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Conserved domains on  [gi|221136985|ref|NP_001137482|]
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SLIT and NTRK-like protein 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 2.01e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIRTgAFSGLKTLKRLHLNNNKLEILREDtFLGLESLEYLQADYNY 145
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 221136985 146 ISAIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886  194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR_8 pfam13855
Leucine rich repeat;
399-459 4.93e-14

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 4.93e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221136985  399 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
378-529 4.89e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 4.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 378 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 457
Cdd:COG4886  139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221136985 458 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 529
Cdd:COG4886  216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-579 1.29e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 1.29e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 221136985   529 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 579
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
216-252 2.04e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 2.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 221136985   216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 2.01e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIRTgAFSGLKTLKRLHLNNNKLEILREDtFLGLESLEYLQADYNY 145
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 221136985 146 ISAIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886  194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR_8 pfam13855
Leucine rich repeat;
399-459 4.93e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 4.93e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221136985  399 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 3.21e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 3.21e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221136985   86 SNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
378-529 4.89e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 4.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 378 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 457
Cdd:COG4886  139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221136985 458 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 529
Cdd:COG4886  216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 357-530 1.82e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 357 VNCQERKFTNISDLQPkPTSPKKLYLTGNYLQTVykNDLLEYSSLDLLHLGNNRIAVIqEGaFTNLTSLRRLYLNGNYLE 436
Cdd:cd21340    7 LYLNDKNITKIDNLSL-CKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 437 VLypSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslPDNIFG-----------G------------ 493
Cdd:cd21340   82 VV--EGLENLTNLEELHIENQRLPPGEKLTFD------------------PRSLAAlsnslrvlnisGnnidsleplapl 141

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 221136985 494 TALTRLNLRNNHFSHL-PVKGVLDQLPAFIQIDLQENP 530
Cdd:cd21340  142 RNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTGNP 179
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-579 1.29e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 1.29e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 221136985   529 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 579
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-260 4.34e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 4.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  67 LFLNGNLLTRLyPNeFVNYSNAVTLHLGNNGLQEIRTgaFSGLKTLKRLHLNNNKLEILRedtflGLESLEYLQA----- 141
Cdd:cd21340   29 LYLYDNKITKI-EN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLEElhien 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 142 -----------DYNYISAIeagafskLNKLKVLILNDNLLLSLpSNVFRFVLLTHLDLRGNRLKVM-PFAGVLEHIGGIM 209
Cdd:cd21340  100 qrlppgekltfDPRSLAAL-------SNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLeELLDLLSSWPSLR 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 221136985 210 EIQLEENPwnctcdLLPLKAWLDTITVFVGEIVCetpfrLHGKDVTQLTRQ 260
Cdd:cd21340  172 ELDLTGNP------VCKKPKYRDKIILASKSLEV-----LDGKEITDTERQ 211
LRRCT smart00082
Leucine rich repeat C-terminal domain;
216-252 2.04e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 2.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 221136985   216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-193 1.14e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKL--EILREdtfLG-LESLEYLQ 140
Cdd:PLN00113 142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIPRE---LGqMKSLKWIY 218

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 221136985 141 ADYNYISA---IEAGAFSKLNKLKvLILNdNLLLSLPSNVFRFVLLTHLDLRGNRL 193
Cdd:PLN00113 219 LGYNNLSGeipYEIGGLTSLNHLD-LVYN-NLTGPIPSSLGNLKNLQYLFLYQNKL 272
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 380-457 2.42e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221136985 380 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYN 457
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN 222
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 2.01e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIRTgAFSGLKTLKRLHLNNNKLEILREDtFLGLESLEYLQADYNY 145
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 221136985 146 ISAIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886  194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-217 2.40e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 2.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIrTGAFSGLKTLKRLHLNNNKLEILrEDTFLGLESLEYLQADYNY 145
Cdd:COG4886  140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221136985 146 ISAIEAgAFSKLNKLKVLILNDNLLLSLPSnVFRFVLLTHLDLRGNRLKVMPFAGVLEHIGgimEIQLEENP 217
Cdd:COG4886  217 LTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLANLTNLK---TLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
399-459 4.93e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 4.93e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221136985  399 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 3.21e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 3.21e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221136985   86 SNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
378-529 4.89e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 4.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 378 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 457
Cdd:COG4886  139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221136985 458 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 529
Cdd:COG4886  216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
111-170 1.33e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 1.33e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  111 TLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLL 170
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-530 9.38e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 9.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 358 NCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEV 437
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 438 LyPSMFDGLQSLQYLYLEYNVIKEIkpltfdalinlqllflnnnllrslpDNIFGGTALTRLNLRNNHFSHLPvkgVLDQ 517
Cdd:COG4886  220 L-PEPLANLTNLETLDLSNNQLTDL-------------------------PELGNLTNLEELDLSNNQLTDLP---PLAN 270

                        170
                 ....*....|...
gi 221136985 518 LPAFIQIDLQENP 530
Cdd:COG4886  271 LTNLKTLDLSNNQ 283
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 357-530 1.82e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 357 VNCQERKFTNISDLQPkPTSPKKLYLTGNYLQTVykNDLLEYSSLDLLHLGNNRIAVIqEGaFTNLTSLRRLYLNGNYLE 436
Cdd:cd21340    7 LYLNDKNITKIDNLSL-CKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 437 VLypSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslPDNIFG-----------G------------ 493
Cdd:cd21340   82 VV--EGLENLTNLEELHIENQRLPPGEKLTFD------------------PRSLAAlsnslrvlnisGnnidsleplapl 141

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 221136985 494 TALTRLNLRNNHFSHL-PVKGVLDQLPAFIQIDLQENP 530
Cdd:cd21340  142 RNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
135-193 2.27e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.27e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  135 SLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRL 193
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
365-527 1.10e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 365 TNISDLqPKPTSP----KKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIqEGAFTNLTSLRRLYLNGNYLEVLyP 440
Cdd:COG4886  169 NQLTDL-PEELGNltnlKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL-P 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 441 SMFdGLQSLQYLYLEYNVIKEIKPLtfdalinlqllflnnnllrslpdniFGGTALTRLNLRNNHFSHLPVKGVLDQLPA 520
Cdd:COG4886  245 ELG-NLTNLEELDLSNNQLTDLPPL-------------------------ANLTNLKTLDLSNNQLTDLKLKELELLLGL 298


                 ....*..
gi 221136985 521 FIQIDLQ 527
Cdd:COG4886  299 NSLLLLL 305
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-579 1.29e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 1.29e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 221136985   529 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 579
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
423-506 4.17e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  423 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslpdnifGGTALTRLNLR 502
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS-----------------------GLPSLRYLDLS 57


                  ....
gi 221136985  503 NNHF 506
Cdd:pfam13855  58 GNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
365-504 9.90e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 9.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 365 TNISDLQP---KPTSPKKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIQEgaFTNLTSLRRLYLNGNYLEVLYPS 441
Cdd:COG4886  192 NQITDLPEplgNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL 268

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221136985 442 MfdGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNN 504
Cdd:COG4886  269 A--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR_8 pfam13855
Leucine rich repeat;
67-122 5.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 221136985   67 LFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKL 122
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-260 4.34e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 4.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  67 LFLNGNLLTRLyPNeFVNYSNAVTLHLGNNGLQEIRTgaFSGLKTLKRLHLNNNKLEILRedtflGLESLEYLQA----- 141
Cdd:cd21340   29 LYLYDNKITKI-EN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLEElhien 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 142 -----------DYNYISAIeagafskLNKLKVLILNDNLLLSLpSNVFRFVLLTHLDLRGNRLKVM-PFAGVLEHIGGIM 209
Cdd:cd21340  100 qrlppgekltfDPRSLAAL-------SNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLeELLDLLSSWPSLR 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 221136985 210 EIQLEENPwnctcdLLPLKAWLDTITVFVGEIVCetpfrLHGKDVTQLTRQ 260
Cdd:cd21340  172 ELDLTGNP------VCKKPKYRDKIILASKSLEV-----LDGKEITDTERQ 211
LRRCT smart00082
Leucine rich repeat C-terminal domain;
216-252 2.04e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 2.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 221136985   216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-197 3.50e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  40 NVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTL-HLGNNGLQEIRTGAFSGLKTLKRLHLN 118
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLlSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221136985 119 NNKLEILREDTFLGLESLEYLQADYNyisaieaGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP 152
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-193 1.14e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKL--EILREdtfLG-LESLEYLQ 140
Cdd:PLN00113 142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIPRE---LGqMKSLKWIY 218

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 221136985 141 ADYNYISA---IEAGAFSKLNKLKvLILNdNLLLSLPSNVFRFVLLTHLDLRGNRL 193
Cdd:PLN00113 219 LGYNNLSGeipYEIGGLTSLNHLD-LVYN-NLTGPIPSSLGNLKNLQYLFLYQNKL 272
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 96-191 2.06e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985   96 NGLQEIRTGAFSGLKTLKRLHLNNNkLEILREDTFLG--LESLEYLqadyNYISAIEAGAFSKLNKLKVLILNDNlLLSL 173
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNcsLTSITIP----SSLTSIGEYAFSNCSNLKSITLPSN-LTSI 93

                          90
                  ....*....|....*...
gi 221136985  174 PSNVFRFVLLTHLDLRGN 191
Cdd:pfam13306  94 GSYAFSNCSLKSITIPSS 111
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 380-457 2.42e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221136985 380 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYN 457
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN 222
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
338-529 3.74e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 338 LTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEg 417
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD- 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 418 aFTNLTSLRRLYLNGNylevlypSMFDGLQSLQYLYLEYNVIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALT 497
Cdd:COG4886   92 -LGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL------------------------PEELANLTNLK 139

                        170       180       190
                 ....*....|....*....|....*....|..
gi 221136985 498 RLNLRNNHFSHLPVkgVLDQLPAFIQIDLQEN 529
Cdd:COG4886  140 ELDLSNNQLTDLPE--PLGNLTNLKSLDLSNN 169
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 82-217 4.29e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  82 FVNYSNAVTLHLGNNGLQEIRTGAFSGL---KTLKRLHLNNNKLEILREDTFL-GL----ESLEYLQADYNYISAIE--- 150
Cdd:cd00116   77 LTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLLAkGLkdlpPALEKLVLGRNRLEGAScea 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985 151 -AGAFSKLNKLKVLILNDN---------LLLSLPSNvfrfVLLTHLDLRGNRLK---VMPFAGVLEHIGGIMEIQLEENP 217
Cdd:cd00116  157 lAKALRANRDLKELNLANNgigdagiraLAEGLKAN----CNLEVLDLNNNGLTdegASALAETLASLKSLEVLNLGDNN 232
PLN03150 PLN03150
hypothetical protein; Provisional
 91-170 4.95e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 4.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221136985  91 LHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLL 170
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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