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Conserved domains on  [gi|120433602|ref|NP_000710|]
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voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 [Homo sapiens]

Protein Classification

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type calcium channel subunit alpha-1; voltage-dependent L-type calcium channel subunit alpha-1( domain architecture ID 11999372)

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
123-416 2.61e-69

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 233.31  E-value: 2.61e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   123 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   203 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   283 AIIGLELFMGKMHKtcynqegiadvpaeddpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 362
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 120433602   363 EGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK 416
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1218-1487 3.72e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 229.85  E-value: 3.72e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1218 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKP-KHYFCDAWNTFDALIVVGSI 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1296 VDIAITEVNpaehtqcspsmnaeenSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYA 1375
Cdd:pfam00520   81 ISLVLSSVG----------------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFA 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1376 VIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFY 1455
Cdd:pfam00520  145 IIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIY 206
                          250       260       270
                   ....*....|....*....|....*....|..
gi 120433602  1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1487
Cdd:pfam00520  207 FVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
899-1176 3.20e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.09  E-value: 3.20e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   899 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHkgsFCRNYFNILDLLVVS 978
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   979 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1057
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1058 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1137
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 120433602  1138 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1176
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
523-764 2.14e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 184.78  E-value: 2.14e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   523 SNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFVVCGGI 600
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   601 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 759
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 120433602   760 ESLTS 764
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1559-1633 5.21e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 134.26  E-value: 5.21e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 120433602  1559 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1633
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C super family cl25181
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1653-2088 2.80e-33

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


The actual alignment was detected with superfamily member pfam16885:

Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 133.59  E-value: 2.80e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1653 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkeavsaaseddifrragglfgnhvsyyqsdgrsafpqtfttqrplhinK 1732
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEE-----------------------------------------------------E 27
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1733 AGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAirvqevawkls 1812
Cdd:pfam16885   28 EEGQEGEEEEDSKDPKAPIGSQPPSRSRISVSLPVGDRLPDSLSLGPSDDDGGAPNSRQPSVPQTGSHT----------- 96
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1813 snrcHSRESQAAMAGQEETSQDETYEVK-MNHDTEACSEPSLLSteML-SYQDDENRQLTLP---EEDKRDIRQSPKRGF 1887
Cdd:pfam16885   97 ----HRRSSGVLMFTIPEEGSSQPKGTKgQDKQDEEEEVPDQLS--YLdEQAGTPSRPVLLPphrPQHYPLREPVDRRRL 170
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1888 LRSASLGRRASFHLECLKRQkdrggdiSQKTVLPLhlvhhqalavaglspllqrshsPASFPRPFATPPA-TPGSRGWPP 1966
Cdd:pfam16885  171 LPPTPAGRKPSFNIQCLRRQ-------GSCEDLPI----------------------PGTYHRGRNSGPSrAQGSWATPP 221
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1967 QP-----VPTLRLEgvesseklnssfpsihcgswaETTPGGG--GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEA 2039
Cdd:pfam16885  222 QRgrllyAPLLLVE---------------------EGAAGEGylGKSPGPLRTFTCLRVPGTHSDPSHGKRGSADSLVEA 280
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 120433602  2040 VLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ 2088
Cdd:pfam16885  281 VLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 329
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1496-1549 3.44e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 116.98  E-value: 3.44e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 120433602  1496 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1549
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
123-416 2.61e-69

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 233.31  E-value: 2.61e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   123 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   203 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   283 AIIGLELFMGKMHKtcynqegiadvpaeddpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 362
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 120433602   363 EGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK 416
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1218-1487 3.72e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 229.85  E-value: 3.72e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1218 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKP-KHYFCDAWNTFDALIVVGSI 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1296 VDIAITEVNpaehtqcspsmnaeenSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYA 1375
Cdd:pfam00520   81 ISLVLSSVG----------------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFA 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1376 VIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFY 1455
Cdd:pfam00520  145 IIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIY 206
                          250       260       270
                   ....*....|....*....|....*....|..
gi 120433602  1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1487
Cdd:pfam00520  207 FVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
899-1176 3.20e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.09  E-value: 3.20e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   899 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHkgsFCRNYFNILDLLVVS 978
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   979 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1057
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1058 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1137
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 120433602  1138 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1176
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
523-764 2.14e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 184.78  E-value: 2.14e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   523 SNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFVVCGGI 600
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   601 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 759
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 120433602   760 ESLTS 764
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1559-1633 5.21e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 134.26  E-value: 5.21e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 120433602  1559 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1633
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1653-2088 2.80e-33

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 133.59  E-value: 2.80e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1653 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkeavsaaseddifrragglfgnhvsyyqsdgrsafpqtfttqrplhinK 1732
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEE-----------------------------------------------------E 27
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1733 AGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAirvqevawkls 1812
Cdd:pfam16885   28 EEGQEGEEEEDSKDPKAPIGSQPPSRSRISVSLPVGDRLPDSLSLGPSDDDGGAPNSRQPSVPQTGSHT----------- 96
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1813 snrcHSRESQAAMAGQEETSQDETYEVK-MNHDTEACSEPSLLSteML-SYQDDENRQLTLP---EEDKRDIRQSPKRGF 1887
Cdd:pfam16885   97 ----HRRSSGVLMFTIPEEGSSQPKGTKgQDKQDEEEEVPDQLS--YLdEQAGTPSRPVLLPphrPQHYPLREPVDRRRL 170
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1888 LRSASLGRRASFHLECLKRQkdrggdiSQKTVLPLhlvhhqalavaglspllqrshsPASFPRPFATPPA-TPGSRGWPP 1966
Cdd:pfam16885  171 LPPTPAGRKPSFNIQCLRRQ-------GSCEDLPI----------------------PGTYHRGRNSGPSrAQGSWATPP 221
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1967 QP-----VPTLRLEgvesseklnssfpsihcgswaETTPGGG--GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEA 2039
Cdd:pfam16885  222 QRgrllyAPLLLVE---------------------EGAAGEGylGKSPGPLRTFTCLRVPGTHSDPSHGKRGSADSLVEA 280
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 120433602  2040 VLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ 2088
Cdd:pfam16885  281 VLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 329
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1496-1549 3.44e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 116.98  E-value: 3.44e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 120433602  1496 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1549
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1611-1641 3.32e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 65.32  E-value: 3.32e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 120433602   1611 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVG 1641
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
123-416 2.61e-69

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 233.31  E-value: 2.61e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   123 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   203 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   283 AIIGLELFMGKMHKtcynqegiadvpaeddpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 362
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 120433602   363 EGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK 416
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1218-1487 3.72e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 229.85  E-value: 3.72e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1218 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKP-KHYFCDAWNTFDALIVVGSI 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1296 VDIAITEVNpaehtqcspsmnaeenSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYA 1375
Cdd:pfam00520   81 ISLVLSSVG----------------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFA 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1376 VIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFY 1455
Cdd:pfam00520  145 IIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIY 206
                          250       260       270
                   ....*....|....*....|....*....|..
gi 120433602  1456 FISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1487
Cdd:pfam00520  207 FVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
899-1176 3.20e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.09  E-value: 3.20e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   899 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHkgsFCRNYFNILDLLVVS 978
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   979 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1057
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1058 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1137
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 120433602  1138 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1176
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
523-764 2.14e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 184.78  E-value: 2.14e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   523 SNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFVVCGGI 600
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   601 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602   680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 759
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 120433602   760 ESLTS 764
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1559-1633 5.21e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 134.26  E-value: 5.21e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 120433602  1559 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1633
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1653-2088 2.80e-33

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 133.59  E-value: 2.80e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1653 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkeavsaaseddifrragglfgnhvsyyqsdgrsafpqtfttqrplhinK 1732
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEE-----------------------------------------------------E 27
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1733 AGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAirvqevawkls 1812
Cdd:pfam16885   28 EEGQEGEEEEDSKDPKAPIGSQPPSRSRISVSLPVGDRLPDSLSLGPSDDDGGAPNSRQPSVPQTGSHT----------- 96
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1813 snrcHSRESQAAMAGQEETSQDETYEVK-MNHDTEACSEPSLLSteML-SYQDDENRQLTLP---EEDKRDIRQSPKRGF 1887
Cdd:pfam16885   97 ----HRRSSGVLMFTIPEEGSSQPKGTKgQDKQDEEEEVPDQLS--YLdEQAGTPSRPVLLPphrPQHYPLREPVDRRRL 170
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1888 LRSASLGRRASFHLECLKRQkdrggdiSQKTVLPLhlvhhqalavaglspllqrshsPASFPRPFATPPA-TPGSRGWPP 1966
Cdd:pfam16885  171 LPPTPAGRKPSFNIQCLRRQ-------GSCEDLPI----------------------PGTYHRGRNSGPSrAQGSWATPP 221
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1967 QP-----VPTLRLEgvesseklnssfpsihcgswaETTPGGG--GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEA 2039
Cdd:pfam16885  222 QRgrllyAPLLLVE---------------------EGAAGEGylGKSPGPLRTFTCLRVPGTHSDPSHGKRGSADSLVEA 280
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 120433602  2040 VLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ 2088
Cdd:pfam16885  281 VLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 329
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1496-1549 3.44e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 116.98  E-value: 3.44e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 120433602  1496 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1549
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1611-1641 3.32e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 65.32  E-value: 3.32e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 120433602   1611 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVG 1641
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1246-1480 2.53e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 56.52  E-value: 2.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1246 LFKIAMNILNMLFTGLFTVEMILKlIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRIS- 1324
Cdd:pfam08016    8 LFILLCEIVFVVFFLYFVVEEILK-IRKHRPSYLRSVWNLLDLAIVILSVVLIVLNIYRDFLADRLIKSVEASPVTFIDf 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1325 -------------------ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFqalpyvALLIVMLFFIYAVIGMQVFGki 1385
Cdd:pfam08016   87 drvaqldnlyriilaflvfLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGF------ALMFVIFFFAYAQFGYLLFG-- 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120433602  1386 alndtteiNRNNNFQTFPQAVLLLFR-CATGEAWQDIMlacmpgkkcapesepsnstegetPCGSSFAVFYFISFYMLCA 1464
Cdd:pfam08016  159 --------TQAPNFSNFVKSILTLFRtILGDFGYNEIF-----------------------SGNRVLGPLLFLTFVFLVI 207
                          250
                   ....*....|....*.
gi 120433602  1465 FLIINLFVAVIMDNFD 1480
Cdd:pfam08016  208 FILLNLFLAIINDSYV 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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