Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 65301119   552 GFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLD 592
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|....*
gi 65301119  47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 65301119     85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 65301119   298 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 65301119   340 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 374
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 65301119 127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:cd00112   1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 65301119    445 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 480
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 65301119   552 GFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLD 592
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 65301119   510 HIYWTDSGNK-TISVATVDGGRRRTLFSRNLSEPRAIAVDP 549
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|....*
gi 65301119  47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 65301119     85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|...
gi 65301119   262 ASQFACRSGECVHLGWRCDGDRDCKDKSDEADC 294
Cdd:pfam00057   5 PNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 493 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRT-----LFSRNLSEPRAIAVDPlRGFMYWSDWGDQaKIEK 567
Cdd:cd05819  51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 568 SGLNGVDRQTLVSDNIEW-----PNGITLDlLSQRLYWVDSKLHQLSSIDfSGGNRKTLISSTDF----LSHPFGIAVFE 638
Cdd:cd05819 128 FDPDGEFLTTFGSGGSGPgqfngPTGVAVD-SDGNIYVADTGNHRIQVFD-PDGNFLTTFGSTGTgpgqFNYPTGIAVDS 205

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 65301119 639 D-KVFWTDLENEAIFSANRLNGLEISI-----LAENLNNPHDIVI 677
Cdd:cd05819 206 DgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|..
gi 65301119  86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

DNA-binding beta-propeller fold protein YncE [General function prediction only];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 508 HKHIYWTDSGNKTISVATVDGGRRRTLFSRNlSEPRAIAVDPLRGFMYWSDWGDQAkieksgLNGVDRQTL-VSDNI--- 583
Cdd:COG3391  79 GRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR------VSVIDTATGkVVATIpvg 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 584 EWPNGITLDLLSQRLYWVDSKLHQLS----SIDFSGGnrkTLISSTDFLSHPFGIAVFED--KVFWTDLENEaifSANRL 657
Cdd:COG3391 152 AGPHGIAVDPDGKRLYVANSGSNTVSvivsVIDTATG---KVVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGG 225

                ....*...
gi 65301119 658 NGlEISIL 665
Cdd:COG3391 226 SN-TVSVI 232

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 65301119    45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 65301119    298 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 330
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 65301119    261 TASQFACRSGECVHLGWRCDGDRDCKDKSDE 291
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 65301119    206 CGPREFRCGGdggGACIPERWVCDRQFDCEDRSDE 240
Cdd:smart00192   2 CPPGEFQCDN---GRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 65301119 127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:cd00112   1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 65301119    376 DIDECKDPDACSQ--ICVNYKGYFKCECYPGYE 406
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 65301119    127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADE 160
Cdd:smart00192   2 CPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|...
gi 65301119 376 DIDECKDPDACS--QICVNYKGYFKCECYPGYE 406
Cdd:cd00054   1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 65301119   552 GFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLD 592
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 65301119   510 HIYWTDSGNK-TISVATVDGGRRRTLFSRNLSEPRAIAVDP 549
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|....*
gi 65301119  47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 65301119     85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|...
gi 65301119   262 ASQFACRSGECVHLGWRCDGDRDCKDKSDEADC 294
Cdd:pfam00057   5 PNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 493 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRT-----LFSRNLSEPRAIAVDPlRGFMYWSDWGDQaKIEK 567
Cdd:cd05819  51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 568 SGLNGVDRQTLVSDNIEW-----PNGITLDlLSQRLYWVDSKLHQLSSIDfSGGNRKTLISSTDF----LSHPFGIAVFE 638
Cdd:cd05819 128 FDPDGEFLTTFGSGGSGPgqfngPTGVAVD-SDGNIYVADTGNHRIQVFD-PDGNFLTTFGSTGTgpgqFNYPTGIAVDS 205

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 65301119 639 D-KVFWTDLENEAIFSANRLNGLEISI-----LAENLNNPHDIVI 677
Cdd:cd05819 206 DgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|..
gi 65301119  86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 493 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-----NLSEPRAIAVDPlRGFMYWSDWG------- 560
Cdd:cd05819   4 PGELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFGSFgsgdgQFNEPAGVAVDS-DGNLYVADTGnhriqkf 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 561 --DQAKIEKSGLNGVDRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFSGGNRKTL---ISSTDFLSHPFGIA 635
Cdd:cd05819  82 dpDGNFLASFGGSGDGDGEFNG-----PRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVA 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 65301119 636 VF-EDKVFWTDLENEAI--FSAnrlNGLEISILAEN------LNNPHDIVI 677
Cdd:cd05819 156 VDsDGNIYVADTGNHRIqvFDP---DGNFLTTFGSTgtgpgqFNYPTGIAV 203

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 65301119   639 DKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVIFH 679
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 65301119   596 QRLYWVDSKLHQ-LSSIDFSGGNRKTLIssTDFLSHPFGIAVFE 638
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....
gi 65301119    84 KTCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 65301119   340 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 374
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 493 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN-----LSEPRAIAVDPlRGFMYWSDWGDQaKIEK 567
Cdd:cd05819  98 DGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVDS-DGNIYVADTGNH-RIQV 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 568 SGLNGvDRQTLVSDNIEW------PNGITLDlLSQRLYWVDSKLHQLSSIDFSGGNRKTL---ISSTDFLSHPFGIAVFE 638
Cdd:cd05819 175 FDPDG-NFLTTFGSTGTGpgqfnyPTGIAVD-SDGNIYVADSGNNRVQVFDPDGAGFGGNgnfLGSDGQFNRPSGLAVDS 252

                ....*...
gi 65301119 639 D-KVFWTD 645
Cdd:cd05819 253 DgNLYVAD 260

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 65301119 127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:cd00112   1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 495 QLHSPEGLAVDWVHkHIYWTDSGNKTISVATVDGGRRRTLFSR-----NLSEPRAIAVDPLrGFMYWSD-WGDqaKIEKS 568
Cdd:cd14956  11 QFKDPRGIAVDADD-NVYVADARNGRIQVFDKDGTFLRRFGTTgdgpgQFGRPRGLAVDKD-GWLYVADyWGD--RIQVF 86

                ....*....
gi 65301119 569 GLNGVDRQT 577
Cdd:cd14956  87 TLTGELQTI 95

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 65301119    376 DIDECKDPDACSQ--ICVNYKGYFKCECYPGYE 406
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 65301119   127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 65301119    445 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 480
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|...
gi 65301119 376 DIDECKDPDACS--QICVNYKGYFKCECYPGYE 406
Cdd:cd00054   1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 65301119   462 NRIYWCDLSYRKIYSayMDKASDpKEQEVLIDEQLHSPEGLAVDW 506
Cdd:pfam00058   1 GRLYWTDSSLRASIS--SADLNG-SDRKTLFTDDLQHPNAIAVDP 42

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 492 IDEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGG----RRRTLFSRNLSEPRAIAVDPLrgfmywsdwGDQAKIEK 567
Cdd:cd14961  94 VRKSFSLPWGVAVN-PSGEILVTDSEAGKLFVLTVDFKlgilKKGQKLCSQLCRPRFVAVSRL---------GAVAVTEH 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 65301119 568 SGLNGVDRQtlvsdniewpngitldllSQRLYWVDSKLHQLSSIDFSGGNrktlISSTDFLsHPFGIAV-FEDKVFWTDL 646
Cdd:cd14961 164 LFANGTRSS------------------STRVKVFSSGGQLLGQIDSFGLN----LVFPSLI-CASGVAFdSEGNVIVADT 220

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 65301119 647 ENEAIFSANRLNGleISILaenlnnphDIVIFHELKQPRApdaceLSVQPNG 698
Cdd:cd14961 221 GSGAILCLGKPEG--FPIL--------KPIVTQGLSRPVG-----LAVTPDG 257