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Conserved domains on  [gi|2462522768|ref|XP_054223566|]
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organic anion transporter 7 isoform X1 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 109-433 1.81e-125

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17374:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 341  Bit Score: 367.39  E-value: 1.81e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 109 SDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGT 188
Cdd:cd17374     1 SEADTEPCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 189 CAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVP 268
Cdd:cd17374    81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 269 YFVIFLTSSWLLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnic 348
Cdd:cd17374   161 FFLFFLYSWWLP-------------------------------------------------------------------- 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 349 KRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVP 428
Cdd:cd17374   173 KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVP 252


                  ....*
gi 2462522768 429 QGEKT 433
Cdd:cd17374   253 QEMQT 257
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 109-433 1.81e-125

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 367.39  E-value: 1.81e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 109 SDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGT 188
Cdd:cd17374     1 SEADTEPCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 189 CAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVP 268
Cdd:cd17374    81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 269 YFVIFLTSSWLLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnic 348
Cdd:cd17374   161 FFLFFLYSWWLP-------------------------------------------------------------------- 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 349 KRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVP 428
Cdd:cd17374   173 KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVP 252


                  ....*
gi 2462522768 429 QGEKT 433
Cdd:cd17374   253 QEMQT 257
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 11-429 1.90e-90

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 283.45  E-value: 1.90e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768  11 GDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVhildndtvsdNDTGALSQDALLRISIPLDSNMRPEKCRR 90
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRL----------PDAANLSSRCELNLTLPRLPDGRPESCLR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768  91 FVHPQWQLLHLNGTFPNTS----DADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHL 166
Cdd:TIGR00898  71 FMVDQWANPSLLGCEPLKLsdlgLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 167 SDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFM 246
Cdd:TIGR00898 151 SDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 247 TLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKnardtLTLEILKSTMKK 326
Cdd:TIGR00898 231 LLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK-----LPAEVLSLSLEK 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 327 ELeAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNR 406
Cdd:TIGR00898 306 DL-SSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGR 384

                         410       420
                  ....*....|....*....|...
gi 2462522768 407 RASQMLLMFLLAICLLAIIFVPQ 429
Cdd:TIGR00898 385 RYTMAASLLLAGVALLLLLFVPV 407
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
141-429 2.74e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 76.94  E-value: 2.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:COG2814    43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALAL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 221 IAEWAT--HRFQAMGITLGMCPSGIAF-MTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLlesarwliinnkpeegLK 297
Cdd:COG2814   123 IADLVPpeRRGRALGLLGAGLGLGPALgPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL----------------LP 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 298 ELRKAAHRSGMKNARDTLTLeilkstmkkeleaaqkkkpslcemlhmpnicKRISLLSFTRFANFMAYFGLNLHVQHLGN 377
Cdd:COG2814   187 ESRPAARARLRGSLRELLRR-------------------------------PRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 378 NVF--------LLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQ 429
Cdd:COG2814   236 EVLglsasaagLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS 295
MFS_1 pfam07690
Major Facilitator Superfamily;
141-427 3.23e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 73.61  E-value: 3.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 221 IAEWATHRFQAMGITLGMCPSGIAFMT---LAGLAFAIRDWHILQLVVSVPYFVIFLTsswllesarWLIINNKPEEGLK 297
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALgplLGGLLASLFGWRAAFLILAILSLLAAVL---------LLLPRPPPESKRP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 298 ELRKAAHRSGMKNARDTLTLEILKStmkkeleaaqkkkpslcemlhmpnickrISLLSFTRFANFMAYFGLNLHVQHLGN 377
Cdd:pfam07690 181 KPAEEARLSLIVAWKALLRDPVLWL----------------------------LLALLLFGFAFFGLLTYLPLYQEVLGL 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462522768 378 NVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFV 427
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL 282
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 155-286 9.10e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 50.73  E-value: 9.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 155 GMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGI---AAMSlitNTIMLIAEWATHRFQA 231
Cdd:PRK11551   62 GLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVglgGALP---NLIALTSEAVGPRLRG 138

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462522768 232 MGITLGMC--PSGIAFMTLAGLAFAI-RDW-HILQLVVSVPYFVIFLTSSWLLESARWL 286
Cdd:PRK11551  139 TAVSLMYCgvPFGGALASVIGVLAAGdAAWrHIFYVGGVGPLLLVPLLMRWLPESRAFA 197
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 109-433 1.81e-125

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 367.39  E-value: 1.81e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 109 SDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGT 188
Cdd:cd17374     1 SEADTEPCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 189 CAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVP 268
Cdd:cd17374    81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 269 YFVIFLTSSWLLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnic 348
Cdd:cd17374   161 FFLFFLYSWWLP-------------------------------------------------------------------- 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 349 KRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVP 428
Cdd:cd17374   173 KRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVP 252


                  ....*
gi 2462522768 429 QGEKT 433
Cdd:cd17374   253 QEMQT 257
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 11-429 1.90e-90

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 283.45  E-value: 1.90e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768  11 GDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVhildndtvsdNDTGALSQDALLRISIPLDSNMRPEKCRR 90
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRL----------PDAANLSSRCELNLTLPRLPDGRPESCLR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768  91 FVHPQWQLLHLNGTFPNTS----DADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHL 166
Cdd:TIGR00898  71 FMVDQWANPSLLGCEPLKLsdlgLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 167 SDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFM 246
Cdd:TIGR00898 151 SDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 247 TLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKnardtLTLEILKSTMKK 326
Cdd:TIGR00898 231 LLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK-----LPAEVLSLSLEK 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 327 ELeAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNR 406
Cdd:TIGR00898 306 DL-SSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGR 384

                         410       420
                  ....*....|....*....|...
gi 2462522768 407 RASQMLLMFLLAICLLAIIFVPQ 429
Cdd:TIGR00898 385 RYTMAASLLLAGVALLLLLFVPV 407
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 114-433 4.36e-73

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 233.08  E-value: 4.36e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 114 EPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALA 193
Cdd:cd17446     4 EPCTDGWVYDKSEFPSTIITEWDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 194 PTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQA-MGITLGMCPSgIAFMTLAGLAFAIRDWHILQLVVSVPYFVI 272
Cdd:cd17446    84 PSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAvVGTLLGYCYT-LGQLILAGVAYAIRDWRWLQLAVSLPFFIF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 273 FLTSSWLLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkKPSLCemlhmpnickris 352
Cdd:cd17446   163 FLYSWWFP------------------------------------------------------RITFC------------- 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 353 lLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQGEK 432
Cdd:cd17446   176 -LSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQDLQ 254


                  .
gi 2462522768 433 T 433
Cdd:cd17446   255 T 255
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 119-431 6.16e-47

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 164.68  E-value: 6.16e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 119 GWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLI 198
Cdd:cd17317     1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 199 YCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSW 278
Cdd:cd17317    81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 279 LLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnicKRISLLSFTR 358
Cdd:cd17317   161 LP--------------------------------------------------------------------RRTIIVGLIW 172

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462522768 359 FANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQGE 431
Cdd:cd17317   173 FVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDE 245
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 109-434 1.74e-37

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 139.48  E-value: 1.74e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 109 SDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGT 188
Cdd:cd17447     1 SDLPVVPCQNGWVYDHSTFSSTIATEWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 189 CAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVP 268
Cdd:cd17447    81 ASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 269 YFVIFLTSSWLlesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnic 348
Cdd:cd17447   161 CAPGIITWWWV--------------------------------------------------------------------- 171

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 349 KRISLLS-FTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFV 427
Cdd:cd17447   172 PKISLCTgIVWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILI 251


                  ....*..
gi 2462522768 428 PQGEKTP 434
Cdd:cd17447   252 PSEFTVV 258
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 109-289 1.50e-25

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 106.78  E-value: 1.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 109 SDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGT 188
Cdd:cd17376     1 TQIEQEPCLDGWEYSQDVYLSTIVTEWNLVCEDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 189 CAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP-SGIAFMTLAGLAFAIRDWHILQLVVSV 267
Cdd:cd17376    81 LQIFSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVRILFSTLGVCIfYAIGYMLLPLFAYFIRDWRMLLLALTL 160

                         170       180
                  ....*....|....*....|....*..
gi 2462522768 268 PYFVI-----FLTSSWLLESARWLIIN 289
Cdd:cd17376   161 PGVLCvplwwFIPITTIMSLLLWMAIS 187
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 113-280 4.78e-24

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 102.43  E-value: 4.78e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 113 MEPCVDGWVYDRISfsSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAAL 192
Cdd:cd17379     5 LSPCQDGWVYNTPR--SSIVTEFNLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 193 APTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQ-AMGITLGMCPSgIAFMTLAGLAFAIRDWHILQLVVSVPYFv 271
Cdd:cd17379    83 SPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRrTVGIVYQMFFT-LGLLILPGIAYFIPHWRWLQLAVTLPNF- 160


                  ....*....
gi 2462522768 272 IFLTSSWLL 280
Cdd:cd17379   161 LFLLYYWFI 169
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 115-280 2.42e-18

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 85.96  E-value: 2.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 115 PCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAP 194
Cdd:cd17375     7 SCSDGFVYDQSKWESSIVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 195 TFLIYCSLRFLSGIAAMSLITNTIMLIAE--------WAT---HRFQAMGItlgmcpsgiafMTLAGLAFAIRDWHILQL 263
Cdd:cd17375    87 DYYSFVIVRFLLAMVSSGYLVVVFVYVTEftgikartWASmhvHAFFAVGI-----------MVVALVGYLVRTWWIYQI 155

                         170
                  ....*....|....*..
gi 2462522768 264 VVSVPYfVIFLTSSWLL 280
Cdd:cd17375   156 ILSLVT-IPFILCCWML 171
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 128-369 8.29e-18

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 84.72  E-value: 8.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 128 SSTIVTEWDLvcDSQSLTSVAKFVfMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSG 207
Cdd:TIGR00895  40 APAISAEWGL--DPVQLGFLFSAG-LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 208 IAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMT---LAGLAFAIRDWHILQLVVSV-PYFVIFLTSSWLLESA 283
Cdd:TIGR00895 117 LGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVggfLAGWLIPVFGWRSLFYVGGIaPLLLLLLLMRFLPESI 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 284 RWLIInNKPEEGLKELRKAAHRSGMKnardtltleilKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFM 363
Cdd:TIGR00895 197 DFLVS-KRPETVRRIVNAIAPQMQAE-----------AQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLV 264


                  ....*.
gi 2462522768 364 AYFGLN 369
Cdd:TIGR00895 265 GVYFLT 270
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 126-433 6.83e-16

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 78.55  E-value: 6.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 126 SFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSD-RFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRF 204
Cdd:cd17378    16 GSKVSIVSEWGLICAGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 205 LSGIAAMSLITNTIMLIAE--WATHRFQA-----MGITLGmcpsgiaFMTLAGLAF-AIRDWHILQLVVSVPyfVIFLTS 276
Cdd:cd17378    96 LTGFGRSGIGTCALVLATEpvGPKWRGQVgmstfFFFVLG-------FMSLPGIAYlNGSSWRVLYFWTSIP--ALIYCI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 277 SWLLesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkpslcemlhmpnICKRISLLSF 356
Cdd:cd17378   167 LVYL------------------------------------------------------------------FARRLLAVMV 180

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462522768 357 TRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQGEKT 433
Cdd:cd17378   181 IGFGIGMVYYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTT 257
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
141-429 2.74e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 76.94  E-value: 2.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:COG2814    43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALAL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 221 IAEWAT--HRFQAMGITLGMCPSGIAF-MTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLlesarwliinnkpeegLK 297
Cdd:COG2814   123 IADLVPpeRRGRALGLLGAGLGLGPALgPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL----------------LP 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 298 ELRKAAHRSGMKNARDTLTLeilkstmkkeleaaqkkkpslcemlhmpnicKRISLLSFTRFANFMAYFGLNLHVQHLGN 377
Cdd:COG2814   187 ESRPAARARLRGSLRELLRR-------------------------------PRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 378 NVF--------LLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQ 429
Cdd:COG2814   236 EVLglsasaagLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS 295
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 121-433 2.88e-15

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 76.74  E-value: 2.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 121 VYDRISFSStIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFV-LRWCYLQVaIVGTCAALAPTFLIY 199
Cdd:cd17377    18 VHFSSSFTS-IVSEWFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVyLTGLALDI-LFAYFNALAPSYEFF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 200 CSLRFLSGI--AAMSLItnTIMLIAEWATHRFQAMGITLG-MC-PSGIAFMTLAGlaFAIRDWHILQLVVSVPYFVIFLt 275
Cdd:cd17377    96 AVSRFLVGVmnGGMSLV--AFVLLNECVGKSYWALAGSLGgLFfAVGIAQYALLG--YFIRSWRTLAVVVNLQGTLVFL- 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 276 sswllesarwliinnkpeeglkelrkaahrsgmknardtltleilkstmkkeleaaqkkkPSLCemlhmpnICKRISLLS 355
Cdd:cd17377   171 ------------------------------------------------------------LSLF-------IPGRTLILM 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 356 FTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLAN--CVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQGEKT 433
Cdd:cd17377   184 YVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYplCIYLINQKWSGRRRTLAGFLFLGGIACLLVMFVPEKKDS 263
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 112-288 1.54e-14

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 74.43  E-value: 1.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 112 DMEPCVDGWVYDRISFS-STIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCA 190
Cdd:cd17443     4 LAVLCTGGWPFSAAAGLgSNLVTEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 191 ALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPyf 270
Cdd:cd17443    84 ALSASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLP-- 161

                         170
                  ....*....|....*...
gi 2462522768 271 VIFLTSSWLLESARWLII 288
Cdd:cd17443   162 LLLLLLYWCFPSRNGLIL 179
MFS_1 pfam07690
Major Facilitator Superfamily;
141-427 3.23e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 73.61  E-value: 3.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 221 IAEWATHRFQAMGITLGMCPSGIAFMT---LAGLAFAIRDWHILQLVVSVPYFVIFLTsswllesarWLIINNKPEEGLK 297
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALgplLGGLLASLFGWRAAFLILAILSLLAAVL---------LLLPRPPPESKRP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 298 ELRKAAHRSGMKNARDTLTLEILKStmkkeleaaqkkkpslcemlhmpnickrISLLSFTRFANFMAYFGLNLHVQHLGN 377
Cdd:pfam07690 181 KPAEEARLSLIVAWKALLRDPVLWL----------------------------LLALLLFGFAFFGLLTYLPLYQEVLGL 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462522768 378 NVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFV 427
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL 282
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 124-278 1.17e-13

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 71.80  E-value: 1.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 124 RISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLR 203
Cdd:cd17444    17 RAGLVQNIVSKWDLVCDSSWKVHIAKFSLLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLR 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462522768 204 FLSGIAAMSLITNTIMLIAEWA--THRFQAMGITLGMCPSGIAFMtlAGLAFAIRDWHILQLVVSVPYfvIFLTSSW 278
Cdd:cd17444    97 FFEGFCLAGIILSLYALRIELCppGHRFMITMVASFIAMAGQFLM--PGLAALCRDWQVLQAVIICPF--LLMLSYW 169
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 151-288 1.41e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 71.00  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWAT--HR 228
Cdd:COG0477    57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFParER 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462522768 229 FQAMGITLGMCPSGIAFMTLAGLAF-AIRDWHILQLVVSVPYFVIFLTSSWLLESARWLII 288
Cdd:COG0477   137 GRALGLWGAAIGLGLALGPLLGGLLvAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLA 197
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 116-278 1.84e-13

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 71.34  E-value: 1.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 116 CVDGWVY-DRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAP 194
Cdd:cd17445     8 CDAGWNYtGLPGLTNNIVTEWDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 195 TFLIYCSLRFLSG--IAAMSLITNTIMLIAEWATHRFQAMgITLGMCPSGIAFMTLaGLAFAIRDWHILQLVVSVPyFVI 272
Cdd:cd17445    88 SPSLFMAMRFLLGaaLAGVYLTLYLTRLELCDPPQRLLVA-MAGGLTMVGGHFLLL-GLALGCGSWRVLQGTITAP-LSL 164


                  ....*.
gi 2462522768 273 FLTSSW 278
Cdd:cd17445   165 FLCYGC 170
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 116-274 4.19e-13

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 70.32  E-value: 4.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 116 CVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPT 195
Cdd:cd17316     9 FFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 196 FLIYCSLRFLSGIAAMSLITNTIMLIAEWATHR-------FQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVP 268
Cdd:cd17316    89 PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKrrgfalgLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALP 168


                  ....*.
gi 2462522768 269 YFVIFL 274
Cdd:cd17316   169 ALLALL 174
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 119-287 4.99e-13

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 70.41  E-value: 4.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 119 GWVYDRISFS------STIVTEWDLVCDSQSLTSvakFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAAL 192
Cdd:cd17371     7 GWALDGFDLLllglvlPALIAEFGLDEAEAGLLG---TVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 193 APTFLIYCSLRFLSGIAAMSLITNTIMLIAE-WAT-HRFQAMGITLGMCPSGIAFMT-LAGLAFAIRD----WHILQLVV 265
Cdd:cd17371    84 AQNYWQLLILRALAGLGFGGEWAAGAALMAEyVPArHRGKALGYVQSGWAVGWLLATlLAALLFPLLPpeiaWRVLFLLG 163

                         170       180
                  ....*....|....*....|..
gi 2462522768 266 SVPYFVIFLTSSWLLESARWLI 287
Cdd:cd17371   164 ALPALLVLFIRRFVKEPPQWQA 185
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
122-280 1.15e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 68.74  E-value: 1.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 122 YDRISFS---STIVTEWDLvcdSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLI 198
Cdd:COG2271    24 LDRSNLSvaaPPLQADLGL---SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQ 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 199 YCSLRFLSGIAAMSLITNTIMLIAEWAT--HRFQAMGITLGMCPSGIAFMTLAGLAFAIR-DWHILQLVVSVPYFVIFLT 275
Cdd:COG2271   101 LLLLRFLLGLGEAGFFPAALKLIAEWFPpkERGRALGIFNAGGPLGGALAPPLLGWLLAAfGWRAAFLILGLPGLLLALL 180


                  ....*
gi 2462522768 276 SSWLL 280
Cdd:COG2271   181 RFWLL 185
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 151-426 3.04e-12

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 68.06  E-value: 3.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWC-YLQV--AIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWA-T 226
Cdd:cd17357    57 IFFIGGAIGSFISAFLANRFGRKNGLLISnALLVvsSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISpS 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 227 HRFQAMGItlgMCPSGIAFMTLAGLAFAIR-------DWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEglkel 299
Cdd:cd17357   137 ELRGALGS---LTQIGVTLGILLGQVFGLPsvlgtetLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEE----- 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 300 rkAAHRSGMKNARDTLTLEILKSTMKKELEA-AQKKKPSLCEMLHMPNICKRISL---LSFTR-FANFMA--YFG----- 367
Cdd:cd17357   209 --EAEKSLKFLRGIEDDVDQELEEIKKESEQmGDQKQVSLMQLLRDPSLRLPLLLvlvVSASQqFSGINAifFYStfife 286

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 368 -LNLHVQHlgnnVFLLQTLFGAVILLANCVAPWALKYMNRRAsqmLLMFLLAICLLAIIF 426
Cdd:cd17357   287 nAGFSPQL----AEWANLGIGIVNVLSTIVGPFLIEKVGRRP---LLLISLSVCAVALLL 339
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 122-429 3.81e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 67.45  E-value: 3.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 122 YDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCS 201
Cdd:cd06174    10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 202 LRFLSGIAAMSLITNTIMLIAEWA--THRFQAMGITLGMCPSGIAFMTLAGLAFAIR---DWHILQLVVSVPYFVIFLTS 276
Cdd:cd06174    90 GRFLLGLGSGLIDPAVLALIADLFpeRERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAVFLIAAALALLAAILL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 277 SWLLESARWLIINNKPEEGLKELrkaahrsgmknardtltleilkstmKKELEAAQKKKPSLCEMLhmpnickrISLLSF 356
Cdd:cd06174   170 LLVVPDPPESARAKNEEASSKSV-------------------------LKLLKRVLKNPGLWLLLL--------AIFLVN 216

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462522768 357 TRFANFMAYFGLNLHVQHLGNNVF--LLQTLFGAVILLANCVAPWALKY-MNRRASQMLLMFLLAICLLAIIFVPQ 429
Cdd:cd06174   217 LAYYSFSTLLPLFLLDLGGLSVAVagLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPS 292
Sugar_tr pfam00083
Sugar (and other) transporter;
151-422 9.48e-12

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 66.53  E-value: 9.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRrfvlRWCYLQVA---IVGT----CAALAPTFLIYCSLRFLSGIaAMSLITNTI-MLIA 222
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGR----KKSLLIANvlfVIGAvlqgAAKGKWSVYQLIVGRVLVGI-GVGGASVLApMYIS 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 223 EWA--THR------FQ---AMGITLGMCpsgiaFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNK 291
Cdd:pfam00083 129 EIApkKLRgalgslYQlaiTFGILLAYI-----FGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGR 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 292 PEEGLKELRKaahrsGMKNARDTLTLEILKSTMKKELEAaqkKKPSLCEMLHMPNICKR----ISLLSFTRFA--NFMAY 365
Cdd:pfam00083 204 LEEAREVLAK-----LRGVPDVDRELDEIKDSLEAGQEA---EKASWKELFSTKTRRQRlligVMLQIFQQLTgiNAIFY 275

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462522768 366 FG----LNLHVQhlgnNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLL 422
Cdd:pfam00083 276 YSttifENLGLS----DSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFV 332
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 153-274 9.59e-12

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 66.07  E-value: 9.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 153 MAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAM 232
Cdd:cd17365    44 LFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSL 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462522768 233 GITLGMCPSGIAFMTLAGLAFAIRD---WHILQLVVSVPYFVIFL 274
Cdd:cd17365   124 AVTLMFCGYPLGAALGGFLAAALIPafgWRSVFLLGGVPPLILLP 168
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
151-428 7.38e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 63.36  E-value: 7.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQ 230
Cdd:COG2223    48 IPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRR 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 231 --AMGITLGMCPSGIAFMT-LAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLesarwliinNKPEEGLKELRKAAHRSg 307
Cdd:COG2223   128 glALGLAAGGGNLGAAVAAfLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFL---------RDPPAGAAAAAKASLRD- 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 308 mknardtlTLEILKStmkkeleaaqkkkpslcemlhmpnicKRISLLSFTRFANFMAYFGLNLHVQHLGNNVF------- 380
Cdd:COG2223   198 --------QLEALRD--------------------------PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFglsaata 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2462522768 381 -LLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVP 428
Cdd:COG2223   244 gLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL 292
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 120-274 9.26e-11

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 62.92  E-value: 9.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 120 WVYDRISFSST-IVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLI 198
Cdd:cd17373     1 WDYGIRAGLVQnAVSKWDLVCDNGWKVHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTM 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462522768 199 YCSLRFLSGIAAMSLITNTIMLIAEWA--THRFQamgITLGMCPSGIA-FMTLAGLAFAIRDWHILQLVVSVPYFVIFL 274
Cdd:cd17373    81 FSTLRFLEGFCLAGIILTLYLLRLELCdpGKRLM---ITMVASLVAVAgQFLMPGLAALCRDWRVLQALIICPFLLMLL 156
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 155-301 3.05e-09

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 58.74  E-value: 3.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 155 GMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAP-TFLIYCSlRFLSGIaAMSLITNTI-MLIAEWATHRFQ-A 231
Cdd:cd17358    53 GALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKdVWMLYLG-RFLAGF-GGGAASVVVpVYIAEIAPKNVRgA 130

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462522768 232 MG-ITLGMCPSGIAFMTLAGLAFairDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRK 301
Cdd:cd17358   131 LGsLNQLLVNIGILLGYVLGSFL---PWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQF 198
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 141-428 4.98e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 57.97  E-value: 4.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:cd17325    29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMAL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 221 IAEWAT--HRFQAMGITLGMCPSGIAF-MTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARwliinnkpeeglk 297
Cdd:cd17325   109 IADIAPpeERGRAMGIFSSAIGLGFLIgPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR------------- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 298 elrkaahrsgmknardtltleilkSTMKKELEAAQKKKPSLCEMLHMPnickRISLLSFTRFANFMA----YFGLNLHVQ 373
Cdd:cd17325   176 ------------------------PPPNKRAVSAARLRSGLRLLLRDR----RLLALFLAIFVLAFAfgalEPFLPLYAA 227

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462522768 374 HLGN-NVFLLQTLFGAVILLANCVAPWALKYMNR--RASQMLL-MFLLAICLLAIIFVP 428
Cdd:cd17325   228 ELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRigRKPLILIgLLLSAVALLLLPLAT 286
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 151-300 4.22e-08

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 54.88  E-value: 4.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQ 230
Cdd:cd17433    49 VVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVR 128

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462522768 231 AmgiTLGMCPS-----GIAFMTLAGLAFairDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300
Cdd:cd17433   129 G---TLGSCVQlmvviGIMGAYLAGLVL---DWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALR 197
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 153-292 4.93e-08

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 54.88  E-value: 4.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 153 MAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHR---- 228
Cdd:cd17359    46 LLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEirgr 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462522768 229 ---FQAMGITLGMCpsgIAFMTLAGLA-FAIRDWHILQ------LVVSVPYFVIFLTSSWLLESARWLIINNKP 292
Cdd:cd17359   126 lvsLNQLMIVFGQL---LAYIVNYLIAnAGGADWLGAEgwrwmlGLEAIPAILFLLGMLFIPESPRWLVSKGKP 196
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 141-255 1.40e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 53.33  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLrFLSGIAAMSLITNTIML 220
Cdd:cd17478   228 SLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVL 306

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462522768 221 IAE-WATHRFQAMGITLGMCpsgiafMTLAGLAFAI 255
Cdd:cd17478   307 AQElLPGNVGLASGLMMGLS------FGLGGIGAPV 336
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 134-286 3.76e-07

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 52.12  E-value: 3.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 134 EWDLVCDSQSLTSVAKFVfmaGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIaAMSL 213
Cdd:cd17441    28 EWRLPSWQVALLTSVVFI---GMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGF-GIGG 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462522768 214 ITNTIMLIAEWATHRFQAMGITLGMC--PSGIAF-MTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWL 286
Cdd:cd17441   104 VPQSVTLYAEFLPMKSRAKCILLIEVfwALGTVFeVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESARYW 179
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
141-244 5.47e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.13  E-value: 5.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:COG2814   241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320

                          90       100
                  ....*....|....*....|....
gi 2462522768 221 IAEWATHRFQAMGITLGMCPSGIA 244
Cdd:COG2814   321 VAELAPPEARGRASGLYNSAFFLG 344
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 151-282 5.68e-07

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 51.42  E-value: 5.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLqVAIVGTCA-ALAPTFLIYCSLRFLSGIaAMSLITNTI-MLIAEWA-TH 227
Cdd:cd17315    42 SLLLGAAIGSLFGGPLADRFGRRKSLLIAAV-LYVIGALLsALAPNVWVLIVGRFLLGL-GVGLASVLVpLYISEIApAK 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462522768 228 RFQAMGITLGMCPS-GIAFMTLAGLAFAIRD---WHILQLVVSVPYFVIFLTSSWLLES 282
Cdd:cd17315   120 IRGALGTLNQLMITfGILLAYLLGLALSLSPpgwWRLMFALAAVPALLQLLLMFFLPES 178
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 155-286 9.10e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 50.73  E-value: 9.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 155 GMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGI---AAMSlitNTIMLIAEWATHRFQA 231
Cdd:PRK11551   62 GLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVglgGALP---NLIALTSEAVGPRLRG 138

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462522768 232 MGITLGMC--PSGIAFMTLAGLAFAI-RDW-HILQLVVSVPYFVIFLTSSWLLESARWL 286
Cdd:PRK11551  139 TAVSLMYCgvPFGGALASVIGVLAAGdAAWrHIFYVGGVGPLLLVPLLMRWLPESRAFA 197
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 151-281 1.63e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 49.88  E-value: 1.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATH--R 228
Cdd:cd17474    42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGgeR 121

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462522768 229 FQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLE 281
Cdd:cd17474   122 AKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLP 174
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 142-346 2.39e-06

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 49.64  E-value: 2.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 142 QSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLqVAIVGTC----AALAPTFLIYCSLRFLSGIAAmSLITNT 217
Cdd:cd17431    49 TTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNL-LAFAGAAlmglSKLAKSYEMLILGRFIIGLYC-GLTTGL 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 218 I-MLIAEWA-TH------RFQAMGITLGMCPSGIafmtlAGLAFAIRD---WHILQLVVSVPYFVIFLTSSWLLESARWL 286
Cdd:cd17431   127 VpMYIGEISpTAlrgalgTLHQLGIVVGILISQI-----FGLEFILGTeelWPLLLGFTIVPAILQLALLPFCPESPRYL 201

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462522768 287 IINNKPEEglkelrKAahRSGMKNARDTLTLEILKSTMKKELEAAQK-KKPSLCEMLHMPN 346
Cdd:cd17431   202 LINRNEEE------EA--KSVLKKLRGTTDVSEDIQEMKEESRQMMReKKVTILELFRSSS 254
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
150-274 3.44e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.08  E-value: 3.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 150 FVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLIT--NTIMLIAEWATH 227
Cdd:COG0738    50 FAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVaaNPYVAALGPETA 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462522768 228 R-----FQAM---GITLGmcPSGIAFMTLAGLAFAirdWHILQLVVSVPYFVIFL 274
Cdd:COG0738   130 AsrlnlLHAFfslGALLG--PLLGGLLILLGLSLS---WHLPYLILAVLLLLLAL 179
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 151-284 8.13e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.54  E-value: 8.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWA--THR 228
Cdd:cd17324    42 AYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVppEKR 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462522768 229 FQAMGI-----TLGMCpSGIAFMTLAGLAFairDWHILQLVVSVPYFVIFLTSSWLLESAR 284
Cdd:cd17324   122 GRAIGLvfsglTLGLV-LGRPLGGLLGQLL---GWRAAFLAIAVLALLAALLLWRLLPSLP 178
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 123-208 1.53e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.80  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 123 DRISFSSTIVTEWDLVCDSQSLTSVAKFV------FMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTF 196
Cdd:cd17330     8 DALGFGIVFPVLPFYVREFNKLGASGYYVgllqssYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL 87

                          90
                  ....*....|..
gi 2462522768 197 LIYCSLRFLSGI 208
Cdd:cd17330    88 WLLFLARFLDGL 99
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 141-258 1.68e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 46.88  E-value: 1.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLqVAIVGTCAALAPTFLIYCSLRF--LSGIAAMSLITNTI 218
Cdd:cd17355   243 SPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYA-LRALGLALLLLLPFPPLALLLFaaLFGLGWGATVPLTA 321

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462522768 219 MLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDW 258
Cdd:cd17355   322 ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDR 361
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
141-280 1.90e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.40  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRR--FVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTI 218
Cdd:COG2271   214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462522768 219 MLIAEWATHRF--QAMGITLGMCPSGIAFM-TLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLL 280
Cdd:COG2271   294 ALAAELFPKKArgTASGLVNTFGFLGGALGpLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
151-285 6.29e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.84  E-value: 6.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLqVAIVGT-CAALAPTFLIYCSLRFLSGIaAMSLITNTIMLIA--EWATH 227
Cdd:COG0738   254 LFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL-LAAVGLlLALLAPGPWLALIGLALVGL-GLSLMFPTIFSLAldGLGKR 331

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462522768 228 RFQAMGITLGMCPSGIAFMTLA-GLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARW 285
Cdd:COG0738   332 TAAAVSAVLIMGIVGGAIGPPLiGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 151-215 6.63e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 44.86  E-value: 6.63e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGrrfvLRWC-YLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLIT 215
Cdd:cd17502   127 VFGIASVAGPLIGGAFTDHLS----WRWCfYINLPIGGLALALLRTILLSSIFGFLFGGALFGLIY 188
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 141-227 6.98e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.86  E-value: 6.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCylqvAIVGTCAALAPTFLIYCSLR-----FLSGIAAMSLIT 215
Cdd:cd17477   221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGC----ALLGALAALLLPLVPGLPLAllvllFLWGGAAGPLYT 296

                          90
                  ....*....|..
gi 2462522768 216 NTIMLIAEWATH 227
Cdd:cd17477   297 LALALAGDRLPG 308
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 151-234 8.20e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.49  E-value: 8.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIaAMSLITNTIM-LIAEWATHRF 229
Cdd:cd17325   243 AQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGL-GLGLVFPATLaLLADIVPPEG 321


                  ....*..
gi 2462522768 230 Q--AMGI 234
Cdd:cd17325   322 RgtAMGL 328
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
140-254 9.41e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.51  E-value: 9.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 140 DSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPT-----FLIYCslrFLSGIAAMSLI 214
Cdd:COG2211   261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnlwlLLVLA---ALAGIGLGAIL 337

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2462522768 215 TNTIMLIA------EWATHRfQAMGITLGMcpsgIAFMTLAGLAFA 254
Cdd:COG2211   338 VLPWAMLAdvvdydEWKTGR-RREGLYFGI----FTFAIKLGQALA 378
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 151-210 1.61e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 43.72  E-value: 1.61e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLqVAIVGTCA-ALAPTFLIYCSLRFLSGIAA 210
Cdd:cd17320    42 AYLLGFALGQLLYGPLSDRFGRRPVLLAGLL-LFILASLLcALASSIEQLLIARFLQGLGA 101
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 150-273 1.76e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 43.36  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 150 FVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALA----PTFLIYCSLrFLSGIAAMSLITNTIMLIAEWA 225
Cdd:cd17316   220 LLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsgsPTLLLLLLF-ILSFFVGGVWGALYAYLAELFP 298

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462522768 226 TH-RFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIF 273
Cdd:cd17316   299 TEvRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 157-284 3.02e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 42.95  E-value: 3.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 157 MVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWAT----HRF--- 229
Cdd:cd17473    49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEgeerAKMlgl 128

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462522768 230 QAMGITLGmcpsGIAFMTLAGLAFAIrDWHILQLVVSVPYFVIFLTSSWLLESAR 284
Cdd:cd17473   129 QSAAMSLG----GVVFLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFLPEPAR 178
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 119-279 3.48e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 42.52  E-value: 3.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 119 GWVYDR-----ISFSSTIV-TEWDLVCDSQSLTSVAKFVfmaGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAAL 192
Cdd:cd17372     7 GWVAEAmemmlLSFVGPAVqCEWNLSAWQVALITSVVFA---GMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 193 APTFLIYCSLRFLSGIaAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIR---DWHILQLVVSVPY 269
Cdd:cd17372    84 APNYMWLIILRCLVGL-GLGGGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMprlGWRWLLAFSSVPS 162

                         170
                  ....*....|
gi 2462522768 270 FVIFLTSSWL 279
Cdd:cd17372   163 SLLLVFYRWT 172
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 154-285 3.69e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 42.64  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 154 AGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFL----SGIAAMslitnTI-MLIAEWATHR 228
Cdd:cd17360    46 AGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLvglgVGIASM-----TVpLYIAEAAPPR 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462522768 229 FQAMGITL-GMCPSG---IAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARW 285
Cdd:cd17360   121 IRGRLVTInVLFITGgqfVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPESPRW 181
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 125-250 3.73e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 42.56  E-value: 3.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 125 ISFSSTIVTEWDlVCDSQSLTSVAkfVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRF 204
Cdd:cd17323    19 SPALPQIAEDFH-VSEEVANLGVS--LFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRF 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462522768 205 LSGIAAMSLITNTIMLIAE-WATH-RFQAMGITLGMCPSGIAFMTLAG 250
Cdd:cd17323    96 LQGFFGSSPLAIGAGTIADlFTPEeRGKAMGVYSLGPLLGPALGPIIG 143
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 134-309 4.48e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 42.66  E-value: 4.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 134 EWDLvCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCylqVAIVGTCAALAP-----TFLIYCslRFLSGI 208
Cdd:TIGR01299 194 EKDL-CIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLIC---LSVNGFFAFFSSfvqgyGFFLFC--RLLSGF 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 209 AAMSLITNTIMLIAE-----------------WATHRFQAMGITLGMCPS-GIAFMTlaGLAFAIRDWHILQLVVSVPYF 270
Cdd:TIGR01299 268 GIGGAIPIVFSYFAEflaqekrgehlswlcmfWMIGGIYAAAMAWAIIPHyGWSFQM--GSAYQFHSWRVFVIVCAFPCV 345

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462522768 271 VIFLTSSWLLESARWLIINNKPEEGLKELrKAAHRSGMK 309
Cdd:TIGR01299 346 FAIGALTFMPESPRFFLENGKHDEAWMIL-KLIHDTNMR 383
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 150-265 1.39e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 40.70  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 150 FVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIA--AMSLITNTIMLIAEWATH 227
Cdd:cd17393    41 LALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAngALDVAMNAQGVAVERAYG 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462522768 228 R-----FQAMGiTLGMCPSGIAFMTLAGLAFAiRDWHILQLVV 265
Cdd:cd17393   121 RpimssLHAMW-SLGGLAGALLGAAAIGAGVS-PGVHLLAAAV 161
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 151-255 1.56e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.62  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVggiLGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEW--ATHR 228
Cdd:cd17321    42 LAFAALLL---LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATfpGERR 118

                          90       100
                  ....*....|....*....|....*..
gi 2462522768 229 FQAMGItlgmcpsgiaFMTLAGLAFAI 255
Cdd:cd17321   119 GRALGL----------WGAVVGIGAAL 135
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 151-299 1.66e-03

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 40.59  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQ 230
Cdd:cd17434    49 VFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVR 128

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462522768 231 AMgitLGMCPSGIA-FMTLAGLAFA-IRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299
Cdd:cd17434   129 GA---LGACPQIMAvFGSLALYALGlLLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKAL 196
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 138-309 2.10e-03

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 40.40  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 138 VCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNT 217
Cdd:cd17439    29 MCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 218 IMLIAE-----------------WATHRFQAMGITLGMCPS-GIAFMTlaGLAFAIRDWHILQLVVSVPYFVIFLTSSWL 279
Cdd:cd17439   109 FSYFSEflaqekrgehlswlcmfWMIGGIYASAMAWAIIPHyGWSFQM--GSAYQFHSWRVFVLVCAFPSVFAIGALTTM 186

                         170       180       190
                  ....*....|....*....|....*....|
gi 2462522768 280 LESARWLIINNKPEEGLKELrKAAHRSGMK 309
Cdd:cd17439   187 PESPRFFLENGKHDEAWMVL-KQVHDTNMR 215
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 138-309 2.55e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 40.16  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 138 VCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCylqVAIVGTCAALAP-----TFLIYCslRFLSGIAAMS 212
Cdd:cd17363    29 MCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIA---LSVNGVFAFLSSfvqgyGFFLFC--RLLSGIGIGG 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 213 LITNTIMLIAE-----------------WATHRFQAMGITLGMCPS-GIAFMTlaGLAFAIRDWHILQLVVSVPYFVIFL 274
Cdd:cd17363   104 SIPIVFSYFAEflarekrgehlswlcmfWMIGGLYASAMAWAIIPHyGWGFSM--GTAYQFHSWRVFVIVCALPSVASVV 181

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2462522768 275 TSSWLLESARWLIINNKPEEGLKELRKaAHRSGMK 309
Cdd:cd17363   182 ALTFMPESPRFLLEVGKHDEAWMILKQ-VHDTNMR 215
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 141-305 3.89e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.13  E-value: 3.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:cd17329    33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAM 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 221 IAEWATHRFQAMGITLG--MCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKE 298
Cdd:cd17329   113 IADVTTPENRTRAFSLLywAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRG 192


                  ....*..
gi 2462522768 299 LRKAAHR 305
Cdd:cd17329   193 YKIVLRD 199
2_A_01_02 TIGR00880
Multidrug resistance protein;
152-250 3.95e-03

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 37.63  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 152 FMAGMMVGGILGGHLSDRFGRRFVLrWCYLQVAIVGTC-AALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWAT--HR 228
Cdd:TIGR00880   7 YALGQLIYSPLSGLLTDRFGRKPVL-LVGLFIFVLSTAmFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPpeER 85

                          90       100
                  ....*....|....*....|..
gi 2462522768 229 FQAMGITLGMCPSGIAFMTLAG 250
Cdd:TIGR00880  86 GVALGLMSAGIALGPLLGPPLG 107
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 141-196 4.17e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 39.16  E-value: 4.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTF 196
Cdd:cd17393   233 SAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSV 288
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 141-259 4.21e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.07  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIML 220
Cdd:cd17324   232 SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR 311

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462522768 221 IAEWAT-HRFQAMGITLGMCPSGIAFMT-LAGLAFAIRDWH 259
Cdd:cd17324   312 VLRLAPeARGLASSLYLAAYNLGGALGAaLGGLVLDHGGWA 352
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 151-255 4.98e-03

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 39.15  E-value: 4.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 151 VFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQ 230
Cdd:cd17327    49 VFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQ 128

                          90       100
                  ....*....|....*....|....*
gi 2462522768 231 AMGITLGMCPSGIAFMTLAGLAFAI 255
Cdd:cd17327   129 AKRIAFFYAAAGLGSIFGGLLAYGV 153
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 158-251 5.05e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.05  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 158 VGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTF--------LIYCSLRFLSGIAAMSLITNTIMLIAEWA--TH 227
Cdd:cd17369    59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYaqigilapILLVLLRLLQGLALGGEWGGAVLMAVEHAppKR 138

                          90       100
                  ....*....|....*....|....*....
gi 2462522768 228 R-----FQAMGITLGMCPSGIAFMTLAGL 251
Cdd:cd17369   139 RgfygsFPQLGAPVGLLLATGVFLLLSAL 167
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 150-326 6.13e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 38.76  E-value: 6.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 150 FVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHR- 228
Cdd:cd17328    41 TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEk 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 229 ------FQAMGITLGmcpSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARwliinnkpeeglkelRKA 302
Cdd:cd17328   121 rtralgVFYFAIPLG---SGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVREPP---------------RGA 182

                         170       180
                  ....*....|....*....|....
gi 2462522768 303 AHRSGMKNARDTLTLEILKSTMKK 326
Cdd:cd17328   183 AEGGVMAKSTATSFLADLKALAKN 206
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 150-236 6.25e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 38.71  E-value: 6.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 150 FVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEW--ATH 227
Cdd:cd17319    45 SAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWfpARE 124


                  ....*....
gi 2462522768 228 RFQAMGITL 236
Cdd:cd17319   125 RGRATGLFN 133
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
141-280 6.43e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 38.70  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462522768 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAmsLITNTIM- 219
Cdd:COG2807    51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI--AVGNVLLp 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462522768 220 -LIAEWATHRF-QAMGI-TLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTssWLL 280
Cdd:COG2807   129 gLIKRWFPDRVgLMTGLyTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLL--WLP 190
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 157-208 6.48e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 38.36  E-value: 6.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462522768 157 MVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGI 208
Cdd:cd17390    45 LFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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