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Conserved domains on  [gi|614458156|ref|NP_001009609|]
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sperm protein associated with the nucleus on the X chromosome N3 [Homo sapiens]

Protein Classification

SPAN-X domain-containing protein( domain architecture ID 10538540)

SPAN-X domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPAN-X pfam07458
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-95 1.43e-38

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


:

Pssm-ID: 400025  Cd Length: 94  Bit Score: 125.81  E-value: 1.43e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458156    1 MEQPTSSTNGEKTKSPCESNNKkNDEMQEVPNRVLAPEQSLKNTKTSEYPIIFVYYLRKGKKINSNQLENEQSQENSINP 80
Cdd:pfam07458   1 MEQPTSSTNGEKRKSPCDSNNA-NDEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKISSNQLENDQSRENSINP 79

                          90
                  ....*....|....*
gi 614458156   81 IQKEEDEGVDLSEGS 95
Cdd:pfam07458  80 LQMEEEEFMEIREES 94
CobT2 super family cl34772
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 67-141 6.02e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


The actual alignment was detected with superfamily member COG4547:

Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 35.54  E-value: 6.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 614458156  67 QLENEQSQENSINPIQKEEDEGVDLSEGSSNEDEDlgpceGPSKEDKDLDSSEGSSQEDEDlGLSEGSSQDSGED 141
Cdd:COG4547  206 DLAEELGEDEDEEDEDDEDDSGEQEEDEEDGEDED-----EESDEGAEAEDAEASGDDAEE-GESEAAEAESDEM 274
 
Name Accession Description Interval E-value
SPAN-X pfam07458
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-95 1.43e-38

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


Pssm-ID: 400025  Cd Length: 94  Bit Score: 125.81  E-value: 1.43e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458156    1 MEQPTSSTNGEKTKSPCESNNKkNDEMQEVPNRVLAPEQSLKNTKTSEYPIIFVYYLRKGKKINSNQLENEQSQENSINP 80
Cdd:pfam07458   1 MEQPTSSTNGEKRKSPCDSNNA-NDEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKISSNQLENDQSRENSINP 79

                          90
                  ....*....|....*
gi 614458156   81 IQKEEDEGVDLSEGS 95
Cdd:pfam07458  80 LQMEEEEFMEIREES 94
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 67-141 6.02e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 35.54  E-value: 6.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 614458156  67 QLENEQSQENSINPIQKEEDEGVDLSEGSSNEDEDlgpceGPSKEDKDLDSSEGSSQEDEDlGLSEGSSQDSGED 141
Cdd:COG4547  206 DLAEELGEDEDEEDEDDEDDSGEQEEDEEDGEDED-----EESDEGAEAEDAEASGDDAEE-GESEAAEAESDEM 274
 
Name Accession Description Interval E-value
SPAN-X pfam07458
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-95 1.43e-38

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


Pssm-ID: 400025  Cd Length: 94  Bit Score: 125.81  E-value: 1.43e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458156    1 MEQPTSSTNGEKTKSPCESNNKkNDEMQEVPNRVLAPEQSLKNTKTSEYPIIFVYYLRKGKKINSNQLENEQSQENSINP 80
Cdd:pfam07458   1 MEQPTSSTNGEKRKSPCDSNNA-NDEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKISSNQLENDQSRENSINP 79

                          90
                  ....*....|....*
gi 614458156   81 IQKEEDEGVDLSEGS 95
Cdd:pfam07458  80 LQMEEEEFMEIREES 94
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 67-141 6.02e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 35.54  E-value: 6.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 614458156  67 QLENEQSQENSINPIQKEEDEGVDLSEGSSNEDEDlgpceGPSKEDKDLDSSEGSSQEDEDlGLSEGSSQDSGED 141
Cdd:COG4547  206 DLAEELGEDEDEEDEDDEDDSGEQEEDEEDGEDED-----EESDEGAEAEDAEASGDDAEE-GESEAAEAESDEM 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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