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Conserved domains on  [gi|195972881|ref|NP_001124435|]
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nuclear envelope integral membrane protein 1 isoform a precursor [Homo sapiens]

Protein Classification

nuclear envelope integral membrane protein( domain architecture ID 10562949)

nuclear envelope integral membrane protein similar to Nemp1, which is a RanGTP-binding protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NEMP pfam10225
NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from ...
154-398 2.08e-115

NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from animals and plants, including NEMP1 from Xenopus laevis. NEMP1 is a RanGTP-binding protein and is involved in eye development.


:

Pssm-ID: 463008  Cd Length: 249  Bit Score: 338.03  E-value: 2.08e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195972881  154 IVIRRFDPKLFLVFLLGLMLFFCGDLLSRSQIFYYSTGMTVGIVASLLIIIFILSKFMPKKSPIYVILVGGWSFSLYLIQ 233
Cdd:pfam10225   4 LEEERFDFWRLLVFLLGILLFLLAPTLSRSVVFYYSSGMSLGILASLLILLFQLSKLLPKKSTFYLLLYGGWGVSLYLLQ 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195972881  234 LVFKNLQEIWRCYWQYLLSYVLTVGFMSFAVCYKYGPLENERSINLLTWTLQLMGLCFMYSGIQIPHIALAIIIIALCTK 313
Cdd:pfam10225  84 QLSENLRSILVEYRIYVLGYVLIVGLISFAVCYRHGPVTDERSINLLKWTLQLLGLVLIYQSSQDPEAAFAILIALLCSK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195972881  314 NLehPIQWLYITCRKVCKGAEKPV---PPRLLTEEEYRIQGEVETRKALEELREFCNSPDCSAWKTVSRIQSPKRFADFV 390
Cdd:pfam10225 164 NY--PLSLLSYLRRKWKRRKWFPWkppKRRLLTEEEYREQGEIETRKALEELREYCNSPDCSSWKTVSRLQDPKRFATFV 241

                  ....*...
gi 195972881  391 EGSSHLTP 398
Cdd:pfam10225 242 EGGSHLTP 249
 
Name Accession Description Interval E-value
NEMP pfam10225
NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from ...
154-398 2.08e-115

NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from animals and plants, including NEMP1 from Xenopus laevis. NEMP1 is a RanGTP-binding protein and is involved in eye development.


Pssm-ID: 463008  Cd Length: 249  Bit Score: 338.03  E-value: 2.08e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195972881  154 IVIRRFDPKLFLVFLLGLMLFFCGDLLSRSQIFYYSTGMTVGIVASLLIIIFILSKFMPKKSPIYVILVGGWSFSLYLIQ 233
Cdd:pfam10225   4 LEEERFDFWRLLVFLLGILLFLLAPTLSRSVVFYYSSGMSLGILASLLILLFQLSKLLPKKSTFYLLLYGGWGVSLYLLQ 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195972881  234 LVFKNLQEIWRCYWQYLLSYVLTVGFMSFAVCYKYGPLENERSINLLTWTLQLMGLCFMYSGIQIPHIALAIIIIALCTK 313
Cdd:pfam10225  84 QLSENLRSILVEYRIYVLGYVLIVGLISFAVCYRHGPVTDERSINLLKWTLQLLGLVLIYQSSQDPEAAFAILIALLCSK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195972881  314 NLehPIQWLYITCRKVCKGAEKPV---PPRLLTEEEYRIQGEVETRKALEELREFCNSPDCSAWKTVSRIQSPKRFADFV 390
Cdd:pfam10225 164 NY--PLSLLSYLRRKWKRRKWFPWkppKRRLLTEEEYREQGEIETRKALEELREYCNSPDCSSWKTVSRLQDPKRFATFV 241

                  ....*...
gi 195972881  391 EGSSHLTP 398
Cdd:pfam10225 242 EGGSHLTP 249
 
Name Accession Description Interval E-value
NEMP pfam10225
NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from ...
154-398 2.08e-115

NEMP family; This entry includes a group of nuclear envelope integral membrane proteins from animals and plants, including NEMP1 from Xenopus laevis. NEMP1 is a RanGTP-binding protein and is involved in eye development.


Pssm-ID: 463008  Cd Length: 249  Bit Score: 338.03  E-value: 2.08e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195972881  154 IVIRRFDPKLFLVFLLGLMLFFCGDLLSRSQIFYYSTGMTVGIVASLLIIIFILSKFMPKKSPIYVILVGGWSFSLYLIQ 233
Cdd:pfam10225   4 LEEERFDFWRLLVFLLGILLFLLAPTLSRSVVFYYSSGMSLGILASLLILLFQLSKLLPKKSTFYLLLYGGWGVSLYLLQ 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195972881  234 LVFKNLQEIWRCYWQYLLSYVLTVGFMSFAVCYKYGPLENERSINLLTWTLQLMGLCFMYSGIQIPHIALAIIIIALCTK 313
Cdd:pfam10225  84 QLSENLRSILVEYRIYVLGYVLIVGLISFAVCYRHGPVTDERSINLLKWTLQLLGLVLIYQSSQDPEAAFAILIALLCSK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195972881  314 NLehPIQWLYITCRKVCKGAEKPV---PPRLLTEEEYRIQGEVETRKALEELREFCNSPDCSAWKTVSRIQSPKRFADFV 390
Cdd:pfam10225 164 NY--PLSLLSYLRRKWKRRKWFPWkppKRRLLTEEEYREQGEIETRKALEELREYCNSPDCSSWKTVSRLQDPKRFATFV 241

                  ....*...
gi 195972881  391 EGSSHLTP 398
Cdd:pfam10225 242 EGGSHLTP 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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