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Conserved domains on  [gi|2462602740|ref|XP_054208672|]
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peptidyl-glycine alpha-amidating monooxygenase isoform X27 [Homo sapiens]

Protein Classification

peptidyl-glycine alpha-amidating monooxygenase( domain architecture ID 10471209)

peptidyl-glycine alpha-amidating monooxygenase is a bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 500-777 3.53e-134

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


:

Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 400.10  E-value: 3.53e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 500 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 579
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 580 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 659
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 660 SPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 738
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDE-DGRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2462602740 739 GLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRK 777
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGK 267
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 196-342 1.23e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 461021  Cd Length: 157  Bit Score: 204.41  E-value: 1.23e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 196 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 264
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 265 LP--QAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 342
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 59-168 6.22e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 460053  Cd Length: 130  Bit Score: 103.49  E-value: 6.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740  59 LDIRMPGVT-PKQSDTYFCMSMRIP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 131
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462602740 132 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 168
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 500-777 3.53e-134

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 400.10  E-value: 3.53e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 500 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 579
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 580 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 659
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 660 SPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 738
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDE-DGRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2462602740 739 GLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRK 777
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGK 267
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 196-342 1.23e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 204.41  E-value: 1.23e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 196 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 264
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 265 LP--QAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 342
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 59-168 6.22e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 103.49  E-value: 6.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740  59 LDIRMPGVT-PKQSDTYFCMSMRIP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 131
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462602740 132 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 168
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
501-715 1.86e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 70.88  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 501 ALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYqqigLGPIEEDTILVIDPNNAAVLQS--SGKNlf 578
Cdd:COG3391    38 AAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLY----VANSGSGRVSVIDLATGKVVATipVGGG-- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 579 ylPHGLSIDKDGNY-WVTDVALHQVFKLDPNNKEgpvliLGRSMQPGSdqnhfcQPTDVAVDPGTGAIYVSDGYCN--SR 655
Cdd:COG3391   112 --PRGLAVDPDGGRlYVADSGNGRVSVIDTATGK-----VVATIPVGA------GPHGIAVDPDGKRLYVANSGSNtvSV 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462602740 656 IVQ-FSP-SGKFITQWgeessgssPLPGQftvPHSLALVPLLGQLCVADRENG-------RIQCFKTDT 715
Cdd:COG3391   179 IVSvIDTaTGKVVATI--------PVGGG---PVGVAVSPDGRRLYVANRGSNtsnggsnTVSVIDLAT 236
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 683-711 7.43e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.38  E-value: 7.43e-04
                          10        20
                  ....*....|....*....|....*....
gi 2462602740 683 FTVPHSLALVPLlGQLCVADRENGRIQCF 711
Cdd:pfam01436   1 FNRPHGVAVDSN-GDIYVADSENHRVQVF 28
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 500-777 3.53e-134

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 400.10  E-value: 3.53e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 500 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 579
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 580 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 659
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 660 SPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 738
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDE-DGRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2462602740 739 GLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRK 777
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGK 267
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 196-342 1.23e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 204.41  E-value: 1.23e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 196 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 264
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 265 LP--QAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 342
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 515-732 2.52e-37

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 140.92  E-value: 2.52e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 515 SGVALDPKNNLVIFHRGDHvwdgnsfdskfvyqqiglgpieedTILVIDPNNAAVLQ--SSGKNL--FYLPHGLSIDKDG 590
Cdd:cd05819    11 QGIAVDSSGNIYVADTGNN------------------------RIQVFDPDGNFITSfgSFGSGDgqFNEPAGVAVDSDG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 591 NYWVTDVALHQVFKLDPNNKEgpVLILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWG 670
Cdd:cd05819    67 NLYVADTGNHRIQKFDPDGNF--LASFGGS---GDGDGEFNGPRGIAVDS-SGNIYVAD-TGNHRIQKFDPDGEFLTTFG 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602740 671 EESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTkEFVREIKHSSFGRNVF 732
Cdd:cd05819   140 SGGSG----PGQFNGPTGVAVDS-DGNIYVADTGNHRIQVFDPDG-NFLTTFGSTGTGPGQF 195
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 572-732 2.16e-28

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 115.11  E-value: 2.16e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 572 SSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpvlILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGY 651
Cdd:cd05819     1 GTGPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGN-----FITSFGSFGSGDGQFNEPAGVAVDS-DGNLYVADTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 652 cNSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTkEFVREIKHSSFGRNV 731
Cdd:cd05819    75 -NHRIQKFDPDGNFLASFG--GSGDG--DGEFNGPRGIAVDS-SGNIYVADTGNHRIQKFDPDG-EFLTTFGSGGSGPGQ 147


                  .
gi 2462602740 732 F 732
Cdd:cd05819   148 F 148
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 578-714 1.05e-27

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 113.15  E-value: 1.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 578 FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpvlILGRSMQPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIV 657
Cdd:cd14956   106 FNAPRGVAVDADGNLYVADFGNQRIQKFDPDGS-----FLRQWGGTGIEPGSFNYPRGVAVDPD-GTLYVADTY-NDRIQ 178

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462602740 658 QFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTD 714
Cdd:cd14956   179 VFDNDGAFLRKWGGRGTG----PGQFNYPYGIAIDP-DGNVFVADFGNNRIQKFTAD 230
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 59-168 6.22e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 103.49  E-value: 6.22e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740  59 LDIRMPGVT-PKQSDTYFCMSMRIP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 131
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462602740 132 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 168
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 573-714 1.01e-24

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 104.58  E-value: 1.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 573 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPVLILGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVSDGYc 652
Cdd:cd14955   104 SGDGQFNSPSGIAVDSAGNVYVTDSGNNRIQKFDSSG--TFITKWGSF---GSGDGQFNSPTGIAVD-SAGNVYVADTG- 176

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602740 653 NSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFKTD 714
Cdd:cd14955   177 NNRIQKFTSTGTFLTKWGSEGSG----DGQFNAPYGIA-VDSAGNVYVADTGNNRIQKFDSS 233
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 515-709 7.88e-23

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 98.93  E-value: 7.88e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 515 SGVALDPKNNLVIFHRGDH---VWDGnsfDSKFVYQQIGLG--------PI-----EEDTILVIDPNNAAVLQ------- 571
Cdd:cd05819    58 AGVAVDSDGNLYVADTGNHriqKFDP---DGNFLASFGGSGdgdgefngPRgiavdSSGNIYVADTGNHRIQKfdpdgef 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 572 -------SSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPVLILGrsmQPGSDQNHFCQPTDVAVDPgTGA 644
Cdd:cd05819   135 lttfgsgGSGPGQFNGPTGVAVDSDGNIYVADTGNHRIQVFDPDG--NFLTTFG---STGTGPGQFNYPTGIAVDS-DGN 208

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462602740 645 IYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQ 709
Cdd:cd05819   209 IYVADSG-NNRVQVFDPDGAGFGGNGNFLGS----DGQFNRPSGLAVDS-DGNLYVADTGNNRIQ 267
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 557-720 8.61e-23

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 98.89  E-value: 8.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 557 DTILVIDPNNAAVL--------------QSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPVLILGRsmq 622
Cdd:cd14956    24 DNVYVADARNGRIQvfdkdgtflrrfgtTGDGPGQFGRPRGLAVDKDGWLYVADYWGDRIQVFTLTGE--LQTIGGS--- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 623 PGSDQNHFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVAD 702
Cdd:cd14956    99 SGSGPGQFNAPRGVAVDA-DGNLYVADFG-NQRIQKFDPDGSFLRQWGGTGIE----PGSFNYPRGVAVDP-DGTLYVAD 171

                         170
                  ....*....|....*...
gi 2462602740 703 RENGRIQCFKTDTKeFVR 720
Cdd:cd14956   172 TYNDRIQVFDNDGA-FLR 188
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 513-711 9.75e-23

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 98.80  E-value: 9.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 513 QVSGVALDPKNNLvifhrgdHVWD-GNS----FDSKFVY------------QQIGLGPIEEDT---ILVIDPNNAAV--L 570
Cdd:cd14955    64 SPTGIAVDSDGNV-------YVADtGNHriqkFDSTGTFltkwgssgsgdgQFNSPSGIAVDSagnVYVTDSGNNRIqkF 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 571 QSSGKNL------------FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPVLILGRsmqPGSDQNHFCQPTDVAV 638
Cdd:cd14955   137 DSSGTFItkwgsfgsgdgqFNSPTGIAVDSAGNVYVADTGNNRIQKFTSTG--TFLTKWGS---EGSGDGQFNAPYGIAV 211

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462602740 639 DpGTGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCF 711
Cdd:cd14955   212 D-SAGNVYVADTG-NNRIQKFDSSGTFITKWGSEGSG----DGQFNSPSGIA-VDSAGNVYVADSGNNRIQKF 277
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 573-719 3.15e-22

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 97.26  E-value: 3.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 573 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPVLILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVSDGYc 652
Cdd:cd14955    57 SGDGQFYSPTGIAVDSDGNVYVADTGNHRIQKFDSTG--TFLTKWGSS---GSGDGQFNSPSGIAVDS-AGNVYVTDSG- 129

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462602740 653 NSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFkTDTKEFV 719
Cdd:cd14955   130 NNRIQKFDSSGTFITKWG--SFGSG--DGQFNSPTGIA-VDSAGNVYVADTGNNRIQKF-TSTGTFL 190
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 573-714 2.25e-21

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 94.95  E-value: 2.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 573 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVLILGRSmqPGSDQNHFCQPTDVAVDpGTGAIYVSDGYc 652
Cdd:cd14955    10 SGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDST---GTFLTKWGS--SGSGDGQFYSPTGIAVD-SDGNVYVADTG- 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602740 653 NSRIVQFSPSGKFITQWGEESSGSsplpGQFTVPHSLAlVPLLGQLCVADRENGRIQCFKTD 714
Cdd:cd14955    83 NHRIQKFDSTGTFLTKWGSSGSGD----GQFNSPSGIA-VDSAGNVYVTDSGNNRIQKFDSS 139
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 574-729 1.15e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 89.57  E-value: 1.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 574 GKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPVLILGRSMQpgsdqnhFCQPTDVAVDPGTGAIYVSDGYcN 653
Cdd:cd14962    52 GPNRFVSPIGVAIDANGNLYVSDAELGKVFVFDRDGK--FLRAIGAGAL-------FKRPTGIAVDPAGKRLYVVDTL-A 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462602740 654 SRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVReikhsSFGR 729
Cdd:cd14962   122 HKVKVFDLDGRLLFDIGKRGSG----PGEFNLPTDLAVDR-DGNLYVTDTMNFRVQIFDADGK-FLR-----SFGE 186
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 624-711 5.33e-19

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 88.02  E-value: 5.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 624 GSDQNHFCQPTDVAVDpGTGAIYVSDgYCNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADR 703
Cdd:cd14955     9 GSGDGQFNSPSGIAVD-SAGNVYVAD-TGNNRIQKFDSTGTFLTKWGSSGSG----DGQFYSPTGIA-VDSDGNVYVADT 81


                  ....*...
gi 2462602740 704 ENGRIQCF 711
Cdd:cd14955    82 GNHRIQKF 89
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 511-711 8.85e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 87.34  E-value: 8.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 511 PGQ---VSGVALDPKNNLVIfhrgdhvwdgnsfdSKFVYQQIglgpieedtiLVIDPNNAAVLQSSGKNL----FYLPHG 583
Cdd:cd14956   103 PGQfnaPRGVAVDADGNLYV--------------ADFGNQRI----------QKFDPDGSFLRQWGGTGIepgsFNYPRG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 584 LSIDKDGNYWVTDVALH--QVFkldpNNKEGPVLILGrsmQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFSP 661
Cdd:cd14956   159 VAVDPDGTLYVADTYNDriQVF----DNDGAFLRKWG---GRGTGPGQFNYPYGIAIDP-DGNVFVADFG-NNRIQKFTA 229

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462602740 662 SGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCF 711
Cdd:cd14956   230 DGTFLTSWGSPGTG----PGQFKNPWGVVVDA-DGTVYVADSNNNRVQRF 274
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 516-711 8.25e-18

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 84.52  E-value: 8.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 516 GVALDPKNNLVIFHRGDH---VWDGN-SFDSKFVYQQIGLGPIEEdtilvidpnnaavlqssgknlfylPHGLSIDKDGN 591
Cdd:cd14954   122 GVAVDSEGRIYVSDTRNHrvqVFDSDgQFIRKFGFEGAGPGQLDS------------------------PRGVAVNPDGN 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 592 YWVTDVALHQVFKLDPNNKegPVLILGrsmQPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGE 671
Cdd:cd14954   178 IVVSDFNNHRLQVFDPDGQ--FLRFFG---SEGSGNGQFKRPRGVAVDDE-GNIIVADSG-NHRVQVFSPDGEFLCSFGT 250

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2462602740 672 ESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCF 711
Cdd:cd14954   251 EGNG----EGQFDRPSGVAVTP-DGRIVVVDRGNHRIQVF 285
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 572-736 1.39e-17

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 83.85  E-value: 1.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 572 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLILGRSmqPGSDQNHFCQPTDVAVDpGTGAIYVSD 649
Cdd:cd14957    11 GSGNGQFNTPRGIAVDSAGNIYVADTGNNriQVF-----TSSGVYSYSIGS--GGTGSGQFNSPYGIAVD-SNGNIYVAD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 650 gYCNSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFkTDTKEFVREIKHSSFGR 729
Cdd:cd14957    83 -TDNNRIQVFNSSGVYQYSIG--TGGSG--DGQFNGPYGIA-VDSNGNIYVADTGNHRIQVF-TSSGTFSYSIGSGGTGP 155


                  ....*..
gi 2462602740 730 NVFAISY 736
Cdd:cd14957   156 GQFNGPQ 162
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 554-770 2.28e-17

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 82.72  E-value: 2.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 554 IEEDTILVIDPNN--AAVLQSSGKNL------------FYLPHGLSIDKDGNYWVTDVA--LHQVFkldpnNKEGPVLil 617
Cdd:cd14963    17 VSDGRIYVADTNNhrVQVFDYEGKFKksfggpgtgpgeFKYPYGIAVDSDGNIYVADLYngRIQVF-----DPDGKFL-- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 618 gRSMQPGSDQNHFCQPTDVAVDPGTgaIYVSD-GYcnSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLG 696
Cdd:cd14963    90 -KYFPEKKDRVKLISPAGLAIDDGK--LYVSDvKK--HKVIVFDLEGKLLLEFGKPGSE----PGELSYPNGIAVDE-DG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 697 QLCVADRENGRIQCFKTDTKeFVREIKHSSFGRNVFA----ISYIP-GLLFAV------------NGKPH--FGDQEPVQ 757
Cdd:cd14963   160 NIYVADSGNGRIQVFDKNGK-FIKELNGSPDGKSGFVnprgIAVDPdGNLYVVdnlshrvyvfdeQGKELftFGGRGKDD 238

                         250
                  ....*....|...
gi 2462602740 758 GfVMNFSNGEIID 770
Cdd:cd14963   239 G-QFNLPNGLFID 250
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 572-711 2.83e-17

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 82.70  E-value: 2.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 572 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpNNKEGPVLILGrsmQPGSDQNHFCQPTDVAVDpGTGAIYVSD 649
Cdd:cd14957   152 GTGPGQFNGPQGIAVDSDGNIYVADTGNHriQVF----TSSGTFQYTFG---SSGSGPGQFSDPYGIAVD-SDGNIYVAD 223

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602740 650 gYCNSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCF 711
Cdd:cd14957   224 -TGNHRIQVFTSSGAYQYSIG--TSGSG--NGQFNYPYGIA-VDNDGKIYVADSNNNRIQVF 279
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 572-728 6.73e-14

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 72.68  E-value: 6.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 572 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVL-ILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVS 648
Cdd:cd14957    58 GTGSGQFNSPYGIAVDSNGNIYVADTDNNriQVF-----NSSGVYQySIGTG---GSGDGQFNGPYGIAVDS-NGNIYVA 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 649 DGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPLlGQLCVADRENGRIQCFkTDTKEFVREIKHSSFG 728
Cdd:cd14957   129 DTG-NHRIQVFTSSGTFSYSIGSGGTG----PGQFNGPQGIAVDSD-GNIYVADTGNHRIQVF-TSSGTFQYTFGSSGSG 201
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 550-732 1.14e-13

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 72.20  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 550 GLGPIEEDTILVIDPNN--AAVLQSSGKNL------------FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkegpvl 615
Cdd:cd14954    28 GVAVDKDGRIIVADRSNnrVQVFDPDGKFLrkfgsygsrdgqFDRPAGVAVNSRGRIIVADKDNHRIQVFDLN------- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 616 ilGRSM----QPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGEESsgssPLPGQFTVPHSLAL 691
Cdd:cd14954   101 --GRFLlkfgERGTKNGQFNYPWGVAVDSE-GRIYVSDTR-NHRVQVFDSDGQFIRKFGFEG----AGPGQLDSPRGVAV 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462602740 692 VPLlGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRNVF 732
Cdd:cd14954   173 NPD-GNIVVSDFNNHRLQVFDPDGQ-FLRFFGSEGSGNGQF 211
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 578-720 1.32e-13

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 72.20  E-value: 1.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 578 FYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGP-VLILGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVSDGYcNS 654
Cdd:cd14954    23 LCRPWGVAVDKDGRIIVADRSNNrvQVF-----DPDGKfLRKFGSY---GSRDGQFDRPAGVAVN-SRGRIIVADKD-NH 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462602740 655 RIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFKTDTKeFVR 720
Cdd:cd14954    93 RIQVFDLNGRFLLKFGERGTK----NGQFNYPWGVA-VDSEGRIYVSDTRNHRVQVFDSDGQ-FIR 152
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 515-708 1.66e-13

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 72.18  E-value: 1.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 515 SGVALDPKNNLVIFHRGDHvwdgnsfdskfvyqqiglgpieedTILVIDPN-------------------NAAvlqssgk 575
Cdd:cd14953    26 SGVAVDAAGNLYVADRGNH------------------------RIRKITPDgvvttvagtgtagfadgggAAA------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 576 nLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVL------ILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSD 649
Cdd:cd14953    75 -QFNTPSGVAVDAAGNLYVADTGNHRIRKITPD---GVVStlagtgTAGFSDDGGATAAQFNYPTGVAVDA-AGNLYVAD 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462602740 650 GYcNSRIVQFSPSGKFITQWGEESSGSSPL-PG---QFTVPHSLAlVPLLGQLCVADRENGRI 708
Cdd:cd14953   150 TG-NHRIRKITPDGVVTTVAGTGGAGYAGDgPAtaaQFNNPTGVA-VDAAGNLYVADRGNHRI 210
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
501-715 1.86e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 70.88  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 501 ALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYqqigLGPIEEDTILVIDPNNAAVLQS--SGKNlf 578
Cdd:COG3391    38 AAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLY----VANSGSGRVSVIDLATGKVVATipVGGG-- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 579 ylPHGLSIDKDGNY-WVTDVALHQVFKLDPNNKEgpvliLGRSMQPGSdqnhfcQPTDVAVDPGTGAIYVSDGYCN--SR 655
Cdd:COG3391   112 --PRGLAVDPDGGRlYVADSGNGRVSVIDTATGK-----VVATIPVGA------GPHGIAVDPDGKRLYVANSGSNtvSV 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462602740 656 IVQ-FSP-SGKFITQWgeessgssPLPGQftvPHSLALVPLLGQLCVADRENG-------RIQCFKTDT 715
Cdd:COG3391   179 IVSvIDTaTGKVVATI--------PVGGG---PVGVAVSPDGRRLYVANRGSNtsnggsnTVSVIDLAT 236
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
557-718 5.04e-13

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 70.05  E-value: 5.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 557 DTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEgpvLILGRSMQPGSdqnhfcQPTDV 636
Cdd:COG4257    80 NRIGRIDPKTGEITTFALPGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGE---VTEFPLPTGGA------GPYGI 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 637 AVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWgeessgssPLPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTK 716
Cdd:COG4257   151 AVDP-DGNLWVTD-FGANAIGRIDPDTGTLTEY--------ALPTPGAGPRGLAVDP-DGNLWVADTGSGRIGRFDPKTG 219


                  ..
gi 2462602740 717 EF 718
Cdd:COG4257   220 TV 221
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 559-711 5.63e-13

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 69.92  E-value: 5.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 559 ILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNY-WVTDVALHQVFKLDPNNKEgpvliLGRSMQPGSDQNHFCQPTDVA 637
Cdd:cd14962    80 VFVFDRDGKFLRAIGAGALFKRPTGIAVDPAGKRlYVVDTLAHKVKVFDLDGRL-----LFDIGKRGSGPGEFNLPTDLA 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 638 VDPgTGAIYVSDGYcNSRIVQFSPSGKFITQWGE-------------------------ESS------------------ 674
Cdd:cd14962   155 VDR-DGNLYVTDTM-NFRVQIFDADGKFLRSFGErgdgpgsfarpkgiavdsegniyvvDAAfdnvqifnpegellltvg 232

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2462602740 675 GSSPLPGQFTVPHSLAlVPLLGQLCVADRENGRIQCF 711
Cdd:cd14962   233 GPGSGPGEFYLPSGIA-IDKDDRIYVVDQFNRRIQVF 268
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 503-715 5.70e-13

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 70.00  E-value: 5.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 503 DWPGVYLLPgqvSGVALDPKNNLVIFHrgdhvwDGNS----FDSK-FVYQQIGlgPIEEDTILVIDPNNAAV-------- 569
Cdd:cd14961     5 GWPGTLNNP---TGVAVTPTGRVVVAD------DGNKriqvFDSDgNCLQQFG--PKGDAGQDIRYPLDVAVtpdghivv 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 570 ----------------LQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSmqpgsdQNHFCQP 633
Cdd:cd14961    74 tdagdrsvkvfsfdgrLKLFVRKSFSLPWGVAVNPSGEILVTDSEAGKLFVLTVDFKLGILKKGQKL------CSQLCRP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 634 TDVAVDPgTGAIYVSD-------GYCNSRIVQFSPSGKFITQWGeeSSGSSPLPGQFTVPHSLAlVPLLGQLCVADRENG 706
Cdd:cd14961   148 RFVAVSR-LGAVAVTEhlfangtRSSSTRVKVFSSGGQLLGQID--SFGLNLVFPSLICASGVA-FDSEGNVIVADTGSG 223


                  ....*....
gi 2462602740 707 RIQCFKTDT 715
Cdd:cd14961   224 AILCLGKPE 232
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
557-718 1.70e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 68.51  E-value: 1.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 557 DTILVIDPNNAAVLQSSgKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPnnKEGPV-LILGrsmqPGSDQNhfcqPTD 635
Cdd:COG4257    38 GRIGRLDPATGEFTEYP-LGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDP--KTGEItTFAL----PGGGSN----PHG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 636 VAVDPGtGAIYVSDGYcNSRIVQFSP-SGKFitqwgeeSSGSSPLPGQFtvPHSLALVPlLGQLCVADRENGRIQCFKTD 714
Cdd:COG4257   107 IAFDPD-GNLWFTDQG-GNRIGRLDPaTGEV-------TEFPLPTGGAG--PYGIAVDP-DGNLWVTDFGANAIGRIDPD 174


                  ....
gi 2462602740 715 TKEF 718
Cdd:COG4257   175 TGTL 178
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 569-711 2.20e-12

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 68.09  E-value: 2.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 569 VLQSSGKNLFYLPH-----------GLSIDkDGNYWVTDVALHQVFKLDPNNKEgpVLILGRsmqPGSDQNHFCQPTDVA 637
Cdd:cd14963    81 VFDPDGKFLKYFPEkkdrvklispaGLAID-DGKLYVSDVKKHKVIVFDLEGKL--LLEFGK---PGSEPGELSYPNGIA 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 638 VDPgTGAIYVSD-GycNSRIVQFSPSGKFITQWGEESSGSSPL------------------------------------- 679
Cdd:cd14963   155 VDE-DGNIYVADsG--NGRIQVFDKNGKFIKELNGSPDGKSGFvnprgiavdpdgnlyvvdnlshrvyvfdeqgkelftf 231

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2462602740 680 ------PGQFTVPHSLALVPLlGQLCVADRENGRIQCF 711
Cdd:cd14963   232 ggrgkdDGQFNLPNGLFIDDD-GRLYVTDRENNRVAVY 268
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
557-722 2.49e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 68.12  E-value: 2.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 557 DTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQpgsdqnhfcQPTDV 636
Cdd:COG4257   123 NRIGRLDPATGEVTEFPLPTGGAGPYGIAVDPDGNLWVTDFGANAIGRIDPDTGTLTEYALPTPGA---------GPRGL 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 637 AVDPgTGAIYVSDGYcNSRIVQFSPSGKFITQWgeessgssPLPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTK 716
Cdd:COG4257   194 AVDP-DGNLWVADTG-SGRIGRFDPKTGTVTEY--------PLPGGGARPYGVAVDG-DGRVWFAESGANRIVRFDPDTE 262


                  ....*.
gi 2462602740 717 EFVREI 722
Cdd:COG4257   263 LTEYVL 268
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 559-712 3.79e-12

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 67.37  E-value: 3.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 559 ILVIDPNNAAVL--QSSGKNLFYL-------PHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpvlILGRSMQPGSDQNH 629
Cdd:cd14960    77 IIIADYDNKWVSifSPDGKFKSKIgagklmgPKGVAVDRNGHIIVVDNKACCVFIFQPNGK-----LVTRFGSRGNGDRQ 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 630 FCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPLlGQLCVADRENGRIQ 709
Cdd:cd14960   152 FAGPHFAAVNN-NNEIIVTD-FHNHSVKVFNAEGEFLFKFGSNGEG----NGQFNAPTGVAVDSN-GNIIVADWGNSRIQ 224


                  ...
gi 2462602740 710 CFK 712
Cdd:cd14960   225 VFD 227
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 515-659 7.38e-12

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 66.57  E-value: 7.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 515 SGVALDPKNNLVIFHRGDHVwdgnsfdskfvyqqiglgpieedtILVIDPNNAAVL----QSSGKNLFYLPHGLSIDKDG 590
Cdd:cd05819   152 TGVAVDSDGNIYVADTGNHR------------------------IQVFDPDGNFLTtfgsTGTGPGQFNYPTGIAVDSDG 207

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602740 591 NYWVTDVALHQVFKLDPNNKEGPvlilgrsmQPGSDQNH---FCQPTDVAVDPgTGAIYVSDGYcNSRIVQF 659
Cdd:cd05819   208 NIYVADSGNNRVQVFDPDGAGFG--------GNGNFLGSdgqFNRPSGLAVDS-DGNLYVADTG-NNRIQVF 269
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
581-718 2.00e-11

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 65.43  E-value: 2.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 581 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRsmqpgsdqnhFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFS 660
Cdd:COG4257    19 PRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGG----------GSGPHGIAVDP-DGNLWFTDNG-NNRIGRID 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462602740 661 PSGKFITQWgeessgssPLPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKEF 718
Cdd:COG4257    87 PKTGEITTF--------ALPGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRLDPATGEV 135
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 515-708 5.13e-11

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 64.86  E-value: 5.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 515 SGVALDPKNNLVIFHRGDHVwdgnsfdskfvyqqiglgpieedtILVIDPN--------NAAVLQSSGKN----LFYLPH 582
Cdd:cd14953   135 TGVAVDAAGNLYVADTGNHR------------------------IRKITPDgvvttvagTGGAGYAGDGPataaQFNNPT 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 583 GLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVL-ILGRSMQPGSDQNH-----FCQPTDVAVDpGTGAIYVSDgYCNSRI 656
Cdd:cd14953   191 GVAVDAAGNLYVADRGNHRIRKITPD---GVVTtVAGTGTAGFSGDGGataaqLNNPTGVAVD-AAGNLYVAD-SGNHRI 265

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462602740 657 VQFSPSGKFIT----QWGEESSGSSPLPGQFTVPHSLALVPlLGQLCVADRENGRI 708
Cdd:cd14953   266 RKITPAGVVTTvaggGAGFSGDGGPATSAQFNNPTGVAVDA-AGNLYVADTGNNRI 320
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 608-711 2.01e-10

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 62.57  E-value: 2.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 608 NNKEGPVLILGRSmqpGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPH 687
Cdd:cd14954     4 RAKGRPLLSFGKE---GSKDGELCRPWGVAVDKD-GRIIVADRS-NNRVQVFDPDGKFLRKFGSYGSR----DGQFDRPA 74

                          90       100
                  ....*....|....*....|....
gi 2462602740 688 SLAlVPLLGQLCVADRENGRIQCF 711
Cdd:cd14954    75 GVA-VNSRGRIIVADKDNHRIQVF 97
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 623-711 3.74e-10

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 61.51  E-value: 3.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 623 PGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLAlVPLLGQLCVAD 702
Cdd:cd14957    10 NGSGNGQFNTPRGIAVDSA-GNIYVADTG-NNRIQVFTSSGVYSYSIG--SGGTG--SGQFNSPYGIA-VDSNGNIYVAD 82


                  ....*....
gi 2462602740 703 RENGRIQCF 711
Cdd:cd14957    83 TDNNRIQVF 91
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 581-708 5.50e-10

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 60.68  E-value: 5.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 581 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLilgrsmqPGSDQNhfcQPTDVAVDpGTGAIYVSDGYcNSRIVQFS 660
Cdd:cd14952    12 PGGVAVDAAGNVYVADSGNNRVLKLAAGSTTQTVL-------PFTGLY---QPQGVAVD-AAGTVYVTDFG-NNRVLKLA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462602740 661 PSgkfitqwgeeSSGSSPLPgqFT---VPHSLAlVPLLGQLCVADRENGRI 708
Cdd:cd14952    80 AG----------STTQTVLP--FTglnDPTGVA-VDAAGNVYVADTGNNRV 117
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 578-708 7.92e-10

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 61.01  E-value: 7.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 578 FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVLILGRSMQPGSD-----QNHFCQPTDVAVDPGtGAIYVSDGYc 652
Cdd:cd14953    22 FNSPSGVAVDAAGNLYVADRGNHRIRKITPD---GVVTTVAGTGTAGFAdgggaAAQFNTPSGVAVDAA-GNLYVADTG- 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 653 NSRIVQFSPSGKFITQWGEESSGSSPLPG----QFTVPHSLAlVPLLGQLCVADRENGRI 708
Cdd:cd14953    97 NHRIRKITPDGVVSTLAGTGTAGFSDDGGataaQFNYPTGVA-VDAAGNLYVADTGNHRI 155
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 511-657 9.99e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 57.30  E-value: 9.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 511 PGQVS---GVALDPKNNLvifhrgdHVWDGNSfdskfvyqqiglgpieeDTILVIDPNNAAVLQSSGK----NLFYLPHG 583
Cdd:cd14963   144 PGELSypnGIAVDEDGNI-------YVADSGN-----------------GRIQVFDKNGKFIKELNGSpdgkSGFVNPRG 199

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462602740 584 LSIDKDGNYWVTDVALHQVFKLDPNNKEgpVLILGrsmQPGSDQNHFCQPTDVAVDpGTGAIYVSDgYCNSRIV 657
Cdd:cd14963   200 IAVDPDGNLYVVDNLSHRVYVFDEQGKE--LFTFG---GRGKDDGQFNLPNGLFID-DDGRLYVTD-RENNRVA 266
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 622-714 1.33e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 56.91  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 622 QPGSDQNHFCQPTDVAVDPGTGAIYVSDGycNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVA 701
Cdd:cd14956     4 GRGSGPGQFKDPRGIAVDADDNVYVADAR--NGRIQVFDKDGTFLRRFGTTGDG----PGQFGRPRGLAVDK-DGWLYVA 76

                          90
                  ....*....|...
gi 2462602740 702 DRENGRIQCFKTD 714
Cdd:cd14956    77 DYWGDRIQVFTLT 89
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 581-658 9.11e-08

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 53.75  E-value: 9.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462602740 581 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLilgrsmqPGSDQNHfcqPTDVAVDPgTGAIYVSDgYCNSRIVQ 658
Cdd:cd14952   180 PSGVAVDTAGNVYVTDHGNNRVLKLAAGSTTPTVL-------PFTGLNG---PLGVAVDA-AGNVYVAD-RGNDRVVK 245
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 581-708 4.59e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 51.82  E-value: 4.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 581 PHGLSIDKDGNYWVTDVALHQVFKLDPnnkegpvlilGRSMQ---PGSDQNHfcqPTDVAVDPGtGAIYVSDGYcNSRIV 657
Cdd:cd14952    96 PTGVAVDAAGNVYVADTGNNRVLKLAA----------GSNTQtvlPFTGLSN---PDGVAVDGA-GNVYVTDTG-NNRVL 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462602740 658 QFsPSGkfitqwgeeSSGSSPLPgqFT---VPHSLAlVPLLGQLCVADRENGRI 708
Cdd:cd14952   161 KL-AAG---------STTQTVLP--FTglnSPSGVA-VDTAGNVYVTDHGNNRV 201
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 573-666 9.23e-07

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 51.12  E-value: 9.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 573 SGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLilgrsMQ---PGSDQNHFCQPTDVAVDPGTGAIYV 647
Cdd:cd14959    16 SGEGQFNSPSGFCLGEDEDILVADTNNHriQVF-----DKEGEFK-----FQfgiPGKRDGQLWYPNKVAVCRVTGRYVV 85

                          90       100
                  ....*....|....*....|
gi 2462602740 648 SD-GYCNSRIVQFSPSGKFI 666
Cdd:cd14959    86 TDrGNPRHRMQIFTKRGQFV 105
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 571-660 1.72e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 50.34  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 571 QSSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLilgRSM-QPGSDQNHFCQPTDVAVDpGTGAIYV 647
Cdd:cd14957   198 SGSGPGQFSDPYGIAVDSDGNIYVADTGNHriQVF-----TSSGAYQ---YSIgTSGSGNGQFNYPYGIAVD-NDGKIYV 268

                          90
                  ....*....|...
gi 2462602740 648 SDGYcNSRIVQFS 660
Cdd:cd14957   269 ADSN-NNRIQVFN 280
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 624-772 4.44e-06

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 49.19  E-value: 4.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 624 GSDQNHFCQPTDVAVDpGTGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGSsplpGQFTVPHSLALVPLLGQLCVADR 703
Cdd:cd14959    15 GSGEGQFNSPSGFCLG-EDEDILVADTN-NHRIQVFDKEGEFKFQFGIPGKRD----GQLWYPNKVAVCRVTGRYVVTDR 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462602740 704 ENG--RIQCFkTDTKEFVREikhssfgrnvFAISYI--PGLLfAVNGKPHFGDQEPVQGFVMNFS-NGEIIDIF 772
Cdd:cd14959    89 GNPrhRMQIF-TKRGQFVRK----------FGARYLqhVRGL-TVDAAGHIIVVESKVMRVFIFDeSGNVLKWF 150
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 559-712 4.53e-06

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 49.27  E-value: 4.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 559 ILVIDPNNAAVL--QSSGK------------NLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLILGRSMQ 622
Cdd:cd14960   119 IIVVDNKACCVFifQPNGKlvtrfgsrgngdRQFAGPHFAAVNNNNEIIVTDFHNHsvKVF-----NAEGEFLFKFGSNG 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 623 PGSDQnhFCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWGeesSGSSPLPGqftvPHSLALVPlLGQLCVAD 702
Cdd:cd14960   194 EGNGQ--FNAPTGVAVDS-NGNIIVAD-WGNSRIQVFDSSGSFLSYIN---TSADPLYG----PQGLALTS-DGHVVVAD 261

                         170
                  ....*....|
gi 2462602740 703 RENgriQCFK 712
Cdd:cd14960   262 SGN---HCFK 268
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 624-717 1.87e-05

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 47.27  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 624 GSDQNHFCQPTDVAVDPgTGAIYVSD-GycNSRIVQFSPSGKFITQWGEESSGS----SPLP------------------ 680
Cdd:cd14961     4 GGWPGTLNNPTGVAVTP-TGRVVVADdG--NKRIQVFDSDGNCLQQFGPKGDAGqdirYPLDvavtpdghivvtdagdrs 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462602740 681 ---------------GQFTVPHSLALVPLlGQLCVADRENGRIQCFKTDTKE 717
Cdd:cd14961    81 vkvfsfdgrlklfvrKSFSLPWGVAVNPS-GEILVTDSEAGKLFVLTVDFKL 131
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 554-714 2.75e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 46.42  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 554 IEEDTILVIDPNNAAV---LQSSGknlfyLPHGLSIDKDGNYWVTDvALHQVFKLDPNNKEgPVLILGRSMQPGSdqnhf 630
Cdd:COG3386    26 IPGGRIHRYDPDGGAVevfAEPSG-----RPNGLAFDPDGRLLVAD-HGRGLVRFDPADGE-VTVLADEYGKPLN----- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 631 cQPTDVAVDPGtGAIYVSD---GYCNSRIVQFSPSGKFitqwgeessgsSPLPGQFTVPHSLALVPLLGQLCVADRENGR 707
Cdd:COG3386    94 -RPNDGVVDPD-GRLYFTDmgeYLPTGALYRVDPDGSL-----------RVLADGLTFPNGIAFSPDGRTLYVADTGAGR 160


                  ....*..
gi 2462602740 708 IQCFKTD 714
Cdd:COG3386   161 IYRFDLD 167
MALA cd12811
Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia ...
 633-738 7.28e-05

Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia sympodialis allergen Mala s 1 which is localized in the cell wall and exposed on the cell surface. It can elicit specific IgE and T-cell activity in patients with atopic eczema (AE), a chronic inflammatory disease. Mala s 1 does not show any significant sequence homology to characterized proteins. However, its structure is a beta-propeller which is a novel fold among allergens.


Pssm-ID: 411995 [Multi-domain]  Cd Length: 304  Bit Score: 45.70  E-value: 7.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 633 PTDVAVDPgTGAIYVSDGYCNSrIVQFSPSGKFITQWGEESSGSSPLPGqFTvphSLALVPLLGQLCVADRENGRIQCFK 712
Cdd:cd12811   123 FQDSAQDS-DGNSYVVGALPPA-IAKVSPDGKTVTPWFLEAPNGSTRPG-YT---GIAYIPEDNVLLASGGEPGQLTRFD 196

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462602740 713 TD----TKEFVReIKHSSFGRNVFAIsYIP 738
Cdd:cd12811   197 LSsatpTPIPVK-ISGENFGGLDDGE-KLP 224
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
632-720 4.35e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 43.08  E-value: 4.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 632 QPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWgeessgsspLPGQFTVPHSLALVPLlGQLCVADRENGRIQCF 711
Cdd:COG4257    18 GPRDVAVDP-DGAVWFTD-QGGGRIGRLDPATGEFTEY---------PLGGGSGPHGIAVDPD-GNLWFTDNGNNRIGRI 85


                  ....*....
gi 2462602740 712 KTDTKEFVR 720
Cdd:COG4257    86 DPKTGEITT 94
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 683-711 7.43e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.38  E-value: 7.43e-04
                          10        20
                  ....*....|....*....|....*....
gi 2462602740 683 FTVPHSLALVPLlGQLCVADRENGRIQCF 711
Cdd:pfam01436   1 FNRPHGVAVDSN-GDIYVADSENHRVQVF 28
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
645-745 2.89e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602740 645 IYVSDGYcNSRIVQFSP-SGKFITQWgeeSSGSSPlpgqftvpHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIK 723
Cdd:COG3391    82 LYVANSG-SGRVSVIDLaTGKVVATI---PVGGGP--------RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIP 149

                          90       100
                  ....*....|....*....|....
gi 2462602740 724 hssFGRNVFAISYIP--GLLFAVN 745
Cdd:COG3391   150 ---VGAGPHGIAVDPdgKRLYVAN 170
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
554-607 3.50e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.00  E-value: 3.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462602740 554 IEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDP 607
Cdd:COG4257   206 TGSGRIGRFDPKTGTVTEYPLPGGGARPYGVAVDGDGRVWFAESGANRIVRFDP 259
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 630-659 3.68e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 3.68e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462602740 630 FCQPTDVAVDPGtGAIYVSDgYCNSRIVQF 659
Cdd:pfam01436   1 FNRPHGVAVDSN-GDIYVAD-SENHRVQVF 28
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 665-711 6.84e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 39.10  E-value: 6.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462602740 665 FITQWGEESSGSsplpGQFTVPHSLAlVPLLGQLCVADRENGRIQCF 711
Cdd:cd14955     1 FVTQWGSYGSGD----GQFNSPSGIA-VDSAGNVYVADTGNNRIQKF 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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