNDAReLARRVGPEgRVVGIDRSEAML-ALAKERAAGLGPNVEFVRGDADGLPF 83

                         90
                 ....*....|.
gi 223556008 257 PVEKVDVIISE 267
Cdd:PRK08317  84 PDGSFDAVRSD 94
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
 196-283 1.84e-03

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 39.64  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008  196 VVLDVGCGTGILSMFAAKAG-AKKVLGVDQSEILYQAM-DIIRLNKLEDTITLIKGKIEEVhLPVEKVDVIIsewMGYFL 273
Cdd:pfam02475 102 VVVDMFAGIGPFSIPIAKHSkARRVYAIELNPESYKYLkENIKLNKVEDVVKPILGDVREV-ILEDVADRVV---MNLPG 177

                          90
                  ....*....|
gi 223556008  274 LFESMLDSVL 283
Cdd:pfam02475 178 SAHEFLDKAF 187
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
172-266 2.00e-03

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 39.88  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 172 LKDKirteSYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAgAKKVLGVDQSEILyqamdIIRLNKL---EDTITLIK 248
Cdd:PRK14896  12 LIDD----RVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKR-AKKVYAIELDPRL-----AEFLRDDeiaAGNVEIIE 81

                         90
                 ....*....|....*...
gi 223556008 249 GKIEEVHLPveKVDVIIS 266
Cdd:PRK14896  82 GDALKVDLP--EFNKVVS 97
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 193-266 2.30e-03

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 39.76  E-value: 2.30e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223556008 193 KDKVVLDVGCGTGILS-MFAAKAGAKKVLGVDQSEilyQAMDIIRLN---KLEDTITLIKGKIEEvHLPVEKVDVIIS 266
Cdd:PRK09328 108 EPLRVLDLGTGSGAIAlALAKERPDAEVTAVDISP---EALAVARRNakhGLGARVEFLQGDWFE-PLPGGRFDLIVS 181
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 193-266 3.49e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 38.34  E-value: 3.49e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223556008  193 KDKVVLDVGCGTGILSMFAAKAGAK-KVLGVDQSeilYQAMDI----IRLNKLEDTITLIKGKIEEVhlPVEKVDVIIS 266
Cdd:pfam05175  31 LSGKVLDLGCGAGVLGAALAKESPDaELTMVDIN---ARALESarenLAANGLENGEVVASDVYSGV--EDGKFDLIIS 104
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 194-294 5.30e-03

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 38.69  E-value: 5.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008 194 DKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDI-IRLNKLEDTITLIKGKIEEV-HLPVEKVDVIIsewMGY 271
Cdd:COG2520  181 GERVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDAVEYLKEnIRLNKVEDRVTPILGDAREVaPELEGKADRII---MNL 257

                         90       100
                 ....*....|....*....|...
gi 223556008 272 FLLFESMLDSVLYAknkyLAKGG 294
Cdd:COG2520  258 PHSADEFLDAALRA----LKPGG 276
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
195-265 6.75e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 38.35  E-value: 6.75e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223556008 195 KVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEIlyqAMDIIRLN----KLEDT-ITLIKGKIEEV--HLPVEKVDVII 265
Cdd:COG2521  134 DRVLDTCTGLGYTAIEALKRGAREVITVEKDPN---VLELAELNpwsrELANErIKIILGDASEVikTFPDESFDAII 208
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 197-259 6.94e-03

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 38.21  E-value: 6.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 223556008 197 VLDVGCGTGILSMFAAKAGAK--KVLGVDQSE-ILYQAMDIIRLNKLEDTITLIKGKIEevHLPVE 259
Cdd:PRK00216  55 VLDLACGTGDLAIALAKAVGKtgEVVGLDFSEgMLAVGREKLRDLGLSGNVEFVQGDAE--ALPFP 118
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 185-266 9.70e-03

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 37.72  E-value: 9.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223556008  185 IYQNPHIFKdkvVLDVGCGTGILSMFAAKAGA-KKVLGVDQS-EILYQAMDIIRLNKLEDTITLIKGKIEEvHLPVEKVD 262
Cdd:TIGR00536 109 LISQPPILH---ILDLGTGSGCIALALAYEFPnAEVIAVDISpDALAVAEENAEKNQLEHRVEFIQSNLFE-PLAGQKID 184


                  ....
gi 223556008  263 VIIS 266
Cdd:TIGR00536 185 IIVS 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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