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Conserved domains on  [gi|2462588874|ref|XP_054202047|]
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target of Nesh-SH3 isoform X56 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10637190)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-27 subunit beta that associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 429-849 9.12e-17

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 86.92  E-value: 9.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  429 PRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPE--RTTSAGTITPKISKSPEPTWTT 506
Cdd:PHA03247  2551 PPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGdpRGPAPPSPLPPDTHAPDPPPPS 2630

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  507 PAPGKTQfiSLKPKIPLSPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTLAPRKTKRPGRRPRPRPRPKTTPSPEVP 586
Cdd:PHA03247  2631 PSPAANE--PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP 2708

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  587 KSKPalePATIQPEPLVPTTASKPSERPKTTHRPDAPQIQPGSKPP--KQLLPKPQTTAEPD--MPPTKSVSEPVPFETE 662
Cdd:PHA03247  2709 EPAP---HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGPPapAPPAAPAAGPPRRLTR 2785

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  663 APSMTIVPTTDIEP-----------VTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDfGPITPGtssAP 731
Cdd:PHA03247  2786 PAVASLSESRESLPspwdpadppaaVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-GSVAPG---GD 2861

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  732 TTTTKRTRRPHPKPKTTPHPEV-----------PQTKLAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPS 800
Cdd:PHA03247  2862 VRRRPPSRSPAAKPAAPARPPVrrlarpavsrsTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP 2941

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 2462588874  801 PEVSYTTPAPKDVLLPHKPYPEVSQSEPAPLEtrgIPFIPMISPSPSQE 849
Cdd:PHA03247  2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVA---VPRFRVPQPAPSRE 2987
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1090-1181 2.63e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 2.63e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874 1090 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNP 1167
Cdd:cd00063      2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 2462588874 1168 LGEGPVSNTVAFST 1181
Cdd:cd00063     80 GGESPPSESVTVTT 93
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 729-1022 7.67e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 7.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  729 SAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKQT------PR-------------------APPKPKTSPRP----RIP 779
Cdd:PHA03247  2490 FAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPvgepvhPRmltwirgleelasddagdpPPPLPPAAPPAapdrSVP 2569

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  780 QTQPVPKVPQ-RVTAKPKTSPSPEVSYTTPAPKDvllPHKPYPEVSQSEPAPLETRGiPFIPMISPSPSQEELQTTLEET 858
Cdd:PHA03247  2570 PPRPAPRPSEpAVTSRARRPDAPPQSARPRAPVD---DRGDPRGPAPPSPLPPDTHA-PDPPPPSPSPAANEPDPHPPPT 2645

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  859 DQSTQEPFTTKIPRTTELAKTTQAPHR-FYTTVRPRTSDKPHIRPVLNRTTT--RPTRPKPSGMPSGNGVGTGVKQAPRP 935
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARRLGRaAQASSPPQRPRRRAARPTVGSLTSlaDPPPPPPTPEPAPHALVSATPLPPGP 2725

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  936 SGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPpnnvTGKPGSAGiiSSGPITTPPlRSTPRPTGTPLERIETDI 1015
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT----AGPPAPAP--PAAPAAGPP-RRLTRPAVASLSESRESL 2798


                   ....*..
gi 2462588874 1016 KQPTVPA 1022
Cdd:PHA03247  2799 PSPWDPA 2805
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 124-202 2.13e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.13e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874   124 PLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPNDRFYTIRYREKDKEKKWIFQICPA----TETIVENLKPNTVYEF 199
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTEYEF 72


                    ...
gi 2462588874   200 GVK 202
Cdd:smart00060   73 RVR 75
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-849 9.12e-17

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 86.92  E-value: 9.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  429 PRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPE--RTTSAGTITPKISKSPEPTWTT 506
Cdd:PHA03247  2551 PPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGdpRGPAPPSPLPPDTHAPDPPPPS 2630

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  507 PAPGKTQfiSLKPKIPLSPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTLAPRKTKRPGRRPRPRPRPKTTPSPEVP 586
Cdd:PHA03247  2631 PSPAANE--PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP 2708

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  587 KSKPalePATIQPEPLVPTTASKPSERPKTTHRPDAPQIQPGSKPP--KQLLPKPQTTAEPD--MPPTKSVSEPVPFETE 662
Cdd:PHA03247  2709 EPAP---HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGPPapAPPAAPAAGPPRRLTR 2785

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  663 APSMTIVPTTDIEP-----------VTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDfGPITPGtssAP 731
Cdd:PHA03247  2786 PAVASLSESRESLPspwdpadppaaVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-GSVAPG---GD 2861

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  732 TTTTKRTRRPHPKPKTTPHPEV-----------PQTKLAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPS 800
Cdd:PHA03247  2862 VRRRPPSRSPAAKPAAPARPPVrrlarpavsrsTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP 2941

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 2462588874  801 PEVSYTTPAPKDVLLPHKPYPEVSQSEPAPLEtrgIPFIPMISPSPSQE 849
Cdd:PHA03247  2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVA---VPRFRVPQPAPSRE 2987
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1090-1181 2.63e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 2.63e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874 1090 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNP 1167
Cdd:cd00063      2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 2462588874 1168 LGEGPVSNTVAFST 1181
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1091-1171 4.78e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 4.78e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  1091 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQMTNQTFS-TVENLKPNTSYEFQVKPKNPL 1168
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 2462588874  1169 GEG 1171
Cdd:smart00060   81 GEG 83
PHA03247 PHA03247
large tegument protein UL36; Provisional
 729-1022 7.67e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 7.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  729 SAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKQT------PR-------------------APPKPKTSPRP----RIP 779
Cdd:PHA03247  2490 FAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPvgepvhPRmltwirgleelasddagdpPPPLPPAAPPAapdrSVP 2569

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  780 QTQPVPKVPQ-RVTAKPKTSPSPEVSYTTPAPKDvllPHKPYPEVSQSEPAPLETRGiPFIPMISPSPSQEELQTTLEET 858
Cdd:PHA03247  2570 PPRPAPRPSEpAVTSRARRPDAPPQSARPRAPVD---DRGDPRGPAPPSPLPPDTHA-PDPPPPSPSPAANEPDPHPPPT 2645

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  859 DQSTQEPFTTKIPRTTELAKTTQAPHR-FYTTVRPRTSDKPHIRPVLNRTTT--RPTRPKPSGMPSGNGVGTGVKQAPRP 935
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARRLGRaAQASSPPQRPRRRAARPTVGSLTSlaDPPPPPPTPEPAPHALVSATPLPPGP 2725

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  936 SGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPpnnvTGKPGSAGiiSSGPITTPPlRSTPRPTGTPLERIETDI 1015
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT----AGPPAPAP--PAAPAAGPP-RRLTRPAVASLSESRESL 2798


                   ....*..
gi 2462588874 1016 KQPTVPA 1022
Cdd:PHA03247  2799 PSPWDPA 2805
fn3 pfam00041
Fibronectin type III domain;
1091-1174 1.64e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874 1091 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQMTNQTFS-TVENLKPNTSYEFQVKPKNP 1167
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 2462588874 1168 LGEGPVS 1174
Cdd:pfam00041   79 GGEGPPS 85
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 395-816 1.30e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  395 PTTSDEPEISDSYTATSDRILDSIPPKTSRTLEQPRATLAP-------SETPF-VPQKLEIFTSPEMQPTTPAPQQTTSI 466
Cdd:pfam05109  310 PASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAfwawpnnTETDFkCKWTLTSGTPSGCENISGAFASNRTF 389

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  467 PSTPKRRPRPKPPRTKPERTTSAGTITPKI--SKSPEPTWTTPAPGKTQFISLKPKIPLsPEVTH-----TKPA---PEP 536
Cdd:pfam05109  390 DITVSGLGTAPKTLIITRTATNATTTTHKVifSKAPESTTTSPTLNTTGFAAPNTTTGL-PSSTHvptnlTAPAstgPTV 468

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  537 QTLLPSQSTIGPETPGTKPST-TLAPRKTKRPGRRPRPRPRPKTTPSPEVPKSKPALEPATIQPEPLVPTTASKPSERPK 615
Cdd:pfam05109  469 STADVTSPTPAGTTSGASPVTpSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAV 548

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  616 TTHRPDAPQIQPGSKPPKqllPKPQTTAEPDMPPTKSVSEPVPFETEAPSMTIVPTTDIEPVTV--RTEATVTTLAPKTS 693
Cdd:pfam05109  549 TTPTPNATSPTPAVTTPT---PNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLggTSSTPVVTSPPKNA 625

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  694 QRTRTRRPRPKHKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKQTPRAP-PKPKT 772
Cdd:pfam05109  626 TSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPaPRPGT 705

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2462588874  773 SPRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLP 816
Cdd:pfam05109  706 TSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVP 749
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
907-1186 1.46e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.15  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  907 TTTRPTRPKPSGMPSGNGVGTGVKQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGI 986
Cdd:COG3401     48 TKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATT 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  987 ISSGPITTPPLRSTPRPTGTPLERIETDIKQPTVPASGEELENITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNS--- 1063
Cdd:COG3401    128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTyyy 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874 1064 -PCSITDSVKRFPKEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQMT 1142
Cdd:COG3401    208 rVAATDTGGESAPSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATV 282

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 2462588874 1143 NQTFSTVENLKPNTSYEFQVKPKNPLG-EGPVSNTVAFSTESADP 1186
Cdd:COG3401    283 TTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1085-1229 1.87e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.76  E-value: 1.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874 1085 TSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqmtNQTFSTVENLKPNTSYEFQV 1162
Cdd:COG3401    324 LTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGLTPGTTYYYKV 397

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462588874 1163 KPKNPLG-EGPVSNTVAFSTESADPRVSEPVSAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVG 1229
Cdd:COG3401    398 TAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG 465
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 124-202 2.13e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.13e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874   124 PLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPNDRFYTIRYREKDKEKKWIFQICPA----TETIVENLKPNTVYEF 199
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTEYEF 72


                    ...
gi 2462588874   200 GVK 202
Cdd:smart00060   73 RVR 75
fn3 pfam00041
Fibronectin type III domain;
123-202 2.20e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.25  E-value: 2.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  123 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPND-RFYTIRYREKDKEKKWIFQICPATET--IVENLKPNTVYEF 199
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 2462588874  200 GVK 202
Cdd:pfam00041   72 RVQ 74
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 548-781 7.98e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 43.60  E-value: 7.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  548 PETPGTK----PSTTLAPRKTKRPGRRPRPRPRPKTTPSPEVPKSKPALEPATIQPEPLVPTTASKPseRPKTTHRPDAP 623
Cdd:NF033839   284 PKEPGNKkpsaPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETP--KPEVKPQPEKP 361

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  624 QIQPGSKPPKqllPKPQTTAEPDMPPTKSVSEPvpfETEAPSMTIVPTTDIEPVTVRTEATVTTLAPKtsqrtrtrRPRP 703
Cdd:NF033839   362 KPEVKPQPEK---PKPEVKPQPETPKPEVKPQP---EKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQ--------PEKP 427

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462588874  704 KHKTTPRPETLQTKLDFGPITPGTSSAPTTTTkrtrrphPKPKTTPHPEVPQTKLAPKQTPRAPPKPKTSPRPRIPQT 781
Cdd:NF033839   428 KPEVKPQPEKPKPEVKPQPEKPKPEVKPQPET-------PKPEVKPQPEKPKPEVKPQPEKPKPDNSKPQADDKKPST 498
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-202 8.81e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.79  E-value: 8.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  123 KPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpndrFYTIRYREKDKE--KKWIFQICPATETIVENLKPNTVYEFG 200
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFR 73


                   ..
gi 2462588874  201 VK 202
Cdd:cd00063     74 VR 75
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 741-811 3.80e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.54  E-value: 3.80e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462588874  741 PHPKPKTTPHPEVPqtklAPKqtpraPPKPKTSPRPRIPQTQ--------PVPKVPQRVTAKPktSPSPEVSYTTPAPK 811
Cdd:NF033838   418 EQPQPAPAPQPEKP----APK-----PEKPAEQPKAEKPADQqaeedyarRSEEEYNRLTQQQ--PPKTEKPAQPSTPK 485
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 722-1093 8.76e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 8.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  722 PITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAP----KQTPRAPPKPKTSPRPRI-PQTQPVPkvPQRVTAKPK 796
Cdd:pfam03154  189 PGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhtliQQTPTLHPQRLPSPHPPLqPMTQPPP--PSQVSPQPL 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  797 TSPSPEVSYT-TPAPKDVLLPHKPYPEVSQSEPAPL---ETRGIPFIPMISPSPSQEELQTTLEETDQSTQEPfttkiPR 872
Cdd:pfam03154  267 PQPSLHGQMPpMPHSLQTGPSHMQHPVPPQPFPLTPqssQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQP-----PR 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  873 TTELAKttqAPHRFYTTVRPRTSDKPHI-RPVLNRTTTRPTRPKPSGMPSgngvgtgvkQAPRPSGADRNVSVDSTHPTK 951
Cdd:pfam03154  342 EQPLPP---APLSMPHIKPPPTTPIPQLpNPQSHKHPPHLSGPSPFQMNS---------NLPPPPALKPLSSLSTHHPPS 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  952 KPGTRRPPLPPRPTHPRRKPLPPNnVTGKPGSAGIISSGPittPPLRSTPRPTGTPLErietdiKQPTVPasgeelenit 1031
Cdd:pfam03154  410 AHPPPLQLMPQSQQLPPPPAQPPV-LTQSQSLPPPAASHP---PTSGLHQVPSQSPFP------QHPFVP---------- 469

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462588874 1032 dfsSSPTRETDPLGKPRFKGPHVRYIQKPDNSPCSITDSV-------------KRFPKEEATEGNATSPPQNPPT 1093
Cdd:pfam03154  470 ---GGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVpaavscplppvqiKEEALDEAEEPESPPPPPRSPS 541
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 429-849 9.12e-17

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 86.92  E-value: 9.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  429 PRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPE--RTTSAGTITPKISKSPEPTWTT 506
Cdd:PHA03247  2551 PPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGdpRGPAPPSPLPPDTHAPDPPPPS 2630

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  507 PAPGKTQfiSLKPKIPLSPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTLAPRKTKRPGRRPRPRPRPKTTPSPEVP 586
Cdd:PHA03247  2631 PSPAANE--PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTP 2708

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  587 KSKPalePATIQPEPLVPTTASKPSERPKTTHRPDAPQIQPGSKPP--KQLLPKPQTTAEPD--MPPTKSVSEPVPFETE 662
Cdd:PHA03247  2709 EPAP---HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGPPapAPPAAPAAGPPRRLTR 2785

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  663 APSMTIVPTTDIEP-----------VTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDfGPITPGtssAP 731
Cdd:PHA03247  2786 PAVASLSESRESLPspwdpadppaaVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-GSVAPG---GD 2861

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  732 TTTTKRTRRPHPKPKTTPHPEV-----------PQTKLAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPS 800
Cdd:PHA03247  2862 VRRRPPSRSPAAKPAAPARPPVrrlarpavsrsTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP 2941

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 2462588874  801 PEVSYTTPAPKDVLLPHKPYPEVSQSEPAPLEtrgIPFIPMISPSPSQE 849
Cdd:PHA03247  2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVA---VPRFRVPQPAPSRE 2987
PHA03247 PHA03247
large tegument protein UL36; Provisional
 419-824 2.31e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.83  E-value: 2.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  419 PPKTSRTLEQPRATLAPSETPFvpqkleiftSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERTTSAGTITPKISK 498
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPPPP---------SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  499 SPE---PTWTTPAPGKTQFISLKPKIPLSPEvthtkPAPEPQTLLPSQSTIGPETPGTKPSTTLAP--RKTKRPGRRPRP 573
Cdd:PHA03247  2679 PPQrprRRAARPTVGSLTSLADPPPPPPTPE-----PAPHALVSATPLPPGPAAARQASPALPAAPapPAVPAGPATPGG 2753

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  574 RPRPKTTPSPEVPKSK--PALEPATIQPEPLVPTTASKPSERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEPDMPPTK 651
Cdd:PHA03247  2754 PARPARPPTTAGPPAPapPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  652 SVSEPVPFETEAPSMTIVPTTDIEP-VTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFGPITPGTSSA 730
Cdd:PHA03247  2834 AQPTAPPPPPGPPPPSLPLGGSVAPgGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQA 2913

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  731 PTTTTKRTRRPHPkPKTTPHPEVPQTKLAPKQtPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAP 810
Cdd:PHA03247  2914 PPPPQPQPQPPPP-PQPQPPPPPPPRPQPPLA-PTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS 2991

                          410
                   ....*....|....
gi 2462588874  811 KDVLLPHKPYPEVS 824
Cdd:PHA03247  2992 STPPLTGHSLSRVS 3005
PHA03247 PHA03247
large tegument protein UL36; Provisional
 586-1013 3.40e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 74.97  E-value: 3.40e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  586 PKSKPALEPATiqPEPLVPTT--ASKPSERPKTT--HRPDAPQIQ--------PGSKPPKQLLPKPQTTAEPDMPPTKSV 653
Cdd:PHA03247  2553 PPLPPAAPPAA--PDRSVPPPrpAPRPSEPAVTSraRRPDAPPQSarprapvdDRGDPRGPAPPSPLPPDTHAPDPPPPS 2630

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  654 SEPVPFETEAPSMTIVPttdiEPVTVRTEATVTTLA-PKTSQRTRTRRPRPKHKTTPRPETLQTkldfgPITPGTSSA-- 730
Cdd:PHA03247  2631 PSPAANEPDPHPPPTVP----PPERPRDDPAPGRVSrPRRARRLGRAAQASSPPQRPRRRAARP-----TVGSLTSLAdp 2701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  731 PTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKQTPRAPPKPKTSPR-------PRIPQTQPVPKVPQRVT--AKPKTSPSP 801
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAgpatpggPARPARPPTTAGPPAPAppAAPAAGPPR 2781

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  802 EVSYTTPAPKDVLLPHKPYPEVSQSEPAPLETRGIPFIPMISPSPSQEELQTTLEETDQSTQEPFTTKIPRTTELA---- 877
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVApggd 2861

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  878 -----KTTQAPHRFYTTVRPRTSDKPhiRPVLNRTTT-------RPTRPKPSGMPSGNGVGTGVKQAPRPSGADRnvsvd 945
Cdd:PHA03247  2862 vrrrpPSRSPAAKPAAPARPPVRRLA--RPAVSRSTEsfalppdQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP----- 2934

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462588874  946 sTHPTKKPGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGII-----SSGPITTPPLRSTPRPTGTPLERIET 1013
Cdd:PHA03247  2935 -PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPrfrvpQPAPSREAPASSTPPLTGHSLSRVSS 3006
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1090-1181 2.63e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 2.63e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874 1090 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNP 1167
Cdd:cd00063      2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 2462588874 1168 LGEGPVSNTVAFST 1181
Cdd:cd00063     80 GGESPPSESVTVTT 93
PHA03247 PHA03247
large tegument protein UL36; Provisional
 331-751 3.23e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.34  E-value: 3.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  331 SARPTTVTPETVPRSTKPTTSSALDVSETTLASSEKPWIVPT-AKISEDSKVLQPQTATYDvfSSPTTSDEPEISDSYTA 409
Cdd:PHA03247  2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPApGRVSRPRRARRLGRAAQA--SSPPQRPRRRAARPTVG 2693

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  410 TSDRILDsiPPKTSRTLE-QPRATLAPSETPFVPQKL-EIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERTT 487
Cdd:PHA03247  2694 SLTSLAD--PPPPPPTPEpAPHALVSATPLPPGPAAArQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  488 SAGTITPkiskspePTWTTPAPGKTQFISLKPKIPLSPEvthtkPAPEPQTLLPSQSTigpETPGTKPSTTLAPRKTKRP 567
Cdd:PHA03247  2772 PAAPAAG-------PPRRLTRPAVASLSESRESLPSPWD-----PADPPAAVLAPAAA---LPPAASPAGPLPPPTSAQP 2836

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  568 GRRPRPRPRPKTTPSPE--VPKSKPALEPATIQPEPLVPTTASKPSER-------PKTTHRPDAPQIQPGSKPPKQLLPK 638
Cdd:PHA03247  2837 TAPPPPPGPPPPSLPLGgsVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlarpavSRSTESFALPPDQPERPPQPQAPPP 2916

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  639 PQTTAEPDMPPTKSVSEPVPFETEAPsmtIVPTTDIEPVtvrteatvttlapktsqrtrtrrprpkhkttPRPETLQTKL 718
Cdd:PHA03247  2917 PQPQPQPPPPPQPQPPPPPPPRPQPP---LAPTTDPAGA-------------------------------GEPSGAVPQP 2962

                          410       420       430
                   ....*....|....*....|....*....|...
gi 2462588874  719 DFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHP 751
Cdd:PHA03247  2963 WLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1091-1171 4.78e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 4.78e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  1091 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQMTNQTFS-TVENLKPNTSYEFQVKPKNPL 1168
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 2462588874  1169 GEG 1171
Cdd:smart00060   81 GEG 83
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 652-852 6.39e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 54.32  E-value: 6.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  652 SVSEPVPFETEAPSMTIVPTTDIEPVTvrTEATVTTLAPKTSQRTRtrrprpKHKTTPRPETLQTKLDFGPitpgTSSAP 731
Cdd:PRK10263   315 PITEPVAVAAAATTATQSWAAPVEPVT--QTPPVASVDVPPAQPTV------AWQPVPGPQTGEPVIAPAP----EGYPQ 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  732 TTTTKRTRRPHPKPKTTPHPEVPQTKLAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYttpAPK 811
Cdd:PRK10263   383 QSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTF---APQ 459

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2462588874  812 DVLLPHKPYPEVSQSEPAPLETRGIPFIPMISPSPSQEELQ 852
Cdd:PRK10263   460 STYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETK 500
PHA03247 PHA03247
large tegument protein UL36; Provisional
 729-1022 7.67e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 7.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  729 SAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKQT------PR-------------------APPKPKTSPRP----RIP 779
Cdd:PHA03247  2490 FAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPvgepvhPRmltwirgleelasddagdpPPPLPPAAPPAapdrSVP 2569

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  780 QTQPVPKVPQ-RVTAKPKTSPSPEVSYTTPAPKDvllPHKPYPEVSQSEPAPLETRGiPFIPMISPSPSQEELQTTLEET 858
Cdd:PHA03247  2570 PPRPAPRPSEpAVTSRARRPDAPPQSARPRAPVD---DRGDPRGPAPPSPLPPDTHA-PDPPPPSPSPAANEPDPHPPPT 2645

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  859 DQSTQEPFTTKIPRTTELAKTTQAPHR-FYTTVRPRTSDKPHIRPVLNRTTT--RPTRPKPSGMPSGNGVGTGVKQAPRP 935
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARRLGRaAQASSPPQRPRRRAARPTVGSLTSlaDPPPPPPTPEPAPHALVSATPLPPGP 2725

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  936 SGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPpnnvTGKPGSAGiiSSGPITTPPlRSTPRPTGTPLERIETDI 1015
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT----AGPPAPAP--PAAPAAGPP-RRLTRPAVASLSESRESL 2798


                   ....*..
gi 2462588874 1016 KQPTVPA 1022
Cdd:PHA03247  2799 PSPWDPA 2805
fn3 pfam00041
Fibronectin type III domain;
1091-1174 1.64e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874 1091 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQMTNQTFS-TVENLKPNTSYEFQVKPKNP 1167
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 2462588874 1168 LGEGPVS 1174
Cdd:pfam00041   79 GGEGPPS 85
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 548-921 4.41e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.15  E-value: 4.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  548 PETPGTKPSTTLAPRKTKRPGRRPRPRPRPKTTPSPEVPKSKPALEpATIQPEPlvpTTASKPSERPKTTHRPDAPQIQP 627
Cdd:PTZ00449   511 PEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGE-VGKKPGP---AKEHKPSKIPTLSKKPEFPKDPK 586

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  628 GSKPPKQllPK----PQTTAEPDMPPTKSVSEPV-----PFETEAPSMTIVPTTDIEPVTVR----TEATVTTLAPKTSQ 694
Cdd:PTZ00449   587 HPKDPEE--PKkpkrPRSAQRPTRPKSPKLPELLdipksPKRPESPKSPKRPPPPQRPSSPErpegPKIIKSPKPPKSPK 664

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  695 RTRTRRPRPK------HKTTPRPETLQT-KLDFGPITPGTSSAPTTTTKRTRRPHPKPkttphPEVPQTKLAPKQTPRAP 767
Cdd:PTZ00449   665 PPFDPKFKEKfyddylDAAAKSKETKTTvVLDESFESILKETLPETPGTPFTTPRPLP-----PKLPRDEEFPFEPIGDP 739

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  768 PKPKTSP----------RPRIPQTQPVPKVPQRVTAKPKTspsPEVSYTTPAPKDvllPHKPYPEVSQSEPAPLETRgiP 837
Cdd:PTZ00449   740 DAEQPDDiefftppeeeRTFFHETPADTPLPDILAEEFKE---EDIHAETGEPDE---AMKRPDSPSEHEDKPPGDH--P 811

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  838 FIPMISPSPSQEELQTTLEETD------QSTQEPFTTKIPRT-TELAKTTQAPH-------------------------- 884
Cdd:PTZ00449   812 SLPKKRHRLDGLALSTTDLESDagriakDASGKIVKLKRSKSfDDLTTVEEAEEmgaearkivvdddgteaddedthppe 891

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2462588874  885 -RFYTTVRPRTSDKPHIRPVLNRTTTRPTRPKPSGMPS 921
Cdd:PTZ00449   892 eKHKSEVRRRRPPKKPSKPKKPSKPKKPKKPDSAFIPS 929
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 741-827 5.53e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 47.50  E-value: 5.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  741 PHPKPKTTPHPEVPQTKLAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLPHKPY 820
Cdd:PRK14950   366 PQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEKPKYT 445


                   ....*..
gi 2462588874  821 PEVSQSE 827
Cdd:PRK14950   446 PPAPPKE 452
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 754-839 1.01e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 46.86  E-value: 1.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  754 PQTKLAPKQTPRAPPKPKTSPRP-RIPQTQPVPKVPQRVTAKPKTSPSPEvSYTTPAPKDVLLPHKPYPEVSQSEPAPLE 832
Cdd:PRK14954   376 NDGGVAPSPAGSPDVKKKAPEPDlPQPDRHPGPAKPEAPGARPAELPSPA-SAPTPEQQPPVARSAPLPPSPQASAPRNV 454


                   ....*..
gi 2462588874  833 TRGIPFI 839
Cdd:PRK14954   455 ASGKPGV 461
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 583-801 1.03e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 46.46  E-value: 1.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  583 PEVPKSKPALEPATIQPEPLVPTTASKPSER--PK---TTHRPDAPQIQ-PGSKPPKQLLPKPQTTAEPDMPPTKSVSEP 656
Cdd:PLN03209   328 VPPKESDAADGPKPVPTKPVTPEAPSPPIEEepPQpkaVVPRPLSPYTAyEDLKPPTSPIPTPPSSSPASSKSVDAVAKP 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  657 VPFETEAPSMTIVPTTDIEPVTVRTE--------ATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTklDFGPITPGTS 728
Cdd:PLN03209   408 AEPDVVPSPGSASNVPEVEPAQVEAKktrplspyARYEDLKPPTSPSPTAPTGVSPSVSSTSSVPAVP--DTAPATAATD 485

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  729 SA-PTTTTKRTRRPHP-----KPKTTPHPEVPQTKLAPKQTPRAPP----KPKTSPRPRIPQTQPVPK----VPQRVTAK 794
Cdd:PLN03209   486 AAaPPPANMRPLSPYAvyddlKPPTSPSPAAPVGKVAPSSTNEVVKvgnsAPPTALADEQHHAQPKPRplspYTMYEDLK 565


                   ....*..
gi 2462588874  795 PKTSPSP 801
Cdd:PLN03209   566 PPTSPTP 572
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 395-816 1.30e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  395 PTTSDEPEISDSYTATSDRILDSIPPKTSRTLEQPRATLAP-------SETPF-VPQKLEIFTSPEMQPTTPAPQQTTSI 466
Cdd:pfam05109  310 PASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAfwawpnnTETDFkCKWTLTSGTPSGCENISGAFASNRTF 389

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  467 PSTPKRRPRPKPPRTKPERTTSAGTITPKI--SKSPEPTWTTPAPGKTQFISLKPKIPLsPEVTH-----TKPA---PEP 536
Cdd:pfam05109  390 DITVSGLGTAPKTLIITRTATNATTTTHKVifSKAPESTTTSPTLNTTGFAAPNTTTGL-PSSTHvptnlTAPAstgPTV 468

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  537 QTLLPSQSTIGPETPGTKPST-TLAPRKTKRPGRRPRPRPRPKTTPSPEVPKSKPALEPATIQPEPLVPTTASKPSERPK 615
Cdd:pfam05109  469 STADVTSPTPAGTTSGASPVTpSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAV 548

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  616 TTHRPDAPQIQPGSKPPKqllPKPQTTAEPDMPPTKSVSEPVPFETEAPSMTIVPTTDIEPVTV--RTEATVTTLAPKTS 693
Cdd:pfam05109  549 TTPTPNATSPTPAVTTPT---PNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLggTSSTPVVTSPPKNA 625

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  694 QRTRTRRPRPKHKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKQTPRAP-PKPKT 772
Cdd:pfam05109  626 TSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPaPRPGT 705

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2462588874  773 SPRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLP 816
Cdd:pfam05109  706 TSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVP 749
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
907-1186 1.46e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.15  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  907 TTTRPTRPKPSGMPSGNGVGTGVKQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGI 986
Cdd:COG3401     48 TKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATT 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  987 ISSGPITTPPLRSTPRPTGTPLERIETDIKQPTVPASGEELENITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNS--- 1063
Cdd:COG3401    128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTyyy 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874 1064 -PCSITDSVKRFPKEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQMT 1142
Cdd:COG3401    208 rVAATDTGGESAPSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATV 282

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 2462588874 1143 NQTFSTVENLKPNTSYEFQVKPKNPLG-EGPVSNTVAFSTESADP 1186
Cdd:COG3401    283 TTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1085-1229 1.87e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.76  E-value: 1.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874 1085 TSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqmtNQTFSTVENLKPNTSYEFQV 1162
Cdd:COG3401    324 LTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGLTPGTTYYYKV 397

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462588874 1163 KPKNPLG-EGPVSNTVAFSTESADPRVSEPVSAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVG 1229
Cdd:COG3401    398 TAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG 465
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 607-1005 1.97e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.93  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  607 ASKPSERPKTTHRPDAPQIQPGSkpPKQLLPKPQTTAEPDMPPTKSVSEPVPFETEAPS--MTIVPTTDIEPVTVRTEAT 684
Cdd:PHA03307    17 GGEFFPRPPATPGDAADDLLSGS--QGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPgpGTEAPANESRSTPTWSLST 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  685 VTTLAPKTSQRTRTRRPRPKhKTTPRPETlqtkldfgPITPGTSSAPttttkrtrrPHPKPKTTPHPEVPQTKLAPKQTP 764
Cdd:PHA03307    95 LAPASPAREGSPTPPGPSSP-DPPPPTPP--------PASPPPSPAP---------DLSEMLRPVGSPGPPPAASPPAAG 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  765 RAPPKPKTSPRPRIPQTQPVPKVPQrvTAKPKTSPSPEVSYTTPAPKDVLLPHKPYPEVS--QSEPAPLETRGIPFIPMI 842
Cdd:PHA03307   157 ASPAAVASDAASSRQAALPLSSPEE--TARAPSSPPAEPPPSTPPAAASPRPPRRSSPISasASSPAPAPGRSAADDAGA 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  843 SPSPSqeelqttLEETDQSTQEPFTTKIPRTTELAKTTQAPHRFYTTVRPRTSDKPHIRPvlnRTTTRPTRPKPSGMPSG 922
Cdd:PHA03307   235 SSSDS-------SSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASS---SSSPRERSPSPSPSSPG 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  923 NGVGTGVKQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGIISSGPITTPPLRSTPR 1002
Cdd:PHA03307   305 SGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGR 384


                   ...
gi 2462588874 1003 PTG 1005
Cdd:PHA03307   385 PTR 387
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 719-804 2.01e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 46.04  E-value: 2.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  719 DFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKQTPRAPPKPKTSPRPriPQTQPVPKVPQRVTAKPKTS 798
Cdd:PRK12270    35 DYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAA--AAAPAAPPAAAAAAAPAAAA 112


                   ....*.
gi 2462588874  799 PSPEVS 804
Cdd:PRK12270   113 VEDEVT 118
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 124-202 2.13e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.13e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874   124 PLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPNDRFYTIRYREKDKEKKWIFQICPA----TETIVENLKPNTVYEF 199
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTEYEF 72


                    ...
gi 2462588874   200 GVK 202
Cdd:smart00060   73 RVR 75
fn3 pfam00041
Fibronectin type III domain;
123-202 2.20e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.25  E-value: 2.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  123 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPND-RFYTIRYREKDKEKKWIFQICPATET--IVENLKPNTVYEF 199
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 2462588874  200 GVK 202
Cdd:pfam00041   72 RVQ 74
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
663-846 4.30e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 4.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  663 APSMTIVPTTDIEPVTVRTEAT--VTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFGPITPGTSSAPTtttkrtrr 740
Cdd:PRK12323   380 APVAQPAPAAAAPAAAAPAPAAppAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA-------- 451

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  741 phPKPKTTPHPEVPqtklAPKQTPRAPPKPKTSPRPR---IPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLPH 817
Cdd:PRK12323   452 --PAPAAAPAAAAR----PAAAGPRPVAAAAAAAPARaapAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAES 525

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2462588874  818 KPYPEVSQSEP-----------APLETRGIPFIPMISPSP 846
Cdd:PRK12323   526 IPDPATADPDDafetlapapaaAPAPRAAAATEPVVAPRP 565
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 590-658 4.60e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 44.42  E-value: 4.60e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462588874  590 PALEPATIQPEPLVPTtASKPSERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEPDMPPTKSVSEPVP 658
Cdd:PRK14950   362 PVPAPQPAKPTAAAPS-PVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAP 429
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 320-776 5.32e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 5.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  320 AESKTPEVEKISARPTTVTPETVPRSTKPTTSSALDVSETTLASSEKPWIVPTAKISEDSKVLQPQTATYDVFSSPTTSD 399
Cdd:pfam03154   87 GASDTEEPERATAKKSKTQEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQI 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  400 EPEISDSYTATSDRILDSIPPKTSRTleQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPP 479
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTT--QAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPS 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  480 RTKPERTTSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTL 559
Cdd:pfam03154  245 PHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQR 324

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  560 AprKTKRPGRRPRPRPRPKTTPSPEVPKSKPALEPATIQPEPLVPTTASKpsERPKTTHRPDAPQIQPGSKPPKQLlpKP 639
Cdd:pfam03154  325 I--HTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSH--KHPPHLSGPSPFQMNSNLPPPPAL--KP 398

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  640 QTTAEPDMPPTksvSEPVPFETEAPSMTIVPTTDIEPVTVRTEATVTTLA----PKTSQRTRTRRPRPKHKTTPRPETLQ 715
Cdd:pfam03154  399 LSSLSTHHPPS---AHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAAshppTSGLHQVPSQSPFPQHPFVPGGPPPI 475

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462588874  716 TKldfgPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKQT----------PRAPPKPKTSPRP 776
Cdd:pfam03154  476 TP----PSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIkeealdeaeePESPPPPPRSPSP 542
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 420-787 5.42e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.68  E-value: 5.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  420 PKTSRTLEQPRATLAP-----SETPFVPQKLEIFTSPE-----MQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERTTSA 489
Cdd:PTZ00449   597 PKRPRSAQRPTRPKSPklpelLDIPKSPKRPESPKSPKrppppQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFY 676

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  490 GTITPKISKSPEpTWTTPAPGKTQFISLKPKIPLSPEVTHTKPAPepqtlLPSQSTIGPETPGTKPSTTLAPRktkrpgr 569
Cdd:PTZ00449   677 DDYLDAAAKSKE-TKTTVVLDESFESILKETLPETPGTPFTTPRP-----LPPKLPRDEEFPFEPIGDPDAEQ------- 743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  570 rprprPRPKTTPSPEVPKSKPALEPATIQPEPLVPTTASKPSERPKTTHRPDAPQIQPGSkpPKQLLPKPqTTAEPDMPP 649
Cdd:PTZ00449   744 -----PDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAMKRPDS--PSEHEDKP-PGDHPSLPK 815

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  650 TKSVSE-----PVPFETEAPSMTIVPTTdiEPVTVRTEATVTTLApktsqrtrtrrprpkhkttprpeTLQTKLDFGPIT 724
Cdd:PTZ00449   816 KRHRLDglalsTTDLESDAGRIAKDASG--KIVKLKRSKSFDDLT-----------------------TVEEAEEMGAEA 870

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462588874  725 PGTSSAPTTTTKRTRRPHPkPKTTPHPEVPQTKlaPKQTPRAPPKPKTSPRPRIPQTQPVPKV 787
Cdd:PTZ00449   871 RKIVVDDDGTEADDEDTHP-PEEKHKSEVRRRR--PPKKPSKPKKPSKPKKPKKPDSAFIPSI 930
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 548-781 7.98e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 43.60  E-value: 7.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  548 PETPGTK----PSTTLAPRKTKRPGRRPRPRPRPKTTPSPEVPKSKPALEPATIQPEPLVPTTASKPseRPKTTHRPDAP 623
Cdd:NF033839   284 PKEPGNKkpsaPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETP--KPEVKPQPEKP 361

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  624 QIQPGSKPPKqllPKPQTTAEPDMPPTKSVSEPvpfETEAPSMTIVPTTDIEPVTVRTEATVTTLAPKtsqrtrtrRPRP 703
Cdd:NF033839   362 KPEVKPQPEK---PKPEVKPQPETPKPEVKPQP---EKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQ--------PEKP 427

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462588874  704 KHKTTPRPETLQTKLDFGPITPGTSSAPTTTTkrtrrphPKPKTTPHPEVPQTKLAPKQTPRAPPKPKTSPRPRIPQT 781
Cdd:NF033839   428 KPEVKPQPEKPKPEVKPQPEKPKPEVKPQPET-------PKPEVKPQPEKPKPEVKPQPEKPKPDNSKPQADDKKPST 498
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 718-850 8.17e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.92  E-value: 8.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  718 LDFGPITP--GTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKQTPRAPPKPKTSP-RPRIPQTQPV----PKVPQR 790
Cdd:PRK10263   736 LDDGPHEPlfTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPqQPVAPQPQYQqpqqPVAPQP 815

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462588874  791 VTAKPKTSPSPEVSY------TTPAPKDVLLpHKPYPEVSQSEPAPLETRGIPFIPMISPSPSQEE 850
Cdd:PRK10263   816 QYQQPQQPVAPQPQYqqpqqpVAPQPQDTLL-HPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSEVE 880
PRK11633 PRK11633
cell division protein DedD; Provisional
 722-811 8.26e-04

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 42.30  E-value: 8.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  722 PITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPqtkLAPKQTPRAPPKPKtsPRPRiPQTQPVPKVPQRVTAKPKTSPSP 801
Cdd:PRK11633    64 PTQPPEGAAEAVRAGDAAAPSLDPATVAPPNTP---VEPEPAPVEPPKPK--PVEK-PKPKPKPQQKVEAPPAPKPEPKP 137

                           90
                   ....*....|
gi 2462588874  802 EVSyTTPAPK 811
Cdd:PRK11633   138 VVE-EKAAPT 146
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-202 8.81e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.79  E-value: 8.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  123 KPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpndrFYTIRYREKDKE--KKWIFQICPATETIVENLKPNTVYEFG 200
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEFR 73


                   ..
gi 2462588874  201 VK 202
Cdd:cd00063     74 VR 75
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 317-553 2.06e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 42.25  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  317 ALPAESKTPEVEKISArPTTVTPETvPRSTKPTTSSALDVSETTLASSEKPWIVPT-AKISEDSKVLQPQTATYDVFSS- 394
Cdd:pfam17823  129 SLPAAIAALPSEAFSA-PRAAACRA-NASAAPRAAIAAASAPHAASPAPRTAASSTtAASSTTAASSAPTTAASSAPATl 206

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  395 -PTTSDEPEISDSYTATSDRILDSIPPKTS--RTLEQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPK 471
Cdd:pfam17823  207 tPARGISTAATATGHPAAGTALAAVGNSSPaaGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHM 286

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  472 RRPRPKPPRTKPERTTSAGTIT------PKISKSPEPT------------------------WTTPAPGKTQFISLKPKI 521
Cdd:pfam17823  287 PSDTMARNPAAPMGAQAQGPIIqvstdqPVHNTAGEPTpspsnttlepntpksvastnlavvTTTKAQAKEPSASPVPVL 366

                          250       260       270
                   ....*....|....*....|....*....|....
gi 2462588874  522 PLS--PEVTHTKPAPEPQTLLPSQSTIGPETPGT 553
Cdd:pfam17823  367 HTSmiPEVEATSPTTQPSPLLPTQGAAGPGILLA 400
PHA03378 PHA03378
EBNA-3B; Provisional
 589-799 2.06e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.75  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  589 KPALEPATIQPEPLVPTTASKPSERPKTTHRPDAPQIQ---PGSKPPKQ----LLPKPQTTAE-------------PDMP 648
Cdd:PHA03378   575 QPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQshiPETSAPRQwpmpLRPIPMRPLRmqpitfnvlvfptPHQP 654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  649 PTKSVSEPVPFETEAPSMTIVPTT---------DIEPVTVRTEATVTT-LAPKTSQRTRTRRPRPKHKTTPRPETLQTKL 718
Cdd:PHA03378   655 PQVEITPYKPTWTQIGHIPYQPSPtgantmlpiQWAPGTMQPPPRAPTpMRPPAAPPGRAQRPAAATGRARPPAAAPGRA 734

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  719 DFGPITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTS 798
Cdd:PHA03378   735 RPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAA 814


                   .
gi 2462588874  799 P 799
Cdd:PHA03378   815 P 815
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
519-745 2.32e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 2.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  519 PKIPLSPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTLAPRktkrpgrrprprprpKTTPSPEVPKSKPALEPATIQ 598
Cdd:PRK12323   374 PATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAAR---------------AVAAAPARRSPAPEALAAARQ 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  599 PEPLVPTTASKPSERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEPDMPPTKSVSEPVPFETEAPSMTIVPTTDIEPVT 678
Cdd:PRK12323   439 ASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAP 518

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462588874  679 VRTEAtvttlapktsqrtrtrrprpkhKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRRPHPKP 745
Cdd:PRK12323   519 AGWVA----------------------ESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAP 563
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 743-830 2.36e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 42.14  E-value: 2.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  743 PKPKTTPHPEVPQTKLAPKQTPRAPPKPKTSPRPripQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLPHKPYPE 822
Cdd:COG3266    265 SAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSA---VALPAAPAAAAAAAAPAEAAAPQPTAAKPVVTETAAPAAPAPE 341


                   ....*...
gi 2462588874  823 VSQSEPAP 830
Cdd:COG3266    342 AAAAAAAP 349
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 491-725 2.53e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 2.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  491 TITPKIskSPEPTWTTPAPGKTQfislkpkiplsPEVTHTKPAPEPQTLLPSQSTIGPETPGTKPSTTLAPRKTKRPGRR 570
Cdd:PRK10263   368 TGEPVI--APAPEGYPQQSQYAQ-----------PAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYY 434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  571 PRPRPRPKTTPSPEVPKSKPALEP-ATIQPEPLV--PTTASKPSERPKTTHRPDAPQIQPG------SKPP--------- 632
Cdd:PRK10263   435 APAPEQPVAGNAWQAEEQQSTFAPqSTYQTEQTYqqPAAQEPLYQQPQPVEQQPVVEPEPVveetkpARPPlyyfeevee 514

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  633 ------KQLLPKPQTTAEPDMPPtksvsEPVPFETEAPSMTIVPTTDIEPVTVRTEATV--TTLAPKTSQRTRTRRPRPK 704
Cdd:PRK10263   515 krarerEQLAAWYQPIPEPVKEP-----EPIKSSLKAPSVAAVPPVEAAAAVSPLASGVkkATLATGAAATVAAPVFSLA 589

                          250       260
                   ....*....|....*....|.
gi 2462588874  705 HKTTPRPetlQTKLDFGPITP 725
Cdd:PRK10263   590 NSGGPRP---QVKEGIGPQLP 607
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 722-810 2.64e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.10  E-value: 2.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  722 PITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTklAPKQTPRAPPKPKTSPRPRiPQTQPVPKVPQRVTAKPKTSPSP 801
Cdd:PRK14950   362 PVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAAN--IPPKEPVRETATPPPVPPR-PVAPPVPHTPESAPKLTRAAIPV 438


                   ....*....
gi 2462588874  802 EVSYTTPAP 810
Cdd:PRK14950   439 DEKPKYTPP 447
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 317-783 3.34e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.83  E-value: 3.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  317 ALPAESKTPEVEKISARPTTVTPETVPRSTKPTTSSALDVSETTLASsekpwivPTAKISEDSKVLQPQTATYDVFSSPT 396
Cdd:pfam05109  395 GLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAA-------PNTTTGLPSSTHVPTNLTAPASTGPT 467

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  397 TSDEPEISDSYTATSDRILDSIPPKTsrtleqPRATLAPSETPFVpqkleifTSPEMQPTTPAPQQTTSIPSTPKRRPRP 476
Cdd:pfam05109  468 VSTADVTSPTPAGTTSGASPVTPSPS------PRDNGTESKAPDM-------TSPTSAVTTPTPNATSPTPAVTTPTPNA 534

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  477 KPPRTKPERTTSAGTITPKISKSPEPTWTTPAPGKTqFISLKPKIPLSPEVTHTKPAPEPQTLLPS-QSTIGPETPGTKP 555
Cdd:pfam05109  535 TSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNAT-IPTLGKTSPTSAVTTPTPNATSPTVGETSpQANTTNHTLGGTS 613

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  556 STTLAPRKTKRPGRRPRPRPRPKTTPSPEVPKSKPALEPATIQPEPLVPTTASKP---SERPktTHRPDAPQIQPGSKPP 632
Cdd:pfam05109  614 STPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPlltSAHP--TGGENITQVTPASTST 691

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  633 KQL-----LPKPQTTAEPDMPPTKSVS-EPVPFETEAPSMTIVPTTDIEPVTVRTEATVTTLAPKTSQRTRTRRPRPKH- 705
Cdd:pfam05109  692 HHVstsspAPRPGTTSQASGPGNSSTStKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHg 771

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  706 -KTTPRPETlqtklDFGpitpGTSSAPTTTTKRtrrphpkpkTTPHPEVPQTKLAPKQTPRAPP-KPKTSPRPRIPQTQP 783
Cdd:pfam05109  772 aRTSTEPTT-----DYG----GDSTTPRTRYNA---------TTYLPPSTSSKLRPRWTFTSPPvTTAQATVPVPPTSQP 833
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 725-830 3.59e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 3.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  725 PGTSSAPTTTTKRTRRPHPKPKTT----PHPEVPQTKLAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVtakpktsPS 800
Cdd:PRK14951   375 PAEKKTPARPEAAAPAAAPVAQAAaapaPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAV-------AL 447

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462588874  801 PEVSYTTPAPKDVLLPHK--PYPEVSQSEPAP 830
Cdd:PRK14951   448 APAPPAQAAPETVAIPVRvaPEPAVASAAPAP 479
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 741-811 3.80e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.54  E-value: 3.80e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462588874  741 PHPKPKTTPHPEVPqtklAPKqtpraPPKPKTSPRPRIPQTQ--------PVPKVPQRVTAKPktSPSPEVSYTTPAPK 811
Cdd:NF033838   418 EQPQPAPAPQPEKP----APK-----PEKPAEQPKAEKPADQqaeedyarRSEEEYNRLTQQQ--PPKTEKPAQPSTPK 485
PRK10905 PRK10905
cell division protein DamX; Validated
 593-694 4.44e-03

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 40.69  E-value: 4.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  593 EPATIQP---EPLVPTTASKPSERPKTTHRPDAPQIQPGSKppkqllpKPQTTAE-PDMPPTKSVSEPVPFETEAPSMTI 668
Cdd:PRK10905   126 EPATVAPvrnGNASRQTAKTQTAERPATTRPARKQAVIEPK-------KPQATAKtEPKPVAQTPKRTEPAAPVASTKAP 198

                           90       100
                   ....*....|....*....|....*.
gi 2462588874  669 VPTTDIEPVTVRTEATVTTLAPKTSQ 694
Cdd:PRK10905   199 AATSTPAPKETATTAPVQTASPAQTT 224
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 582-776 5.67e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 5.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  582 SPEVPKSKPALEPATIQPEPLVPTTASKPsERPKTTHRPDAPQIQPGSKPPKQLLPKPQTTAEPDMPPTKSVS-EPVPFE 660
Cdd:PRK07764   596 GGEGPPAPASSGPPEEAARPAAPAAPAAP-AAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDgWPAKAG 674

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  661 TEAPSMTIVPTTDIEPVTVRTEATvttlapktsqrtrtRRPRPKHKTTPRPETLQTKLDFGPITPGTSSAPTTTTKRTRR 740
Cdd:PRK07764   675 GAAPAAPPPAPAPAAPAAPAGAAP--------------AQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP 740

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2462588874  741 PHPKPKTTPHPEVPQTKLAPKQTPRAPPKPKTSPRP 776
Cdd:PRK07764   741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPP 776
Orthopox_A5L pfam06193
Orthopoxvirus A5L protein-like; This family includes several Orthopoxvirus A5L proteins. The ...
 755-875 7.19e-03

Orthopoxvirus A5L protein-like; This family includes several Orthopoxvirus A5L proteins. The vaccinia virus WR A5L open reading frame (corresponding to open reading frame A4L in vaccinia virus Copenhagen) encodes an immunodominant late protein found in the core of the vaccinia virion. The A5 protein appears to be required for the immature virion to form the brick-shaped intracellular mature virion.


Pssm-ID: 283778 [Multi-domain]  Cd Length: 216  Bit Score: 39.58  E-value: 7.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  755 QTKLAPKQTPRAPPKPKTSPRP-RIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLPHKPYPEVSQSEPAPLET 833
Cdd:pfam06193   61 DNMLAASRQPIQPLQPTIHITPiEIPTPAPTPKPRQQELGTPSTSCTQNSDASIACSTDIVTPPQPPIVATVCTPTPTDG 140

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2462588874  834 RgIPFIPMISPSP---SQEELQTTLEETDQSTQEPFTTKIPRTTE 875
Cdd:pfam06193  141 R-ICTTADQNPNPgatIQKELDNMALKDLMSSVEKDMCQLQAESE 184
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 722-1093 8.76e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 8.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  722 PITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAP----KQTPRAPPKPKTSPRPRI-PQTQPVPkvPQRVTAKPK 796
Cdd:pfam03154  189 PGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhtliQQTPTLHPQRLPSPHPPLqPMTQPPP--PSQVSPQPL 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  797 TSPSPEVSYT-TPAPKDVLLPHKPYPEVSQSEPAPL---ETRGIPFIPMISPSPSQEELQTTLEETDQSTQEPfttkiPR 872
Cdd:pfam03154  267 PQPSLHGQMPpMPHSLQTGPSHMQHPVPPQPFPLTPqssQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQP-----PR 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  873 TTELAKttqAPHRFYTTVRPRTSDKPHI-RPVLNRTTTRPTRPKPSGMPSgngvgtgvkQAPRPSGADRNVSVDSTHPTK 951
Cdd:pfam03154  342 EQPLPP---APLSMPHIKPPPTTPIPQLpNPQSHKHPPHLSGPSPFQMNS---------NLPPPPALKPLSSLSTHHPPS 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588874  952 KPGTRRPPLPPRPTHPRRKPLPPNnVTGKPGSAGIISSGPittPPLRSTPRPTGTPLErietdiKQPTVPasgeelenit 1031
Cdd:pfam03154  410 AHPPPLQLMPQSQQLPPPPAQPPV-LTQSQSLPPPAASHP---PTSGLHQVPSQSPFP------QHPFVP---------- 469

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462588874 1032 dfsSSPTRETDPLGKPRFKGPHVRYIQKPDNSPCSITDSV-------------KRFPKEEATEGNATSPPQNPPT 1093
Cdd:pfam03154  470 ---GGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVpaavscplppvqiKEEALDEAEEPESPPPPPRSPS 541
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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