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Conserved domains on  [gi|209447096|ref|NP_001129292|]
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inactive cell surface hyaluronidase CEMIP2 isoform b [Homo sapiens]

Protein Classification

G8 and PANDER_like_TMEM2 domain-containing protein( domain architecture ID 11185741)

protein containing domains G8, PANDER_like_TMEM2, and ILEI

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PANDER_like_TMEM2 cd13938
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ...
 220-387 1.25e-86

PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized.


:

Pssm-ID: 260112  Cd Length: 168  Bit Score: 278.44  E-value: 1.25e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  220 KFIGVEAGGTLELHGARKASWTLLARTLNSSGLPFG-SYTFEK-DFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRL 297
Cdd:cd13938     1 KFIGVGAGGTLEIHGKKKLSWTLLTKTVLHPGLPKGgGYSFERsWGSRGINVRVIDEDTGEVLESDRFDTYESEDESKRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  298 QEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQErLGSELIQGLGYRQAWALVGVIDGGStSCNESVRNYENHSSGGKA 377
Cdd:cd13938    81 AEFLDQIPPGRIVALAVGDEASKNLEDSARKKIRE-LGSKEIDHLGYRQPWAFVGVKGGPS-SAVEDRREYEGHSTTGTA 158

                         170
                  ....*....|
gi 209447096  378 LAQREFYTVD 387
Cdd:cd13938   159 LAAREFFTVF 168
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 133-244 2.73e-37

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 136.20  E-value: 2.73e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096   133 VVIKEGDMLRL-TSDATVHSIVIQdgGLLVFGDNKdgsrNITLRTHYILIQdGGALHIGAEKCRYKSKATITLYG-KSDE 210
Cdd:pfam10162   14 VVIPAGQTVLLdVSSPTLKSLVIQ--GTLIFDDDK----NITLRARYILVQ-GGRLIIGSEDCPFQGKATITLHGrPELD 86

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 209447096   211 GESMPTFGKKFIGVEAGGTLELHGA-RKASWTLLA 244
Cdd:pfam10162   87 DDDGPNYGSKVIGVRNGGTLELHGQpPTVTWTKLA 121
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 1181-1265 1.72e-12

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


:

Pssm-ID: 464817  Cd Length: 89  Bit Score: 64.20  E-value: 1.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  1181 GVLLLVVDPCSvpFRLTEKTVF---PLADVSRIEEYLKtGIPPRSIVLLSTRGEI---KQLNISHLLVPLGLAKPAHLYD 1254
Cdd:pfam15711    2 GINVVVVDACT--GKVLDSKSFdtySYSDSSRLANFLK-SIPDGSIVLIATKDEAsskLSDEARKALESLGSSKIDNLGF 78

                           90
                   ....*....|.
gi 209447096  1255 KGSTIFLGFSG 1265
Cdd:pfam15711   79 RDSWAFIGFKG 89
 
Name Accession Description Interval E-value
PANDER_like_TMEM2 cd13938
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ...
 220-387 1.25e-86

PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized.


Pssm-ID: 260112  Cd Length: 168  Bit Score: 278.44  E-value: 1.25e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  220 KFIGVEAGGTLELHGARKASWTLLARTLNSSGLPFG-SYTFEK-DFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRL 297
Cdd:cd13938     1 KFIGVGAGGTLEIHGKKKLSWTLLTKTVLHPGLPKGgGYSFERsWGSRGINVRVIDEDTGEVLESDRFDTYESEDESKRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  298 QEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQErLGSELIQGLGYRQAWALVGVIDGGStSCNESVRNYENHSSGGKA 377
Cdd:cd13938    81 AEFLDQIPPGRIVALAVGDEASKNLEDSARKKIRE-LGSKEIDHLGYRQPWAFVGVKGGPS-SAVEDRREYEGHSTTGTA 158

                         170
                  ....*....|
gi 209447096  378 LAQREFYTVD 387
Cdd:cd13938   159 LAAREFFTVF 168
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 133-244 2.73e-37

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 136.20  E-value: 2.73e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096   133 VVIKEGDMLRL-TSDATVHSIVIQdgGLLVFGDNKdgsrNITLRTHYILIQdGGALHIGAEKCRYKSKATITLYG-KSDE 210
Cdd:pfam10162   14 VVIPAGQTVLLdVSSPTLKSLVIQ--GTLIFDDDK----NITLRARYILVQ-GGRLIIGSEDCPFQGKATITLHGrPELD 86

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 209447096   211 GESMPTFGKKFIGVEAGGTLELHGA-RKASWTLLA 244
Cdd:pfam10162   87 DDDGPNYGSKVIGVRNGGTLELHGQpPTVTWTKLA 121
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 265-353 5.86e-25

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 100.03  E-value: 5.86e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096   265 RGLNVRVIDQDTAKILESERFDTHEYrNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQErLGSELIQGLGY 344
Cdd:pfam15711    1 RGINVVVVDACTGKVLDSKSFDTYSY-SDSSRLANFLKSIPDGSIVLIATKDEASSKLSDEARKALES-LGSSKIDNLGF 78


                   ....*....
gi 209447096   345 RQAWALVGV 353
Cdd:pfam15711   79 RDSWAFIGF 87
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 1181-1265 1.72e-12

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 64.20  E-value: 1.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  1181 GVLLLVVDPCSvpFRLTEKTVF---PLADVSRIEEYLKtGIPPRSIVLLSTRGEI---KQLNISHLLVPLGLAKPAHLYD 1254
Cdd:pfam15711    2 GINVVVVDACT--GKVLDSKSFdtySYSDSSRLANFLK-SIPDGSIVLIATKDEAsskLSDEARKALESLGSSKIDNLGF 78

                           90
                   ....*....|.
gi 209447096  1255 KGSTIFLGFSG 1265
Cdd:pfam15711   79 RDSWAFIGFKG 89
PANDER_like_KIAA1199 cd13941
PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a ...
 1162-1276 5.96e-05

PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a protein associated with poor survival when upregulated in human cancer, as well as with nonsyndromic loss of hearing when mutated. It contains a C-terminal domain similar to the Pancreatic-derived factor PANDER; the function of this PANDER-like domain has not been characterized.


Pssm-ID: 260115  Cd Length: 157  Bit Score: 44.80  E-value: 5.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096 1162 RGDPSVISVNGTDFTFRSAGVLLLVVDPCSvpFRLTEKTVFPLADV----SRIEEYLkTGIPPRSIVLLSTRGE-IKQLN 1236
Cdd:cd13941    22 KDDFAYIEVDGKKFFLSEDGIQVVVIDGHS--GKVVDTTSFRNSILqgipAQLENYV-TNIKDNSIVLITSKGRlVSRGP 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 209447096 1237 ISHLLVPLGLAKPAHLYDKGStiFLGFSGNFKPSWTKLFT 1276
Cdd:cd13941    99 WTKVLEKLGADQGFKLKEKMA--FVGFKGSFRPVWVKLVT 136
 
Name Accession Description Interval E-value
PANDER_like_TMEM2 cd13938
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ...
 220-387 1.25e-86

PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized.


Pssm-ID: 260112  Cd Length: 168  Bit Score: 278.44  E-value: 1.25e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  220 KFIGVEAGGTLELHGARKASWTLLARTLNSSGLPFG-SYTFEK-DFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRL 297
Cdd:cd13938     1 KFIGVGAGGTLEIHGKKKLSWTLLTKTVLHPGLPKGgGYSFERsWGSRGINVRVIDEDTGEVLESDRFDTYESEDESKRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  298 QEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQErLGSELIQGLGYRQAWALVGVIDGGStSCNESVRNYENHSSGGKA 377
Cdd:cd13938    81 AEFLDQIPPGRIVALAVGDEASKNLEDSARKKIRE-LGSKEIDHLGYRQPWAFVGVKGGPS-SAVEDRREYEGHSTTGTA 158

                         170
                  ....*....|
gi 209447096  378 LAQREFYTVD 387
Cdd:cd13938   159 LAAREFFTVF 168
PANDER_like cd13936
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ...
 234-385 1.70e-38

Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer.


Pssm-ID: 260110  Cd Length: 149  Bit Score: 140.93  E-value: 1.70e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  234 GARKASWTLLartLNSSGLPF-GSYTFEKD-FSRGLNVRVIDQDTAKILESERFDTHEyRNESRRLQEFLRFQDPGRIVA 311
Cdd:cd13936     1 LEVKIASGGG---GNYAKICVnGGVLFDGDkSGRGINVVVINGDTGKVIATKTFDTYG-AGASNDMIDFLNSVPPGSIVL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209447096  312 IAVGDSAAKSLLQGTIQMIQErLGSELIQGLGYRQAWALVGVIdGGSTSCNESVRNYENHSS-GGKALAQREFYT 385
Cdd:cd13936    77 IATKDDASKSLKDEARRALES-LGSSLIQNLGFRDSWAFVGQK-GIKRPSTEQHEISPKNSSwGGPALIQTCFPL 149
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 133-244 2.73e-37

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 136.20  E-value: 2.73e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096   133 VVIKEGDMLRL-TSDATVHSIVIQdgGLLVFGDNKdgsrNITLRTHYILIQdGGALHIGAEKCRYKSKATITLYG-KSDE 210
Cdd:pfam10162   14 VVIPAGQTVLLdVSSPTLKSLVIQ--GTLIFDDDK----NITLRARYILVQ-GGRLIIGSEDCPFQGKATITLHGrPELD 86

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 209447096   211 GESMPTFGKKFIGVEAGGTLELHGA-RKASWTLLA 244
Cdd:pfam10162   87 DDDGPNYGSKVIGVRNGGTLELHGQpPTVTWTKLA 121
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 265-353 5.86e-25

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 100.03  E-value: 5.86e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096   265 RGLNVRVIDQDTAKILESERFDTHEYrNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQErLGSELIQGLGY 344
Cdd:pfam15711    1 RGINVVVVDACTGKVLDSKSFDTYSY-SDSSRLANFLKSIPDGSIVLIATKDEASSKLSDEARKALES-LGSSKIDNLGF 78


                   ....*....
gi 209447096   345 RQAWALVGV 353
Cdd:pfam15711   79 RDSWAFIGF 87
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 1181-1265 1.72e-12

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 64.20  E-value: 1.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  1181 GVLLLVVDPCSvpFRLTEKTVF---PLADVSRIEEYLKtGIPPRSIVLLSTRGEI---KQLNISHLLVPLGLAKPAHLYD 1254
Cdd:pfam15711    2 GINVVVVDACT--GKVLDSKSFdtySYSDSSRLANFLK-SIPDGSIVLIATKDEAsskLSDEARKALESLGSSKIDNLGF 78

                           90
                   ....*....|.
gi 209447096  1255 KGSTIFLGFSG 1265
Cdd:pfam15711   79 RDSWAFIGFKG 89
PANDER_GnT-1_2_like cd13937
PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1, ...
 260-360 1.92e-10

PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 participates in O-mannosyl glycosylation and may be responsible for creating GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moieties on alpha dystroglycan and other O-mannosylated proteins. The domain characterized by this model lies N-terminal to the catalytic domain. Its function has not been determined.


Pssm-ID: 260111  Cd Length: 148  Bit Score: 60.39  E-value: 1.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  260 EKDFSRGLNVRVIDQDTAKILESERFDTHEyRNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQErLGSELI 339
Cdd:cd13937    26 EAEAGRGIHVVVLNQATGSVMAQRVFDTYS-PGEDEAMILFLNMVSDGRILIFTIKDEGSFHLKDEARSLLKK-LGSQKV 103

                          90       100
                  ....*....|....*....|.
gi 209447096  340 QGLGYRQAWALVGVIDGGSTS 360
Cdd:cd13937   104 SKLGWRDMWAMVTRKGGPVYG 124
ILEI_FAM3C cd13940
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ...
 265-352 4.80e-08

Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development.


Pssm-ID: 260114  Cd Length: 171  Bit Score: 54.20  E-value: 4.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  265 RGLNVRVIDQDTAKILESERFDTheYRNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQErLGSELIQGLGY 344
Cdd:cd13940    50 RGLNIALVNGETGEVLKTGFFDM--YSGDVKPLLEFLKSIKPGSIVLVASFDDPATKLNDEARKLFAE-LGSSSIKSLGF 126


                  ....*...
gi 209447096  345 RQAWALVG 352
Cdd:cd13940   127 RDNWVFVG 134
PANDER_FAM3B cd13939
Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a ...
 260-376 1.14e-07

Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. PANDER induces apoptosis of insulin-secreting beta-cells when over-expressed in vitro. It has been associated with the progression of type 2 diabetes by downregulating beta cell function as well as insulin sensitivity in the liver.


Pssm-ID: 260113  Cd Length: 175  Bit Score: 53.00  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096  260 EKDFSRGLNVRVIDQDTAKILESERFDTHEYRNeSRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQErLGSELI 339
Cdd:cd13939    44 EGNSNRGINIAVVSYETGKVVATKYFDMYEGDF-SGPMIEFINKIPKKSLVFVVTHDDGSTKLKDPAKKAIED-LGSKEI 121

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 209447096  340 QGLGYRQAWALVGVidGGSTSCNESVRNYENHSSGGK 376
Cdd:cd13939   122 RNLKFRSAWVFIAA--KGFQLPDNIEKEKINHSDGSK 156
PANDER_like_KIAA1199 cd13941
PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a ...
 1162-1276 5.96e-05

PANDER-like domain of KIAA1199 and similar proteins; KIAA1199 has been characterized as a protein associated with poor survival when upregulated in human cancer, as well as with nonsyndromic loss of hearing when mutated. It contains a C-terminal domain similar to the Pancreatic-derived factor PANDER; the function of this PANDER-like domain has not been characterized.


Pssm-ID: 260115  Cd Length: 157  Bit Score: 44.80  E-value: 5.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209447096 1162 RGDPSVISVNGTDFTFRSAGVLLLVVDPCSvpFRLTEKTVFPLADV----SRIEEYLkTGIPPRSIVLLSTRGE-IKQLN 1236
Cdd:cd13941    22 KDDFAYIEVDGKKFFLSEDGIQVVVIDGHS--GKVVDTTSFRNSILqgipAQLENYV-TNIKDNSIVLITSKGRlVSRGP 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 209447096 1237 ISHLLVPLGLAKPAHLYDKGStiFLGFSGNFKPSWTKLFT 1276
Cdd:cd13941    99 WTKVLEKLGADQGFKLKEKMA--FVGFKGSFRPVWVKLVT 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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