NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|10834982|ref|NP_000590|]
View 

insulin-like growth factor-binding protein 5 precursor [Homo sapiens]

Protein Classification

insulin-like growth factor-binding protein( domain architecture ID 11254546)

insulin-like growth factor-binding protein (IGFBP) controls the bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 25-101 3.30e-28

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


:

Pssm-ID: 197525  Cd Length: 75  Bit Score: 102.93  E-value: 3.30e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 10834982     25 VHCEPCDEkalSMCPPSPLGC-ELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCL 101
Cdd:smart00121   1 ARCPPCDP---ARCPPCPPGCaELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 192-263 7.48e-19

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.11  E-value: 7.48e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10834982   192 CRRHMEASLQELKASPRmvPRAVYLPNCDRKGFYKRKQCKPSRGRkrgiCWCVDKYGMKLPGMEYVDGDFQC 263
Cdd:pfam00086   1 CERERARALEQAASGRP--ASGLYIPNCDEDGFYKPVQCHGSTGY----CWCVDPEGQEIPGTRTRGGDPDC 66
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 25-101 3.30e-28

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 102.93  E-value: 3.30e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 10834982     25 VHCEPCDEkalSMCPPSPLGC-ELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCL 101
Cdd:smart00121   1 ARCPPCDP---ARCPPCPPGCaELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 192-263 7.48e-19

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.11  E-value: 7.48e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10834982   192 CRRHMEASLQELKASPRmvPRAVYLPNCDRKGFYKRKQCKPSRGRkrgiCWCVDKYGMKLPGMEYVDGDFQC 263
Cdd:pfam00086   1 CERERARALEQAASGRP--ASGLYIPNCDEDGFYKPVQCHGSTGY----CWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 191-263 2.42e-16

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 71.73  E-value: 2.42e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 10834982 191 PCRRHMEASLQELkasPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRkrgiCWCVDKYGMKLPGMEYVDGDFQC 263
Cdd:cd00191   1 PCERERASALESL---AGPKLSGLYVPQCDEDGNYEPVQCHGSTGY----CWCVDPDGEEIPGTRTRGGPPNC 66
IGFBP pfam00219
Insulin-like growth factor binding protein;
28-80 4.17e-15

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 67.74  E-value: 4.17e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 10834982    28 EPCDEkalSMCPPSPLGC-ELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRC 80
Cdd:pfam00219   3 PPCDP---ERCPPPPPGCpAGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 216-265 3.54e-13

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 62.40  E-value: 3.54e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 10834982    216 LPNCDRKGFYKRKQCKPSRGrkrgICWCVDKYGMKLPGMEYVDGDFQCHT 265
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGSSG----QCWCVDATGREIPGTRTEGGDPDCPS 46
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 25-101 3.30e-28

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 102.93  E-value: 3.30e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 10834982     25 VHCEPCDEkalSMCPPSPLGC-ELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCL 101
Cdd:smart00121   1 ARCPPCDP---ARCPPCPPGCaELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 192-263 7.48e-19

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.11  E-value: 7.48e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10834982   192 CRRHMEASLQELKASPRmvPRAVYLPNCDRKGFYKRKQCKPSRGRkrgiCWCVDKYGMKLPGMEYVDGDFQC 263
Cdd:pfam00086   1 CERERARALEQAASGRP--ASGLYIPNCDEDGFYKPVQCHGSTGY----CWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 191-263 2.42e-16

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 71.73  E-value: 2.42e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 10834982 191 PCRRHMEASLQELkasPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRkrgiCWCVDKYGMKLPGMEYVDGDFQC 263
Cdd:cd00191   1 PCERERASALESL---AGPKLSGLYVPQCDEDGNYEPVQCHGSTGY----CWCVDPDGEEIPGTRTRGGPPNC 66
IGFBP pfam00219
Insulin-like growth factor binding protein;
28-80 4.17e-15

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 67.74  E-value: 4.17e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 10834982    28 EPCDEkalSMCPPSPLGC-ELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRC 80
Cdd:pfam00219   3 PPCDP---ERCPPPPPGCpAGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 216-265 3.54e-13

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 62.40  E-value: 3.54e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 10834982    216 LPNCDRKGFYKRKQCKPSRGrkrgICWCVDKYGMKLPGMEYVDGDFQCHT 265
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGSSG----QCWCVDATGREIPGTRTEGGDPDCPS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH