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Conserved domains on  [gi|4503591|ref|NP_000112|]
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erythropoietin receptor precursor [Homo sapiens]

Protein Classification

EpoR_lig-bind and FN3 domain-containing protein( domain architecture ID 10557304)

EpoR_lig-bind and FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 37-140 1.49e-40

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


:

Pssm-ID: 401127  Cd Length: 104  Bit Score: 141.40  E-value: 1.49e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503591     37 SKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPgNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSS 116
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPT-TYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSL 79

                          90       100
                  ....*....|....*....|....*
gi 4503591    117 FVPLELRV-TAASGAPRYHRVIHIN 140
Cdd:pfam09067  80 FVPLHITVvATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 146-244 4.36e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 4.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503591  146 DAPVGLVARlADESGHVVLRWLPPPETPmTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARma 225
Cdd:cd00063   2 SPPTNLRVT-DVTSTSVTLSWTPPEDDG-GPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-- 77

                        90
                ....*....|....*....
gi 4503591  226 epsFGGFWSAWSEPVSLLT 244
Cdd:cd00063  78 ---NGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 37-140 1.49e-40

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 141.40  E-value: 1.49e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503591     37 SKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPgNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSS 116
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPT-TYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSL 79

                          90       100
                  ....*....|....*....|....*
gi 4503591    117 FVPLELRV-TAASGAPRYHRVIHIN 140
Cdd:pfam09067  80 FVPLHITVvATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 146-244 4.36e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 4.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503591  146 DAPVGLVARlADESGHVVLRWLPPPETPmTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARma 225
Cdd:cd00063   2 SPPTNLRVT-DVTSTSVTLSWTPPEDDG-GPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-- 77

                        90
                ....*....|....*....
gi 4503591  226 epsFGGFWSAWSEPVSLLT 244
Cdd:cd00063  78 ---NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 146-223 1.04e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 1.04e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4503591     146 DAPVGLVARLADESgHVVLRWLPPPETPMTSHI-RYEVDVSAGNGagSVQRVEILEGRTECVLSNLRGRTRYTFAVRAR 223
Cdd:smart00060   2 SPPSNLRVTDVTST-SVTLSWEPPPDDGITGYIvGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
146-223 5.18e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 5.18e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4503591    146 DAPVGLVARLADESGhVVLRWLPPPETPmtSHI-RYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRAR 223
Cdd:pfam00041   1 SAPSNLTVTDVTSTS-LTVSWTPPPDGN--GPItGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 37-140 1.49e-40

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 141.40  E-value: 1.49e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503591     37 SKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPgNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSS 116
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPT-TYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSL 79

                          90       100
                  ....*....|....*....|....*
gi 4503591    117 FVPLELRV-TAASGAPRYHRVIHIN 140
Cdd:pfam09067  80 FVPLHITVvATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 146-244 4.36e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 4.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503591  146 DAPVGLVARlADESGHVVLRWLPPPETPmTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARma 225
Cdd:cd00063   2 SPPTNLRVT-DVTSTSVTLSWTPPEDDG-GPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-- 77

                        90
                ....*....|....*....
gi 4503591  226 epsFGGFWSAWSEPVSLLT 244
Cdd:cd00063  78 ---NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 146-223 1.04e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 1.04e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4503591     146 DAPVGLVARLADESgHVVLRWLPPPETPMTSHI-RYEVDVSAGNGagSVQRVEILEGRTECVLSNLRGRTRYTFAVRAR 223
Cdd:smart00060   2 SPPSNLRVTDVTST-SVTLSWEPPPDDGITGYIvGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
146-223 5.18e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 5.18e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4503591    146 DAPVGLVARLADESGhVVLRWLPPPETPmtSHI-RYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRAR 223
Cdd:pfam00041   1 SAPSNLTVTDVTSTS-LTVSWTPPPDGN--GPItGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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