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Conserved domains on  [gi|2462529770|ref|XP_054226971|]
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transmembrane protein 132B isoform X1 [Homo sapiens]

Protein Classification

TMEM132 and TMEM132D_C domain-containing protein( domain architecture ID 11723006)

protein containing domains TMEM132D_N, TMEM132, and TMEM132D_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 319-661 0e+00

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


:

Pssm-ID: 465003  Cd Length: 344  Bit Score: 527.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 319 EVLNTAILTGKPVSVPVKVVGVQEDGSVVDVSESVECKSADEDVIKVSNNCDSIFVNGKEMKSKVDTIVNFTHQHFTSQF 398
Cdd:pfam16070   1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 399 EVTVWAPRLPLQIEISDTELSQIKGWRIPV-AANRRPTRESDDEDDEEKKGRGCSLQYQHATVRVLTQFVAESPDLGQLT 477
Cdd:pfam16070  81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIgSNKRRPARDSEDEEEDDRKGRGCRLQYQHATVRVLARFVAEDADTGQVS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 478 YMLGPDWQFDITDLVTEFMKVEEPKIAQLQDGRTLAGREPGITTVQVLSPLSDSILAEKTVIVLDDRVTIAELGVQLVAG 557
Cdd:pfam16070 161 YLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 558 MSLSLQPHRADKRAIVSTAAALDVLQSPQQEAIVSSWILFSDGSVTPLDIYDPKDYSVTVSSLDEMVVSVQANLESKWPI 637
Cdd:pfam16070 241 LSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWPV 320

                         330       340
                  ....*....|....*....|....
gi 2462529770 638 VVAEGEGQGPLIKLEMMISEPCQK 661
Cdd:pfam16070 321 VVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 760-841 1.28e-43

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464814  Cd Length: 84  Bit Score: 152.45  E-value: 1.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 760 TSFPTQGKSP--DPNNPSDLTVTSRGLTDLEIGMYALLCVFCLAILVFLINCVAFAWKYRHKRFAVSEQGNIPHSHDWVW 837
Cdd:pfam15706   1 TNFPAQTDAPnnNGESEGDLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWVW 80


                  ....
gi 2462529770 838 LGNE 841
Cdd:pfam15706  81 LGRE 84
TMEM132D_N super family cl24319
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 1-58 6.46e-29

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


The actual alignment was detected with superfamily member pfam15705:

Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 112.32  E-value: 6.46e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462529770   1 MDKFPFNWKLKSHILDSSIYSNRPKVQTLFYVTGMGWDDSDLTEDLPCVKMFAFPEAR 58
Cdd:pfam15705  72 PNKFTFNWKLRAHILDSRVYSSRPKVQVLFYIAGRDWDDYDPSERLPCVRLFAFRETR 129
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 319-661 0e+00

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 527.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 319 EVLNTAILTGKPVSVPVKVVGVQEDGSVVDVSESVECKSADEDVIKVSNNCDSIFVNGKEMKSKVDTIVNFTHQHFTSQF 398
Cdd:pfam16070   1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 399 EVTVWAPRLPLQIEISDTELSQIKGWRIPV-AANRRPTRESDDEDDEEKKGRGCSLQYQHATVRVLTQFVAESPDLGQLT 477
Cdd:pfam16070  81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIgSNKRRPARDSEDEEEDDRKGRGCRLQYQHATVRVLARFVAEDADTGQVS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 478 YMLGPDWQFDITDLVTEFMKVEEPKIAQLQDGRTLAGREPGITTVQVLSPLSDSILAEKTVIVLDDRVTIAELGVQLVAG 557
Cdd:pfam16070 161 YLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 558 MSLSLQPHRADKRAIVSTAAALDVLQSPQQEAIVSSWILFSDGSVTPLDIYDPKDYSVTVSSLDEMVVSVQANLESKWPI 637
Cdd:pfam16070 241 LSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWPV 320

                         330       340
                  ....*....|....*....|....
gi 2462529770 638 VVAEGEGQGPLIKLEMMISEPCQK 661
Cdd:pfam16070 321 VVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 760-841 1.28e-43

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 152.45  E-value: 1.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 760 TSFPTQGKSP--DPNNPSDLTVTSRGLTDLEIGMYALLCVFCLAILVFLINCVAFAWKYRHKRFAVSEQGNIPHSHDWVW 837
Cdd:pfam15706   1 TNFPAQTDAPnnNGESEGDLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWVW 80


                  ....
gi 2462529770 838 LGNE 841
Cdd:pfam15706  81 LGRE 84
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 1-58 6.46e-29

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 112.32  E-value: 6.46e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462529770   1 MDKFPFNWKLKSHILDSSIYSNRPKVQTLFYVTGMGWDDSDLTEDLPCVKMFAFPEAR 58
Cdd:pfam15705  72 PNKFTFNWKLRAHILDSRVYSSRPKVQVLFYIAGRDWDDYDPSERLPCVRLFAFRETR 129
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 319-661 0e+00

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 527.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 319 EVLNTAILTGKPVSVPVKVVGVQEDGSVVDVSESVECKSADEDVIKVSNNCDSIFVNGKEMKSKVDTIVNFTHQHFTSQF 398
Cdd:pfam16070   1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 399 EVTVWAPRLPLQIEISDTELSQIKGWRIPV-AANRRPTRESDDEDDEEKKGRGCSLQYQHATVRVLTQFVAESPDLGQLT 477
Cdd:pfam16070  81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIgSNKRRPARDSEDEEEDDRKGRGCRLQYQHATVRVLARFVAEDADTGQVS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 478 YMLGPDWQFDITDLVTEFMKVEEPKIAQLQDGRTLAGREPGITTVQVLSPLSDSILAEKTVIVLDDRVTIAELGVQLVAG 557
Cdd:pfam16070 161 YLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 558 MSLSLQPHRADKRAIVSTAAALDVLQSPQQEAIVSSWILFSDGSVTPLDIYDPKDYSVTVSSLDEMVVSVQANLESKWPI 637
Cdd:pfam16070 241 LSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWPV 320

                         330       340
                  ....*....|....*....|....
gi 2462529770 638 VVAEGEGQGPLIKLEMMISEPCQK 661
Cdd:pfam16070 321 VVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 760-841 1.28e-43

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 152.45  E-value: 1.28e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462529770 760 TSFPTQGKSP--DPNNPSDLTVTSRGLTDLEIGMYALLCVFCLAILVFLINCVAFAWKYRHKRFAVSEQGNIPHSHDWVW 837
Cdd:pfam15706   1 TNFPAQTDAPnnNGESEGDLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWVW 80


                  ....
gi 2462529770 838 LGNE 841
Cdd:pfam15706  81 LGRE 84
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 1-58 6.46e-29

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 112.32  E-value: 6.46e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462529770   1 MDKFPFNWKLKSHILDSSIYSNRPKVQTLFYVTGMGWDDSDLTEDLPCVKMFAFPEAR 58
Cdd:pfam15705  72 PNKFTFNWKLRAHILDSRVYSSRPKVQVLFYIAGRDWDDYDPSERLPCVRLFAFRETR 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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