NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462527304|ref|XP_054225789|]
View 

tubby protein homolog isoform X8 [Homo sapiens]

Protein Classification

tubby family protein( domain architecture ID 11242254)

tubby (TUB) family protein similar to Mus musculus tubby protein that binds to membranes containing phosphatidylinositol 4,5-bisphosphate and functions in signal transduction from heterotrimeric G protein-coupled receptors

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
210-455 6.51e-141

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 403.88  E-value: 6.51e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304 210 LRPAPQGITIKCRITRDKKGMdrGMYPTYFLHLDREDGKK-VFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS 288
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPGDGgKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304 289 NLMGTKFTVYDN-----GVNPQKASSSTLESG--TLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEH 361
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKvsPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304 362 eTLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLC 441
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|....
gi 2462527304 442 ALQAFAIALSSFDS 455
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 1-191 3.80e-43

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


:

Pssm-ID: 465092  Cd Length: 196  Bit Score: 150.73  E-value: 3.80e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304   1 MVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASakrtkaaataggqggaarke 80
Cdd:pfam16322  19 MVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIYHVQEAAPRSAKRSGAHAALGTQG-------------------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304  81 kkGKHKGTSGPAA-LAEDKSEAQGPVQILTVGQS----DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMS-FDEDE 154
Cdd:pfam16322  79 --GDGKGIDGPAAfLTEEPQDSGSELQILSVGDSptspPPDEELQEPGASGEEESSKQDLGDEMQKKGISSSMNfDEEEE 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2462527304 155 EDEEENSSSSSQLNSN---TRPSSATSRKSVREAASAPSP 191
Cdd:pfam16322 157 DEEEESSSRSSQLNSNeesTRPSSATSKKSSSEVGSSPSP 196
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
210-455 6.51e-141

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 403.88  E-value: 6.51e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304 210 LRPAPQGITIKCRITRDKKGMdrGMYPTYFLHLDREDGKK-VFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS 288
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPGDGgKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304 289 NLMGTKFTVYDN-----GVNPQKASSSTLESG--TLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEH 361
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKvsPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304 362 eTLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLC 441
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|....
gi 2462527304 442 ALQAFAIALSSFDS 455
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 1-191 3.80e-43

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 150.73  E-value: 3.80e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304   1 MVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASakrtkaaataggqggaarke 80
Cdd:pfam16322  19 MVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIYHVQEAAPRSAKRSGAHAALGTQG-------------------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304  81 kkGKHKGTSGPAA-LAEDKSEAQGPVQILTVGQS----DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMS-FDEDE 154
Cdd:pfam16322  79 --GDGKGIDGPAAfLTEEPQDSGSELQILSVGDSptspPPDEELQEPGASGEEESSKQDLGDEMQKKGISSSMNfDEEEE 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2462527304 155 EDEEENSSSSSQLNSN---TRPSSATSRKSVREAASAPSP 191
Cdd:pfam16322 157 DEEEESSSRSSQLNSNeesTRPSSATSKKSSSEVGSSPSP 196
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
210-455 6.51e-141

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 403.88  E-value: 6.51e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304 210 LRPAPQGITIKCRITRDKKGMdrGMYPTYFLHLDREDGKK-VFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS 288
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPGDGgKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304 289 NLMGTKFTVYDN-----GVNPQKASSSTLESG--TLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEH 361
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKvsPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304 362 eTLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLC 441
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|....
gi 2462527304 442 ALQAFAIALSSFDS 455
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 1-191 3.80e-43

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 150.73  E-value: 3.80e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304   1 MVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASakrtkaaataggqggaarke 80
Cdd:pfam16322  19 MVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIYHVQEAAPRSAKRSGAHAALGTQG-------------------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527304  81 kkGKHKGTSGPAA-LAEDKSEAQGPVQILTVGQS----DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMS-FDEDE 154
Cdd:pfam16322  79 --GDGKGIDGPAAfLTEEPQDSGSELQILSVGDSptspPPDEELQEPGASGEEESSKQDLGDEMQKKGISSSMNfDEEEE 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2462527304 155 EDEEENSSSSSQLNSN---TRPSSATSRKSVREAASAPSP 191
Cdd:pfam16322 157 DEEEESSSRSSQLNSNeesTRPSSATSKKSSSEVGSSPSP 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH