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Conserved domains on  [gi|224591414|ref|NP_001013715|]
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low-density lipoprotein receptor class A domain-containing protein 2 precursor [Homo sapiens]

Protein Classification

CUB and LDLa domain-containing protein( domain architecture ID 10207598)

CUB and LDLa domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 176-204 1.13e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.13e-08
                         10        20
                 ....*....|....*....|....*....
gi 224591414 176 YFRCQNGRCIPSSLVCDpwGMDNCGDGSD 204
Cdd:cd00112    5 EFRCANGRCIPSSWVCD--GEDDCGDGSD 31
CUB super family cl00049
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 60-152 3.40e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


The actual alignment was detected with superfamily member cd00041:

Pssm-ID: 412131 [Multi-domain]  Cd Length: 113  Bit Score: 42.01  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591414  60 PDTDCgLWVQAAAPGDRIRFQFRFFLVysltpappalntsspAPADPCaPGSYLQFYEGPPGAPRPLGsPLCGLNIPVPV 139
Cdd:cd00041   24 NNLNC-VWTIEAPPGYRIRLTFEDFDL---------------ESSPNC-SYDYLEIYDGPSTSSPLLG-RFCGSTLPPPI 85

                         90
                 ....*....|...
gi 224591414 140 ASSGPFLGLRLVT 152
Cdd:cd00041   86 ISSGNSLTVRFRS 98
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 176-204 1.13e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.13e-08
                         10        20
                 ....*....|....*....|....*....
gi 224591414 176 YFRCQNGRCIPSSLVCDpwGMDNCGDGSD 204
Cdd:cd00112    5 EFRCANGRCIPSSWVCD--GEDDCGDGSD 31
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 176-204 1.23e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 1.23e-08
                           10        20
                   ....*....|....*....|....*....
gi 224591414   176 YFRCQNGRCIPSSLVCDpwGMDNCGDGSD 204
Cdd:smart00192   6 EFQCDNGRCIPSSWVCD--GVDDCGDGSD 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
177-204 3.14e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 3.14e-06
                          10        20
                  ....*....|....*....|....*...
gi 224591414  177 FRCQNGRCIPSSLVCDpwGMDNCGDGSD 204
Cdd:pfam00057   8 FQCGSGECIPRSWVCD--GDPDCGDGSD 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 60-152 3.40e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 42.01  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591414  60 PDTDCgLWVQAAAPGDRIRFQFRFFLVysltpappalntsspAPADPCaPGSYLQFYEGPPGAPRPLGsPLCGLNIPVPV 139
Cdd:cd00041   24 NNLNC-VWTIEAPPGYRIRLTFEDFDL---------------ESSPNC-SYDYLEIYDGPSTSSPLLG-RFCGSTLPPPI 85

                         90
                 ....*....|...
gi 224591414 140 ASSGPFLGLRLVT 152
Cdd:cd00041   86 ISSGNSLTVRFRS 98
CUB pfam00431
CUB domain;
60-152 6.14e-04

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 38.43  E-value: 6.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591414   60 PDTDCgLWVQAAAPGDRIRFQFRFFLVYSltpappalntsspapADPCaPGSYLQFYEGPPGAPRPLGsPLCGLNIPVPV 139
Cdd:pfam00431  23 PNKDC-VWLIRAPPGFRVKLTFQDFELED---------------HDEC-GYDYVEIRDGPSASSPLLG-RFCGSGIPEDI 84

                          90
                  ....*....|...
gi 224591414  140 ASSGPFLGLRLVT 152
Cdd:pfam00431  85 VSSSNQMTIKFVS 97
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 176-204 1.13e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.13e-08
                         10        20
                 ....*....|....*....|....*....
gi 224591414 176 YFRCQNGRCIPSSLVCDpwGMDNCGDGSD 204
Cdd:cd00112    5 EFRCANGRCIPSSWVCD--GEDDCGDGSD 31
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 176-204 1.23e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 1.23e-08
                           10        20
                   ....*....|....*....|....*....
gi 224591414   176 YFRCQNGRCIPSSLVCDpwGMDNCGDGSD 204
Cdd:smart00192   6 EFQCDNGRCIPSSWVCD--GVDDCGDGSD 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
177-204 3.14e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 3.14e-06
                          10        20
                  ....*....|....*....|....*...
gi 224591414  177 FRCQNGRCIPSSLVCDpwGMDNCGDGSD 204
Cdd:pfam00057   8 FQCGSGECIPRSWVCD--GDPDCGDGSD 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 60-152 3.40e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 42.01  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591414  60 PDTDCgLWVQAAAPGDRIRFQFRFFLVysltpappalntsspAPADPCaPGSYLQFYEGPPGAPRPLGsPLCGLNIPVPV 139
Cdd:cd00041   24 NNLNC-VWTIEAPPGYRIRLTFEDFDL---------------ESSPNC-SYDYLEIYDGPSTSSPLLG-RFCGSTLPPPI 85

                         90
                 ....*....|...
gi 224591414 140 ASSGPFLGLRLVT 152
Cdd:cd00041   86 ISSGNSLTVRFRS 98
CUB pfam00431
CUB domain;
60-152 6.14e-04

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 38.43  E-value: 6.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591414   60 PDTDCgLWVQAAAPGDRIRFQFRFFLVYSltpappalntsspapADPCaPGSYLQFYEGPPGAPRPLGsPLCGLNIPVPV 139
Cdd:pfam00431  23 PNKDC-VWLIRAPPGFRVKLTFQDFELED---------------HDEC-GYDYVEIRDGPSASSPLLG-RFCGSGIPEDI 84

                          90
                  ....*....|...
gi 224591414  140 ASSGPFLGLRLVT 152
Cdd:pfam00431  85 VSSSNQMTIKFVS 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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