NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|192449447|ref|NP_001122306|]
View 

myelin proteolipid protein isoform 1 [Homo sapiens]

Protein Classification

myelin proteolipid family protein( domain architecture ID 10472648)

myelin proteolipid family protein similar to human myelin proteolipid protein (PLP) that plays an important role in the formation or maintenance of the multilamellar structure of myelin

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
5-273 7.71e-109

Myelin proteolipid protein (PLP or lipophilin);


:

Pssm-ID: 460144  Cd Length: 231  Bit Score: 314.23  E-value: 7.71e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192449447    5 ECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGA 84
Cdd:pfam01275   2 DCCVRCLGRVPYASLIATILCFAGVALFCGCGHRALTLTVLMLETVFHRNYQDYELLATWIDAFQYVIYGIAAFFFLLGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192449447   85 LLLAEGFYTTGAVRQIFGDYKTTICGKGLSATvtggqkgrgsrgqhqahslervchclgkwlghpdkFVGITYALTVVWL 164
Cdd:pfam01275  82 LLLAEGFLTTGATKQVYGAFRSTVGGRCSCAV-----------------------------------FMGITYVLALVWL 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192449447  165 LVFACSAVPVYIYFNTWTTCQSIAFPSKtsasiGSLCADARMYGVLPWNAFPGKVCGSN-LLSICKTAEFQMTFHLFIAA 243
Cdd:pfam01275 127 LVFAFLAIPVFIFTNFWSTCQNINVLST-----NQLCIDFRQFGFLPWNATPGKVCGMTeLKAFCKDYEEKMTFHLFILA 201

                         250       260       270
                  ....*....|....*....|....*....|
gi 192449447  244 FVGAAATLVSLLTFMIAATYNFAVLKLMGR 273
Cdd:pfam01275 202 FAGAGATLLALVHYLMCLTANYAHLRDHGR 231
 
Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
5-273 7.71e-109

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 460144  Cd Length: 231  Bit Score: 314.23  E-value: 7.71e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192449447    5 ECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGA 84
Cdd:pfam01275   2 DCCVRCLGRVPYASLIATILCFAGVALFCGCGHRALTLTVLMLETVFHRNYQDYELLATWIDAFQYVIYGIAAFFFLLGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192449447   85 LLLAEGFYTTGAVRQIFGDYKTTICGKGLSATvtggqkgrgsrgqhqahslervchclgkwlghpdkFVGITYALTVVWL 164
Cdd:pfam01275  82 LLLAEGFLTTGATKQVYGAFRSTVGGRCSCAV-----------------------------------FMGITYVLALVWL 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192449447  165 LVFACSAVPVYIYFNTWTTCQSIAFPSKtsasiGSLCADARMYGVLPWNAFPGKVCGSN-LLSICKTAEFQMTFHLFIAA 243
Cdd:pfam01275 127 LVFAFLAIPVFIFTNFWSTCQNINVLST-----NQLCIDFRQFGFLPWNATPGKVCGMTeLKAFCKDYEEKMTFHLFILA 201

                         250       260       270
                  ....*....|....*....|....*....|
gi 192449447  244 FVGAAATLVSLLTFMIAATYNFAVLKLMGR 273
Cdd:pfam01275 202 FAGAGATLLALVHYLMCLTANYAHLRDHGR 231
PLP smart00002
Myelin proteolipid protein (PLP or lipophilin);
179-238 7.44e-35

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 128322  Cd Length: 60  Bit Score: 119.90  E-value: 7.44e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 192449447   179 NTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFH 238
Cdd:smart00002   1 NTWTTCQSITFPEKTTTSIGTLCVDARQYGILPWNAFPGKVCGSNLLSICKTSEFQMTFH 60
 
Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
5-273 7.71e-109

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 460144  Cd Length: 231  Bit Score: 314.23  E-value: 7.71e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192449447    5 ECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGA 84
Cdd:pfam01275   2 DCCVRCLGRVPYASLIATILCFAGVALFCGCGHRALTLTVLMLETVFHRNYQDYELLATWIDAFQYVIYGIAAFFFLLGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192449447   85 LLLAEGFYTTGAVRQIFGDYKTTICGKGLSATvtggqkgrgsrgqhqahslervchclgkwlghpdkFVGITYALTVVWL 164
Cdd:pfam01275  82 LLLAEGFLTTGATKQVYGAFRSTVGGRCSCAV-----------------------------------FMGITYVLALVWL 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192449447  165 LVFACSAVPVYIYFNTWTTCQSIAFPSKtsasiGSLCADARMYGVLPWNAFPGKVCGSN-LLSICKTAEFQMTFHLFIAA 243
Cdd:pfam01275 127 LVFAFLAIPVFIFTNFWSTCQNINVLST-----NQLCIDFRQFGFLPWNATPGKVCGMTeLKAFCKDYEEKMTFHLFILA 201

                         250       260       270
                  ....*....|....*....|....*....|
gi 192449447  244 FVGAAATLVSLLTFMIAATYNFAVLKLMGR 273
Cdd:pfam01275 202 FAGAGATLLALVHYLMCLTANYAHLRDHGR 231
PLP smart00002
Myelin proteolipid protein (PLP or lipophilin);
179-238 7.44e-35

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 128322  Cd Length: 60  Bit Score: 119.90  E-value: 7.44e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 192449447   179 NTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFH 238
Cdd:smart00002   1 NTWTTCQSITFPEKTTTSIGTLCVDARQYGILPWNAFPGKVCGSNLLSICKTSEFQMTFH 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH