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Conserved domains on  [gi|2462606765|ref|XP_054210584|]
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lysine-specific histone demethylase 2 isoform X7 [Homo sapiens]

Protein Classification

lysine-specific histone demethylase 1B( domain architecture ID 13726372)

lysine-specific histone demethylase 1B (KDM1B) demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor

EC:  1.14.99.66
Gene Symbol:  KDM1B
Gene Ontology:  GO:0008270|GO:0050660|GO:0032452|GO:0042393|GO:0034720
PubMed:  23266887|23260659

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02328 super family cl33466
lysine-specific histone demethylase 1 homolog
 302-819 3.07e-97

lysine-specific histone demethylase 1 homolog


The actual alignment was detected with superfamily member PLN02328:

Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 321.17  E-value: 3.07e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 302 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LSVGADQYLLPKDY 380
Cdd:PLN02328  163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 381 HNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVwDDKSFKGVTV----GRGAQIVNGCINNPVALMCEQLGI 456
Cdd:PLN02328  237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV-KTMKMKGDGVvaaaDLGGSVLTGINGNPLGVLARQLGL 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 457 SMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRK---DKTQLQDVPLGEKIEeiykAFIKESGIQFSELEG 533
Cdd:PLN02328  316 PLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQER 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 534 QVLQFHLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTT 613
Cdd:PLN02328  392 MLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 614 dGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGL 693
Cdd:PLN02328  471 -GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGE 546

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 694 FAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVK 771
Cdd:PLN02328  547 FFLFYSYSSVSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFhpKGIVVPDPVQAVCTRWGKDCFTYGSYSYVA 626

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 2462606765 772 TGGSGEAYDIIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02328  627 VGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 4.42e-09

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 52.70  E-value: 4.42e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462606765 138 YWVQCTKpeCRKWRQLTKEIQlTPQIAKTYRCGMKPNTAIKpetsdHCSLPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPDPKYN-----SCDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 302-819 3.07e-97

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 321.17  E-value: 3.07e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 302 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LSVGADQYLLPKDY 380
Cdd:PLN02328  163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 381 HNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVwDDKSFKGVTV----GRGAQIVNGCINNPVALMCEQLGI 456
Cdd:PLN02328  237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV-KTMKMKGDGVvaaaDLGGSVLTGINGNPLGVLARQLGL 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 457 SMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRK---DKTQLQDVPLGEKIEeiykAFIKESGIQFSELEG 533
Cdd:PLN02328  316 PLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQER 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 534 QVLQFHLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTT 613
Cdd:PLN02328  392 MLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 614 dGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGL 693
Cdd:PLN02328  471 -GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGE 546

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 694 FAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVK 771
Cdd:PLN02328  547 FFLFYSYSSVSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFhpKGIVVPDPVQAVCTRWGKDCFTYGSYSYVA 626

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 2462606765 772 TGGSGEAYDIIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02328  627 VGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 399-819 2.59e-76

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 254.72  E-value: 2.59e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 399 RQLHNFGIKVTVLEAKDRIGGRVWDDKsFKGVTVGRGAQIVNGCiNNPVALMCEQLGI----SMHKFGERCDLIQEGGRI 474
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 475 tDPTIDKRMDFHFNALLDVVSEWR-KDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQ-----------VLQFHLSN 542
Cdd:pfam01593  86 -YPGDFRRVPAGWEGLLEFGRLLSiPEKLRLGLAALASDALDEFDLDDFSLAESLLFLGRRgpgdvevwdrlIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 543 LEYACGSNLHQVSARS----WDHNEFFAQFAGDHTLLTPGYSVIIEKLAE---GLDIQLKSPVQCIDYSGDEVQVTTTDG 615
Cdd:pfam01593 165 LPFASGAFAGDPSELSaglaLPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTDG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 616 TGYSAQKVLVTVPLALLQkgAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDsKVQGADFFGHVPPSASKRGLFA 695
Cdd:pfam01593 245 EVIEADAVIVTVPLGVLK--RILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWP-DLGLLGLLSELLTGLGTAFSWL 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 696 VFYDMDPQKKHSVLMS-VIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGG 774
Cdd:pfam01593 322 TFPNRAPPGKGLLLLVyVGPGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLPQYGP 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 2462606765 775 SGEAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:pfam01593 401 GHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
399-821 8.16e-75

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 250.61  E-value: 8.16e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 399 RQLHNFGIKVTVLEAKDRIGGRVW-DDKSFKGVTVGRGAQIVNGcinNPVALM--CEQLGISMHKFGERCD---LIQEGG 472
Cdd:COG1231    24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFPNENGnalLYLGGK 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 473 RITDPTIDKRMDFHF-------NALLDVVSEWRKDKTQLQDVPLGEkieeiykaFIKESGIQFSelegqVLQFHLSNLEY 545
Cdd:COG1231   101 RVRAGEIAADLRGVAellakllRALAAALDPWAHPAAELDRESLAE--------WLRRNGASPS-----ARRLLGLLGAG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 546 ACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGL--DIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKV 623
Cdd:COG1231   168 EYGADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAV 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 624 LVTVPLALLQKgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSKRGLFAVFYDMD 701
Cdd:COG1231   248 IVTVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSN 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 702 PQ-KKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD 780
Cdd:COG1231   318 GPdGGAGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGP 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 2462606765 781 IIAEdIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 821
Cdd:COG1231   397 ALAE-PDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 4.42e-09

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 52.70  E-value: 4.42e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462606765 138 YWVQCTKpeCRKWRQLTKEIQlTPQIAKTYRCGMKPNTAIKpetsdHCSLPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPDPKYN-----SCDAPEEI 46
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 405-776 3.06e-04

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 44.06  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 405 GIKVTVLEAKDRIGGRVWDDKSfKGVTVGRGAQIVNGcINNPVALMCEQLGIS----MHKFGERCDLIQEGGRITDPT-I 479
Cdd:TIGR00562  29 PVELTLVEASDRVGGKIQTVKE-DGYLIERGPDSFLE-RKKSAPDLVKDLGLEhvlvSDATGQRYVLVNRGKLMPVPTkI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 480 DKRMDFHFNAL---LDVVSEWRKDKTQLQDVPLG---------EKIEEIYKAFIkeSGIQFSELEGQVL-----QFHLSN 542
Cdd:TIGR00562 107 APFVKTGLFSLggkLRAGMDFIRPASPGKDESVEefvrrrfgdEVVENLIEPLL--SGIYAGDPSKLSLkstfpKFYQTE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 543 LEYacGS---------NLHQvSARSWDHNEFFAQFAGdhtlltpGYSVIIEKLAEGLDIQLK-------SPVQCIDYSGD 606
Cdd:TIGR00562 185 QKH--GSlilgmkktrNLPQ-GSGLQLTAKKQGQDFQ-------TLATGLETLPEEIEKRLKltkvykgTKVTKLSHRGS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 607 EVQVTTTDGTGYSAQKVLVTVPlallQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGadfFGHVPP 686
Cdd:TIGR00562 255 NYTLELDNGVTVETDSVVVTAP----HKAAAGLLSELSNSASSHLDKIHSPPVANVNLGFPEGSVDGELEG---FGFLIS 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 687 SASKRGLFAVFYD------MDPQKKhSVLMSVIAGEAVASVRTLDDKQVLQqcmATLRELFKEQEVP-DPTKYFVTRWST 759
Cdd:TIGR00562 328 RSSKFAILGCIFTsklfpnRAPPGK-TLLTAYIGGATDESIVDLSENEIIN---IVLRDLKKVLNINnEPEMLCVTRWHR 403

                         410       420
                  ....*....|....*....|....*.
gi 2462606765 760 ---------DPWIQMAYSFVKTGGSG 776
Cdd:TIGR00562 404 aipqyhvghDQRLKEARELLESAYPG 429
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 302-819 3.07e-97

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 321.17  E-value: 3.07e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 302 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LSVGADQYLLPKDY 380
Cdd:PLN02328  163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 381 HNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVwDDKSFKGVTV----GRGAQIVNGCINNPVALMCEQLGI 456
Cdd:PLN02328  237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV-KTMKMKGDGVvaaaDLGGSVLTGINGNPLGVLARQLGL 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 457 SMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRK---DKTQLQDVPLGEKIEeiykAFIKESGIQFSELEG 533
Cdd:PLN02328  316 PLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQER 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 534 QVLQFHLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTT 613
Cdd:PLN02328  392 MLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 614 dGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGL 693
Cdd:PLN02328  471 -GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGE 546

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 694 FAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVK 771
Cdd:PLN02328  547 FFLFYSYSSVSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFhpKGIVVPDPVQAVCTRWGKDCFTYGSYSYVA 626

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 2462606765 772 TGGSGEAYDIIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02328  627 VGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
PLN03000 PLN03000
amine oxidase
 307-820 1.89e-96

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 320.81  E-value: 1.89e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 307 YLALRNLILALWYTNCKEALTPQKCIphiivrGLVRIRCVQEVERILYFMTRKGLINTGVLSVGADQYllPKDYHNKSVI 386
Cdd:PLN03000  117 YILIRNHIISKWRENISSWVTKEMFL------GSIPKHCSSLLDSAYNYLVTHGYINFGIAQAIKDKF--PAQSSKSSVV 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 387 IIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDK---SFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGE 463
Cdd:PLN03000  189 IVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKmeaNRVGAAADLGGSVLTGTLGNPLGIIARQLGSSLYKVRD 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 464 RCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTQLQ-DVPLGEKIEeiykAFIKESGIQFSELEGQVLQFHLSN 542
Cdd:PLN03000  269 KCPLYRVDGKPVDPDVDLKVEVAFNQLLDKASKLRQLMGDVSmDVSLGAALE----TFRQVSGNDVATEEMGLFNWHLAN 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 543 LEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTTDGTgYSAQK 622
Cdd:PLN03000  345 LEYANAGLVSKLSLAFWDQDDPY-DMGGDHCFLPGGNGRLVQALAENVPILYEKTVQTIRYGSNGVKVIAGNQV-YEGDM 422

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 623 VLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGLFAVFYDMDP 702
Cdd:PLN03000  423 VLCTVPLGVLKNGSIKFVPELPQRKLDCIKRLGFGLLNKVAMLFPYVFWSTDL---DTFGHLTEDPNYRGEFFLFYSYAP 499

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 703 QKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQ--EVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD 780
Cdd:PLN03000  500 VAGGPLLIALVAGEAAHKFETMPPTDAVTRVLHILRGIYEPQgiNVPDPLQTVCTRWGGDPFSLGSYSNVAVGASGDDYD 579

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 2462606765 781 IIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKIA 820
Cdd:PLN03000  580 ILAESVgDGRLFFAGEATTRRYPATMHGAFVTGLREAANMA 620
PLN02529 PLN02529
lysine-specific histone demethylase 1
 307-819 8.97e-96

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 315.29  E-value: 8.97e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 307 YLALRNLILALWYTNCKEALTpqkciphiivRGLVRIRCVQEVERILY----FMTRKGLINTGVLSVGADQylLPKDYHN 382
Cdd:PLN02529   93 YIVVRNHILARWRSNVGIWLS----------KGQIKETVSSEYEHLISaaydFLLYNGYINFGVSPSFASP--IPEEGTE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 383 KSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDK-SFKG--VTVGRGAQIVNGCINNPVALMCEQLGISMH 459
Cdd:PLN02529  161 GSVIIVGAGLAGLAAARQLLSFGFKVVVLEGRNRPGGRVYTQKmGRKGqfAAVDLGGSVITGIHANPLGVLARQLSIPLH 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 460 KFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTQL-QDVPLGEKIEEIYKAFikesGIQFSELEGQVLQF 538
Cdd:PLN02529  241 KVRDNCPLYKPDGALVDKEIDSNIEFIFNKLLDKVTELRQIMGGFaNDISLGSVLERLRQLY----GVARSTEERQLLDW 316

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 539 HLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTTDGTgY 618
Cdd:PLN02529  317 HLANLEYANAGCLSDLSAAYWDQDDPY-EMGGDHCFLAGGNWRLINALCEGVPIFYGKTVDTIKYGNDGVEVIAGSQV-F 394

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 619 SAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGLFAVFY 698
Cdd:PLN02529  395 QADMVLCTVPLGVLKKRTIRFEPELPRRKLAAIDRLGFGLLNKVAMVFPSVFWGEEL---DTFGCLNESSNKRGEFFLFY 471

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 699 DMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSG 776
Cdd:PLN02529  472 GYHTVSGGPALVALVAGEAAQRFENTDPSTLLHRVLSVLRGIYnpKGINVPDPIQTICTRWGSDPLSYGSYSHVRVQSSG 551

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 2462606765 777 EAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02529  552 SDYDILAESVSGRLFFAGEATTRQYPATMHGAFLSGLREASRI 594
PLN02976 PLN02976
amine oxidase
 383-819 5.96e-83

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 291.00  E-value: 5.96e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765  383 KSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDKSFKGVTVGRGAQIVNGC--------INNPVALMCEQL 454
Cdd:PLN02976   694 KKIIVVGAGPAGLTAARHLQRQGFSVTVLEARSRIGGRVYTDRSSLSVPVDLGASIITGVeadvaterRPDPSSLICAQL 773

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765  455 GISMHKFGERCDL--IQEGGRITDpTIDKRMDFHFNALLD----VVSE-----------------------------WRK 499
Cdd:PLN02976   774 GLELTVLNSDCPLydVVTGEKVPA-DLDEALEAEYNSLLDdmvlLVAQkgehamkmsledgleyalkrrrmprpgvdIDE 852

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765  500 DKTQLQDVPL--GEKIEEIYKAFIKESGIQF-SELEGQVLQFHLSNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLT 576
Cdd:PLN02976   853 TELGNAADDLydSASTGVDGGHCEKESKEDVlSPLERRVMNWHFAHLEYGCAALLKEVSLPYWNQDDVYGGFGGAHCMIK 932

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765  577 PGYSVIIEKLAEGLDIQLKSPVQCIDYSGDE----------VQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEK 646
Cdd:PLN02976   933 GGYSNVVESLAEGLDIHLNHVVTDVSYGSKDagasgssrkkVKVSTSNGSEFLGDAVLITVPLGCLKAETIKFSPPLPDW 1012

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765  647 KMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDD 726
Cdd:PLN02976  1013 KYSSIQRLGFGVLNKVVLEFPEVFWDDSV---DYFGATAEETDLRGQCFMFWNVKKTVGAPVLIALVVGKAAIDGQSMSS 1089

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765  727 KQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIQGTVFFAGEATNRHFPQTVT 806
Cdd:PLN02976  1090 SDHVNHALMVLRKLFGEALVPDPVASVVTDWGRDPFSYGAYSYVAIGASGEDYDILGRPVENCLFFAGEATCKEHPDTVG 1169

                          490
                   ....*....|...
gi 2462606765  807 GAYLSGVREASKI 819
Cdd:PLN02976  1170 GAMMSGLREAVRI 1182
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 399-819 2.59e-76

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 254.72  E-value: 2.59e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 399 RQLHNFGIKVTVLEAKDRIGGRVWDDKsFKGVTVGRGAQIVNGCiNNPVALMCEQLGI----SMHKFGERCDLIQEGGRI 474
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 475 tDPTIDKRMDFHFNALLDVVSEWR-KDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQ-----------VLQFHLSN 542
Cdd:pfam01593  86 -YPGDFRRVPAGWEGLLEFGRLLSiPEKLRLGLAALASDALDEFDLDDFSLAESLLFLGRRgpgdvevwdrlIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 543 LEYACGSNLHQVSARS----WDHNEFFAQFAGDHTLLTPGYSVIIEKLAE---GLDIQLKSPVQCIDYSGDEVQVTTTDG 615
Cdd:pfam01593 165 LPFASGAFAGDPSELSaglaLPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTDG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 616 TGYSAQKVLVTVPLALLQkgAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDsKVQGADFFGHVPPSASKRGLFA 695
Cdd:pfam01593 245 EVIEADAVIVTVPLGVLK--RILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWP-DLGLLGLLSELLTGLGTAFSWL 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 696 VFYDMDPQKKHSVLMS-VIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGG 774
Cdd:pfam01593 322 TFPNRAPPGKGLLLLVyVGPGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLPQYGP 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 2462606765 775 SGEAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:pfam01593 401 GHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
399-821 8.16e-75

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 250.61  E-value: 8.16e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 399 RQLHNFGIKVTVLEAKDRIGGRVW-DDKSFKGVTVGRGAQIVNGcinNPVALM--CEQLGISMHKFGERCD---LIQEGG 472
Cdd:COG1231    24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFPNENGnalLYLGGK 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 473 RITDPTIDKRMDFHF-------NALLDVVSEWRKDKTQLQDVPLGEkieeiykaFIKESGIQFSelegqVLQFHLSNLEY 545
Cdd:COG1231   101 RVRAGEIAADLRGVAellakllRALAAALDPWAHPAAELDRESLAE--------WLRRNGASPS-----ARRLLGLLGAG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 546 ACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGL--DIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKV 623
Cdd:COG1231   168 EYGADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAV 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 624 LVTVPLALLQKgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSKRGLFAVFYDMD 701
Cdd:COG1231   248 IVTVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSN 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 702 PQ-KKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD 780
Cdd:COG1231   318 GPdGGAGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGP 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 2462606765 781 IIAEdIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 821
Cdd:COG1231   397 ALAE-PDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
PLN02268 PLN02268
probable polyamine oxidase
 384-819 3.55e-70

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 237.66  E-value: 3.55e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 384 SVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDKSFkGVTVGRGAQIVNG-CINNPVALMCEQLGISMHKFG 462
Cdd:PLN02268    2 SVIVIGGGIAGIAAARALHDASFKVTLLESRDRIGGRVHTDYSF-GFPVDMGASWLHGvCNENPLAPLIGRLGLPLYRTS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 463 -----------ERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDktQLQDVPLGEKIEEIYK--AFIKESGIQFs 529
Cdd:PLN02268   81 gdnsvlydhdlESYALFDMDGNQVPQELVTKVGETFERILEETEKVRDE--HEEDMSLLQAISIVLErhPELRLEGLAH- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 530 elegQVLQFHLSNLEYACGSNLHQVSARSWDHNEFFAqfaGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQ 609
Cdd:PLN02268  158 ----EVLQWYLCRMEGWFAADADTISLKSWDQEELLE---GGHGLMVRGYDPVINTLAKGLDIRLNHRVTKIVRRYNGVK 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 610 VTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSkvqgADFFGHVPPSAS 689
Cdd:PLN02268  231 VTVEDGTTFVADAAIIAVPLGVLKANIIKFEPELPEWKEEAISDLGVGIENKIALHFDSVFWPN----VEFLGVVAPTSY 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 690 KRGLfavFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKeqEVPDPTKYFVTRWSTDPWIQMAYSF 769
Cdd:PLN02268  307 GCSY---FLNLHKATGHPVLVYMPAGRLARDIEKLSDEAAANFAMSQLKKMLP--DATEPVQYLVSRWGSDPNSLGCYSY 381

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462606765 770 VKTGGSGEAYDIIAEDIqGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02268  382 DLVGKPHDLYERLRAPV-DNLFFAGEATSSDFPGSVHGAYSTGVMAAEEC 430
PLN02676 PLN02676
polyamine oxidase
 384-819 7.49e-42

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 159.88  E-value: 7.49e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 384 SVIIIGAGPAGLAAARQLHNFGIK-VTVLEAKDRIGGRVwDDKSFKGVTVGRGA---QIVNGCINNPVALMCEQLGISMh 459
Cdd:PLN02676   28 SVIIVGAGMSGISAAKTLSEAGIEdILILEATDRIGGRM-RKANFAGVSVELGAnwvEGVGGPESNPIWELANKLKLRT- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 460 kFGERCDLI------QEGGRITDPTIDKRMDfhfnaLLDVVSEW------RKDKTQLQDVPLgEKIEEIYKAFIKesgiq 527
Cdd:PLN02676  106 -FYSDFDNLssniykQDGGLYPKKVVQKSMK-----VADASDEFgenlsiSLSAKKAVDISI-LTAQRLFGQVPK----- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 528 fSELEgQVLQFHLSNLEYAcgSNLHQVSARSWDHNEFFAQFAGDHTLLTP--GYSVIIEKLAEG---------LD--IQL 594
Cdd:PLN02676  174 -TPLE-MVIDYYNYDYEFA--EPPRVTSLKNTEPNPTFVDFGEDEYFVADprGYESLVYYLAEQflstksgkiTDprLKL 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 595 KSPVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSK 674
Cdd:PLN02676  250 NKVVREISYSKNGVTVKTEDGSVYRAKYVIVSVSLGVLQSDLIKFKPPLPDWKIEAIYQFDMAVYTKIFLKFPYKFWPSG 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 675 vQGADFFGHvppSASKRGLFAVFYDMDPQKKHS--VLMSVIAGEAvASVRTLDDKQVLQQCMATLRELFKEQeVPDPTKY 752
Cdd:PLN02676  330 -PGTEFFLY---AHERRGYYPFWQHLENEYPGSnvLFVTVTDEES-RRIEQQPDSETKAEIMEVLRKMFGPN-IPEATDI 403

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462606765 753 FVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIqGTVFFAGEATNRHFPQTVTGAYLSGVrEASKI 819
Cdd:PLN02676  404 LVPRWWSNRFFKGSYSNWPIGVSRYEFDQIRAPV-GRVYFTGEHTSEKYNGYVHGAYLAGI-DTAND 468
PLN02568 PLN02568
polyamine oxidase
 407-819 9.93e-39

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 151.91  E-value: 9.93e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 407 KVTVLEAKDRIGGRVwDDKSFKGVTVGRGAQIVNGCINNPV--------ALMCEQLGISMHKFGERCDLIQEGGRITDPT 478
Cdd:PLN02568   35 ELTVVEGGDRIGGRI-NTSEFGGERIEMGATWIHGIGGSPVykiaqeagSLESDEPWECMDGFPDRPKTVAEGGFEVDPS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 479 IDKRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIE----------------------EIYKAFIKE-------SGIQFS 529
Cdd:PLN02568  114 IVESISTLFRGLMDDAQGKLIEPSEVDEVDFVKLAAkaarvcesggggsvgsflrrglDAYWDSVSAdeqikgyGGWSRK 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 530 ELEGQVLQFHlSNLE--YACGSNLHQVSarsWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLD---IQLKSPVQCIDYS 604
Cdd:PLN02568  194 LLEEAIFTMH-ENTQrtYTSADDLSTLD---LAAESEYRMFPGEEITIAKGYLSVIEALASVLPpgtIQLGRKVTRIEWQ 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 605 GDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQ----FNPPLSEKKMKAINSLGAGIIEKIALQFPYRFwDSKVQGAD- 679
Cdd:PLN02568  270 DEPVKLHFADGSTMTADHVIVTVSLGVLKAGIGEdsglFSPPLPDFKTDAISRLGFGVVNKLFVELSPRP-DGSPEDVAk 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 680 -------FFGHVPPSASK------RGLFAVFydmdP-QKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQE 745
Cdd:PLN02568  349 fpflqmaFHRSDSEARHDkipwwmRRTASIC----PiHKNSSVLLSWFAGKEALELEKLSDEEIIRGVQTTLSSFLKRRV 424

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 746 VPDP---------------------TKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIQGT------------VFF 792
Cdd:PLN02568  425 AGLGsqshplcnggassndgsrwkfVKVLKSKWGTDPLFLGSYSYVAVGSSGDDLDRMAEPLPRIsdhdqaggpplqLLF 504

                         490       500
                  ....*....|....*....|....*..
gi 2462606765 793 AGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02568  505 AGEATHRTHYSTTHGAYFSGLREANRL 531
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 4.42e-09

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 52.70  E-value: 4.42e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462606765 138 YWVQCTKpeCRKWRQLTKEIQlTPQIAKTYRCGMKPNTAIKpetsdHCSLPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPDPKYN-----SCDAPEEI 46
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 394-757 4.79e-08

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 56.38  E-value: 4.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 394 GLAAARQLHNFGIKVTVLEAKDRIGGRVwddKSF--KGVTVGRGAQIVngCINNPVAL-MCEQLGIS--MHKFGERCDLI 468
Cdd:COG1232    13 GLTAAYRLAKAGHEVTVLEASDRVGGLI---RTVevDGFRIDRGPHSF--LTRDPEVLeLLRELGLGdeLVWPNTRKSYI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 469 QEGGRITD-PTidKRMDFHFNALLDVVSEWR-------KDKTQLQDVPLGEKI-----EEIYKAFIKE--SGIqFS---- 529
Cdd:COG1232    88 YYGGKLHPlPQ--GPLALLRSPLLSLAGKLRallellaPRRPPGEDESLAEFVrrrfgREVYERLVEPllEGV-YAgdpd 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 530 ELEGQ-VLQFhLSNLEYACGSNLHQVSA--RSWDHNEFFAQFAGdhtlltpGYSVIIEKLAEGL---DIQLKSPVQCIDY 603
Cdd:COG1232   165 ELSADwAFPR-LKRLELEHGSLIKGALAlrKGAKAGEVFGYLRG-------GLGTLVEALAEALeagEIRLGTRVTAIER 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 604 SGDEVQVTTTDGTGYSAQKVLVTVPLALLQKgAIQFNPPLSEKKMKAINSLGAGIiekIALQFPyrfwDSKVQGADFFGH 683
Cdd:COG1232   237 EGGGWRVTTSDGETIEADAVVSATPAPALAR-LLAPLPPEVAAALAGIPYASVAV---VALGFD----RPDLPPPDGFGW 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 684 VPPSASKRGLFAVFY------DMDPQKKHSVLMSvIAGEAVASVRTLDDKQVLQQCMATLRELFKEQevPDPTKYFVTRW 757
Cdd:COG1232   309 LVPRDEGVPILAVTFssnkwpHRAPDGKVLLRLE-VGGAGDPELWQLSDEELVALALADLRKLLGID--AEPVDTRVVRW 385
PRK07233 PRK07233
hypothetical protein; Provisional
 578-656 2.81e-07

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 53.74  E-value: 2.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 578 GYSVIIEKLAE-----GLDIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKgaiqFNPPLSEK---KMK 649
Cdd:PRK07233  196 GFATLIDALAEaiearGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPILAR----LVPDLPADvlaRLR 271


                  ....*..
gi 2462606765 650 AINSLGA 656
Cdd:PRK07233  272 RIDYQGV 278
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
 292-363 5.35e-05

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 42.16  E-value: 5.35e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462606765 292 DELYEFPEY----SRDPTMYLALRNLILALWYTNCKEALTPQKCiphiivRGLVRIrCVQEVERILYFMTRKGLIN 363
Cdd:pfam04433   9 IEKRLLPEFfngkSKTPEVYLEIRNFILNLWRENPKEYLTKTDA------RRALKG-DVNLISRIHEFLERWGLIN 77
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 405-776 3.06e-04

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 44.06  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 405 GIKVTVLEAKDRIGGRVWDDKSfKGVTVGRGAQIVNGcINNPVALMCEQLGIS----MHKFGERCDLIQEGGRITDPT-I 479
Cdd:TIGR00562  29 PVELTLVEASDRVGGKIQTVKE-DGYLIERGPDSFLE-RKKSAPDLVKDLGLEhvlvSDATGQRYVLVNRGKLMPVPTkI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 480 DKRMDFHFNAL---LDVVSEWRKDKTQLQDVPLG---------EKIEEIYKAFIkeSGIQFSELEGQVL-----QFHLSN 542
Cdd:TIGR00562 107 APFVKTGLFSLggkLRAGMDFIRPASPGKDESVEefvrrrfgdEVVENLIEPLL--SGIYAGDPSKLSLkstfpKFYQTE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 543 LEYacGS---------NLHQvSARSWDHNEFFAQFAGdhtlltpGYSVIIEKLAEGLDIQLK-------SPVQCIDYSGD 606
Cdd:TIGR00562 185 QKH--GSlilgmkktrNLPQ-GSGLQLTAKKQGQDFQ-------TLATGLETLPEEIEKRLKltkvykgTKVTKLSHRGS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 607 EVQVTTTDGTGYSAQKVLVTVPlallQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGadfFGHVPP 686
Cdd:TIGR00562 255 NYTLELDNGVTVETDSVVVTAP----HKAAAGLLSELSNSASSHLDKIHSPPVANVNLGFPEGSVDGELEG---FGFLIS 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606765 687 SASKRGLFAVFYD------MDPQKKhSVLMSVIAGEAVASVRTLDDKQVLQqcmATLRELFKEQEVP-DPTKYFVTRWST 759
Cdd:TIGR00562 328 RSSKFAILGCIFTsklfpnRAPPGK-TLLTAYIGGATDESIVDLSENEIIN---IVLRDLKKVLNINnEPEMLCVTRWHR 403

                         410       420
                  ....*....|....*....|....*.
gi 2462606765 760 ---------DPWIQMAYSFVKTGGSG 776
Cdd:TIGR00562 404 aipqyhvghDQRLKEARELLESAYPG 429
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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