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Conserved domains on  [gi|2462604235|ref|XP_054209394|]
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complement component C6 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MACPF smart00457
membrane-attack complex / perforin;
313-514 1.20e-59

membrane-attack complex / perforin;


:

Pssm-ID: 214671  Cd Length: 195  Bit Score: 202.28  E-value: 1.20e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235  313 FIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLT 392
Cdd:smart00457   1 FLVARDTVRNRLYSVKLDELPLALEFLKALRDLPDTYNRGAYARFIDDYGTHYITSATLGGEYSLLLVLDKESLERKGLT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235  393 EEEAKHCVRIEtkkRVLFAKKTKVEHrCTTNKLSEKHEGSFiqGAEKSISLIRGGRSEYGAALAWEKGSSGLeekTFSEW 472
Cdd:smart00457  81 SEDISKCLAGS---SNSFAGSVSAEH-CLQSSSYIKYLSTS--LRRESHTQVLGGHVTVLCDLLRGPSSNSL---DFSDW 151

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2462604235  473 LESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEY 514
Cdd:smart00457 152 AESVPNEPVLIDVSLAPIYELLPPNPELSQKREALRQALRSY 193
FIMAC smart00057
factor I membrane attack complex;
890-962 5.25e-20

factor I membrane attack complex;


:

Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 84.52  E-value: 5.25e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462604235  890 CGYDTCYDWEKCSASTskCVCLLPPQCFKGGnQLYCVKMGSStsEKTLNICEVGTIRCANRKMEILHPGKCLA 962
Cdd:smart00057   1 CAKGFCQLWQKCSAST--CVCKLPYECPKAG-TDVCVEDGRS--EKTLTYCKQGALRCLNQKYKFLHIGSCTA 68
FIMAC smart00057
factor I membrane attack complex;
787-867 1.48e-16

factor I membrane attack complex;


:

Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 74.89  E-value: 1.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235  787 KLKGHCQLGQKQSGSECICMSPEEdcrnaCFpllgsHHSEDLCVFDTDSndYFTSPACKFLAEKCLnNQQLHFLHIGSCQ 866
Cdd:smart00057   1 CAKGFCQLWQKCSASTCVCKLPYE-----CP-----KAGTDVCVEDGRS--EKTLTYCKQGALRCL-NQKYKFLHIGSCT 67


                   .
gi 2462604235  867 D 867
Cdd:smart00057  68 A 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 587-642 2.56e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.83  E-value: 2.56e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462604235  587 WGCWSSWSTCDAT---YKRSRTRECNNPAPQRGGKRCEGEKRQEEDCtfsimenNGQPC 642
Cdd:smart00209   1 WSEWSEWSPCSVTcggGVQTRTRSCCSPPPQNGGGPCTGEDVETRAC-------NEQPC 52
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 142-173 2.51e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.51e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462604235 142 NKFRCDSGRCIARKLECNGENDCGDNSDERDC 173
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 663-719 3.74e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 3.74e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462604235 663 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQ 719
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
PHA02831 super family cl31511
EEV host range protein; Provisional
 663-785 4.03e-09

EEV host range protein; Provisional


The actual alignment was detected with superfamily member PHA02831:

Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 58.47  E-value: 4.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 663 CPQPVPPENGFIRNEKQLYLVGEDVEISC----LTGFETVGYQYFRCLpDGTWRQGDVECQRTECIKPVVQEVLtITPFQ 738
Cdd:PHA02831   78 CKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNETVKCI-NKQWVPKYPVCKLIRCKYPALQNGF-LNVFE 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462604235 739 RLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPISNsltCEKDTL 785
Cdd:PHA02831  156 KKFYYGDIVNFKCKKGFILLGSSVSTCDINSiWYPGIPK---CVKDKV 200
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 26-79 1.64e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.64e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462604235   26 HYAWTQWTSCSKTCNSGTQSRHRQIVVdkyYQENFCEQICSKQ--ETRECNWQRCP 79
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGEdvETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
85-133 8.50e-05

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 40.86  E-value: 8.50e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462604235  85 GDFGPWSDCDPCIEKQSKVRSVLRPSQF-GGQPCTAPLVAFQPCiPSKLC 133
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFpGGEPCTGDDIETQAC-KMDKC 49
 
Name Accession Description Interval E-value
MACPF smart00457
membrane-attack complex / perforin;
313-514 1.20e-59

membrane-attack complex / perforin;


Pssm-ID: 214671  Cd Length: 195  Bit Score: 202.28  E-value: 1.20e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235  313 FIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLT 392
Cdd:smart00457   1 FLVARDTVRNRLYSVKLDELPLALEFLKALRDLPDTYNRGAYARFIDDYGTHYITSATLGGEYSLLLVLDKESLERKGLT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235  393 EEEAKHCVRIEtkkRVLFAKKTKVEHrCTTNKLSEKHEGSFiqGAEKSISLIRGGRSEYGAALAWEKGSSGLeekTFSEW 472
Cdd:smart00457  81 SEDISKCLAGS---SNSFAGSVSAEH-CLQSSSYIKYLSTS--LRRESHTQVLGGHVTVLCDLLRGPSSNSL---DFSDW 151

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2462604235  473 LESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEY 514
Cdd:smart00457 152 AESVPNEPVLIDVSLAPIYELLPPNPELSQKREALRQALRSY 193
MACPF pfam01823
MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms ...
 294-514 2.54e-54

MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.


Pssm-ID: 460349  Cd Length: 211  Bit Score: 188.00  E-value: 2.54e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 294 NHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFT-TKAKDLHLSDVFLKALNHLPLEYNSAL---YSRIFDDFGTHYFTSG 369
Cdd:pfam01823   4 SASSEFKKMSDKSKQKKKSLIISKSTCSLYQFTlKRSNKLQLSDEFLQALSDLPDNYDYAAkatYIQFFDKYGTHYITSV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 370 SLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIEtkkrVLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRS 449
Cdd:pfam01823  84 TLGGKIVYVLKLDKSQLEDLKLKGEDVKICLSAS----AGASIGSVNLKGCSKNSSSTKEKKSFNQEIESSITLVIGGTP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462604235 450 EYGAAlawekgssglEEKTFSEWLESVKENPAVIDFELAPIVDLvrnIPCAVTKRNNLRKALQEY 514
Cdd:pfam01823 160 ESIDD----------DSKTYSDWAESVKDNPMPIDFELTPISEL---LKGVPLKKENLRKALEEY 211
FIMAC smart00057
factor I membrane attack complex;
890-962 5.25e-20

factor I membrane attack complex;


Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 84.52  E-value: 5.25e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462604235  890 CGYDTCYDWEKCSASTskCVCLLPPQCFKGGnQLYCVKMGSStsEKTLNICEVGTIRCANRKMEILHPGKCLA 962
Cdd:smart00057   1 CAKGFCQLWQKCSAST--CVCKLPYECPKAG-TDVCVEDGRS--EKTLTYCKQGALRCLNQKYKFLHIGSCTA 68
FIMAC smart00057
factor I membrane attack complex;
787-867 1.48e-16

factor I membrane attack complex;


Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 74.89  E-value: 1.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235  787 KLKGHCQLGQKQSGSECICMSPEEdcrnaCFpllgsHHSEDLCVFDTDSndYFTSPACKFLAEKCLnNQQLHFLHIGSCQ 866
Cdd:smart00057   1 CAKGFCQLWQKCSASTCVCKLPYE-----CP-----KAGTDVCVEDGRS--EKTLTYCKQGALRCL-NQKYKFLHIGSCT 67


                   .
gi 2462604235  867 D 867
Cdd:smart00057  68 A 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 587-642 2.56e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.83  E-value: 2.56e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462604235  587 WGCWSSWSTCDAT---YKRSRTRECNNPAPQRGGKRCEGEKRQEEDCtfsimenNGQPC 642
Cdd:smart00209   1 WSEWSEWSPCSVTcggGVQTRTRSCCSPPPQNGGGPCTGEDVETRAC-------NEQPC 52
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 142-173 2.51e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.51e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462604235 142 NKFRCDSGRCIARKLECNGENDCGDNSDERDC 173
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 663-719 3.74e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 3.74e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462604235 663 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQ 719
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
PHA02831 PHA02831
EEV host range protein; Provisional
 663-785 4.03e-09

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 58.47  E-value: 4.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 663 CPQPVPPENGFIRNEKQLYLVGEDVEISC----LTGFETVGYQYFRCLpDGTWRQGDVECQRTECIKPVVQEVLtITPFQ 738
Cdd:PHA02831   78 CKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNETVKCI-NKQWVPKYPVCKLIRCKYPALQNGF-LNVFE 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462604235 739 RLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPISNsltCEKDTL 785
Cdd:PHA02831  156 KKFYYGDIVNFKCKKGFILLGSSVSTCDINSiWYPGIPK---CVKDKV 200
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
142-173 4.33e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 4.33e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462604235 142 NKFRCDSGRCIARKLECNGENDCGDNSDERDC 173
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 663-718 2.84e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.99  E-value: 2.84e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462604235  663 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVEC 718
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
663-718 8.25e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.81  E-value: 8.25e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462604235 663 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVEC 718
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 142-170 8.35e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.78  E-value: 8.35e-08
                           10        20
                   ....*....|....*....|....*....
gi 2462604235  142 NKFRCDSGRCIARKLECNGENDCGDNSDE 170
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 26-79 1.64e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.64e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462604235   26 HYAWTQWTSCSKTCNSGTQSRHRQIVVdkyYQENFCEQICSKQ--ETRECNWQRCP 79
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGEdvETRACNEQPCP 53
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 663-774 1.65e-07

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 53.89  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 663 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRClPDGTWRQGDVeCQRTECIKPVVQEVLTITPFQRLYR 742
Cdd:PHA02927  148 CQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLC-SGGEWSDPPT-CQIVKCPHPTISNGYLSSGFKRSYS 225

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462604235 743 IGESIELTCPKGFVVAGPSRYTCQ-GNSWTPPI 774
Cdd:PHA02927  226 YNDNVDFKCKYGYKLSGSSSSTCSpGNTWQPEL 258
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 28-78 8.53e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 46.50  E-value: 8.53e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462604235  28 AWTQWTSCSKTCNSGTQSRHRQIVVdkyyQENFCEQIC-SKQETRECNWQRC 78
Cdd:pfam19028   5 EWSEWSECSVTCGGGVQTRTRTVIV----EPQNGGRPCpELLERRPCNLPPC 52
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 723-774 1.45e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 43.28  E-value: 1.45e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462604235  723 CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGN-SWTPPI 774
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENgTWSPPP 53
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 723-781 1.70e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.22  E-value: 1.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 723 CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPIsnsLTCE 781
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGgWSPPP---PTCE 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
85-133 8.50e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 40.86  E-value: 8.50e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462604235  85 GDFGPWSDCDPCIEKQSKVRSVLRPSQF-GGQPCTAPLVAFQPCiPSKLC 133
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFpGGEPCTGDDIETQAC-KMDKC 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 29-80 1.51e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 45.73  E-value: 1.51e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462604235  29 WTQWTSCSKTCNSGTQSRHRQIVVDKyyqenfceqiCSKQETRECNWQRCPI 80
Cdd:PTZ00441  243 WDEWTPCSVTCGKGTHSRSRPILHEG----------CTTHMVEECEEEECPV 284
Sushi pfam00084
Sushi repeat (SCR repeat);
741-773 9.21e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 38.25  E-value: 9.21e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462604235 741 YRIGESIELTCPKGFVVAGPSRYTCQGN-SWTPP 773
Cdd:pfam00084  19 YNYGASVSYECDPGYRLVGSPTITCQEDgTWSPP 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 590-642 5.55e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.72  E-value: 5.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462604235 590 WSSWSTCDATY---KRSRTRECNNPaPQRGGKRCeGEKRQEEDCtfsimenNGQPC 642
Cdd:pfam19028   6 WSEWSECSVTCgggVQTRTRTVIVE-PQNGGRPC-PELLERRPC-------NLPPC 52
 
Name Accession Description Interval E-value
MACPF smart00457
membrane-attack complex / perforin;
313-514 1.20e-59

membrane-attack complex / perforin;


Pssm-ID: 214671  Cd Length: 195  Bit Score: 202.28  E-value: 1.20e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235  313 FIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLT 392
Cdd:smart00457   1 FLVARDTVRNRLYSVKLDELPLALEFLKALRDLPDTYNRGAYARFIDDYGTHYITSATLGGEYSLLLVLDKESLERKGLT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235  393 EEEAKHCVRIEtkkRVLFAKKTKVEHrCTTNKLSEKHEGSFiqGAEKSISLIRGGRSEYGAALAWEKGSSGLeekTFSEW 472
Cdd:smart00457  81 SEDISKCLAGS---SNSFAGSVSAEH-CLQSSSYIKYLSTS--LRRESHTQVLGGHVTVLCDLLRGPSSNSL---DFSDW 151

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2462604235  473 LESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEY 514
Cdd:smart00457 152 AESVPNEPVLIDVSLAPIYELLPPNPELSQKREALRQALRSY 193
MACPF pfam01823
MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms ...
 294-514 2.54e-54

MAC/Perforin domain; The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.


Pssm-ID: 460349  Cd Length: 211  Bit Score: 188.00  E-value: 2.54e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 294 NHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFT-TKAKDLHLSDVFLKALNHLPLEYNSAL---YSRIFDDFGTHYFTSG 369
Cdd:pfam01823   4 SASSEFKKMSDKSKQKKKSLIISKSTCSLYQFTlKRSNKLQLSDEFLQALSDLPDNYDYAAkatYIQFFDKYGTHYITSV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 370 SLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIEtkkrVLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRS 449
Cdd:pfam01823  84 TLGGKIVYVLKLDKSQLEDLKLKGEDVKICLSAS----AGASIGSVNLKGCSKNSSSTKEKKSFNQEIESSITLVIGGTP 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462604235 450 EYGAAlawekgssglEEKTFSEWLESVKENPAVIDFELAPIVDLvrnIPCAVTKRNNLRKALQEY 514
Cdd:pfam01823 160 ESIDD----------DSKTYSDWAESVKDNPMPIDFELTPISEL---LKGVPLKKENLRKALEEY 211
FIMAC smart00057
factor I membrane attack complex;
890-962 5.25e-20

factor I membrane attack complex;


Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 84.52  E-value: 5.25e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462604235  890 CGYDTCYDWEKCSASTskCVCLLPPQCFKGGnQLYCVKMGSStsEKTLNICEVGTIRCANRKMEILHPGKCLA 962
Cdd:smart00057   1 CAKGFCQLWQKCSAST--CVCKLPYECPKAG-TDVCVEDGRS--EKTLTYCKQGALRCLNQKYKFLHIGSCTA 68
FIMAC smart00057
factor I membrane attack complex;
787-867 1.48e-16

factor I membrane attack complex;


Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 74.89  E-value: 1.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235  787 KLKGHCQLGQKQSGSECICMSPEEdcrnaCFpllgsHHSEDLCVFDTDSndYFTSPACKFLAEKCLnNQQLHFLHIGSCQ 866
Cdd:smart00057   1 CAKGFCQLWQKCSASTCVCKLPYE-----CP-----KAGTDVCVEDGRS--EKTLTYCKQGALRCL-NQKYKFLHIGSCT 67


                   .
gi 2462604235  867 D 867
Cdd:smart00057  68 A 68
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 587-642 2.56e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.83  E-value: 2.56e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462604235  587 WGCWSSWSTCDAT---YKRSRTRECNNPAPQRGGKRCEGEKRQEEDCtfsimenNGQPC 642
Cdd:smart00209   1 WSEWSEWSPCSVTcggGVQTRTRSCCSPPPQNGGGPCTGEDVETRAC-------NEQPC 52
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 142-173 2.51e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.51e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462604235 142 NKFRCDSGRCIARKLECNGENDCGDNSDERDC 173
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 663-719 3.74e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 3.74e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462604235 663 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQ 719
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
PHA02831 PHA02831
EEV host range protein; Provisional
 663-785 4.03e-09

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 58.47  E-value: 4.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 663 CPQPVPPENGFIRNEKQLYLVGEDVEISC----LTGFETVGYQYFRCLpDGTWRQGDVECQRTECIKPVVQEVLtITPFQ 738
Cdd:PHA02831   78 CKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNETVKCI-NKQWVPKYPVCKLIRCKYPALQNGF-LNVFE 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462604235 739 RLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPISNsltCEKDTL 785
Cdd:PHA02831  156 KKFYYGDIVNFKCKKGFILLGSSVSTCDINSiWYPGIPK---CVKDKV 200
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
142-173 4.33e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 4.33e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462604235 142 NKFRCDSGRCIARKLECNGENDCGDNSDERDC 173
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 663-718 2.84e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 50.99  E-value: 2.84e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462604235  663 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVEC 718
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
663-718 8.25e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.81  E-value: 8.25e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462604235 663 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVEC 718
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 142-170 8.35e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.78  E-value: 8.35e-08
                           10        20
                   ....*....|....*....|....*....
gi 2462604235  142 NKFRCDSGRCIARKLECNGENDCGDNSDE 170
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 26-79 1.64e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.64e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462604235   26 HYAWTQWTSCSKTCNSGTQSRHRQIVVdkyYQENFCEQICSKQ--ETRECNWQRCP 79
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCS---PPPQNGGGPCTGEdvETRACNEQPCP 53
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 663-774 1.65e-07

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 53.89  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 663 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRClPDGTWRQGDVeCQRTECIKPVVQEVLTITPFQRLYR 742
Cdd:PHA02927  148 CQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLC-SGGEWSDPPT-CQIVKCPHPTISNGYLSSGFKRSYS 225

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462604235 743 IGESIELTCPKGFVVAGPSRYTCQ-GNSWTPPI 774
Cdd:PHA02927  226 YNDNVDFKCKYGYKLSGSSSSTCSpGNTWQPEL 258
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 28-78 8.53e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 46.50  E-value: 8.53e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462604235  28 AWTQWTSCSKTCNSGTQSRHRQIVVdkyyQENFCEQIC-SKQETRECNWQRC 78
Cdd:pfam19028   5 EWSEWSECSVTCGGGVQTRTRTVIV----EPQNGGRPCpELLERRPCNLPPC 52
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 620-772 9.07e-06

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 48.93  E-value: 9.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 620 CEGEKRQeedctFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVppengfirneKQLYLVGEDVEISCLTGFETVG 699
Cdd:PHA02954  101 CKDETKY-----FRCEEKNGNTSWNDTVTCPNAECQPLQLEHGSCQPV----------KEKYSFGEHITINCDVGYEVIG 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462604235 700 YQYFRCLPDgTWRQGDvECQRTECIKPVVQEVLTITPFQrlyrIGESIELTCPKGFVVAGPSRYTCQGNSWTP 772
Cdd:PHA02954  166 ASYISCTAN-SWNVIP-SCQQKCDIPSLSNGLISGSTFS----IGGVIHLSCKSGFTLTGSPSSTCIDGKWNP 232
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 723-774 1.45e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 43.28  E-value: 1.45e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462604235  723 CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGN-SWTPPI 774
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENgTWSPPP 53
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 723-781 1.70e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.22  E-value: 1.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 723 CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPIsnsLTCE 781
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGgWSPPP---PTCE 57
PHA02639 PHA02639
EEV host range protein; Provisional
 663-780 2.31e-05

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 47.35  E-value: 2.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 663 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPD---GTWRQGDVECQRTECIKPVVQEVLTITPFQR 739
Cdd:PHA02639   22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDknnAIWSNKAPFCMLKECNDPPSIINGKIYNKRE 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462604235 740 LYRIGESIELTCP--KG--FVVAGPSRYTC-QGNSWT--PPISNSLTC 780
Cdd:PHA02639  102 MYKVGDEIYYVCNehKGvqYSLVGNEKITCiQDKSWKpdPPICKMINC 149
PHA02817 PHA02817
EEV Host range protein; Provisional
 667-774 3.48e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.09  E-value: 3.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 667 VPPE--NGFIRNEKQLYLVGEDVEISCltGFETVGYQY-------FRCLPDGTWRQGDVECQRTECIKPVVQE-VLTITP 736
Cdd:PHA02817   26 YPPSikNGYIYNKKTEYNIGSNVTFFC--GNNTRGVRYtlvgeknIICEKDGKWNKEFPVCKIIRCRFPALQNgFVNGIP 103

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462604235 737 FQRLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPI 774
Cdd:PHA02817  104 DSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSsWIPKV 142
TSP_1 pfam00090
Thrombospondin type 1 domain;
85-133 8.50e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 40.86  E-value: 8.50e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462604235  85 GDFGPWSDCDPCIEKQSKVRSVLRPSQF-GGQPCTAPLVAFQPCiPSKLC 133
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFpGGEPCTGDDIETQAC-KMDKC 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 29-80 1.51e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 45.73  E-value: 1.51e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462604235  29 WTQWTSCSKTCNSGTQSRHRQIVVDKyyqenfceqiCSKQETRECNWQRCPI 80
Cdd:PTZ00441  243 WDEWTPCSVTCGKGTHSRSRPILHEG----------CTTHMVEECEEEECPV 284
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 82-127 2.98e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.57  E-value: 2.98e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462604235  82 CLLGDFGPWSDCD-PC-IEKQSKVRSVLRPSQFGGQPCTaPLVAFQPC 127
Cdd:pfam19028   1 CVVSEWSEWSECSvTCgGGVQTRTRTVIVEPQNGGRPCP-ELLERRPC 47
TSP_1 pfam00090
Thrombospondin type 1 domain;
29-78 6.39e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.55  E-value: 6.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462604235  29 WTQWTSCSKTCNSGTQSRHRQIVVDKyYQENFCEQicSKQETRECNWQRC 78
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTCKSPF-PGGEPCTG--DDIETQACKMDKC 49
Sushi pfam00084
Sushi repeat (SCR repeat);
741-773 9.21e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 38.25  E-value: 9.21e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462604235 741 YRIGESIELTCPKGFVVAGPSRYTCQGN-SWTPP 773
Cdd:pfam00084  19 YNYGASVSYECDPGYRLVGSPTITCQEDgTWSPP 52
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 678-786 1.76e-03

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 41.61  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604235 678 KQLYLVGEDVEISCLTgfETvgyQYFRCLP---DGTWRQgDVECQRTECiKPVVQEVLTITPFQRLYRIGESIELTCPKG 754
Cdd:PHA02954   88 KPLYEVNSTITLICKD--ET---KYFRCEEkngNTSWND-TVTCPNAEC-QPLQLEHGSCQPVKEKYSFGEHITINCDVG 160

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462604235 755 FVVAGPSRYTCQGNSWTPPISNSLTCEKDTLT 786
Cdd:PHA02954  161 YEVIGASYISCTANSWNVIPSCQQKCDIPSLS 192
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 590-642 5.55e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.72  E-value: 5.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462604235 590 WSSWSTCDATY---KRSRTRECNNPaPQRGGKRCeGEKRQEEDCtfsimenNGQPC 642
Cdd:pfam19028   6 WSEWSECSVTCgggVQTRTRTVIVE-PQNGGRPC-PELLERRPC-------NLPPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 32-78 8.60e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.51  E-value: 8.60e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462604235  32 WTSCSKTCNSGTQSRH---RQIVVDKYYQENFCEQICSKQETRECNWQRC 78
Cdd:pfam19030   6 WGECSVTCGGGVQTRLvqcVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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