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Conserved domains on  [gi|2462608307|ref|XP_054211326|]
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inositol 1,4,5-trisphosphate receptor type 3 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_MIR_ITPR3 cd23289
MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) ...
 252-466 5.18e-161

MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) and similar proteins; ITPR3, also called IP3 receptor isoform 3 (IP3R 3), or InsP3R3, or type 3 inositol 1,4,5-trisphosphate receptor, or type 3 InsP3 receptor, acts as anti-oncogenic channel by propelling pro-apoptotic Ca2+ signals to mitochondria. It is the principal intracellular Ca2+ release channel in cholangiocytes and plays a particularly important role in cancer. ITPR3 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


:

Pssm-ID: 467760 [Multi-domain]  Cd Length: 215  Bit Score: 495.33  E-value: 5.18e-161
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  252 MQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLY 331
Cdd:cd23289      1 MQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  332 RFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRN 411
Cdd:cd23289     81 RFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQSRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRN 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462608307  412 SYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI 466
Cdd:cd23289    161 SYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI 215
Ins145_P3_rec pfam08709
Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding ...
 31-257 3.64e-105

Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.


:

Pssm-ID: 462572 [Multi-domain]  Cd Length: 212  Bit Score: 335.24  E-value: 3.64e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307   31 MSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKEK 110
Cdd:pfam08709    1 MSSFLHIGDIVSLSCEESVNGFISALGLGNDRCFVENKAGDLNDPPKKFRDCVFKICPANSYAAQKELWSAGNRSPNGNS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  111 IADVvllqkLQHAAQMEQKQNdtenkkvhgdvVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGN-EGSWL 189
Cdd:pfam08709   81 LTDA-----LKHASNIEGHQN-----------LQYGSAILLLHVKSNMYLAVLKSSPSLRDKNAMRVVLDEAGNgEGCWF 144

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462608307  190 FIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLH-ASNYELSDNAGcKEVNSVNCNTSWKINLFMQFRDH 257
Cdd:pfam08709  145 IITPAYKQRSEGDNVCVGDEVILVPVSAPIFLHtTSSSELRDNPG-KEVNASFGQTSWKMEPFMSGCEN 212
RYDR_ITPR pfam01365
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 502-697 4.60e-83

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


:

Pssm-ID: 460175  Cd Length: 199  Bit Score: 271.38  E-value: 4.60e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  502 LLEDLVFFVSDVPNN---GQNVLDIMVTKPNRERQKLMREQNILKQVFG---ILKAPFrekggEGPLVRLEELSDQKNAP 575
Cdd:pfam01365    1 LLRDLIFFFAGPEEEelhEEDLLKLMNNKPLRQRQNLMREQGVLETVMEvidLLGAPF-----TGALLFAEDLGEEKNAP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  576 YQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAE---DTITALLHNNRKLLEKHITKTEVETFVSLVRKN 652
Cdd:pfam01365   76 WKKIVRLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQLGSPSLAEgtlDVLTALLMDNPELLLNYIKECHIKSFISLLRKH 155

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2462608307  653 -REPRFLDYLSDLCVSNHIAIPVTQELICKCVLDpkNSDILIRTEL 697
Cdd:pfam01365  156 gRDPRYLDFLSDLCVCNGEAVRENQNLICRLLLP--NPDLLLQTLL 199
RIH_assoc pfam08454
RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) ...
 1892-2001 1.45e-39

RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels. There seems to be no known function for this domain. Also see the IP3-binding domain pfam01365 and pfam02815.


:

Pssm-ID: 462482  Cd Length: 98  Bit Score: 142.66  E-value: 1.45e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 1892 TSVLIMQPILRFLQLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDIMCGSttgglgllglyINEDNVGLVIQTLET 1970
Cdd:pfam08454    1 QEVKIICRILRFLQLLCEGHNLDLQNYLRQQtNNKNSYNLVEETVDLLKAYCKS-----------INEKNIELIIQCLDT 69

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462608307 1971 LTEYCQGPCHENQTCIvtHESNGIDIITALI 2001
Cdd:pfam08454   70 LTEFIQGPCIENQIAL--CESKFLEIANDLL 98
Ion_trans super family cl37996
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 2292-2555 5.85e-04

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


The actual alignment was detected with superfamily member pfam00520:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 44.18  E-value: 5.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 2292 IVALILRSiYYLGIGPTLNILGALNLTNKIVFVVSFV------GNRGTFIRgykamvmDMEFLYHVGYILTSVLGLFAHE 2365
Cdd:pfam00520   16 TIFLALET-YFQPEEPLTTVLEILDYVFTGIFTLEMLlkiiaaGFKKRYFR-------SPWNILDFVVVLPSLISLVLSS 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 2366 -----------LFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGF-LFLKDDFILEVDRLPNNH 2433
Cdd:pfam00520   88 vgslsglrvlrLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYqLFGGKLKTWENPDNGRTN 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 2434 stasplgmphgaaafvdtcsgdkmdcvsglsvpevleedreldsteraCDTLLMCIVTVMNhgLRNGGGVGDILRKPSkD 2513
Cdd:pfam00520  168 ------------------------------------------------FDNFPNAFLWLFQ--TMTTEGWGDIMYDTI-D 196

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 2462608307 2514 ESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQ 2555
Cdd:pfam00520  197 GKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
RYDR_ITPR super family cl03182
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 1218-1330 8.84e-04

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


The actual alignment was detected with superfamily member pfam01365:

Pssm-ID: 460175  Cd Length: 199  Bit Score: 42.96  E-value: 8.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 1218 KKQQRLLKNMDAHKVML---DLLQIPY-----------DKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTP 1283
Cdd:pfam01365   32 RQRQNLMREQGVLETVMeviDLLGAPFtgallfaedlgEEKNAPWKKIVRLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQ 111

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462608307 1284 --------GLLeaETMQHIFLNNYQLC-SEISEPVLQHFVHLLATHGRHVQYLDFL 1330
Cdd:pfam01365  112 lgspslaeGTL--DVLTALLMDNPELLlNYIKECHIKSFISLLRKHGRDPRYLDFL 165
 
Name Accession Description Interval E-value
beta-trefoil_MIR_ITPR3 cd23289
MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) ...
 252-466 5.18e-161

MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) and similar proteins; ITPR3, also called IP3 receptor isoform 3 (IP3R 3), or InsP3R3, or type 3 inositol 1,4,5-trisphosphate receptor, or type 3 InsP3 receptor, acts as anti-oncogenic channel by propelling pro-apoptotic Ca2+ signals to mitochondria. It is the principal intracellular Ca2+ release channel in cholangiocytes and plays a particularly important role in cancer. ITPR3 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467760 [Multi-domain]  Cd Length: 215  Bit Score: 495.33  E-value: 5.18e-161
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  252 MQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLY 331
Cdd:cd23289      1 MQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  332 RFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRN 411
Cdd:cd23289     81 RFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQSRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRN 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462608307  412 SYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI 466
Cdd:cd23289    161 SYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI 215
Ins145_P3_rec pfam08709
Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding ...
 31-257 3.64e-105

Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.


Pssm-ID: 462572 [Multi-domain]  Cd Length: 212  Bit Score: 335.24  E-value: 3.64e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307   31 MSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKEK 110
Cdd:pfam08709    1 MSSFLHIGDIVSLSCEESVNGFISALGLGNDRCFVENKAGDLNDPPKKFRDCVFKICPANSYAAQKELWSAGNRSPNGNS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  111 IADVvllqkLQHAAQMEQKQNdtenkkvhgdvVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGN-EGSWL 189
Cdd:pfam08709   81 LTDA-----LKHASNIEGHQN-----------LQYGSAILLLHVKSNMYLAVLKSSPSLRDKNAMRVVLDEAGNgEGCWF 144

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462608307  190 FIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLH-ASNYELSDNAGcKEVNSVNCNTSWKINLFMQFRDH 257
Cdd:pfam08709  145 IITPAYKQRSEGDNVCVGDEVILVPVSAPIFLHtTSSSELRDNPG-KEVNASFGQTSWKMEPFMSGCEN 212
RYDR_ITPR pfam01365
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 502-697 4.60e-83

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


Pssm-ID: 460175  Cd Length: 199  Bit Score: 271.38  E-value: 4.60e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  502 LLEDLVFFVSDVPNN---GQNVLDIMVTKPNRERQKLMREQNILKQVFG---ILKAPFrekggEGPLVRLEELSDQKNAP 575
Cdd:pfam01365    1 LLRDLIFFFAGPEEEelhEEDLLKLMNNKPLRQRQNLMREQGVLETVMEvidLLGAPF-----TGALLFAEDLGEEKNAP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  576 YQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAE---DTITALLHNNRKLLEKHITKTEVETFVSLVRKN 652
Cdd:pfam01365   76 WKKIVRLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQLGSPSLAEgtlDVLTALLMDNPELLLNYIKECHIKSFISLLRKH 155

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2462608307  653 -REPRFLDYLSDLCVSNHIAIPVTQELICKCVLDpkNSDILIRTEL 697
Cdd:pfam01365  156 gRDPRYLDFLSDLCVCNGEAVRENQNLICRLLLP--NPDLLLQTLL 199
MIR pfam02815
MIR domain; The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may ...
 261-459 7.68e-72

MIR domain; The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function.


Pssm-ID: 397103 [Multi-domain]  Cd Length: 185  Bit Score: 238.80  E-value: 7.68e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  261 VLKGGDVVRLFHAEQEKFLTCDEYKGKlQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGN 340
Cdd:pfam02815    2 YLKGGDVVRLFHSHQDEYLTGSEQQQK-QPFLRITLYPHGDANNSARSLWRIEVVRHDAWRGGLIKWGSPFRLRHLTTGR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  341 YLAAEENPsykgdasdpkaagmGAQGRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRLRHLC 420
Cdd:pfam02815   81 YLHSHEEQ--------------KPPLVEKEDWQKEVSAYGFRGFPGDNDIVEIFEKKSTTGMGSDRIKPGDSYFRLQHVC 146

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2462608307  421 TNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIV 459
Cdd:pfam02815  147 TGCWLFSHSVKLPKWGFGPEQQKVTCAKEGHMDDALTLP 185
RIH_assoc pfam08454
RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) ...
 1892-2001 1.45e-39

RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels. There seems to be no known function for this domain. Also see the IP3-binding domain pfam01365 and pfam02815.


Pssm-ID: 462482  Cd Length: 98  Bit Score: 142.66  E-value: 1.45e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 1892 TSVLIMQPILRFLQLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDIMCGSttgglgllglyINEDNVGLVIQTLET 1970
Cdd:pfam08454    1 QEVKIICRILRFLQLLCEGHNLDLQNYLRQQtNNKNSYNLVEETVDLLKAYCKS-----------INEKNIELIIQCLDT 69

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462608307 1971 LTEYCQGPCHENQTCIvtHESNGIDIITALI 2001
Cdd:pfam08454   70 LTEFIQGPCIENQIAL--CESKFLEIANDLL 98
MIR smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;
140-194 1.76e-05

Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;


Pssm-ID: 197746 [Multi-domain]  Cd Length: 57  Bit Score: 44.25  E-value: 1.76e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462608307   140 GDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTL--DATGNEGSWLFIQPF 194
Cdd:smart00472    1 GGFVRWGDVVRLRHVTTGRYLHSHDEKLPPWGDGQQEVTGygNPAIDANTLWLIEPV 57
MIR smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;
259-315 5.78e-05

Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;


Pssm-ID: 197746 [Multi-domain]  Cd Length: 57  Bit Score: 42.71  E-value: 5.78e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462608307   259 EEVLKGGDVVRLFHAEQEKFLTCDEYK------GKLQVFLRTtlrqsaTSATSSNALWEVEVV 315
Cdd:smart00472    1 GGFVRWGDVVRLRHVTTGRYLHSHDEKlppwgdGQQEVTGYG------NPAIDANTLWLIEPV 57
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 2292-2555 5.85e-04

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 44.18  E-value: 5.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 2292 IVALILRSiYYLGIGPTLNILGALNLTNKIVFVVSFV------GNRGTFIRgykamvmDMEFLYHVGYILTSVLGLFAHE 2365
Cdd:pfam00520   16 TIFLALET-YFQPEEPLTTVLEILDYVFTGIFTLEMLlkiiaaGFKKRYFR-------SPWNILDFVVVLPSLISLVLSS 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 2366 -----------LFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGF-LFLKDDFILEVDRLPNNH 2433
Cdd:pfam00520   88 vgslsglrvlrLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYqLFGGKLKTWENPDNGRTN 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 2434 stasplgmphgaaafvdtcsgdkmdcvsglsvpevleedreldsteraCDTLLMCIVTVMNhgLRNGGGVGDILRKPSkD 2513
Cdd:pfam00520  168 ------------------------------------------------FDNFPNAFLWLFQ--TMTTEGWGDIMYDTI-D 196

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 2462608307 2514 ESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQ 2555
Cdd:pfam00520  197 GKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
RYDR_ITPR pfam01365
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 1218-1330 8.84e-04

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


Pssm-ID: 460175  Cd Length: 199  Bit Score: 42.96  E-value: 8.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 1218 KKQQRLLKNMDAHKVML---DLLQIPY-----------DKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTP 1283
Cdd:pfam01365   32 RQRQNLMREQGVLETVMeviDLLGAPFtgallfaedlgEEKNAPWKKIVRLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQ 111

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462608307 1284 --------GLLeaETMQHIFLNNYQLC-SEISEPVLQHFVHLLATHGRHVQYLDFL 1330
Cdd:pfam01365  112 lgspslaeGTL--DVLTALLMDNPELLlNYIKECHIKSFISLLRKHGRDPRYLDFL 165
beta-trefoil_MIR_PMT cd23276
MIR domain, beta-trefoil fold, found in the family of dolichyl-phosphate-mannose-protein ...
 143-211 5.72e-03

MIR domain, beta-trefoil fold, found in the family of dolichyl-phosphate-mannose-protein mannosyltransferase (PMT); The PMT (EC 2.4.1.109) family includes mammalian protein O-mannosyl-transferases (POMT1 and POMT2) and yeast PMT1-7. PMTs are responsible for O-linked glycosylation of proteins. They catalyze the transfer of mannose to seryl and threonyl residues of secretory proteins. Protein O-glycosylation is essential for cell wall rigidity and cell integrity. Members in this family contain a MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467747 [Multi-domain]  Cd Length: 185  Bit Score: 40.39  E-value: 5.72e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462608307  143 VKYGSVIQLLHMKSNKYLTVNKRlPALLEKNAMRVTldATGNEGSWLFIQPFWKLRSNGDNVVVGDKVI 211
Cdd:cd23276     66 VRDGDEVRLLHKETNRYLRTHDA-AAPVTSKHKEVS--AYPDENEDGDDNDLWVVEIVKDEGKLEDKRI 131
 
Name Accession Description Interval E-value
beta-trefoil_MIR_ITPR3 cd23289
MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) ...
 252-466 5.18e-161

MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) and similar proteins; ITPR3, also called IP3 receptor isoform 3 (IP3R 3), or InsP3R3, or type 3 inositol 1,4,5-trisphosphate receptor, or type 3 InsP3 receptor, acts as anti-oncogenic channel by propelling pro-apoptotic Ca2+ signals to mitochondria. It is the principal intracellular Ca2+ release channel in cholangiocytes and plays a particularly important role in cancer. ITPR3 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467760 [Multi-domain]  Cd Length: 215  Bit Score: 495.33  E-value: 5.18e-161
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  252 MQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLY 331
Cdd:cd23289      1 MQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  332 RFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRN 411
Cdd:cd23289     81 RFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQSRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRN 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462608307  412 SYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI 466
Cdd:cd23289    161 SYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI 215
beta-trefoil_MIR_ITPR cd23277
MIR domain, beta-trefoil fold, found in the family of inositol 1,4,5-trisphosphate receptor ...
 252-466 1.85e-133

MIR domain, beta-trefoil fold, found in the family of inositol 1,4,5-trisphosphate receptor (ITPR); Inositol 1,4,5 trisphosphate receptors (ITPRs) are a family of endoplasmic reticulum Ca2+ channels essential for the control of intracellular Ca2+ levels in virtually every mammalian cell type. Calcium-mediated signaling through ITPRs is essential for the regulation of numerous physiological processes, including fertilization, muscle contraction, apoptosis, secretion, and synaptic plasticity. The ITPR family includes three isoforms (ITPR1, ITPR2 and ITPR3), which can control different cellular processes due to their unique biophysical properties, subcellular localization, and tissue distribution. ITPRs contain an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467748 [Multi-domain]  Cd Length: 204  Bit Score: 415.99  E-value: 1.85e-133
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  252 MQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLY 331
Cdd:cd23277      1 MEYKENLEDVLKGGDVVRLFHAEQEKFLTCDEYKKKQYVFLRTTGRTSATSATSSKALWEVEVVQHDPCRGGAGHWNSLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  332 RFKHLATGNYLAAEENPSYKGDASdpkaagmgaqgRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRN 411
Cdd:cd23277     81 RFKHLATGQYLAAEVDPDPTPDPT-----------RSKLRGAPGKPVYCLVSVPHGNDIASIFELDPTTLQRGDSLVPRS 149

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462608307  412 SYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI 466
Cdd:cd23277    150 SYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKVGTAPIKEDKEAFAIVPVSPSEV 204
beta-trefoil_MIR_ITPR2 cd23288
MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) ...
 246-466 1.90e-127

MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) and similar proteins; ITPR2, also called IP3 receptor isoform 2 (IP3R 2), or InsP3R2, or type 2 inositol 1,4,5-trisphosphate receptor, or type 2 InsP3 receptor, is a key regulator for the activity of calcium ion transmembrane transportation, which plays a critical role in cell cycle and proliferation. It is a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of cAMP-dependent protein kinase (PKA). ITPR2 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467759 [Multi-domain]  Cd Length: 222  Bit Score: 399.80  E-value: 1.90e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  246 WKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAG 325
Cdd:cd23288      1 WKVTLFMKFSDYREDILKGGDVVRLFHAEQEKFLTCDEYKKKQHIFLRTTLRQSATSATSSKALWEIEVVHYDPCRGGAG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  326 HWNGLYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGR-RNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKT 404
Cdd:cd23288     81 QWNSLFRFKHLATGNYLAAEVNPDYRDAQNEGKAVNDGDSPTSKKkRQAAEKIMYTLVSVPHGNDIASLFELDATTLQRA 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462608307  405 DSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI 466
Cdd:cd23288    161 DCLVPRNSYVRLRHLCTNTWVTSTSIPIDTEEERPVMLKIGTCQTKEDKEAFAIVSVPLSEV 222
beta-trefoil_MIR_ITPR1 cd23287
MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ...
 252-471 5.21e-113

MIR domain, beta-trefoil fold, found in inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) and similar proteins; ITPR1, also called IP3 receptor isoform 1 (IP3R 1), or InsP3R1, or type 1 inositol 1,4,5-trisphosphate receptor, or type 1 InsP3 receptor, is an intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. It is involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. It plays a role in endoplasmic reticulum (ER) stress-induced apoptosis. ITPR1 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467758 [Multi-domain]  Cd Length: 222  Bit Score: 358.23  E-value: 5.21e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  252 MQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLY 331
Cdd:cd23287      1 MKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  332 RFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQ--GRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVP 409
Cdd:cd23287     81 RFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQdaSRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVP 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462608307  410 RNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDF 471
Cdd:cd23287    161 RNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPVSPAEVRDLDF 222
Ins145_P3_rec pfam08709
Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding ...
 31-257 3.64e-105

Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.


Pssm-ID: 462572 [Multi-domain]  Cd Length: 212  Bit Score: 335.24  E-value: 3.64e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307   31 MSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKEK 110
Cdd:pfam08709    1 MSSFLHIGDIVSLSCEESVNGFISALGLGNDRCFVENKAGDLNDPPKKFRDCVFKICPANSYAAQKELWSAGNRSPNGNS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  111 IADVvllqkLQHAAQMEQKQNdtenkkvhgdvVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGN-EGSWL 189
Cdd:pfam08709   81 LTDA-----LKHASNIEGHQN-----------LQYGSAILLLHVKSNMYLAVLKSSPSLRDKNAMRVVLDEAGNgEGCWF 144

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462608307  190 FIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLH-ASNYELSDNAGcKEVNSVNCNTSWKINLFMQFRDH 257
Cdd:pfam08709  145 IITPAYKQRSEGDNVCVGDEVILVPVSAPIFLHtTSSSELRDNPG-KEVNASFGQTSWKMEPFMSGCEN 212
RYDR_ITPR pfam01365
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 502-697 4.60e-83

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


Pssm-ID: 460175  Cd Length: 199  Bit Score: 271.38  E-value: 4.60e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  502 LLEDLVFFVSDVPNN---GQNVLDIMVTKPNRERQKLMREQNILKQVFG---ILKAPFrekggEGPLVRLEELSDQKNAP 575
Cdd:pfam01365    1 LLRDLIFFFAGPEEEelhEEDLLKLMNNKPLRQRQNLMREQGVLETVMEvidLLGAPF-----TGALLFAEDLGEEKNAP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  576 YQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAE---DTITALLHNNRKLLEKHITKTEVETFVSLVRKN 652
Cdd:pfam01365   76 WKKIVRLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQLGSPSLAEgtlDVLTALLMDNPELLLNYIKECHIKSFISLLRKH 155

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2462608307  653 -REPRFLDYLSDLCVSNHIAIPVTQELICKCVLDpkNSDILIRTEL 697
Cdd:pfam01365  156 gRDPRYLDFLSDLCVCNGEAVRENQNLICRLLLP--NPDLLLQTLL 199
MIR pfam02815
MIR domain; The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may ...
 261-459 7.68e-72

MIR domain; The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function.


Pssm-ID: 397103 [Multi-domain]  Cd Length: 185  Bit Score: 238.80  E-value: 7.68e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  261 VLKGGDVVRLFHAEQEKFLTCDEYKGKlQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGN 340
Cdd:pfam02815    2 YLKGGDVVRLFHSHQDEYLTGSEQQQK-QPFLRITLYPHGDANNSARSLWRIEVVRHDAWRGGLIKWGSPFRLRHLTTGR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  341 YLAAEENPsykgdasdpkaagmGAQGRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRLRHLC 420
Cdd:pfam02815   81 YLHSHEEQ--------------KPPLVEKEDWQKEVSAYGFRGFPGDNDIVEIFEKKSTTGMGSDRIKPGDSYFRLQHVC 146

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2462608307  421 TNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIV 459
Cdd:pfam02815  147 TGCWLFSHSVKLPKWGFGPEQQKVTCAKEGHMDDALTLP 185
RIH_assoc pfam08454
RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) ...
 1892-2001 1.45e-39

RyR and IP3R Homology associated; This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels. There seems to be no known function for this domain. Also see the IP3-binding domain pfam01365 and pfam02815.


Pssm-ID: 462482  Cd Length: 98  Bit Score: 142.66  E-value: 1.45e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 1892 TSVLIMQPILRFLQLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDIMCGSttgglgllglyINEDNVGLVIQTLET 1970
Cdd:pfam08454    1 QEVKIICRILRFLQLLCEGHNLDLQNYLRQQtNNKNSYNLVEETVDLLKAYCKS-----------INEKNIELIIQCLDT 69

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462608307 1971 LTEYCQGPCHENQTCIvtHESNGIDIITALI 2001
Cdd:pfam08454   70 LTEFIQGPCIENQIAL--CESKFLEIANDLL 98
beta-trefoil_MIR_itr-1-like cd23280
MIR domain, beta-trefoil fold, found in Caenorhabditis elegans inositol 1,4,5-trisphosphate ...
 256-462 9.72e-30

MIR domain, beta-trefoil fold, found in Caenorhabditis elegans inositol 1,4,5-trisphosphate receptor Itr-1 and similar proteins; Itr-1, also called IP3 receptor, or IP3R, or InsP3R, or LET-23 fertility effector 1, is a receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. It binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity. It can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Itr-1 acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping. It affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior. It plays an important role in early embryonic development. It controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis. Itr-1 functions as a component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde, but no other ASH-mediated responses. Itr-1 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467751 [Multi-domain]  Cd Length: 199  Bit Score: 118.64  E-value: 9.72e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  256 DHLEEVLKGGDVVRLFHAEQEKFLTC----DEYKGKLQVFLRTTLRQ-----SATSATSSNALWEVEVVHhDPCRGGAGH 326
Cdd:cd23280      1 KENENFLKGGDVVRLFHKELEAYLSAegsfVDEVLTEDVHLRVRPVDdrkprTLFPPTSGDTFWQIEKED-TPLKGGVIK 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  327 WNGLYRFKHLATGNYLAAEENpsykgdasdpkaagmgaqgrtgrrnageKIKYCLVAVPHGNDIASLFELDPTTLQKTDS 406
Cdd:cd23280     80 WGDQCRLRHLPTGKYLAVDDK----------------------------TGNGKVVLTSDPSDPSTVFRLHPVTKETSEE 131

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462608307  407 fVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLM---------LGTCPTKEDKEAFAIVSVP 462
Cdd:cd23280    132 -VKFGSYVRIEHVATGTWLHAETDEELRRSKKSPAGLswdgaklrkVSLSLERQDDDAFTIQEVD 195
beta-trefoil_MIR cd23263
MIR domain, beta-trefoil fold, found in the MIR (protein mannosyltransferase, IP3R and RyR) ...
 265-437 3.60e-26

MIR domain, beta-trefoil fold, found in the MIR (protein mannosyltransferase, IP3R and RyR) superfamily; The MIR superfamily includes dolichyl-phosphate-mannose-protein mannosyltransferases (PMTs), inositol 1,4,5-trisphosphate receptors (ITPRs/IP3R), ryanodine receptors (RyRs), and stromal cell-derived factor 2 (SDF-2)-like proteins. They all contain a MIR domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The MIR domain may have a ligand transferase function.


Pssm-ID: 467746 [Multi-domain]  Cd Length: 172  Bit Score: 107.47  E-value: 3.60e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  265 GDVVRLFHAEQEKFLTCDEY-----KGKLQVFLRTTLRQsatsaTSSNALWEVEVVHHDPcrGGAGHWNGLYRFKHLATG 339
Cdd:cd23263      1 GDVIWLKHSETGKYLHSHRKnyptgSGQQEVTFESSSRK-----GDTNGLWIIESENGKQ--GGPVKWGDKIRLRHLSTG 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  340 NYLAAEENPSykgdasdpkaagmgaqgrtgrrNAGEKIKYCLVAVPHGnDIASLFELDPT-TLQKTDSFVPRNSYVRLRH 418
Cdd:cd23263     74 KYLSSEEGKK----------------------SPKSNHQEVLCLTDNP-DKSSLFKFEPIgSTKYKQKYVKKDSYFRLKH 130

                          170
                   ....*....|....*....
gi 2462608307  419 LCTNTWIQSTNVPIDIEEE 437
Cdd:cd23263    131 VNTNFWLHSHEKKFNINNK 149
MIR smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;
140-194 1.76e-05

Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;


Pssm-ID: 197746 [Multi-domain]  Cd Length: 57  Bit Score: 44.25  E-value: 1.76e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462608307   140 GDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTL--DATGNEGSWLFIQPF 194
Cdd:smart00472    1 GGFVRWGDVVRLRHVTTGRYLHSHDEKLPPWGDGQQEVTGygNPAIDANTLWLIEPV 57
MIR smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;
259-315 5.78e-05

Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;


Pssm-ID: 197746 [Multi-domain]  Cd Length: 57  Bit Score: 42.71  E-value: 5.78e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462608307   259 EEVLKGGDVVRLFHAEQEKFLTCDEYK------GKLQVFLRTtlrqsaTSATSSNALWEVEVV 315
Cdd:smart00472    1 GGFVRWGDVVRLRHVTTGRYLHSHDEKlppwgdGQQEVTGYG------NPAIDANTLWLIEPV 57
beta-trefoil_MIR_PMT cd23276
MIR domain, beta-trefoil fold, found in the family of dolichyl-phosphate-mannose-protein ...
 243-342 6.33e-05

MIR domain, beta-trefoil fold, found in the family of dolichyl-phosphate-mannose-protein mannosyltransferase (PMT); The PMT (EC 2.4.1.109) family includes mammalian protein O-mannosyl-transferases (POMT1 and POMT2) and yeast PMT1-7. PMTs are responsible for O-linked glycosylation of proteins. They catalyze the transfer of mannose to seryl and threonyl residues of secretory proteins. Protein O-glycosylation is essential for cell wall rigidity and cell integrity. Members in this family contain a MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467747 [Multi-domain]  Cd Length: 185  Bit Score: 46.17  E-value: 6.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  243 NTSWKI---NLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKlqvFLRTTLRQSA----TSATSSNALWEVEVV 315
Cdd:cd23276     44 NNWWQIlkpRGDPSSNPPDPEYVRDGDEVRLLHKETNRYLRTHDAAAP---VTSKHKEVSAypdeNEDGDDNDLWVVEIV 120

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462608307  316 hHDPCRGGAGHWNGL---YRFKHLATGNYL 342
Cdd:cd23276    121 -KDEGKLEDKRIKPLttrFRLRNKKTGCYL 149
beta-trefoil_MIR_RyR cd23278
MIR domain, beta-trefoil fold, found in the family of ryanodine receptor (RyR); RyRs (also ...
 264-347 6.64e-05

MIR domain, beta-trefoil fold, found in the family of ryanodine receptor (RyR); RyRs (also called RYRs) are intracellular Ca(2+) release channels located on the sarco/endoplasmic reticulum (SR/ER). They release calcium Ca(2+) intracellular stores to activate critical functions including muscle contraction and neurotransmitter release. The family includes three closely homologous proteins, RyR1, RyR2 and RyR3. RyR1 is present in skeletal muscle; RyR2 is in heart muscle; and RyR3 is expressed at low levels in many tissues including brain, smooth muscle, and slow-twitch skeletal muscle. RYR2 is the major cellular mediator of calcium-induced calcium release (CICR) in animal cells. RyR1 and RyR2 release Ca2+ from the ER in response to excitation of muscle membranes to promote muscle contraction. RYR3 is involved in force production and calcium handling in extraocular muscle. RYRs contain an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467749 [Multi-domain]  Cd Length: 180  Bit Score: 46.15  E-value: 6.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  264 GGDVVRLFHAEQEKFLTCDEYKGKLQVFlRTTLRQSATSATSSNALWEVEVVHHDPCrGGAGHWNGLYRFKHLATGNYLA 343
Cdd:cd23278      1 GGDVLRLFHGHMDECLTIPAAGSKEDQH-RTVIYEGGAVSTHARSLWRLELLRIKWS-GSHIGWGQPFRLRHVTTGRYLA 78


                   ....
gi 2462608307  344 AEEN 347
Cdd:cd23278     79 LTED 82
beta-trefoil_MIR_RyR1 cd23290
MIR domain, beta-trefoil fold, found in ryanodine receptor 1 (RyR1) and similar proteins; RyR1, ...
 259-346 8.78e-05

MIR domain, beta-trefoil fold, found in ryanodine receptor 1 (RyR1) and similar proteins; RyR1, also called RYR-1, or skeletal muscle calcium release channel, or skeletal muscle ryanodine receptor, or skeletal muscle-type ryanodine receptor, or type 1 ryanodine receptor, is a calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. It can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. It is required for normal embryonic development of muscle fibers and skeletal muscle, as well as for normal heart morphogenesis, skin development and ossification during embryogenesis. RYR-1 forms homotetramer and can also form heterotetramers with RYR-2. RYR-1 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467761 [Multi-domain]  Cd Length: 192  Bit Score: 46.03  E-value: 8.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  259 EEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQvfLRTTLRQSATSATSSNALWEVEvvhhdPCR----GGAGHWNGLYRFK 334
Cdd:cd23290      5 EGYVTGGHVLRLFHGHMDECLTISAADSDDQ--RRLVYYEGGAVCTHARSLWRLE-----PLRiswsGSHLRWGQPLRIR 77

                           90
                   ....*....|..
gi 2462608307  335 HLATGNYLAAEE 346
Cdd:cd23290     78 HVTTGRYLALTE 89
MIR smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;
322-375 1.14e-04

Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;


Pssm-ID: 197746 [Multi-domain]  Cd Length: 57  Bit Score: 41.94  E-value: 1.14e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2462608307   322 GGAGHWNGLYRFKHLATGNYLAAEENPsykgdasdPKAAGMGAQGRTGRRNAGE 375
Cdd:smart00472    1 GGFVRWGDVVRLRHVTTGRYLHSHDEK--------LPPWGDGQQEVTGYGNPAI 46
beta-trefoil_MIR_RyR3 cd23292
MIR domain, beta-trefoil fold, found in ryanodine receptor 3 (RyR3) and similar proteins; RyR3, ...
 262-347 2.17e-04

MIR domain, beta-trefoil fold, found in ryanodine receptor 3 (RyR3) and similar proteins; RyR3, also called RYR-3, or brain ryanodine receptor-calcium release channel, or brain-type ryanodine receptor, or type 3 ryanodine receptor, is a calcium channel that plays a role in cellular calcium signaling. It mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. It also mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. RYR-3 forms homotetramer and also forms heterotetramer with RYR-2. RYR-3 contains an N-terminal MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467763 [Multi-domain]  Cd Length: 187  Bit Score: 44.52  E-value: 2.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307  262 LKGGDVVRLFHAEQEKfLTCDEYKgKLQVFLRTTLRQSATSATSSNALWEVEvvhhdPCR----GGAGHWNGLYRFKHLA 337
Cdd:cd23292      3 LLGGHVVRLFHGHDEC-LTIPSTD-QSDEQHRVVNYEAGGAGTRARSLWRLE-----PLRiswsGSHIRWGQTFRLRHLT 75

                           90
                   ....*....|
gi 2462608307  338 TGNYLAAEEN 347
Cdd:cd23292     76 TGHYLALTED 85
MIR smart00472
Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;
201-251 3.39e-04

Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases;


Pssm-ID: 197746 [Multi-domain]  Cd Length: 57  Bit Score: 40.79  E-value: 3.39e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462608307   201 GDNVVVGDKVILNPVNAGQPLHAS-NYELSDNAGCKEVNSV-----NCNTSWKINLF 251
Cdd:smart00472    1 GGFVRWGDVVRLRHVTTGRYLHSHdEKLPPWGDGQQEVTGYgnpaiDANTLWLIEPV 57
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 2292-2555 5.85e-04

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 44.18  E-value: 5.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 2292 IVALILRSiYYLGIGPTLNILGALNLTNKIVFVVSFV------GNRGTFIRgykamvmDMEFLYHVGYILTSVLGLFAHE 2365
Cdd:pfam00520   16 TIFLALET-YFQPEEPLTTVLEILDYVFTGIFTLEMLlkiiaaGFKKRYFR-------SPWNILDFVVVLPSLISLVLSS 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 2366 -----------LFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGF-LFLKDDFILEVDRLPNNH 2433
Cdd:pfam00520   88 vgslsglrvlrLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYqLFGGKLKTWENPDNGRTN 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 2434 stasplgmphgaaafvdtcsgdkmdcvsglsvpevleedreldsteraCDTLLMCIVTVMNhgLRNGGGVGDILRKPSkD 2513
Cdd:pfam00520  168 ------------------------------------------------FDNFPNAFLWLFQ--TMTTEGWGDIMYDTI-D 196

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 2462608307 2514 ESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQ 2555
Cdd:pfam00520  197 GKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
RYDR_ITPR pfam01365
RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types ...
 1218-1330 8.84e-04

RIH domain; The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels. This region is found in the ryanodine receptor and the inositol-1,4,5- trisphosphate receptor. This domain may form a binding site for IP3.


Pssm-ID: 460175  Cd Length: 199  Bit Score: 42.96  E-value: 8.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462608307 1218 KKQQRLLKNMDAHKVML---DLLQIPY-----------DKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTP 1283
Cdd:pfam01365   32 RQRQNLMREQGVLETVMeviDLLGAPFtgallfaedlgEEKNAPWKKIVRLCYRLLAYSCRGNRKNQEAIAKHLDWLQSQ 111

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462608307 1284 --------GLLeaETMQHIFLNNYQLC-SEISEPVLQHFVHLLATHGRHVQYLDFL 1330
Cdd:pfam01365  112 lgspslaeGTL--DVLTALLMDNPELLlNYIKECHIKSFISLLRKHGRDPRYLDFL 165
beta-trefoil_MIR_PMT cd23276
MIR domain, beta-trefoil fold, found in the family of dolichyl-phosphate-mannose-protein ...
 143-211 5.72e-03

MIR domain, beta-trefoil fold, found in the family of dolichyl-phosphate-mannose-protein mannosyltransferase (PMT); The PMT (EC 2.4.1.109) family includes mammalian protein O-mannosyl-transferases (POMT1 and POMT2) and yeast PMT1-7. PMTs are responsible for O-linked glycosylation of proteins. They catalyze the transfer of mannose to seryl and threonyl residues of secretory proteins. Protein O-glycosylation is essential for cell wall rigidity and cell integrity. Members in this family contain a MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 467747 [Multi-domain]  Cd Length: 185  Bit Score: 40.39  E-value: 5.72e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462608307  143 VKYGSVIQLLHMKSNKYLTVNKRlPALLEKNAMRVTldATGNEGSWLFIQPFWKLRSNGDNVVVGDKVI 211
Cdd:cd23276     66 VRDGDEVRLLHKETNRYLRTHDA-AAPVTSKHKEVS--AYPDENEDGDDNDLWVVEIVKDEGKLEDKRI 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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