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Conserved domains on  [gi|2462587219|ref|XP_054201251|]
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interleukin-17 receptor E isoform X11 [Homo sapiens]

Protein Classification

TIR domain-containing protein( domain architecture ID 581104)

TIR (Toll/interleukin-1 receptor) domain-containing protein

CATH:  3.40.50.10140
PubMed:  32002590|29395922|34868065

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEFIR super family cl23749
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 189-312 1.52e-12

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


The actual alignment was detected with superfamily member pfam08357:

Pssm-ID: 474043  Cd Length: 150  Bit Score: 64.72  E-value: 1.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587219 189 RPVLLLHAADSEAQRRLVGALAELLRAALGggRDVIVDLWEGRHVARVGPLPWLWAArtrvAREQGTVLLLWS------- 261
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYCG--CEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSkgakafc 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462587219 262 ---GADLRPVSGPDPRAAP--------LLALLHAAPRPLLLLAYFsRLCAKGDIPPPLRALP 312
Cdd:pfam08357  75 dkkADKRKGGVGTESQHDLfipalsliLRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLP 135
IL17_R_N super family cl20911
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 110-149 9.49e-08

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


The actual alignment was detected with superfamily member pfam15037:

Pssm-ID: 464460  Cd Length: 388  Bit Score: 53.33  E-value: 9.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462587219 110 QARGSSpvSLDLIIPFLRPGCCVLVWRSDVQFAWKhllCP 149
Cdd:pfam15037 354 QTRAAR--LGEQLLQDLQSGQCVQLWRDDVGFLWA---CP 388
 
Name Accession Description Interval E-value
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 189-312 1.52e-12

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 64.72  E-value: 1.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587219 189 RPVLLLHAADSEAQRRLVGALAELLRAALGggRDVIVDLWEGRHVARVGPLPWLWAArtrvAREQGTVLLLWS------- 261
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYCG--CEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSkgakafc 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462587219 262 ---GADLRPVSGPDPRAAP--------LLALLHAAPRPLLLLAYFsRLCAKGDIPPPLRALP 312
Cdd:pfam08357  75 dkkADKRKGGVGTESQHDLfipalsliLRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLP 135
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 110-149 9.49e-08

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


Pssm-ID: 464460  Cd Length: 388  Bit Score: 53.33  E-value: 9.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462587219 110 QARGSSpvSLDLIIPFLRPGCCVLVWRSDVQFAWKhllCP 149
Cdd:pfam15037 354 QTRAAR--LGEQLLQDLQSGQCVQLWRDDVGFLWA---CP 388
 
Name Accession Description Interval E-value
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 189-312 1.52e-12

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 64.72  E-value: 1.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462587219 189 RPVLLLHAADSEAQRRLVGALAELLRAALGggRDVIVDLWEGRHVARVGPLPWLWAArtrvAREQGTVLLLWS------- 261
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYCG--CEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSkgakafc 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462587219 262 ---GADLRPVSGPDPRAAP--------LLALLHAAPRPLLLLAYFsRLCAKGDIPPPLRALP 312
Cdd:pfam08357  75 dkkADKRKGGVGTESQHDLfipalsliLRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLP 135
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 110-149 9.49e-08

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


Pssm-ID: 464460  Cd Length: 388  Bit Score: 53.33  E-value: 9.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462587219 110 QARGSSpvSLDLIIPFLRPGCCVLVWRSDVQFAWKhllCP 149
Cdd:pfam15037 354 QTRAAR--LGEQLLQDLQSGQCVQLWRDDVGFLWA---CP 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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