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Conserved domains on  [gi|2462537889|ref|XP_054230902|]
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zinc finger MYM-type protein 2 isoform X2 [Homo sapiens]

Protein Classification

zf-FCS and DUF3504 domain-containing protein( domain architecture ID 10534342)

zf-FCS and DUF3504 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 1214-1382 2.26e-77

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


:

Pssm-ID: 463430  Cd Length: 162  Bit Score: 252.57  E-value: 2.26e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537889 1214 IFSRVEEDYLWRIKQLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRHWKKNPLTMEnkACLRYQVsslcgtd 1293
Cdd:pfam12012    1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPREKS--TYLRYYE------- 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537889 1294 NEDKITTGKRKHEDD--EPVFEQIENTANPSRCPVKMFECYLSKSPQNLNQRMDVFYLQPECSSSTDSPVWYTSTSLDRN 1371
Cdd:pfam12012   72 PPDQVETGGRKKRDEgvNKVVEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRN 151

                          170
                   ....*....|.
gi 2462537889 1372 TLENMLVRVLL 1382
Cdd:pfam12012  152 TLESMLTRILL 162
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 484-524 2.89e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 45.05  E-value: 2.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462537889  484 LIMNCCEQCGEYLPSKGAGNnVLVIDGQQKRFCCQSCVSEY 524
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 656-693 6.10e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 44.28  E-value: 6.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  656 DIQLKCNYCKNSFCSKPE--ILEWENKVHQFCSKTCSDDY 693
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTviVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 553-592 2.32e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 42.74  E-value: 2.32e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  553 GKLTTCTGCRTQCRFFDMTQCIGPNGYMEPYCSTACMNSH 592
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 744-780 4.48e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 41.97  E-value: 4.48e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  744 LRCVTCNYCSQLCKKGATK---ELDGVVRDFCSEDCCKKF 780
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVivlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 786-821 1.90e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 40.05  E-value: 1.90e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462537889  786 KAARCDCCKSQGTLKE---RVQWRGEMKHFCDQHCLLRF 821
Cdd:pfam06467    2 VKATCWFCKKLIKNKPtviVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 390-431 2.79e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.66  E-value: 2.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462537889  390 APKKLCVMCKKDITTMKGtiVAQVDSSESFQEFCSTSCLSLY 431
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPT--VIVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 349-385 7.68e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 7.68e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462537889  349 VKVTCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 385
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 442-478 8.81e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.12  E-value: 8.81e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  442 LNKSRCTICGKLTEIRHE---VSFKNMTHKLCSDHCFNRY 478
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 1214-1382 2.26e-77

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


Pssm-ID: 463430  Cd Length: 162  Bit Score: 252.57  E-value: 2.26e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537889 1214 IFSRVEEDYLWRIKQLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRHWKKNPLTMEnkACLRYQVsslcgtd 1293
Cdd:pfam12012    1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPREKS--TYLRYYE------- 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537889 1294 NEDKITTGKRKHEDD--EPVFEQIENTANPSRCPVKMFECYLSKSPQNLNQRMDVFYLQPECSSSTDSPVWYTSTSLDRN 1371
Cdd:pfam12012   72 PPDQVETGGRKKRDEgvNKVVEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRN 151

                          170
                   ....*....|.
gi 2462537889 1372 TLENMLVRVLL 1382
Cdd:pfam12012  152 TLESMLTRILL 162
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 484-524 2.89e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 45.05  E-value: 2.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462537889  484 LIMNCCEQCGEYLPSKGAGNnVLVIDGQQKRFCCQSCVSEY 524
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 656-693 6.10e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 44.28  E-value: 6.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  656 DIQLKCNYCKNSFCSKPE--ILEWENKVHQFCSKTCSDDY 693
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTviVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 553-592 2.32e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 42.74  E-value: 2.32e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  553 GKLTTCTGCRTQCRFFDMTQCIGPNGYMEPYCSTACMNSH 592
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 744-780 4.48e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 41.97  E-value: 4.48e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  744 LRCVTCNYCSQLCKKGATK---ELDGVVRDFCSEDCCKKF 780
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVivlQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
489-526 4.67e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 41.98  E-value: 4.67e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2462537889   489 CEQCGEYLPSKGAGNNVlVIDGQQKRFCCQSCVSEYKQ 526
Cdd:smart00746    1 CSFCGKDIYNPGTGIMV-VNDGKVYYFCSSKCLSKFKK 37
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 786-821 1.90e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 40.05  E-value: 1.90e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462537889  786 KAARCDCCKSQGTLKE---RVQWRGEMKHFCDQHCLLRF 821
Cdd:pfam06467    2 VKATCWFCKKLIKNKPtviVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 390-431 2.79e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.66  E-value: 2.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462537889  390 APKKLCVMCKKDITTMKGtiVAQVDSSESFQEFCSTSCLSLY 431
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPT--VIVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 349-385 7.68e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 7.68e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462537889  349 VKVTCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 385
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 442-478 8.81e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.12  E-value: 8.81e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  442 LNKSRCTICGKLTEIRHE---VSFKNMTHKLCSDHCFNRY 478
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
353-389 9.75e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 38.13  E-value: 9.75e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2462537889   353 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKP 389
Cdd:smart00746    1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
TRASH smart00746
metallochaperone-like domain;
749-781 1.46e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 37.74  E-value: 1.46e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462537889   749 CNYCSQLCKKGATKEL---DGVVRDFCSEDCCKKFQ 781
Cdd:smart00746    1 CSFCGKDIYNPGTGIMvvnDGKVYYFCSSKCLSKFK 36
TRASH smart00746
metallochaperone-like domain;
661-696 4.95e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 36.20  E-value: 4.95e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2462537889   661 CNYCKNSFCSK--PEILEWENKVHQFCSKTCSDDYKKL 696
Cdd:smart00746    1 CSFCGKDIYNPgtGIMVVNDGKVYYFCSSKCLSKFKKK 38
 
Name Accession Description Interval E-value
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
 1214-1382 2.26e-77

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


Pssm-ID: 463430  Cd Length: 162  Bit Score: 252.57  E-value: 2.26e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537889 1214 IFSRVEEDYLWRIKQLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRHWKKNPLTMEnkACLRYQVsslcgtd 1293
Cdd:pfam12012    1 VFSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPREKS--TYLRYYE------- 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462537889 1294 NEDKITTGKRKHEDD--EPVFEQIENTANPSRCPVKMFECYLSKSPQNLNQRMDVFYLQPECSSSTDSPVWYTSTSLDRN 1371
Cdd:pfam12012   72 PPDQVETGGRKKRDEgvNKVVEQHENSENPLRCPVKLYEFYLSKCPESVKQRKDVFYLQPEPSCVPDSPLWYSSQPLGRN 151

                          170
                   ....*....|.
gi 2462537889 1372 TLENMLVRVLL 1382
Cdd:pfam12012  152 TLESMLTRILL 162
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 484-524 2.89e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 45.05  E-value: 2.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462537889  484 LIMNCCEQCGEYLPSKGAGNnVLVIDGQQKRFCCQSCVSEY 524
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVI-VLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 656-693 6.10e-06

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 44.28  E-value: 6.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  656 DIQLKCNYCKNSFCSKPE--ILEWENKVHQFCSKTCSDDY 693
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTviVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 553-592 2.32e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 42.74  E-value: 2.32e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  553 GKLTTCTGCRTQCRFFDMTQCIGPNGYMEPYCSTACMNSH 592
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 744-780 4.48e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 41.97  E-value: 4.48e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  744 LRCVTCNYCSQLCKKGATK---ELDGVVRDFCSEDCCKKF 780
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVivlQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
489-526 4.67e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 41.98  E-value: 4.67e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2462537889   489 CEQCGEYLPSKGAGNNVlVIDGQQKRFCCQSCVSEYKQ 526
Cdd:smart00746    1 CSFCGKDIYNPGTGIMV-VNDGKVYYFCSSKCLSKFKK 37
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 786-821 1.90e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 40.05  E-value: 1.90e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462537889  786 KAARCDCCKSQGTLKE---RVQWRGEMKHFCDQHCLLRF 821
Cdd:pfam06467    2 VKATCWFCKKLIKNKPtviVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 390-431 2.79e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.66  E-value: 2.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462537889  390 APKKLCVMCKKDITTMKGtiVAQVDSSESFQEFCSTSCLSLY 431
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPT--VIVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 349-385 7.68e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.51  E-value: 7.68e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462537889  349 VKVTCANCKKPLQKGQTAY--QRKGSAHLFCSTTCLSSF 385
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 442-478 8.81e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.12  E-value: 8.81e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462537889  442 LNKSRCTICGKLTEIRHE---VSFKNMTHKLCSDHCFNRY 478
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
Arc_trans_TRASH pfam08394
Archaeal TRASH domain; This region is found in the C-terminus of a number of archaeal ...
 661-695 9.45e-04

Archaeal TRASH domain; This region is found in the C-terminus of a number of archaeal transcriptional regulators. It is thought to function as a metal-sensing regulatory module.


Pssm-ID: 285580  Cd Length: 37  Bit Score: 38.22  E-value: 9.45e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462537889  661 CNYCKNSFCSKPEILEWENKVHQFCSKTCSDDYKK 695
Cdd:pfam08394    1 CDYCGKEIVGEPITYKLKNKVYYFCCPTCLSQLKK 35
TRASH smart00746
metallochaperone-like domain;
353-389 9.75e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 38.13  E-value: 9.75e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2462537889   353 CANCKKPLQKGQTA--YQRKGSAHLFCSTTCLSSFSHKP 389
Cdd:smart00746    1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
TRASH smart00746
metallochaperone-like domain;
749-781 1.46e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 37.74  E-value: 1.46e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2462537889   749 CNYCSQLCKKGATKEL---DGVVRDFCSEDCCKKFQ 781
Cdd:smart00746    1 CSFCGKDIYNPGTGIMvvnDGKVYYFCSSKCLSKFK 36
TRASH smart00746
metallochaperone-like domain;
661-696 4.95e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 36.20  E-value: 4.95e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2462537889   661 CNYCKNSFCSK--PEILEWENKVHQFCSKTCSDDYKKL 696
Cdd:smart00746    1 CSFCGKDIYNPgtGIMVVNDGKVYYFCSSKCLSKFKKK 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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