NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|219555661|ref|NP_001137251|]
View 

intraflagellar transport protein 81 homolog isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IFT81_CH pfam18383
Intraflagellar transport 81 calponin homology domain; This is the N-terminal domain found in ...
 3-126 3.48e-65

Intraflagellar transport 81 calponin homology domain; This is the N-terminal domain found in IFT81 proteins. Crystal structure analysis revealed that IFT81-N adopts the fold of a calponin homology (CH) domain with structural similarity to the kinetochore complex component NDC80 with microtubule (MT)-binding properties. Functional analysis show that IFT74 and IFT81 form a tubulin-binding module required for ciliogenesis. It is suggested that IFT81-N binds the globular domain of tubulin to provide specificity, and IFT74-N recognizes the beta-tubulin tail to increase affinity.


:

Pssm-ID: 465736  Cd Length: 124  Bit Score: 210.57  E-value: 3.48e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661    3 DQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATD 82
Cdd:pfam18383   1 ENLKFIVTELNKEPFNKNYNLITFDSLSPEQLLQVLNDVLAEIDPKQKVDIREESPEETAIRILEALRILKYKPPPDIDD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 219555661   83 MSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLE 126
Cdd:pfam18383  81 PSAFRQGLVRGEKLVIYPILYWLLSNVEELKKRAYLARFLVKVE 124
PTZ00121 super family cl31754
MAEBL; Provisional
 138-672 3.63e-09

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.54  E-value: 3.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  138 ADTNKQYEELMEAFKTLHKEYEQLKisgfsTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQwmLKIARQLRVEKE 217
Cdd:PTZ00121 1292 ADEAKKAEEKKKADEAKKKAEEAKK-----ADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEA--EAAADEAEAAEE 1364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  218 REEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKfnlymVTEKFPKELENKKKELHFLQK 297
Cdd:PTZ00121 1365 KAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK-----KADEAKKKAEEKKKADEAKKK 1439

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  298 V--------VSEPAMGHSDLLELESKINEINT--EINQLIEKKMmRNEPIEGKLSLYRQQASIISRKKEAK--AEELQEA 365
Cdd:PTZ00121 1440 AeeakkadeAKKKAEEAKKAEEAKKKAEEAKKadEAKKKAEEAK-KADEAKKKAEEAKKKADEAKKAAEAKkkADEAKKA 1518

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  366 KEKLASLE-REASVKRNQTREFDGTEVLKGDEFKRyVNKLRsKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQ 444
Cdd:PTZ00121 1519 EEAKKADEaKKAEEAKKADEAKKAEEKKKADELKK-AEELK-KAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEE 1596

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  445 QLQTMEEKKGISGYSYTQEELERVSA--LKSEVDEMKG--RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQL---RQK 517
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAeeLKKAEEEKKKveQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAeedKKK 1676

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  518 YQELTQECDEKKSQYDSCAAGLESNRsKLEQEVRRLREECLQEESryhytncmIKNLEVQLRRATDEMKAYISSDQQEKR 597
Cdd:PTZ00121 1677 AEEAKKAEEDEKKAAEALKKEAEEAK-KAEELKKKEAEEKKKAEE--------LKKAEEENKIKAEEAKKEAEEDKKKAE 1747

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 219555661  598 KAIREQYTKNTAEQenLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKqcflKQQSQTSIGQVIQEGGED 672
Cdd:PTZ00121 1748 EAKKDEEEKKKIAH--LKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDK----KIKDIFDNFANIIEGGKE 1816
 
Name Accession Description Interval E-value
IFT81_CH pfam18383
Intraflagellar transport 81 calponin homology domain; This is the N-terminal domain found in ...
 3-126 3.48e-65

Intraflagellar transport 81 calponin homology domain; This is the N-terminal domain found in IFT81 proteins. Crystal structure analysis revealed that IFT81-N adopts the fold of a calponin homology (CH) domain with structural similarity to the kinetochore complex component NDC80 with microtubule (MT)-binding properties. Functional analysis show that IFT74 and IFT81 form a tubulin-binding module required for ciliogenesis. It is suggested that IFT81-N binds the globular domain of tubulin to provide specificity, and IFT74-N recognizes the beta-tubulin tail to increase affinity.


Pssm-ID: 465736  Cd Length: 124  Bit Score: 210.57  E-value: 3.48e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661    3 DQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATD 82
Cdd:pfam18383   1 ENLKFIVTELNKEPFNKNYNLITFDSLSPEQLLQVLNDVLAEIDPKQKVDIREESPEETAIRILEALRILKYKPPPDIDD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 219555661   83 MSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLE 126
Cdd:pfam18383  81 PSAFRQGLVRGEKLVIYPILYWLLSNVEELKKRAYLARFLVKVE 124
PTZ00121 PTZ00121
MAEBL; Provisional
 138-672 3.63e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.54  E-value: 3.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  138 ADTNKQYEELMEAFKTLHKEYEQLKisgfsTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQwmLKIARQLRVEKE 217
Cdd:PTZ00121 1292 ADEAKKAEEKKKADEAKKKAEEAKK-----ADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEA--EAAADEAEAAEE 1364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  218 REEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKfnlymVTEKFPKELENKKKELHFLQK 297
Cdd:PTZ00121 1365 KAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK-----KADEAKKKAEEKKKADEAKKK 1439

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  298 V--------VSEPAMGHSDLLELESKINEINT--EINQLIEKKMmRNEPIEGKLSLYRQQASIISRKKEAK--AEELQEA 365
Cdd:PTZ00121 1440 AeeakkadeAKKKAEEAKKAEEAKKKAEEAKKadEAKKKAEEAK-KADEAKKKAEEAKKKADEAKKAAEAKkkADEAKKA 1518

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  366 KEKLASLE-REASVKRNQTREFDGTEVLKGDEFKRyVNKLRsKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQ 444
Cdd:PTZ00121 1519 EEAKKADEaKKAEEAKKADEAKKAEEKKKADELKK-AEELK-KAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEE 1596

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  445 QLQTMEEKKGISGYSYTQEELERVSA--LKSEVDEMKG--RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQL---RQK 517
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAeeLKKAEEEKKKveQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAeedKKK 1676

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  518 YQELTQECDEKKSQYDSCAAGLESNRsKLEQEVRRLREECLQEESryhytncmIKNLEVQLRRATDEMKAYISSDQQEKR 597
Cdd:PTZ00121 1677 AEEAKKAEEDEKKAAEALKKEAEEAK-KAEELKKKEAEEKKKAEE--------LKKAEEENKIKAEEAKKEAEEDKKKAE 1747

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 219555661  598 KAIREQYTKNTAEQenLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKqcflKQQSQTSIGQVIQEGGED 672
Cdd:PTZ00121 1748 EAKKDEEEKKKIAH--LKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDK----KIKDIFDNFANIIEGGKE 1816
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 183-556 1.64e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.94  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 183 DQLIKRVEHLKKRVETAqnhqwmlkiarqlrvekerEEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAkpESL 262
Cdd:COG1196  196 GELERQLEPLERQAEKA-------------------ERYRELKEELKELEAELLLLKLRELEAELEELEAELEEL--EAE 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 263 MKRLEEEIkfnlymvtekfpKELENKKKELhflqkvvsepamgHSDLLELESKINEINTEINQLIEKKmmrnEPIEGKLS 342
Cdd:COG1196  255 LEELEAEL------------AELEAELEEL-------------RLELEELELELEEAQAEEYELLAEL----ARLEQDIA 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 343 LYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELK 422
Cdd:COG1196  306 RLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELA 385

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 423 AEFGLLQRTEELLKQRHENIQQQLQTMEEKKgISGYSYTQEELERVSALKSEVDEMKgRTLDDMSEMVKKLYSLVSEKKS 502
Cdd:COG1196  386 EELLEALRAAAELAAQLEELEEAEEALLERL-ERLEEELEELEEALAELEEEEEEEE-EALEEAAEEEAELEEEEEALLE 463

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 219555661 503 ALASVIKELRQLRQKYQELTQECDEKKSQYDScAAGLESNRSKLEQEVRRLREE 556
Cdd:COG1196  464 LLAELLEEAALLEAALAELLEELAEAAARLLL-LLEAEADYEGFLEGVKAALLL 516
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 283-556 1.34e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.98  E-value: 1.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   283 KELENKKKEL----HFLQKVVSEPAMGHSDLLELESKINEINTEINQLI---EKKMMRNEPIEGKLSLYRQQASIISRKK 355
Cdd:TIGR02168  680 EELEEKIEELeekiAELEKALAELRKELEELEEELEQLRKELEELSRQIsalRKDLARLEAEVEQLEERIAQLSKELTEL 759

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   356 EAKAEELQEAKEKLASLEREASVKRNQTREfdgtevlKGDEFKRYVNKLRSKSTVFKKKHQiiaELKAEFGLLQRTEELL 435
Cdd:TIGR02168  760 EAEIEELEERLEEAEEELAEAEAEIEELEA-------QIEQLKEELKALREALDELRAELT---LLNEEAANLRERLESL 829

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   436 KQRHENIQQQLQTMEEKKGIsgysyTQEELERVSA----LKSEVDEMKgRTLDDMSEMVKKLYSLVSEKKSALASVIKEL 511
Cdd:TIGR02168  830 ERRIAATERRLEDLEEQIEE-----LSEDIESLAAeieeLEELIEELE-SELEALLNERASLEEALALLRSELEELSEEL 903

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 219555661   512 RQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREE 556
Cdd:TIGR02168  904 RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEE 948
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 329-622 5.75e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.11  E-value: 5.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  329 KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEEL------QEAKEKLASLEREASVKRNQTR---EFDGTEVLKGD---- 395
Cdd:pfam17380 263 QTMTENEFLNQLLHIVQHQKAVSERQQQEKFEKMeqerlrQEKEEKAREVERRRKLEEAEKArqaEMDRQAAIYAEqerm 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  396 --EFKRYVNKLR---SKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKgisgysyTQEElERVSA 470
Cdd:pfam17380 343 amERERELERIRqeeRKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEAARKVK-------ILEE-ERQRK 414

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  471 LKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKE-------LRQLRQKYQELTQECDEKKSQYDSCAAGLESNR 543
Cdd:pfam17380 415 IQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEeqerqqqVERLRQQEEERKRKKLELEKEKRDRKRAEEQRR 494

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  544 SKLEQEVRRLREECLQEESRYHYTNCMIKN-----LEVQLRRATDEMKAyiSSDQQEKRKAIREQYTKNTAEQENLGKKL 618
Cdd:pfam17380 495 KILEKELEERKQAMIEEERKRKLLEKEMEErqkaiYEEERRREAEEERR--KQQEMEERRRIQEQMRKATEERSRLEAME 572


                  ....
gi 219555661  619 REKQ 622
Cdd:pfam17380 573 RERE 576
 
Name Accession Description Interval E-value
IFT81_CH pfam18383
Intraflagellar transport 81 calponin homology domain; This is the N-terminal domain found in ...
 3-126 3.48e-65

Intraflagellar transport 81 calponin homology domain; This is the N-terminal domain found in IFT81 proteins. Crystal structure analysis revealed that IFT81-N adopts the fold of a calponin homology (CH) domain with structural similarity to the kinetochore complex component NDC80 with microtubule (MT)-binding properties. Functional analysis show that IFT74 and IFT81 form a tubulin-binding module required for ciliogenesis. It is suggested that IFT81-N binds the globular domain of tubulin to provide specificity, and IFT74-N recognizes the beta-tubulin tail to increase affinity.


Pssm-ID: 465736  Cd Length: 124  Bit Score: 210.57  E-value: 3.48e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661    3 DQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATD 82
Cdd:pfam18383   1 ENLKFIVTELNKEPFNKNYNLITFDSLSPEQLLQVLNDVLAEIDPKQKVDIREESPEETAIRILEALRILKYKPPPDIDD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 219555661   83 MSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLE 126
Cdd:pfam18383  81 PSAFRQGLVRGEKLVIYPILYWLLSNVEELKKRAYLARFLVKVE 124
PTZ00121 PTZ00121
MAEBL; Provisional
 138-672 3.63e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.54  E-value: 3.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  138 ADTNKQYEELMEAFKTLHKEYEQLKisgfsTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQwmLKIARQLRVEKE 217
Cdd:PTZ00121 1292 ADEAKKAEEKKKADEAKKKAEEAKK-----ADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEA--EAAADEAEAAEE 1364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  218 REEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKfnlymVTEKFPKELENKKKELHFLQK 297
Cdd:PTZ00121 1365 KAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK-----KADEAKKKAEEKKKADEAKKK 1439

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  298 V--------VSEPAMGHSDLLELESKINEINT--EINQLIEKKMmRNEPIEGKLSLYRQQASIISRKKEAK--AEELQEA 365
Cdd:PTZ00121 1440 AeeakkadeAKKKAEEAKKAEEAKKKAEEAKKadEAKKKAEEAK-KADEAKKKAEEAKKKADEAKKAAEAKkkADEAKKA 1518

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  366 KEKLASLE-REASVKRNQTREFDGTEVLKGDEFKRyVNKLRsKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQ 444
Cdd:PTZ00121 1519 EEAKKADEaKKAEEAKKADEAKKAEEKKKADELKK-AEELK-KAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEE 1596

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  445 QLQTMEEKKGISGYSYTQEELERVSA--LKSEVDEMKG--RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQL---RQK 517
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAeeLKKAEEEKKKveQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAeedKKK 1676

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  518 YQELTQECDEKKSQYDSCAAGLESNRsKLEQEVRRLREECLQEESryhytncmIKNLEVQLRRATDEMKAYISSDQQEKR 597
Cdd:PTZ00121 1677 AEEAKKAEEDEKKAAEALKKEAEEAK-KAEELKKKEAEEKKKAEE--------LKKAEEENKIKAEEAKKEAEEDKKKAE 1747

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 219555661  598 KAIREQYTKNTAEQenLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKqcflKQQSQTSIGQVIQEGGED 672
Cdd:PTZ00121 1748 EAKKDEEEKKKIAH--LKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDK----KIKDIFDNFANIIEGGKE 1816
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 183-556 1.64e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.94  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 183 DQLIKRVEHLKKRVETAqnhqwmlkiarqlrvekerEEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAkpESL 262
Cdd:COG1196  196 GELERQLEPLERQAEKA-------------------ERYRELKEELKELEAELLLLKLRELEAELEELEAELEEL--EAE 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 263 MKRLEEEIkfnlymvtekfpKELENKKKELhflqkvvsepamgHSDLLELESKINEINTEINQLIEKKmmrnEPIEGKLS 342
Cdd:COG1196  255 LEELEAEL------------AELEAELEEL-------------RLELEELELELEEAQAEEYELLAEL----ARLEQDIA 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 343 LYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELK 422
Cdd:COG1196  306 RLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELA 385

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 423 AEFGLLQRTEELLKQRHENIQQQLQTMEEKKgISGYSYTQEELERVSALKSEVDEMKgRTLDDMSEMVKKLYSLVSEKKS 502
Cdd:COG1196  386 EELLEALRAAAELAAQLEELEEAEEALLERL-ERLEEELEELEEALAELEEEEEEEE-EALEEAAEEEAELEEEEEALLE 463

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 219555661 503 ALASVIKELRQLRQKYQELTQECDEKKSQYDScAAGLESNRSKLEQEVRRLREE 556
Cdd:COG1196  464 LLAELLEEAALLEAALAELLEELAEAAARLLL-LLEAEADYEGFLEGVKAALLL 516
PTZ00121 PTZ00121
MAEBL; Provisional
 170-651 2.05e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.76  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  170 EIRKdisAMEEEKDQLIKRVEHLKKRVETAQnhqwmlkiarqlRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKS 249
Cdd:PTZ00121 1216 EARK---AEDAKKAEAVKKAEEAKKDAEEAK------------KAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKA 1280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  250 MRQAAADAKPESLMKRLEEEIKfnlymVTEKFPKELENKKKELHFLQKvvSEPAMGHSDLLELESKineintEINQLIEK 329
Cdd:PTZ00121 1281 DELKKAEEKKKADEAKKAEEKK-----KADEAKKKAEEAKKADEAKKK--AEEAKKKADAAKKKAE------EAKKAAEA 1347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  330 KMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLER-EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKS 408
Cdd:PTZ00121 1348 AKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKaDEAKKKAEEDKKKADELKKAAAAKKKADEAKKKA 1427

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  409 TVFKKKHqiiaELKAEFGLLQRTEELLKQRHE--NIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRT--LD 484
Cdd:PTZ00121 1428 EEKKKAD----EAKKKAEEAKKADEAKKKAEEakKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKAdeAK 1503

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  485 DMSEMVKKLYSLvseKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSkleQEVRRLREECLQEESRY 564
Cdd:PTZ00121 1504 KAAEAKKKADEA---KKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKA---EEKKKAEEAKKAEEDKN 1577

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  565 HYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQ 644
Cdd:PTZ00121 1578 MALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE 1657


                  ....*..
gi 219555661  645 LMECKKQ 651
Cdd:PTZ00121 1658 ENKIKAA 1664
PTZ00121 PTZ00121
MAEBL; Provisional
 107-610 4.84e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.61  E-value: 4.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  107 QRTNELKKRAYLARFLIKLEVPSEflQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDisAMEEEKDQLI 186
Cdd:PTZ00121 1302 KKADEAKKKAEEAKKADEAKKKAE--EAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAE--AAEKKKEEAK 1377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  187 KRVEHLKKRVETAQNHQWMLKIARQLRveKEREEylAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRL 266
Cdd:PTZ00121 1378 KKADAAKKKAEEKKKADEAKKKAEEDK--KKADE--LKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKA 1453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  267 EEEIKfnlymvTEKFPKELENKKKELHFLQKvvsepAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQ 346
Cdd:PTZ00121 1454 EEAKK------AEEAKKKAEEAKKADEAKKK-----AEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAK 1522

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  347 QASIISRKKEA-KAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKA-E 424
Cdd:PTZ00121 1523 KADEAKKAEEAkKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLyE 1602

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  425 FGLLQRTEELLKQRHENIQ-QQLQTMEE--KKGISGYSYTQEELERVSALKSEVDEMK------GRTLDDMSEMVKKLYS 495
Cdd:PTZ00121 1603 EEKKMKAEEAKKAEEAKIKaEELKKAEEekKKVEQLKKKEAEEKKKAEELKKAEEENKikaaeeAKKAEEDKKKAEEAKK 1682

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  496 LVSEKKSALASVIKE------LRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRlREECLQEESRYHYTNC 569
Cdd:PTZ00121 1683 AEEDEKKAAEALKKEaeeakkAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKK-AEEAKKDEEEKKKIAH 1761

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 219555661  570 MIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAE 610
Cdd:PTZ00121 1762 LKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKD 1802
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 283-556 1.34e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.98  E-value: 1.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   283 KELENKKKEL----HFLQKVVSEPAMGHSDLLELESKINEINTEINQLI---EKKMMRNEPIEGKLSLYRQQASIISRKK 355
Cdd:TIGR02168  680 EELEEKIEELeekiAELEKALAELRKELEELEEELEQLRKELEELSRQIsalRKDLARLEAEVEQLEERIAQLSKELTEL 759

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   356 EAKAEELQEAKEKLASLEREASVKRNQTREfdgtevlKGDEFKRYVNKLRSKSTVFKKKHQiiaELKAEFGLLQRTEELL 435
Cdd:TIGR02168  760 EAEIEELEERLEEAEEELAEAEAEIEELEA-------QIEQLKEELKALREALDELRAELT---LLNEEAANLRERLESL 829

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   436 KQRHENIQQQLQTMEEKKGIsgysyTQEELERVSA----LKSEVDEMKgRTLDDMSEMVKKLYSLVSEKKSALASVIKEL 511
Cdd:TIGR02168  830 ERRIAATERRLEDLEEQIEE-----LSEDIESLAAeieeLEELIEELE-SELEALLNERASLEEALALLRSELEELSEEL 903

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 219555661   512 RQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREE 556
Cdd:TIGR02168  904 RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEE 948
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 142-457 3.10e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 50.71  E-value: 3.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 142 KQYEELMEAFKTLHKEYEQLKIsgfstAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHqwmlkiARQLRVEKEREEY 221
Cdd:COG1196  213 ERYRELKEELKELEAELLLLKL-----RELEAELEELEAELEELEAELEELEAELAELEAE------LEELRLELEELEL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 222 LAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKpeslmKRLEEEIKfNLYMVTEKFPKELENKKKELHFLQKVVSE 301
Cdd:COG1196  282 ELEEAQAEEYELLAELARLEQDIARLEERRRELEERL-----EELEEELA-ELEEELEELEEELEELEEELEEAEEELEE 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 302 PAMGHSD----LLELESKINEINTEINQLIEKKMM---RNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLER 374
Cdd:COG1196  356 AEAELAEaeeaLLEAEAELAEAEEELEELAEELLEalrAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEE 435

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 375 EASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKG 454
Cdd:COG1196  436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALL 515


                 ...
gi 219555661 455 ISG 457
Cdd:COG1196  516 LAG 518
PRK12704 PRK12704
phosphodiesterase; Provisional
 337-492 3.18e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 50.16  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 337 IEGKLSLYRQQASIISRKKEAKAEELQeaKEKLASLEREASvkrNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQ 416
Cdd:PRK12704  29 AEAKIKEAEEEAKRILEEAKKEAEAIK--KEALLEAKEEIH---KLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLE 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 417 IIAELKAEfglLQRTEELLKQRHENIQQQLQTMEEKkgisgYSYTQEELERVSALKSE------VDEMKGRTLDDMSEMV 490
Cdd:PRK12704 104 LLEKREEE---LEKKEKELEQKQQELEKKEEELEEL-----IEEQLQELERISGLTAEeakeilLEKVEEEARHEAAVLI 175


                 ..
gi 219555661 491 KK 492
Cdd:PRK12704 176 KE 177
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 224-555 6.34e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.67  E-value: 6.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   224 QQKQEQKNQLFHAVQRLQRVQN-------QLKSMRQAAADAKPESLMKRLEEEIKFNLYMvtekfpKELENKKKELHFLQ 296
Cdd:TIGR02168  172 ERRKETERKLERTRENLDRLEDilnelerQLKSLERQAEKAERYKELKAELRELELALLV------LRLEELREELEELQ 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   297 KVVSEPAmghSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEakaeELQEAKEKLASLEREA 376
Cdd:TIGR02168  246 EELKEAE---EELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQ----QKQILRERLANLERQL 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   377 SVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHEN--------------I 442
Cdd:TIGR02168  319 EELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETlrskvaqlelqiasL 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   443 QQQLQTMEEKKGISGYSyTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELT 522
Cdd:TIGR02168  399 NNEIERLEARLERLEDR-RERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQAL 477

                          330       340       350
                   ....*....|....*....|....*....|...
gi 219555661   523 QECDEKKSQYDSCAAGLESNRSKLEQEVRRLRE 555
Cdd:TIGR02168  478 DAAERELAQLQARLDSLERLQENLEGFSEGVKA 510
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
168-382 1.30e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.47  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 168 TAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQL 247
Cdd:COG3206  170 REEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQL 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 248 KSMRQAAADAKPESLMKRLEEEIkfnlymvtekfpKELENKKKELhfLQKVVSEpamgHSDLLELESKINEINTEINQLI 327
Cdd:COG3206  250 GSGPDALPELLQSPVIQQLRAQL------------AELEAELAEL--SARYTPN----HPDVIALRAQIAALRAQLQQEA 311

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 219555661 328 EKKM--MRNEpiegKLSLYRQQASIISRKKEAKAE--ELQEAKEKLASLEREASVKRNQ 382
Cdd:COG3206  312 QRILasLEAE----LEALQAREASLQAQLAQLEARlaELPELEAELRRLEREVEVAREL 366
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 353-622 2.12e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 48.14  E-value: 2.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   353 RKKEAKAEELQEAKEKLASLEREASVKRNQtREFDGTEVLKGDEFK---------RYVNKLRSKSTVFKKKHQIIAELKA 423
Cdd:TIGR02169  170 RKKEKALEELEEVEENIERLDLIIDEKRQQ-LERLRREREKAERYQallkekreyEGYELLKEKEALERQKEAIERQLAS 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   424 EFGLLQRTEELLKQRHENIQQQLQTMEE------KKGISGYSYTQEELERVSALKSEVD---EMKGRTLDDMSEMVKKLY 494
Cdd:TIGR02169  249 LEEELEKLTEEISELEKRLEEIEQLLEElnkkikDLGEEEQLRVKEKIGELEAEIASLErsiAEKERELEDAEERLAKLE 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   495 SLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESnrskLEQEVRRLREECLQEESRYHYTNCMIKNL 574
Cdd:TIGR02169  329 AEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEE----VDKEFAETRDELKDYREKLEKLKREINEL 404

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 219555661   575 EVQLRRATDEMKAYIS--SDQQEKRKAIREQYTKNTAEQENLGKKLREKQ 622
Cdd:TIGR02169  405 KRELDRLQEELQRLSEelADLNAAIAGIEAKINELEEEKEDKALEIKKQE 454
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
159-627 2.24e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.75  E-value: 2.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 159 EQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWML----KIARQLRVEKEREEYLAQQKQEQKNQLF 234
Cdd:PRK03918 193 ELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIeeleKELESLEGSKRKLEEKIRELEERIEELK 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 235 HAVQRLQRVQNQLKSMRQaaaDAKPESLMKRLEEEIKFNLYmvteKFPKELENKKKELHFLQKVVSEPAMGHSDLLELES 314
Cdd:PRK03918 273 KEIEELEEKVKELKELKE---KAEEYIKLSEFYEEYLDELR----EIEKRLSRLEEEINGIEERIKELEEKEERLEELKK 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 315 KINEINTEINQLIEK---------KMMRNEPIEGKLSLY-----RQQASIISRKKEAKAEELQEAKEKLASLEREASVKR 380
Cdd:PRK03918 346 KLKELEKRLEELEERhelyeeakaKKEELERLKKRLTGLtpeklEKELEELEKAKEEIEEEISKITARIGELKKEIKELK 425

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 381 NQTREFDG------------TEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEF----GLLQRTEELLKQRheNIQQ 444
Cdd:PRK03918 426 KAIEELKKakgkcpvcgrelTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELreleKVLKKESELIKLK--ELAE 503

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 445 QLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG------RTLDDMSEMVKKLYSLVSEKKSA---LASVIKELRQLR 515
Cdd:PRK03918 504 QLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGeikslkKELEKLEELKKKLAELEKKLDELeeeLAELLKELEELG 583

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 516 QK-YQELTQECDEKKSQYDSCAAGLESnrsklEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQ 594
Cdd:PRK03918 584 FEsVEELEERLKELEPFYNEYLELKDA-----EKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSE 658

                        490       500       510
                 ....*....|....*....|....*....|...
gi 219555661 595 EKRKAIREQYTKNTAEQENLGKKLREKQKVIRE 627
Cdd:PRK03918 659 EEYEELREEYLELSRELAGLRAELEELEKRREE 691
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 354-563 2.43e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.13  E-value: 2.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 354 KKEAKAEELQEAKEKLASLEREASVKRNQtrefdgtevlkgdefkryVNKLRSKSTVFKKKhqiIAELKAEfglLQRTEE 433
Cdd:COG3883   24 ELSELQAELEAAQAELDALQAELEELNEE------------------YNELQAELEALQAE---IDKLQAE---IAEAEA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 434 LLKQRHENIQQQLQTMEEKKGISGY-------SYTQEELERVSALKSEVDEMKgRTLDDMSEMVKKLyslvSEKKSALAS 506
Cdd:COG3883   80 EIEERREELGERARALYRSGGSVSYldvllgsESFSDFLDRLSALSKIADADA-DLLEELKADKAEL----EAKKAELEA 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 219555661 507 VIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESR 563
Cdd:COG3883  155 KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAA 211
mukB PRK04863
chromosome partition protein MukB;
359-627 7.52e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.10  E-value: 7.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  359 AEELQEAKEKLASLEREASVKRNQTREfdgtevlkgdefkryvnkLRSKSTVFKKKHQIIAELKAEFGLLQrtEELLKQR 438
Cdd:PRK04863  836 EAELRQLNRRRVELERALADHESQEQQ------------------QRSQLEQAKEGLSALNRLLPRLNLLA--DETLADR 895

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  439 HENIQQQLQTMEE-KKGISGYSYTQEELER-VSALKSevDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKEL----- 511
Cdd:PRK04863  896 VEEIREQLDEAEEaKRFVQQHGNALAQLEPiVSVLQS--DPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRahfsy 973

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  512 --------------RQLRQKYQELTQECDEKK----------SQYDSCAAGLESNRSKLEQEVRRLREEClqEESRYHYT 567
Cdd:PRK04863  974 edaaemlaknsdlnEKLRQRLEQAEQERTRAReqlrqaqaqlAQYNQVLASLKSSYDAKRQMLQELKQEL--QDLGVPAD 1051

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  568 ncmiKNLEVQLRRATDEMKAYISSdQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRE 627
Cdd:PRK04863 1052 ----SGAEERARARRDELHARLSA-NRSRRNQLEKQLTFCEAEMDNLTKKLRKLERDYHE 1106
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
179-628 9.56e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.83  E-value: 9.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 179 EEEKDQLIKRVEHLKKRVETAQNhqwMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAAD-- 256
Cdd:PRK03918 144 DESREKVVRQILGLDDYENAYKN---LGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPElr 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 257 AKPESLMKRLEEeikfnlymvTEKFPKELENKKKELHFLQKVVSEPamgHSDLLELESKINEINTEINQLiEKKMMRNEP 336
Cdd:PRK03918 221 EELEKLEKEVKE---------LEELKEEIEELEKELESLEGSKRKL---EEKIRELEERIEELKKEIEEL-EEKVKELKE 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 337 IEGKLSLYRqqasIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDgtevlkgdefkryvnklrskstvfkKKHQ 416
Cdd:PRK03918 288 LKEKAEEYI----KLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE-------------------------EKEE 338

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 417 IIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGySYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLYSL 496
Cdd:PRK03918 339 RLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKK-RLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGEL 417

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 497 VSEKKSaLASVIKELRQLRQKY----QELTQECDEK-KSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMI 571
Cdd:PRK03918 418 KKEIKE-LKKAIEELKKAKGKCpvcgRELTEEHRKElLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELI 496

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 219555661 572 KNLEV--QLRRATDEMKAYISSDQQEKRK---AIREQYTKNTAEQENLGKKLREKQKVIRES 628
Cdd:PRK03918 497 KLKELaeQLKELEEKLKKYNLEELEKKAEeyeKLKEKLIKLKGEIKSLKKELEKLEELKKKL 558
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 337-612 1.79e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 337 IEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQ 416
Cdd:COG1196  237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 417 IIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISgysytQEELERVSALKSEVDEMKGRTLDDMSEMVKKLysl 496
Cdd:COG1196  317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEA-----EAELAEAEEALLEAEAELAEAEEELEELAEEL--- 388

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 497 vSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREEclQEESRYHYTNcmIKNLEV 576
Cdd:COG1196  389 -LEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEA--AEEEAELEEE--EEALLE 463

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 219555661 577 QLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQE 612
Cdd:COG1196  464 LLAELLEEAALLEAALAELLEELAEAAARLLLLLEA 499
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
311-534 2.24e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 311 ELESKINEINTEINQLIEKKMMRNepIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTE 390
Cdd:COG3206  186 ELRKELEEAEAALEEFRQKNGLVD--LSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSP 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 391 VLKG--DEFKRYVNKLRSKSTVFKKKHQIIAELKAEfglLQRTEELLKQRHENIQQQLQTMeekkgisgysyTQEELERV 468
Cdd:COG3206  264 VIQQlrAQLAELEAELAELSARYTPNHPDVIALRAQ---IAALRAQLQQEAQRILASLEAE-----------LEALQARE 329

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 219555661 469 SALKSEVDEMKGRtlddmsemvkklyslvsekksalasvIKELRQLRQKYQELTQECDEKKSQYDS 534
Cdd:COG3206  330 ASLQAQLAQLEAR--------------------------LAELPELEAELRRLEREVEVARELYES 369
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 145-551 2.58e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 44.29  E-value: 2.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   145 EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKrvehlkkrvetaqnhqwmlkiARQLRVEKEREEYLAQ 224
Cdd:TIGR02169  170 RKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAER---------------------YQALLKEKREYEGYEL 228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   225 QKQEQKnqlfhAVQRLQRVQNQLKSmrqaaadakpeslmkrLEEEIkfnlymvtEKFPKELENKKKELHflqkvvsepam 304
Cdd:TIGR02169  229 LKEKEA-----LERQKEAIERQLAS----------------LEEEL--------EKLTEEISELEKRLE----------- 268

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   305 ghsdllELESKINEINTEINQLIEKKMMRnepIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTR 384
Cdd:TIGR02169  269 ------EIEQLLEELNKKIKDLGEEEQLR---VKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIE 339

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   385 EFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLL--------QRTEELLKQRHENIQQQLQTMEEKKGIS 456
Cdd:TIGR02169  340 ELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETrdelkdyrEKLEKLKREINELKRELDRLQEELQRLS 419

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   457 G-YSYTQEELERVSALKSEVDEmkgrTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSc 535
Cdd:TIGR02169  420 EeLADLNAAIAGIEAKINELEE----EKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAE- 494

                          410
                   ....*....|....*.
gi 219555661   536 aagLESNRSKLEQEVR 551
Cdd:TIGR02169  495 ---AEAQARASEERVR 507
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 134-395 4.19e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.90  E-value: 4.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   134 DETVADTNKQYEELMEAFKTLHKEYEQLkiSGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIAR-QL 212
Cdd:TIGR02169  257 TEEISELEKRLEEIEQLLEELNKKIKDL--GEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIdKL 334

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   213 RVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQ---AAADAKPESLMKRLEEeikfnLYMVTEKFPKELENKK 289
Cdd:TIGR02169  335 LAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEevdKEFAETRDELKDYREK-----LEKLKREINELKRELD 409

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   290 KELHFLQKVVSEPAMGHSDLLELESKINEINTEINQL---IEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAK 366
Cdd:TIGR02169  410 RLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKaleIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQ 489

                          250       260
                   ....*....|....*....|....*....
gi 219555661   367 EKLASLEREASVKRNQTREFDGTEVLKGD 395
Cdd:TIGR02169  490 RELAEAEAQARASEERVRGGRAVEEVLKA 518
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 311-587 4.34e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.52  E-value: 4.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   311 ELESKINEINtEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLERE-----ASVKRNQTRE 385
Cdd:TIGR02169  689 ELSSLQSELR-RIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEienvkSELKELEARI 767

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   386 FDGTEVL--------------KGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEE 451
Cdd:TIGR02169  768 EELEEDLhkleealndlearlSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKE 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   452 KKgiSGYSYTQEELE-RVSALKSEVDEMKGRtLDDMSEMVKKLYSLVSEkksalasVIKELRQLRQKYQELTQECDEKKS 530
Cdd:TIGR02169  848 QI--KSIEKEIENLNgKKEELEEELEELEAA-LRDLESRLGDLKKERDE-------LEAQLRELERKIEELEAQIEKKRK 917

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 219555661   531 QydscAAGLESNRSKLEQEVRRLrEECLQEESRYHYTNCMIKNLEVQLRRATDEMKA 587
Cdd:TIGR02169  918 R----LSELKAKLEALEEELSEI-EDPKGEDEEIPEEELSLEDVQAELQRVEEEIRA 969
PTZ00121 PTZ00121
MAEBL; Provisional
 179-644 6.50e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 6.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  179 EEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNqlfhaVQRLQRVQNQLK-SMRQAAADA 257
Cdd:PTZ00121 1101 EEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKR-----VEIARKAEDARKaEEARKAEDA 1175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  258 KPESLMKRLEEEIKFNLYMVTEKFPKELENKKKElhflQKVVSEPAMGHSDLLELES--KINEINTEINQLIEKKMMRNE 335
Cdd:PTZ00121 1176 KKAEAARKAEEVRKAEELRKAEDARKAEAARKAE----EERKAEEARKAEDAKKAEAvkKAEEAKKDAEEAKKAEEERNN 1251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  336 P-----IEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREF--DGTEVLKGDEFKRYVNKLRSKS 408
Cdd:PTZ00121 1252 EeirkfEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAkkKAEEAKKADEAKKKAEEAKKKA 1331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  409 TVFKKKHQiIAELKAEFGLLQ---RTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDD 485
Cdd:PTZ00121 1332 DAAKKKAE-EAKKAAEAAKAEaeaAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADEL 1410

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  486 MSEMVKKLYSLVSEKKSALASVIKELR---QLRQKYQELTQECDEKKSQYDSCAAGLESNRSkleQEVRRLREECLQEES 562
Cdd:PTZ00121 1411 KKAAAAKKKADEAKKKAEEKKKADEAKkkaEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKA---DEAKKKAEEAKKADE 1487

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  563 RYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAIREQYTKNTAEQENLgKKLREKQKVIRESHGPNMKQAKMWRDL 642
Cdd:PTZ00121 1488 AKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEA-KKAEEKKKADELKKAEELKKAEEKKKA 1566


                  ..
gi 219555661  643 EQ 644
Cdd:PTZ00121 1567 EE 1568
COG5022 COG5022
Myosin heavy chain [General function prediction only];
206-455 8.64e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 42.76  E-value: 8.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  206 LKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAAD----AKPESLMKRLEEEIKFNLYMVTEKf 281
Cdd:COG5022   797 IKLQPLLSLLGSRKEYRSYLACIIKLQKTIKREKKLRETEEVEFSLKAEVLiqkfGRSLKAKKRFSLLKKETIYLQSAQ- 875

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  282 pkELENKKKELHFLQKVVSEPAMGHSDLLELESKIneinTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEE 361
Cdd:COG5022   876 --RVELAERQLQELKIDVKSISSLKLVNLELESEI----IELKKSLSSDLIENLEFKTELIARLKKLLNNIDLEEGPSIE 949

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  362 LQEaKEKLASLEREASVKRNQTREFdGTEVLKGDEFKRYVNKLRSKStvfKKKHQIIAELKAEFGLLQRTEELLKQR--- 438
Cdd:COG5022   950 YVK-LPELNKLHEVESKLKETSEEY-EDLLKKSTILVREGNKANSEL---KNFKKELAELSKQYGALQESTKQLKELpve 1024

                         250       260
                  ....*....|....*....|
gi 219555661  439 ---HENIQQQLQTMEEKKGI 455
Cdd:COG5022  1025 vaeLQSASKIISSESTELSI 1044
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 170-671 1.33e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 42.26  E-value: 1.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   170 EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQwmLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKS 249
Cdd:TIGR00618  376 TLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQ--ATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQC 453

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   250 MRQAAADAKPeslMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESK-----INEINTEIN 324
Cdd:TIGR00618  454 EKLEKIHLQE---SAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPArqdidNPGPLTRRM 530

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   325 QLIEKKMMRNEPIEGKLslYRQQASIISRKK--EAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVN 402
Cdd:TIGR00618  531 QRGEQTYAQLETSEEDV--YHQLTSERKQRAslKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAED 608

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   403 KLRSKSTVFKKKHQIIAELKAefgllqrteelLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRT 482
Cdd:TIGR00618  609 MLACEQHALLRKLQPEQDLQD-----------VRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELLAS 677

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   483 LDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQ---EVRRLREECLQ 559
Cdd:TIGR00618  678 RQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQslkELMHQARTVLK 757

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   560 EESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQE---------KRKAIREQYTKN-----TAEQENLGKKLREKQKVI 625
Cdd:TIGR00618  758 ARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLreedthllkTLEAEIGQEIPSdedilNLQCETLVQEEEQFLSRL 837

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 219555661   626 RESHgpnMKQAKMWRDLEQLMECKKQcflKQQSQTSIGQVIQEGGE 671
Cdd:TIGR00618  838 EEKS---ATLGEITHQLLKYEECSKQ---LAQLTQEQAKIIQLSDK 877
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 134-374 1.68e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 1.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   134 DETVADTNKQYEELMEAFKTLHKEYEQLkisgfstaeiRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKiARQLR 213
Cdd:TIGR02168  245 QEELKEAEEELEELTAELQELEEKLEEL----------RLEVSELEEEIEELQKELYALANEISRLEQQKQILR-ERLAN 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   214 VEKEREEYLAQ-----QKQEQKNQLFHAVQ-RLQRVQNQLKSMRQAAADAKP-----ESLMKRLEEEIK------FNLYM 276
Cdd:TIGR02168  314 LERQLEELEAQleeleSKLDELAEELAELEeKLEELKEELESLEAELEELEAeleelESRLEELEEQLEtlrskvAQLEL 393

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   277 VTEKFPKELENKKKELHFLQKVVS---------EPAMGHSDLLELESKINEINTEINQLIEkkmmRNEPIEGKLSLYRQQ 347
Cdd:TIGR02168  394 QIASLNNEIERLEARLERLEDRRErlqqeieelLKKLEEAELKELQAELEELEEELEELQE----ELERLEEALEELREE 469

                          250       260
                   ....*....|....*....|....*..
gi 219555661   348 ASIISRKKEAKAEELQEAKEKLASLER 374
Cdd:TIGR02168  470 LEEAEQALDAAERELAQLQARLDSLER 496
PRK12704 PRK12704
phosphodiesterase; Provisional
 351-528 3.46e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.53  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 351 ISRKKEAKAEElqEAKEKLASLEREAsvkrnqtrefdgtEVLKGDEfkryvnKLRSKSTVFKKKHQIIAELKAEFGLLQR 430
Cdd:PRK12704  28 IAEAKIKEAEE--EAKRILEEAKKEA-------------EAIKKEA------LLEAKEEIHKLRNEFEKELRERRNELQK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 431 TEELLKQRHENIQQQLQTMEEKKgisgySYTQEELERVSALKSEVDEMKgRTLDDM-SEMVKKLYS---LVSE--KKSAL 504
Cdd:PRK12704  87 LEKRLLQKEENLDRKLELLEKRE-----EELEKKEKELEQKQQELEKKE-EELEELiEEQLQELERisgLTAEeaKEILL 160

                        170       180
                 ....*....|....*....|....*....
gi 219555661 505 ASVIKELRQ-----LRQKYQELTQECDEK 528
Cdd:PRK12704 161 EKVEEEARHeaavlIKEIEEEAKEEADKK 189
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
133-621 4.06e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 40.41  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 133 QDETVADTNKQYEELMEAFKTLHKEYEQLKISgfsTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNH------QWML 206
Cdd:PRK02224 228 QREQARETRDEADEVLEEHEERREELETLEAE---IEDLRETIAETEREREELAEEVRDLRERLEELEEErddllaEAGL 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 207 KIARQLRVEKEREEyLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADakpeslmkrLEEEikfnlymvtekfPKELE 286
Cdd:PRK02224 305 DDADAEAVEARREE-LEDRDEELRDRLEECRVAAQAHNEEAESLREDADD---------LEER------------AEELR 362

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 287 NKKKELHflqkvvSEPAMGHSDLLELESKINEINTEINQLIEKkmMRNEPIE-GKLSLYRqqasiisrkkEAKAEELQEA 365
Cdd:PRK02224 363 EEAAELE------SELEEAREAVEDRREEIEELEEEIEELRER--FGDAPVDlGNAEDFL----------EELREERDEL 424

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 366 KEKLASLEREASVKRNQTREfdGTEVL---KGDEFKRYVNKLRSKSTVFKKKHQiIAELKAEFGLLQRTEELLKQRHENI 442
Cdd:PRK02224 425 REREAELEATLRTARERVEE--AEALLeagKCPECGQPVEGSPHVETIEEDRER-VEELEAELEDLEEEVEEVEERLERA 501

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 443 QQ------QLQTMEEKKGISGYSYTQEElERVSALKSEVDEMKGRTLDDMSEMVKKLYSlVSEKKSALASVIKELRQLRQ 516
Cdd:PRK02224 502 EDlveaedRIERLEERREDLEELIAERR-ETIEEKRERAEELRERAAELEAEAEEKREA-AAEAEEEAEEAREEVAELNS 579

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 517 KYQELTQECD------EKKSQYDSCAAGLESNRSKLEQ--EVRRLREECLQEESRYHYtncmiknlevQLRRATDEmkAY 588
Cdd:PRK02224 580 KLAELKERIEslerirTLLAAIADAEDEIERLREKREAlaELNDERRERLAEKRERKR----------ELEAEFDE--AR 647

                        490       500       510
                 ....*....|....*....|....*....|...
gi 219555661 589 ISSDQQEKRKAirEQYtkntaeQENLGKKLREK 621
Cdd:PRK02224 648 IEEAREDKERA--EEY------LEQVEEKLDEL 672
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 329-622 5.75e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.11  E-value: 5.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  329 KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEEL------QEAKEKLASLEREASVKRNQTR---EFDGTEVLKGD---- 395
Cdd:pfam17380 263 QTMTENEFLNQLLHIVQHQKAVSERQQQEKFEKMeqerlrQEKEEKAREVERRRKLEEAEKArqaEMDRQAAIYAEqerm 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  396 --EFKRYVNKLR---SKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKgisgysyTQEElERVSA 470
Cdd:pfam17380 343 amERERELERIRqeeRKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEAARKVK-------ILEE-ERQRK 414

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  471 LKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKE-------LRQLRQKYQELTQECDEKKSQYDSCAAGLESNR 543
Cdd:pfam17380 415 IQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEeqerqqqVERLRQQEEERKRKKLELEKEKRDRKRAEEQRR 494

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661  544 SKLEQEVRRLREECLQEESRYHYTNCMIKN-----LEVQLRRATDEMKAyiSSDQQEKRKAIREQYTKNTAEQENLGKKL 618
Cdd:pfam17380 495 KILEKELEERKQAMIEEERKRKLLEKEMEErqkaiYEEERRREAEEERR--KQQEMEERRRIQEQMRKATEERSRLEAME 572


                  ....
gi 219555661  619 REKQ 622
Cdd:pfam17380 573 RERE 576
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 422-647 5.88e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.04  E-value: 5.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   422 KAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKL-------- 493
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLeaeveqle 746

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   494 --YSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMI 571
Cdd:TIGR02168  747 erIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661   572 KNLEVQLRRATDEMKayissDQQEKRKAIREQYTKNTAEQENLGKKLREKQK------VIRESHGPNMKQAKmwRDLEQL 645
Cdd:TIGR02168  827 ESLERRIAATERRLE-----DLEEQIEELSEDIESLAAEIEELEELIEELESeleallNERASLEEALALLR--SELEEL 899


                   ..
gi 219555661   646 ME 647
Cdd:TIGR02168  900 SE 901
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 169-293 8.06e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 39.42  E-value: 8.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAqnhqwmLKIARQLR--VEKEREEyLAQQKQEQKNQLFHAVQRL-QRVQN 245
Cdd:PRK00409 505 EEAKKLIGEDKEKLNELIASLEELERELEQK------AEEAEALLkeAEKLKEE-LEEKKEKLQEEEDKLLEEAeKEAQQ 577

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 219555661 246 QLKSMRQAAADakpesLMKRLEEEIKFNLYMVTEkfpKELENKKKELH 293
Cdd:PRK00409 578 AIKEAKKEADE-----IIKELRQLQKGGYASVKA---HELIEARKRLN 617
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
169-632 9.44e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 39.25  E-value: 9.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVET-AQNHQWMLKIARQLR--------VEKEREEyLAQQKQEQKnqlfhavQR 239
Cdd:PRK02224 216 AELDEEIERYEEQREQARETRDEADEVLEEhEERREELETLEAEIEdlretiaeTEREREE-LAEEVRDLR-------ER 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 240 LQRVQNQLKSMRQAAA--DAKPESLMKRLEeeikfnlymvtekfpkELENKKKELhflqkvvsepamgHSDLLELESKIN 317
Cdd:PRK02224 288 LEELEEERDDLLAEAGldDADAEAVEARRE----------------ELEDRDEEL-------------RDRLEECRVAAQ 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 318 EINTEINQLIEKKMMRNEPIEGKlslyRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQtreFDGTEVLKGDEF 397
Cdd:PRK02224 339 AHNEEAESLREDADDLEERAEEL----REEAAELESELEEAREAVEDRREEIEELEEEIEELRER---FGDAPVDLGNAE 411

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 398 KRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQ-RHENIQQQLQTMEEKKGISGYSYTQEELE-RVSALKSEV 475
Cdd:PRK02224 412 DFLEELREERDELREREAELEATLRTARERVEEAEALLEAgKCPECGQPVEGSPHVETIEEDRERVEELEaELEDLEEEV 491

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 476 DEMKGR--TLDDMSEMVKKLYSLvSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRL 553
Cdd:PRK02224 492 EEVEERleRAEDLVEAEDRIERL-EERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEA 570

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219555661 554 REECLQEESRYHYTNCMIKNLEvQLRRATDEMKAYIS--SDQQEKRKAIREqytKNTAEQENLGKKlREKQKVIRESHGP 631
Cdd:PRK02224 571 REEVAELNSKLAELKERIESLE-RIRTLLAAIADAEDeiERLREKREALAE---LNDERRERLAEK-RERKRELEAEFDE 645


                 .
gi 219555661 632 N 632
Cdd:PRK02224 646 A 646
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH