|
Name |
Accession |
Description |
Interval |
E-value |
| Caprin-1_C |
pfam12287 |
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ... |
485-800 |
2.70e-172 |
|
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.
:
Pssm-ID: 463522 [Multi-domain] Cd Length: 320 Bit Score: 505.10 E-value: 2.70e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 485 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 558
Cdd:pfam12287 1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 559 ClvttdqASSGSETEFMTSET--PEAAIPP---GKQPSSLASPNPPMAKGSE-QGFQSPPASSSSVTINTAPFQAMQTVF 632
Cdd:pfam12287 81 C------ASSGSEYQFHTSEPpqPEAIDPIqssMSLPSELAPPSPPLSPASQpQVFQSKPASSSGINVNAAPFQSMQTVF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 633 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqetAANYHPDGTIQVSNGSLAFYPAQTN 711
Cdd:pfam12287 155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV-----VGAYHPDGTIQVSNGHLAFYPAQTN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 712 VFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCY 789
Cdd:pfam12287 230 GFPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNY 309
|
330
....*....|.
gi 2462533963 790 KRGGTSGGPRA 800
Cdd:pfam12287 310 KRGGTQSGPRA 320
|
|
| Caprin-1_dimer |
pfam18293 |
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ... |
65-180 |
7.03e-52 |
|
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.
:
Pssm-ID: 436391 Cd Length: 116 Bit Score: 177.41 E-value: 7.03e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 65 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 144
Cdd:pfam18293 1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 2462533963 145 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 180
Cdd:pfam18293 81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
|
|
| C1q |
pfam00386 |
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ... |
864-989 |
5.74e-41 |
|
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.
:
Pssm-ID: 395310 [Multi-domain] Cd Length: 126 Bit Score: 146.66 E-value: 5.74e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 864 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 943
Cdd:pfam00386 1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2462533963 944 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 989
Cdd:pfam00386 79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
|
|
| Atrophin-1 super family |
cl38111 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
247-667 |
1.64e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
The actual alignment was detected with superfamily member pfam03154:
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 49.00 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 247 NKQGEEQPWEADY---ARKPNLPKRWDMLTEPDGQEKKQESFKSWEASgkhQEVSKPAVSLEQRKQDTSKLRSTLPEEQK 323
Cdd:pfam03154 127 NDEGSSDPKDIDQdnrSTSPSIPSPQDNESDSDSSAQQQILQTQPPVL---QAQSGAASPPSPPPPGTTQAATAGPTPSA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 324 KQEISKSKPSPSQwkqdTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSVQSEQNTTKSW--------- 394
Cdd:pfam03154 204 PSVPPQGSPATSQ----PPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmppmp 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 395 ---------------TTPMCEEQDSKQPETPKSWENNVESQKHsltsQSQISPKSWGVATASLIPNDQLLPRKLNTEPKD 459
Cdd:pfam03154 280 hslqtgpshmqhpvpPQPFPLTPQSSQSQVPPGPSPAAPGQSQ----QRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHI 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 460 VPKPvhqpvgsSSTLPKDPVLRKEKLQdlmTQIQGTCNFMQESVLDFD---KPSSAIPTSQPPSATPgSPVaskeqNLSS 536
Cdd:pfam03154 356 KPPP-------TTPIPQLPNPQSHKHP---PHLSGPSPFQMNSNLPPPpalKPLSSLSTHHPPSAHP-PPL-----QLMP 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 537 QSDFLQEPlqATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIP--PGKQPSSLASPNPPMAKGSEQGFQSPPAS 614
Cdd:pfam03154 420 QSQQLPPP--PAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPfvPGGPPPITPPSGPPTSTSSAMPGIQPPSS 497
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 2462533963 615 SSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTASTQTP 667
Cdd:pfam03154 498 ASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTP 550
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Caprin-1_C |
pfam12287 |
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ... |
485-800 |
2.70e-172 |
|
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.
Pssm-ID: 463522 [Multi-domain] Cd Length: 320 Bit Score: 505.10 E-value: 2.70e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 485 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 558
Cdd:pfam12287 1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 559 ClvttdqASSGSETEFMTSET--PEAAIPP---GKQPSSLASPNPPMAKGSE-QGFQSPPASSSSVTINTAPFQAMQTVF 632
Cdd:pfam12287 81 C------ASSGSEYQFHTSEPpqPEAIDPIqssMSLPSELAPPSPPLSPASQpQVFQSKPASSSGINVNAAPFQSMQTVF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 633 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqetAANYHPDGTIQVSNGSLAFYPAQTN 711
Cdd:pfam12287 155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV-----VGAYHPDGTIQVSNGHLAFYPAQTN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 712 VFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCY 789
Cdd:pfam12287 230 GFPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNY 309
|
330
....*....|.
gi 2462533963 790 KRGGTSGGPRA 800
Cdd:pfam12287 310 KRGGTQSGPRA 320
|
|
| Caprin-1_dimer |
pfam18293 |
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ... |
65-180 |
7.03e-52 |
|
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.
Pssm-ID: 436391 Cd Length: 116 Bit Score: 177.41 E-value: 7.03e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 65 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 144
Cdd:pfam18293 1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 2462533963 145 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 180
Cdd:pfam18293 81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
|
|
| C1q |
pfam00386 |
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ... |
864-989 |
5.74e-41 |
|
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.
Pssm-ID: 395310 [Multi-domain] Cd Length: 126 Bit Score: 146.66 E-value: 5.74e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 864 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 943
Cdd:pfam00386 1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2462533963 944 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 989
Cdd:pfam00386 79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
|
|
| C1Q |
smart00110 |
Complement component C1q domain; Globular domain found in many collagens and eponymously in ... |
858-992 |
1.42e-32 |
|
Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.
Pssm-ID: 128420 Cd Length: 135 Bit Score: 122.80 E-value: 1.42e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 858 PQQMRVAFSAARTSNLAPGtlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVplYVNLMKNEEVLV 937
Cdd:smart00110 3 KAQPRSAFSVIRSNRPPPP--GQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNV--KVSLMKNGIQVM 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2462533963 938 SAYANDGAPDHETASNHAILQLFQGDQIWLRLHR--GAIYGSSWKYSTFSGYLLYQD 992
Cdd:smart00110 79 STYDEYQKGLYDVASGGALLQLRQGDQVWLELPDekNGLYAGEYVDSTFSGFLLFPD 135
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
247-667 |
1.64e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 49.00 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 247 NKQGEEQPWEADY---ARKPNLPKRWDMLTEPDGQEKKQESFKSWEASgkhQEVSKPAVSLEQRKQDTSKLRSTLPEEQK 323
Cdd:pfam03154 127 NDEGSSDPKDIDQdnrSTSPSIPSPQDNESDSDSSAQQQILQTQPPVL---QAQSGAASPPSPPPPGTTQAATAGPTPSA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 324 KQEISKSKPSPSQwkqdTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSVQSEQNTTKSW--------- 394
Cdd:pfam03154 204 PSVPPQGSPATSQ----PPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmppmp 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 395 ---------------TTPMCEEQDSKQPETPKSWENNVESQKHsltsQSQISPKSWGVATASLIPNDQLLPRKLNTEPKD 459
Cdd:pfam03154 280 hslqtgpshmqhpvpPQPFPLTPQSSQSQVPPGPSPAAPGQSQ----QRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHI 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 460 VPKPvhqpvgsSSTLPKDPVLRKEKLQdlmTQIQGTCNFMQESVLDFD---KPSSAIPTSQPPSATPgSPVaskeqNLSS 536
Cdd:pfam03154 356 KPPP-------TTPIPQLPNPQSHKHP---PHLSGPSPFQMNSNLPPPpalKPLSSLSTHHPPSAHP-PPL-----QLMP 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 537 QSDFLQEPlqATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIP--PGKQPSSLASPNPPMAKGSEQGFQSPPAS 614
Cdd:pfam03154 420 QSQQLPPP--PAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPfvPGGPPPITPPSGPPTSTSSAMPGIQPPSS 497
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 2462533963 615 SSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTASTQTP 667
Cdd:pfam03154 498 ASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTP 550
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
186-434 |
1.21e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.29 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 186 KNAKEKEVPLEEEMLIQSEkktQLSKTESV-KESESLMEFAQPEIQPQEFLNR---RYMTEVDYSNKQGEEQPWEADYAR 261
Cdd:PTZ00121 1605 KKMKAEEAKKAEEAKIKAE---ELKKAEEEkKKVEQLKKKEAEEKKKAEELKKaeeENKIKAAEEAKKAEEDKKKAEEAK 1681
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 262 KPNLPKR--WDMLTEPDGQEKKQESFKSWEAS--------GKHQEVSKPAVSLEQRK--QDTSKLRSTLPEEQKKQEISK 329
Cdd:PTZ00121 1682 KAEEDEKkaAEALKKEAEEAKKAEELKKKEAEekkkaeelKKAEEENKIKAEEAKKEaeEDKKKAEEAKKDEEEKKKIAH 1761
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 330 SKPSPSQWKQDTPKSKAGYVQEEQKKQETPKLWPVQlQKEQDPKKQTP------KSWTPSVQSEQNTTKSWTTPMCEEQD 403
Cdd:PTZ00121 1762 LKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD-KKIKDIFDNFAniieggKEGNLVINDSKEMEDSAIKEVADSKN 1840
|
250 260 270
....*....|....*....|....*....|.
gi 2462533963 404 SKQPETPkswennvESQKHSLTSQSQISPKS 434
Cdd:PTZ00121 1841 MQLEEAD-------AFEKHKFNKNNENGEDG 1864
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
512-877 |
6.47e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.01 E-value: 6.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 512 AIPTSQPPSATPGSPVAskeqnlssqsdflQEPLQATSSPVTCSSNACLVTT-DQASSGSETEFMTSETPEAAIPPGKQP 590
Cdd:PHA03307 61 ACDRFEPPTGPPPGPGT-------------EAPANESRSTPTWSLSTLAPASpAREGSPTPPGPSSPDPPPPTPPPASPP 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 591 SSLASPNPPMAKGSEQGFQSPPASSSSvtintapfqamqtvfnvnAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPpqc 670
Cdd:PHA03307 128 PSPAPDLSEMLRPVGSPGPPPAASPPA------------------AGASPAAVASDAASSRQAALPLSSPEETARAP--- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 671 qlPSIHVEQTVHSQETAANYHP---DGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGY 747
Cdd:PHA03307 187 --SSPPAEPPPSTPPAAASPRPprrSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPIT 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 748 KGFDTYRGLPSISNGNYSQLQFQA---REYSGAPYSQRDnfqqcyKRGGTSGGPRANSRAGWSDSSQVSSPERDNETFNS 824
Cdd:PHA03307 265 LPTRIWEASGWNGPSSRPGPASSSsspRERSPSPSPSSP------GSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRG 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2462533963 825 GDSGQGDSRSMTPVDVPVTNPAATilpvhvyPLPQQMRVAFSAARTSNLAPGT 877
Cdd:PHA03307 339 AAVSPGPSPSRSPSPSRPPPPADP-------SSPRKRPRPSRAPSSPAASAGR 384
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Caprin-1_C |
pfam12287 |
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ... |
485-800 |
2.70e-172 |
|
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.
Pssm-ID: 463522 [Multi-domain] Cd Length: 320 Bit Score: 505.10 E-value: 2.70e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 485 LQDLMTQIQGTCNFMQESVLDFDKPS-SAIPTSQPPSATP-----GSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNA 558
Cdd:pfam12287 1 LQDLMAQIQGTYNFMQDSMLDFDKPSdSAIVSAQPPSQSPdlsqmVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPSSNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 559 ClvttdqASSGSETEFMTSET--PEAAIPP---GKQPSSLASPNPPMAKGSE-QGFQSPPASSSSVTINTAPFQAMQTVF 632
Cdd:pfam12287 81 C------ASSGSEYQFHTSEPpqPEAIDPIqssMSLPSELAPPSPPLSPASQpQVFQSKPASSSGINVNAAPFQSMQTVF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 633 NVNAPLPPRKEQEIKE-SPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVhsqetAANYHPDGTIQVSNGSLAFYPAQTN 711
Cdd:pfam12287 155 NVNAPVPPRNEQELKEsSQYSSGYNQSFSSQSTQTVPQCQLPSEQLEQTV-----VGAYHPDGTIQVSNGHLAFYPAQTN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 712 VFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYK-GFDTYRG-LPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCY 789
Cdd:pfam12287 230 GFPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGPNGFKgGFDGYRGpFPNTPNGGYGQLQFQARDYSGTPYSQRDGYQQNY 309
|
330
....*....|.
gi 2462533963 790 KRGGTSGGPRA 800
Cdd:pfam12287 310 KRGGTQSGPRA 320
|
|
| Caprin-1_dimer |
pfam18293 |
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ... |
65-180 |
7.03e-52 |
|
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.
Pssm-ID: 436391 Cd Length: 116 Bit Score: 177.41 E-value: 7.03e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 65 RREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSS 144
Cdd:pfam18293 1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 2462533963 145 LYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFE 180
Cdd:pfam18293 81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
|
|
| C1q |
pfam00386 |
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ... |
864-989 |
5.74e-41 |
|
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.
Pssm-ID: 395310 [Multi-domain] Cd Length: 126 Bit Score: 146.66 E-value: 5.74e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 864 AFSAARTSNLAPGTlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAvNVPLYVNLMKNEEVLVSAYAND 943
Cdd:pfam00386 1 AFSAGRTTGLTAPN-EQPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTVD-GKSLYVSLVKNGQEVVSFYDQP 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2462533963 944 GAPDHETASNHAILQLFQGDQIWLRLH--RGAIYGSSWKYSTFSGYLL 989
Cdd:pfam00386 79 QKGSLDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
|
|
| C1Q |
smart00110 |
Complement component C1q domain; Globular domain found in many collagens and eponymously in ... |
858-992 |
1.42e-32 |
|
Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.
Pssm-ID: 128420 Cd Length: 135 Bit Score: 122.80 E-value: 1.42e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 858 PQQMRVAFSAARTSNLAPGtlDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVplYVNLMKNEEVLV 937
Cdd:smart00110 3 KAQPRSAFSVIRSNRPPPP--GQPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNV--KVSLMKNGIQVM 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2462533963 938 SAYANDGAPDHETASNHAILQLFQGDQIWLRLHR--GAIYGSSWKYSTFSGYLLYQD 992
Cdd:smart00110 79 STYDEYQKGLYDVASGGALLQLRQGDQVWLELPDekNGLYAGEYVDSTFSGFLLFPD 135
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
436-866 |
1.10e-07 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 56.08 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 436 GVATASLIPNDQLLPRklNTEPKDVPKPVHQPVGSSSTLPKDPVLRKEKLQDlmtqiqgtcNFMQESVLDFDKPSSAIPT 515
Cdd:pfam05109 447 GLPSSTHVPTNLTAPA--STGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD---------NGTESKAPDMTSPTSAVTT 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 516 SQPPSATPGSPVASKEQNLSSqsdflqePLQATSSPVTCssnaclVTTDQASSGSETEFMTSETPEAAIPP-GK-QPSSL 593
Cdd:pfam05109 516 PTPNATSPTPAVTTPTPNATS-------PTLGKTSPTSA------VTTPTPNATSPTPAVTTPTPNATIPTlGKtSPTSA 582
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 594 ASPNPPMAKGSEQGFQSPPA---------SSSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTAST 664
Cdd:pfam05109 583 VTTPTPNATSPTVGETSPQAnttnhtlggTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDN 662
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 665 QTPPQCQLPSIHveQTVHSQETAANYHPDGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLI-TNSYRS 743
Cdd:pfam05109 663 STSHMPLLTSAH--PTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKnATSPQA 740
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 744 PGGYKgfdtyRGLPSI-SNGNYSQLQFQAREYSGapYSQRDNFQQCYKRGGTSGGPRANSRAGWSDSSQVSSPERDNETF 822
Cdd:pfam05109 741 PSGQK-----TAVPTVtSTGGKANSTTGGKHTTG--HGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSKLRPRWTF 813
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 2462533963 823 NSGdsgqgdsrsmtpvdvPVTNPAATIlpvhvyPLPQQMRVAFS 866
Cdd:pfam05109 814 TSP---------------PVTTAQATV------PVPPTSQPRFS 836
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
247-667 |
1.64e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 49.00 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 247 NKQGEEQPWEADY---ARKPNLPKRWDMLTEPDGQEKKQESFKSWEASgkhQEVSKPAVSLEQRKQDTSKLRSTLPEEQK 323
Cdd:pfam03154 127 NDEGSSDPKDIDQdnrSTSPSIPSPQDNESDSDSSAQQQILQTQPPVL---QAQSGAASPPSPPPPGTTQAATAGPTPSA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 324 KQEISKSKPSPSQwkqdTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSVQSEQNTTKSW--------- 394
Cdd:pfam03154 204 PSVPPQGSPATSQ----PPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmppmp 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 395 ---------------TTPMCEEQDSKQPETPKSWENNVESQKHsltsQSQISPKSWGVATASLIPNDQLLPRKLNTEPKD 459
Cdd:pfam03154 280 hslqtgpshmqhpvpPQPFPLTPQSSQSQVPPGPSPAAPGQSQ----QRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHI 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 460 VPKPvhqpvgsSSTLPKDPVLRKEKLQdlmTQIQGTCNFMQESVLDFD---KPSSAIPTSQPPSATPgSPVaskeqNLSS 536
Cdd:pfam03154 356 KPPP-------TTPIPQLPNPQSHKHP---PHLSGPSPFQMNSNLPPPpalKPLSSLSTHHPPSAHP-PPL-----QLMP 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 537 QSDFLQEPlqATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIP--PGKQPSSLASPNPPMAKGSEQGFQSPPAS 614
Cdd:pfam03154 420 QSQQLPPP--PAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPfvPGGPPPITPPSGPPTSTSSAMPGIQPPSS 497
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 2462533963 615 SSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTASTQTP 667
Cdd:pfam03154 498 ASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTP 550
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
33-375 |
2.78e-05 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 48.18 E-value: 2.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 33 EEVLHNLEfaKELQKTFSGLSLDLLKAQKKAQRREHMLKL----EAEKKKLRTILQVQYVL--QNLTQEHVQKDFKGG-- 104
Cdd:pfam05483 362 EELLRTEQ--QRLEKNEDQLKIITMELQKKSSELEEMTKFknnkEVELEELKKILAEDEKLldEKKQFEKIAEELKGKeq 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 105 -LNGAVYLPSKEL-DYLIKFSKLTCPERNESLSVED---QMEQSSLYFWDLLEGSEKAVVGTT--YKHLKDLLSKLLNSG 177
Cdd:pfam05483 440 eLIFLLQAREKEIhDLEIQLTAIKTSEEHYLKEVEDlktELEKEKLKNIELTAHCDKLLLENKelTQEASDMTLELKKHQ 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 178 yfESIpvpKNAKEKevplEEEMLIQ----SEKKTQL-SKTESVKEseslmEFAQP------EIQPQEFLNRRYMTEVDYS 246
Cdd:pfam05483 520 --EDI---INCKKQ----EERMLKQienlEEKEMNLrDELESVRE-----EFIQKgdevkcKLDKSEENARSIEYEVLKK 585
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 247 NKQGEEQPWEADYARK--PNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQKK 324
Cdd:pfam05483 586 EKQMKILENKCNNLKKqiENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIED 665
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2462533963 325 QEISKSKpspsqwkqdtpkskagyVQEEQKKQETPKLWPVQLQKEQDPKKQ 375
Cdd:pfam05483 666 KKISEEK-----------------LLEEVEKAKAIADEAVKLQKEIDKRCQ 699
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
186-434 |
1.21e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.29 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 186 KNAKEKEVPLEEEMLIQSEkktQLSKTESV-KESESLMEFAQPEIQPQEFLNR---RYMTEVDYSNKQGEEQPWEADYAR 261
Cdd:PTZ00121 1605 KKMKAEEAKKAEEAKIKAE---ELKKAEEEkKKVEQLKKKEAEEKKKAEELKKaeeENKIKAAEEAKKAEEDKKKAEEAK 1681
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 262 KPNLPKR--WDMLTEPDGQEKKQESFKSWEAS--------GKHQEVSKPAVSLEQRK--QDTSKLRSTLPEEQKKQEISK 329
Cdd:PTZ00121 1682 KAEEDEKkaAEALKKEAEEAKKAEELKKKEAEekkkaeelKKAEEENKIKAEEAKKEaeEDKKKAEEAKKDEEEKKKIAH 1761
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 330 SKPSPSQWKQDTPKSKAGYVQEEQKKQETPKLWPVQlQKEQDPKKQTP------KSWTPSVQSEQNTTKSWTTPMCEEQD 403
Cdd:PTZ00121 1762 LKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD-KKIKDIFDNFAniieggKEGNLVINDSKEMEDSAIKEVADSKN 1840
|
250 260 270
....*....|....*....|....*....|.
gi 2462533963 404 SKQPETPkswennvESQKHSLTSQSQISPKS 434
Cdd:PTZ00121 1841 MQLEEAD-------AFEKHKFNKNNENGEDG 1864
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
512-877 |
6.47e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.01 E-value: 6.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 512 AIPTSQPPSATPGSPVAskeqnlssqsdflQEPLQATSSPVTCSSNACLVTT-DQASSGSETEFMTSETPEAAIPPGKQP 590
Cdd:PHA03307 61 ACDRFEPPTGPPPGPGT-------------EAPANESRSTPTWSLSTLAPASpAREGSPTPPGPSSPDPPPPTPPPASPP 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 591 SSLASPNPPMAKGSEQGFQSPPASSSSvtintapfqamqtvfnvnAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPpqc 670
Cdd:PHA03307 128 PSPAPDLSEMLRPVGSPGPPPAASPPA------------------AGASPAAVASDAASSRQAALPLSSPEETARAP--- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 671 qlPSIHVEQTVHSQETAANYHP---DGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGY 747
Cdd:PHA03307 187 --SSPPAEPPPSTPPAAASPRPprrSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPIT 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 748 KGFDTYRGLPSISNGNYSQLQFQA---REYSGAPYSQRDnfqqcyKRGGTSGGPRANSRAGWSDSSQVSSPERDNETFNS 824
Cdd:PHA03307 265 LPTRIWEASGWNGPSSRPGPASSSsspRERSPSPSPSSP------GSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRG 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2462533963 825 GDSGQGDSRSMTPVDVPVTNPAATilpvhvyPLPQQMRVAFSAARTSNLAPGT 877
Cdd:PHA03307 339 AAVSPGPSPSRSPSPSRPPPPADP-------SSPRKRPRPSRAPSSPAASAGR 384
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
512-673 |
7.56e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.77 E-value: 7.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 512 AIPTSQPPSATPGSPVASkeqnLSSQSDFLQEPLQATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIPPGKQPS 591
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVAS----LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPP 2848
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 592 SLaSPNPPMAKGSEqgFQSPPASSSSVTINTAPfqAMQTVFNVNAPLPPRKEQEIKESPYSPgynQSFTTASTQTPPQCQ 671
Cdd:PHA03247 2849 SL-PLGGSVAPGGD--VRRRPPSRSPAAKPAAP--ARPPVRRLARPAVSRSTESFALPPDQP---ERPPQPQAPPPPQPQ 2920
|
..
gi 2462533963 672 LP 673
Cdd:PHA03247 2921 PQ 2922
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
186-414 |
1.07e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 43.21 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 186 KNAKEKEVPLEEEMLIQSEKKTQLSKTESVKESESLM---EFAQPEIQPQEFLNRRYMTEVDYSNKQGEEQPwEADYARK 262
Cdd:PTZ00121 1516 KKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKkaeELKKAEEKKKAEEAKKAEEDKNMALRKAEEAK-KAEEARI 1594
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 263 PNLPKrwdmLTEPDGQEKKQESFKSWEASGKHQEVSKPavslEQRKQDTSKLRSTLPEEQKK-------QEISKSKPSPS 335
Cdd:PTZ00121 1595 EEVMK----LYEEEKKMKAEEAKKAEEAKIKAEELKKA----EEEKKKVEQLKKKEAEEKKKaeelkkaEEENKIKAAEE 1666
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 336 QWKQDTPKSKAGYV---QEEQKKQETpklwpvQLQKEQDPKK---QTPKSWTPSVQ--------SEQNTTKSWTTPMCEE 401
Cdd:PTZ00121 1667 AKKAEEDKKKAEEAkkaEEDEKKAAE------ALKKEAEEAKkaeELKKKEAEEKKkaeelkkaEEENKIKAEEAKKEAE 1740
|
250
....*....|...
gi 2462533963 402 QDSKQPETPKSWE 414
Cdd:PTZ00121 1741 EDKKKAEEAKKDE 1753
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
328-723 |
4.43e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 4.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 328 SKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSVQSEQNTTKSWTTP---------- 397
Cdd:pfam03154 41 SSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREKGASDTEEPERATAKKSKTQEISRPnspsegeges 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 398 ----------------MCEEQDSKQPETPKSWENNVESQKHSLTSQSQISPKSWGVATASLIPnDQLLPRKLNTEPKDVP 461
Cdd:pfam03154 121 sdgrsvndegssdpkdIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASP-PSPPPPGTTQAATAGP 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 462 KPVHQPVGSSSTLP-KDPVLRKEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPTSQPPSATPGSPVASKE--------- 531
Cdd:pfam03154 200 TPSAPSVPPQGSPAtSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmppmp 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 532 QNLSSQSDFLQEPLQATSSPVTCSSNACLV--TTDQASSGSETEFMTSETPEAAIPPGKQPSSLASPNPPMAK------- 602
Cdd:pfam03154 280 HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVppGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMphikppp 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462533963 603 -------GSEQGFQSPPASSSSvtintAPFQamqtvFNVNAPLPPRKEQEIKESPYSPgynQSFTTASTQTPPQCQ-LPS 674
Cdd:pfam03154 360 ttpipqlPNPQSHKHPPHLSGP-----SPFQ-----MNSNLPPPPALKPLSSLSTHHP---PSAHPPPLQLMPQSQqLPP 426
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 2462533963 675 IHVEQTVHSQetAANYHPDGTIQVSNGSLAFYPAQTnvfPRPTQPFVNS 723
Cdd:pfam03154 427 PPAQPPVLTQ--SQSLPPPAASHPPTSGLHQVPSQS---PFPQHPFVPG 470
|
|
| |
