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Conserved domains on  [gi|2462575019|ref|XP_054198867|]
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protein IWS1 homolog isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFIIS_I super family cl00146
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ...
 533-724 2.02e-27

N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme


The actual alignment was detected with superfamily member COG5139:

Pssm-ID: 469629  Cd Length: 397  Bit Score: 115.18  E-value: 2.02e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 533 DFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETF 612
Cdd:COG5139   126 ELGDTGDRQLKAPAASRARRKEDLLEQTVDEISLRLKKRMQDAAKKDNANNLEGRPATGKIKNLPEVSDVLMKKALQDTI 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 613 IDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPsVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSR 692
Cdd:COG5139   206 LDNNILDSVRGWLEPLPDKSLPNIKIQKSLLDVLKTLP-IHTEHLVESGVGRIVYFYTISKKEEKEVRRSAKALVQEWTR 284

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462575019 693 PIFGLTSNYKGmTREEREQRDLEQMPQRRRMN 724
Cdd:COG5139   285 PIIKPSGNYRD-KRIMQLEFDSEKLRKKSVMD 315
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 11-371 1.18e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.77  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  11 QDPPEEDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSverhseNETSDREdglpkghhvTDSENDEPlnlNASDSESE 90
Cdd:NF033609  546 EQPDEPGEIEPIPEDSDSDPGSDSGSDSSNSDSGSDSGS------DSTSDSG---------SDSASDSD---SASDSDSA 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  91 ElhrqkDSDSESEERAeppASDSENEDVNQHGSDSESEETrklpgSDSENEELLNGHASDSENEDVGKHPASDSEIEELQ 170
Cdd:NF033609  608 S-----DSDSASDSDS---ASDSDSASDSDSASDSDSASD-----SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 674

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 171 KSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEelpkpqvSDSESEEPPRHQASDSENEELPKP 250
Cdd:NF033609  675 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDSDSDSDSDSDSDSDSDSDSD 747

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 251 RISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKgpaSDSETEDASRHKQ 330
Cdd:NF033609  748 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDS 824

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2462575019 331 KPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSE 371
Cdd:NF033609  825 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSE 865
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 272-520 6.40e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.45  E-value: 6.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  272 ELPKPRISDSESEdPPRNQASDSENE---ELPKPRVSDSESEGPQKGPASDSETEDASRHKQ-----KPESDDDSDRENK 343
Cdd:TIGR00927  656 EGENGEESGGEAE-QEGETETKGENEsegEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEhegetEAEGTEDEGEIET 734

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  344 GEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDekegeeekvakrkaavlSDSEDEEKASAKKSRVVSDAD 423
Cdd:TIGR00927  735 GEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKE-----------------DEDEGEIQAGEDGEMKGDEGA 797

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  424 DSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADifGESGDEEEEEFTGFNQEDLEE 503
Cdd:TIGR00927  798 EGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDG--GGGSDGGDSEEEEEEEEEEEE 875

                          250
                   ....*....|....*..
gi 2462575019  504 EKGETQVKEAEDSDSDD 520
Cdd:TIGR00927  876 EEEEEEEEEEEEEENEE 892
 
Name Accession Description Interval E-value
COG5139 COG5139
Uncharacterized conserved protein [Function unknown];
533-724 2.02e-27

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227468  Cd Length: 397  Bit Score: 115.18  E-value: 2.02e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 533 DFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETF 612
Cdd:COG5139   126 ELGDTGDRQLKAPAASRARRKEDLLEQTVDEISLRLKKRMQDAAKKDNANNLEGRPATGKIKNLPEVSDVLMKKALQDTI 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 613 IDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPsVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSR 692
Cdd:COG5139   206 LDNNILDSVRGWLEPLPDKSLPNIKIQKSLLDVLKTLP-IHTEHLVESGVGRIVYFYTISKKEEKEVRRSAKALVQEWTR 284

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462575019 693 PIFGLTSNYKGmTREEREQRDLEQMPQRRRMN 724
Cdd:COG5139   285 PIIKPSGNYRD-KRIMQLEFDSEKLRKKSVMD 315
Med26 pfam08711
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ...
 641-694 2.35e-12

TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.


Pssm-ID: 462573 [Multi-domain]  Cd Length: 52  Bit Score: 62.15  E-value: 2.35e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462575019 641 ELLKILQELPsVSQETLKHSGIGRAVMYLYKHPkESRSNKDMAGKLINEWSRPI 694
Cdd:pfam08711   1 KLLKKLEKLP-VTLELLKSTGIGKVVNKLRKHK-ENPEIKKLAKELVKKWKRLV 52
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 11-371 1.18e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.77  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  11 QDPPEEDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSverhseNETSDREdglpkghhvTDSENDEPlnlNASDSESE 90
Cdd:NF033609  546 EQPDEPGEIEPIPEDSDSDPGSDSGSDSSNSDSGSDSGS------DSTSDSG---------SDSASDSD---SASDSDSA 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  91 ElhrqkDSDSESEERAeppASDSENEDVNQHGSDSESEETrklpgSDSENEELLNGHASDSENEDVGKHPASDSEIEELQ 170
Cdd:NF033609  608 S-----DSDSASDSDS---ASDSDSASDSDSASDSDSASD-----SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 674

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 171 KSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEelpkpqvSDSESEEPPRHQASDSENEELPKP 250
Cdd:NF033609  675 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDSDSDSDSDSDSDSDSDSDSD 747

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 251 RISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKgpaSDSETEDASRHKQ 330
Cdd:NF033609  748 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDS 824

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2462575019 331 KPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSE 371
Cdd:NF033609  825 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSE 865
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-334 3.52e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 3.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   16 EDDGGATPVqderdSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNA--SDSESEELH 93
Cdd:PHA03307    28 PGDAADDLL-----SGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSlsTLAPASPAR 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   94 RQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEI----EEL 169
Cdd:PHA03307   103 EGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPlsspEET 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  170 QKSPASDSETEDALKPQISDSESEEPPRHQASDSeneePPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEElPK 249
Cdd:PHA03307   183 ARAPSSPPAEPPPSTPPAAASPRPPRRSSPISAS----ASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENEC-PL 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  250 PRIS--------------DSESEDPPRHQASDSENEELPKP--------------RISDSESEDPPRNQASDSENEELPK 301
Cdd:PHA03307   258 PRPApitlptriweasgwNGPSSRPGPASSSSSPRERSPSPspsspgsgpapsspRASSSSSSSRESSSSSTSSSSESSR 337

                          330       340       350
                   ....*....|....*....|....*....|....
gi 2462575019  302 PR-VSDSESEGPQKGPASDSETEDASRHKQKPES 334
Cdd:PHA03307   338 GAaVSPGPSPSRSPSPSRPPPPADPSSPRKRPRP 371
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 9-300 8.09e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.52  E-value: 8.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   9 SDQDPPEEDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDRE-DGLPKGHHVTDSENDEPLNLNASDS 87
Cdd:NF033609  608 SDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSD 687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  88 ESEELHRQKDSDSESEERAEpPASDSENEDVNQHGSDSESE-ETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEI 166
Cdd:NF033609  688 SDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 766

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 167 EELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQvSDSESEEPPRHQASDSENEE 246
Cdd:NF033609  767 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 845

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462575019 247 LPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSEnEELP 300
Cdd:NF033609  846 SDSDSDSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSK-EPLP 898
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 206-533 1.32e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 206 EEPPKPRMSDSESEELPKPQVSDSEseePPRHQASDSENEELPKPRISDSESeDPPRHQASDSENEELPKpriSDSESED 285
Cdd:NF033609  540 DKPVVPEQPDEPGEIEPIPEDSDSD---PGSDSGSDSSNSDSGSDSGSDSTS-DSGSDSASDSDSASDSD---SASDSDS 612

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 286 PPRNQASDSENEELPKPRVSDSESEGPQKGpASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF 365
Cdd:NF033609  613 ASDSDSASDSDSASDSDSASDSDSASDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 691

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 366 HSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDS 445
Cdd:NF033609  692 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 771

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 446 EEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRG 525
Cdd:NF033609  772 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 851


                  ....*...
gi 2462575019 526 KHMDFLSD 533
Cdd:NF033609  852 SDSDSESD 859
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 156-476 2.62e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.60  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 156 VGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESeelpkpqVSDSESEEPP 235
Cdd:NF033609  544 VPEQPDEPGEIEPIPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDS-------ASDSDSASDS 616

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 236 RHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKG 315
Cdd:NF033609  617 DSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 696

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 316 PA-SDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKv 394
Cdd:NF033609  697 DSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD- 775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 395 AKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKEL-SDKKNEEKDLFGSDSESGNE 473
Cdd:NF033609  776 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSD 855


                  ...
gi 2462575019 474 EEN 476
Cdd:NF033609  856 SES 858
Ebola_NP pfam05505
Ebola nucleoprotein; This family consists of Ebola and Marburg virus nucleoproteins. These ...
 47-298 6.74e-05

Ebola nucleoprotein; This family consists of Ebola and Marburg virus nucleoproteins. These proteins are responsible for encapsidation of genomic RNA. It has been found that nucleoprotein DNA vaccines can offer protection from the virus.


Pssm-ID: 398905  Cd Length: 717  Bit Score: 46.27  E-value: 6.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  47 TGSVERHSENETSdredglpkGHHVTDSENDEPLNLNASDSESEelhrQKDSDSESEERAEPPASDSENEdvNQHGSDSE 126
Cdd:pfam05505 388 TEAITAASLPKTS--------GHYDDDDDIPFPGPINDDDNPGH----QDDDPTDSQDTTIPDVVVDPDD--GSYGEYQS 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 127 SEETrklpGSDSENEELLNGhaSDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPR--HQASDSE 204
Cdd:pfam05505 454 YSEN----GMNAPDDLVLLN--EDEDDLEDTKPVPNRSTKGGQQKNSQKGQHIEGRQTQSRPIQNVPGPHRtiHHASAPL 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 205 NEEPPKPRMSDSESEELPKPQvsdseSEEPPRHQASDSENEELPkPRISDSESED-------------PPRHQASDSENE 271
Cdd:pfam05505 528 TDNDRRNEPSGSTSPRMLTPI-----NEEADPLDDADDETSSLP-PLESDDEEQDrdgtsnrtptvapPAPVYRDHSEKK 601

                         250       260
                  ....*....|....*....|....*..
gi 2462575019 272 ELPKPRISDSESEDPPRNQASDSENEE 298
Cdd:pfam05505 602 ELPQDEQQDQDHTQEARNQDSDNTQSE 628
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 9-321 7.42e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.44  E-value: 7.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   9 SDQDPPEEDDGGAtpvQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSE 88
Cdd:NF033609  602 SDSDSASDSDSAS---DSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  89 SEELHRQKDSDSESEERAEPPA-SDSENEDVNQHGSDSESEETRKlpgSDSENEELLNGHASDSENEDVGKHPASDSEIE 167
Cdd:NF033609  679 DSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 168 ELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEelpkpqvSDSESEEPPRHQASDSENeel 247
Cdd:NF033609  756 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDSDSDSDSDSDSDSD--- 825

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462575019 248 pkpriSDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSE 321
Cdd:NF033609  826 -----SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSK 894
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 16-208 1.55e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 45.37  E-value: 1.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   16 EDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQ 95
Cdd:TIGR00927  707 KGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAG 786

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   96 KDSDSESEERAEPP--ASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDvgkhpasDSEIEELQKSP 173
Cdd:TIGR00927  787 EDGEMKGDEGAEGKveHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQD-------EKGVDGGGGSD 859

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 2462575019  174 ASDSETEDALKPQISDSESEEPPRHQaSDSENEEP 208
Cdd:TIGR00927  860 GGDSEEEEEEEEEEEEEEEEEEEEEE-EEEENEEP 893
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 272-520 6.40e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.45  E-value: 6.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  272 ELPKPRISDSESEdPPRNQASDSENE---ELPKPRVSDSESEGPQKGPASDSETEDASRHKQ-----KPESDDDSDRENK 343
Cdd:TIGR00927  656 EGENGEESGGEAE-QEGETETKGENEsegEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEhegetEAEGTEDEGEIET 734

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  344 GEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDekegeeekvakrkaavlSDSEDEEKASAKKSRVVSDAD 423
Cdd:TIGR00927  735 GEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKE-----------------DEDEGEIQAGEDGEMKGDEGA 797

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  424 DSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADifGESGDEEEEEFTGFNQEDLEE 503
Cdd:TIGR00927  798 EGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDG--GGGSDGGDSEEEEEEEEEEEE 875

                          250
                   ....*....|....*..
gi 2462575019  504 EKGETQVKEAEDSDSDD 520
Cdd:TIGR00927  876 EEEEEEEEEEEEEENEE 892
 
Name Accession Description Interval E-value
COG5139 COG5139
Uncharacterized conserved protein [Function unknown];
533-724 2.02e-27

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227468  Cd Length: 397  Bit Score: 115.18  E-value: 2.02e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 533 DFEMMLQRKKSMSGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETF 612
Cdd:COG5139   126 ELGDTGDRQLKAPAASRARRKEDLLEQTVDEISLRLKKRMQDAAKKDNANNLEGRPATGKIKNLPEVSDVLMKKALQDTI 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 613 IDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPsVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSR 692
Cdd:COG5139   206 LDNNILDSVRGWLEPLPDKSLPNIKIQKSLLDVLKTLP-IHTEHLVESGVGRIVYFYTISKKEEKEVRRSAKALVQEWTR 284

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462575019 693 PIFGLTSNYKGmTREEREQRDLEQMPQRRRMN 724
Cdd:COG5139   285 PIIKPSGNYRD-KRIMQLEFDSEKLRKKSVMD 315
Med26 pfam08711
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ...
 641-694 2.35e-12

TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.


Pssm-ID: 462573 [Multi-domain]  Cd Length: 52  Bit Score: 62.15  E-value: 2.35e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462575019 641 ELLKILQELPsVSQETLKHSGIGRAVMYLYKHPkESRSNKDMAGKLINEWSRPI 694
Cdd:pfam08711   1 KLLKKLEKLP-VTLELLKSTGIGKVVNKLRKHK-ENPEIKKLAKELVKKWKRLV 52
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 11-371 1.18e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.77  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  11 QDPPEEDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSverhseNETSDREdglpkghhvTDSENDEPlnlNASDSESE 90
Cdd:NF033609  546 EQPDEPGEIEPIPEDSDSDPGSDSGSDSSNSDSGSDSGS------DSTSDSG---------SDSASDSD---SASDSDSA 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  91 ElhrqkDSDSESEERAeppASDSENEDVNQHGSDSESEETrklpgSDSENEELLNGHASDSENEDVGKHPASDSEIEELQ 170
Cdd:NF033609  608 S-----DSDSASDSDS---ASDSDSASDSDSASDSDSASD-----SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 674

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 171 KSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEelpkpqvSDSESEEPPRHQASDSENEELPKP 250
Cdd:NF033609  675 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDSDSDSDSDSDSDSDSDSDSD 747

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 251 RISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKgpaSDSETEDASRHKQ 330
Cdd:NF033609  748 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDS 824

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2462575019 331 KPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSE 371
Cdd:NF033609  825 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSE 865
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-334 3.52e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 3.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   16 EDDGGATPVqderdSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNA--SDSESEELH 93
Cdd:PHA03307    28 PGDAADDLL-----SGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSlsTLAPASPAR 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   94 RQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEI----EEL 169
Cdd:PHA03307   103 EGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPlsspEET 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  170 QKSPASDSETEDALKPQISDSESEEPPRHQASDSeneePPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEElPK 249
Cdd:PHA03307   183 ARAPSSPPAEPPPSTPPAAASPRPPRRSSPISAS----ASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENEC-PL 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  250 PRIS--------------DSESEDPPRHQASDSENEELPKP--------------RISDSESEDPPRNQASDSENEELPK 301
Cdd:PHA03307   258 PRPApitlptriweasgwNGPSSRPGPASSSSSPRERSPSPspsspgsgpapsspRASSSSSSSRESSSSSTSSSSESSR 337

                          330       340       350
                   ....*....|....*....|....*....|....
gi 2462575019  302 PR-VSDSESEGPQKGPASDSETEDASRHKQKPES 334
Cdd:PHA03307   338 GAaVSPGPSPSRSPSPSRPPPPADPSSPRKRPRP 371
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 9-300 8.09e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.52  E-value: 8.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   9 SDQDPPEEDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDRE-DGLPKGHHVTDSENDEPLNLNASDS 87
Cdd:NF033609  608 SDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSD 687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  88 ESEELHRQKDSDSESEERAEpPASDSENEDVNQHGSDSESE-ETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEI 166
Cdd:NF033609  688 SDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 766

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 167 EELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQvSDSESEEPPRHQASDSENEE 246
Cdd:NF033609  767 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSD 845

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462575019 247 LPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSEnEELP 300
Cdd:NF033609  846 SDSDSDSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSK-EPLP 898
PRK08581 PRK08581
amidase domain-containing protein;
84-357 1.30e-05

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 48.63  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  84 ASDSESEELHRQKDSDSESEEraeppasDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSEN--EDVGKHPA 161
Cdd:PRK08581   28 DDPQKDSTAKTTSHDSKKSND-------DETSKDTSSKDTDKADNNNTSNQDNNDKKFSTIDSSTSDSNNiiDFIYKNLP 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 162 SDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEelpkpQVSDSESEEPPRHQASD 241
Cdd:PRK08581  101 QTNINQLLTKNKYDDNYSLTTLIQNLFNLNSDISDYEQPRNSEKSTNDSNKNSDSSIK-----NDTDTQSSKQDKADNQK 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 242 SENEELPKPRISDSESEDPPRHQASDSEneelpkpriSDSESEDPPRNQASDSENEEL---PKPRVSDSESEGPQKGPAS 318
Cdd:PRK08581  176 APSSNNTKPSTSNKQPNSPKPTQPNQSN---------SQPASDDTANQKSSSKDNQSMsdsALDSILDQYSEDAKKTQKD 246

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2462575019 319 DSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSD 357
Cdd:PRK08581  247 YASQSKKDKTETSNTKNPQLPTQDELKHKSKPAQSFEND 285
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 206-533 1.32e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.75  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 206 EEPPKPRMSDSESEELPKPQVSDSEseePPRHQASDSENEELPKPRISDSESeDPPRHQASDSENEELPKpriSDSESED 285
Cdd:NF033609  540 DKPVVPEQPDEPGEIEPIPEDSDSD---PGSDSGSDSSNSDSGSDSGSDSTS-DSGSDSASDSDSASDSD---SASDSDS 612

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 286 PPRNQASDSENEELPKPRVSDSESEGPQKGpASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF 365
Cdd:NF033609  613 ASDSDSASDSDSASDSDSASDSDSASDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 691

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 366 HSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDS 445
Cdd:NF033609  692 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 771

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 446 EEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRG 525
Cdd:NF033609  772 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 851


                  ....*...
gi 2462575019 526 KHMDFLSD 533
Cdd:NF033609  852 SDSDSESD 859
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 96-338 1.39e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   96 KDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEellNGHASDSENEDvGKHPASDSEieelqkSPAS 175
Cdd:PHA03307    59 AAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREG---SPTPPGPSSPD-PPPPTPPPA------SPPP 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  176 DSETeDALKPQISDSESEEPPRHQASDSENEEPPKPR-------------MSDSESEELPKPQVSDSESEEPPRHQASDS 242
Cdd:PHA03307   129 SPAP-DLSEMLRPVGSPGPPPAASPPAAGASPAAVASdaassrqaalplsSPEETARAPSSPPAEPPPSTPPAAASPRPP 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  243 EneelPKPRISDSESED---PPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDS----ESEGPQKG 315
Cdd:PHA03307   208 R----RSSPISASASSPapaPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEasgwNGPSSRPG 283

                          250       260
                   ....*....|....*....|...
gi 2462575019  316 PASDSETEDASRHKQKPESDDDS 338
Cdd:PHA03307   284 PASSSSSPRERSPSPSPSSPGSG 306
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 55-333 2.56e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.76  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  55 ENETSDREDGLPKGHHVTDSENDEPlnlnaSDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLP 134
Cdd:PTZ00449  500 EEEDSDKHDEPPEGPEASGLPPKAP-----GDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPT 574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 135 GSDSENEELLNGHASDSENEDVGKHPASDS--------EIEELQKSPASDSETEDALKPQisdseSEEPPRHQASDSENE 206
Cdd:PTZ00449  575 LSKKPEFPKDPKHPKDPEEPKKPKRPRSAQrptrpkspKLPELLDIPKSPKRPESPKSPK-----RPPPPQRPSSPERPE 649

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 207 EPPKPRMSDS-ESEELP-----KPQVSDSESEEPPRHQASDSeNEELPKPRISDSESEDPPRHQASDSENEELPKPRISD 280
Cdd:PTZ00449  650 GPKIIKSPKPpKSPKPPfdpkfKEKFYDDYLDAAAKSKETKT-TVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRD 728

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462575019 281 SES-----EDPPRNQASDSENEELP---KPRVSDSESEGPQKG-PASDSETEDASRHKQKPE 333
Cdd:PTZ00449  729 EEFpfepiGDPDAEQPDDIEFFTPPeeeRTFFHETPADTPLPDiLAEEFKEEDIHAETGEPD 790
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 156-476 2.62e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.60  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 156 VGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESeelpkpqVSDSESEEPP 235
Cdd:NF033609  544 VPEQPDEPGEIEPIPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDS-------ASDSDSASDS 616

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 236 RHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKG 315
Cdd:NF033609  617 DSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 696

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 316 PA-SDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKv 394
Cdd:NF033609  697 DSdSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD- 775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 395 AKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKEL-SDKKNEEKDLFGSDSESGNE 473
Cdd:NF033609  776 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSD 855


                  ...
gi 2462575019 474 EEN 476
Cdd:NF033609  856 SES 858
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 82-341 2.64e-05

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 47.73  E-value: 2.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   82 LNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPA 161
Cdd:PTZ00108  1134 LDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKP 1213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  162 SDSEIEELQKSPASDSETEDALKpqiSDSESEEPPRHQASDSENEEPPKPRMSDSESEELPK--PQVSDSESEEPPrhqa 239
Cdd:PTZ00108  1214 DNKKSNSSGSDQEDDEEQKTKPK---KSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKnaPKRVSAVQYSPP---- 1286

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  240 sdSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASD 319
Cdd:PTZ00108  1287 --PPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSS 1364

                          250       260
                   ....*....|....*....|..
gi 2462575019  320 SETEDASRHKQKPESDDDSDRE 341
Cdd:PTZ00108  1365 SEDDDDSEVDDSEDEDDEDDED 1386
PHA03321 PHA03321
tegument protein VP11/12; Provisional
 192-348 3.80e-05

tegument protein VP11/12; Provisional


Pssm-ID: 223041 [Multi-domain]  Cd Length: 694  Bit Score: 47.26  E-value: 3.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 192 SEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRhqaSDSENE 271
Cdd:PHA03321  427 SRQPPGAPAPRRDNDPPPPPRARPGSTPACARRARAQRARDAGPEYVDPLGALRRLPAGAAPPPEPAAAPS---PATYYT 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 272 EL--PKPRIsdsesedPPRNQASDSENEELPKPRVSDSESEGP-------QKGPASDSETEDASRHKQK-PESDDDSDRE 341
Cdd:PHA03321  504 RMggGPPRL-------PPRNRATETLRPDWGPPAAAPPEQMEDpylepddDRFDRRDGAAAAATSHPREaPAPDDDPIYE 576


                  ....*..
gi 2462575019 342 NKGEDTE 348
Cdd:PHA03321  577 GVSDSEE 583
PTZ00121 PTZ00121
MAEBL; Provisional
 88-461 4.56e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 4.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   88 ESEELHRQKDSDSESEERAEPPASDSENEDvnqhGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIE 167
Cdd:PTZ00121  1392 KADEAKKKAEEDKKKADELKKAAAAKKKAD----EAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAE 1467

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  168 ELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSEN--- 244
Cdd:PTZ00121  1468 EAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEkkk 1547

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  245 -EELPKPR-ISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSET 322
Cdd:PTZ00121  1548 aDELKKAEeLKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKK 1627

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  323 EDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVL 402
Cdd:PTZ00121  1628 AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEEL 1707

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462575019  403 SDSEDEEKASAKKSRVVSDADDSDSDAVSDKS--GKREKTIASDSEEEAGKELSDKKNEEK 461
Cdd:PTZ00121  1708 KKKEAEEKKKAEELKKAEEENKIKAEEAKKEAeeDKKKAEEAKKDEEEKKKIAHLKKEEEK 1768
Ebola_NP pfam05505
Ebola nucleoprotein; This family consists of Ebola and Marburg virus nucleoproteins. These ...
 47-298 6.74e-05

Ebola nucleoprotein; This family consists of Ebola and Marburg virus nucleoproteins. These proteins are responsible for encapsidation of genomic RNA. It has been found that nucleoprotein DNA vaccines can offer protection from the virus.


Pssm-ID: 398905  Cd Length: 717  Bit Score: 46.27  E-value: 6.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  47 TGSVERHSENETSdredglpkGHHVTDSENDEPLNLNASDSESEelhrQKDSDSESEERAEPPASDSENEdvNQHGSDSE 126
Cdd:pfam05505 388 TEAITAASLPKTS--------GHYDDDDDIPFPGPINDDDNPGH----QDDDPTDSQDTTIPDVVVDPDD--GSYGEYQS 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 127 SEETrklpGSDSENEELLNGhaSDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPR--HQASDSE 204
Cdd:pfam05505 454 YSEN----GMNAPDDLVLLN--EDEDDLEDTKPVPNRSTKGGQQKNSQKGQHIEGRQTQSRPIQNVPGPHRtiHHASAPL 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 205 NEEPPKPRMSDSESEELPKPQvsdseSEEPPRHQASDSENEELPkPRISDSESED-------------PPRHQASDSENE 271
Cdd:pfam05505 528 TDNDRRNEPSGSTSPRMLTPI-----NEEADPLDDADDETSSLP-PLESDDEEQDrdgtsnrtptvapPAPVYRDHSEKK 601

                         250       260
                  ....*....|....*....|....*..
gi 2462575019 272 ELPKPRISDSESEDPPRNQASDSENEE 298
Cdd:pfam05505 602 ELPQDEQQDQDHTQEARNQDSDNTQSE 628
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 9-321 7.42e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.44  E-value: 7.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   9 SDQDPPEEDDGGAtpvQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSE 88
Cdd:NF033609  602 SDSDSASDSDSAS---DSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  89 SEELHRQKDSDSESEERAEPPA-SDSENEDVNQHGSDSESEETRKlpgSDSENEELLNGHASDSENEDVGKHPASDSEIE 167
Cdd:NF033609  679 DSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 168 ELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEelpkpqvSDSESEEPPRHQASDSENeel 247
Cdd:NF033609  756 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD-------SDSDSDSDSDSDSDSDSD--- 825

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462575019 248 pkpriSDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSE 321
Cdd:NF033609  826 -----SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSK 894
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 16-208 1.55e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 45.37  E-value: 1.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   16 EDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQ 95
Cdd:TIGR00927  707 KGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAG 786

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   96 KDSDSESEERAEPP--ASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDvgkhpasDSEIEELQKSP 173
Cdd:TIGR00927  787 EDGEMKGDEGAEGKveHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQD-------EKGVDGGGGSD 859

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 2462575019  174 ASDSETEDALKPQISDSESEEPPRHQaSDSENEEP 208
Cdd:TIGR00927  860 GGDSEEEEEEEEEEEEEEEEEEEEEE-EEEENEEP 893
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 120-379 3.91e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.83  E-value: 3.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  120 QHGSDSESEETRKLPGSDSENEELLNGHAS-DSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRH 198
Cdd:TIGR00927  639 EHTGERTGEEGERPTEAEGENGEESGGEAEqEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHE 718

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  199 QASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQAsdSENEELpkpri 278
Cdd:TIGR00927  719 GETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQA--GEDGEM----- 791

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  279 sdsESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDAsrhKQKPESDDDSDRENKGEDTEMQNDSFHSDS 358
Cdd:TIGR00927  792 ---KGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQ---ELNAENQGEAKQDEKGVDGGGGSDGGDSEE 865

                          250       260
                   ....*....|....*....|.
gi 2462575019  359 HMDRKKFHSSDSEEEEHKKQK 379
Cdd:TIGR00927  866 EEEEEEEEEEEEEEEEEEEEE 886
ECM1 pfam05782
Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic ...
 208-317 4.65e-04

Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness.


Pssm-ID: 461739  Cd Length: 518  Bit Score: 43.29  E-value: 4.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 208 PPKPR---MSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESE 284
Cdd:pfam05782   9 PPQTRglpVDHPDTSQHDPPFEGQSEVQPPPSQEAIPVQEEELPPPQLPVEKKVDPPLPQEAIPLQEELPPPQLPIEQKE 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462575019 285 -DPPRNQASD----SENEELPKPRVSDSESEGPQKGPA 317
Cdd:pfam05782  89 iDPPFPQQEEitpsKQREEKPAPLVGQGHPEPESWNPA 126
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 139-346 5.02e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 43.54  E-value: 5.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 139 ENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSEtedALKPqiSDSESEEPPRHQAsdsENEEPPKPRMSDSES 218
Cdd:PRK08691  373 ENTELQSPSAQTAEKETAAKKPQPRPEAETAQTPVQTASA---AAMP--SEGKTAGPVSNQE---NNDVPPWEDAPDEAQ 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 219 EELPKPQVSD------SESEEPPRHQ-----ASDSENE----ELPKPR-ISDSESEDPPRHQASDSENEELPKPRISDSE 282
Cdd:PRK08691  445 TAAGTAQTSAksiqtaSEAETPPENQvsknkAADNETDaplsEVPSENpIQATPNDEAVETETFAHEAPAEPFYGYGFPD 524

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462575019 283 SEDPPRnqasdsENEELPKPrvsDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGED 346
Cdd:PRK08691  525 NDCPPE------DGAEIPPP---DWEHAAPADTAGGGADEEAEAGGIGGNNTPSAPPPEFSTEN 579
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 16-272 5.40e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.45  E-value: 5.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   16 EDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQ 95
Cdd:TIGR00927  639 EHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHE 718

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   96 KDSDSESEERAEPPASDSENEDVNQHG-SDSESEETRKLPGSDSENEELLNGHASDSENEDVGK-HPASDSEIEELQKSP 173
Cdd:TIGR00927  719 GETEAEGTEDEGEIETGEEGEEVEDEGeGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEiQAGEDGEMKGDEGAE 798

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  174 ASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEpprhQASDSENEELPKPRIS 253
Cdd:TIGR00927  799 GKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGGGGS----DGGDSEEEEEEEEEEE 874

                          250
                   ....*....|....*....
gi 2462575019  254 DSESEDPPRHQaSDSENEE 272
Cdd:TIGR00927  875 EEEEEEEEEEE-EEEENEE 892
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 272-520 6.40e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.45  E-value: 6.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  272 ELPKPRISDSESEdPPRNQASDSENE---ELPKPRVSDSESEGPQKGPASDSETEDASRHKQ-----KPESDDDSDRENK 343
Cdd:TIGR00927  656 EGENGEESGGEAE-QEGETETKGENEsegEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEhegetEAEGTEDEGEIET 734

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  344 GEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDekegeeekvakrkaavlSDSEDEEKASAKKSRVVSDAD 423
Cdd:TIGR00927  735 GEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKE-----------------DEDEGEIQAGEDGEMKGDEGA 797

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  424 DSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADifGESGDEEEEEFTGFNQEDLEE 503
Cdd:TIGR00927  798 EGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDG--GGGSDGGDSEEEEEEEEEEEE 875

                          250
                   ....*....|....*..
gi 2462575019  504 EKGETQVKEAEDSDSDD 520
Cdd:TIGR00927  876 EEEEEEEEEEEEEENEE 892
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 103-268 7.81e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 42.66  E-value: 7.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 103 EERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEElqKSPASDSETE-D 181
Cdd:PRK13108  293 DEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGE--STPAVEETSEaD 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 182 ALKPQISDSESEEPPRHQASDS-ENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEElpkPRISDSESEDP 260
Cdd:PRK13108  371 IEREQPGDLAGQAPAAHQVDAEaASAAPEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAG---PGDDPAEPDGI 447


                  ....*...
gi 2462575019 261 PRHQASDS 268
Cdd:PRK13108  448 RRQDDFSS 455
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 3-325 1.06e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019    3 TLLPRGSDQDPPEEDDGGATPVQDER--DSGSDGEDDVNEqHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPL 80
Cdd:PHA03307    94 TLAPASPAREGSPTPPGPSSPDPPPPtpPPASPPPSPAPD-LSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQA 172

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   81 NLNASDSESEElhRQKDSDSE----SEERAEPPASDSENEDVNQHGSDS------ESEETRKLPGSDSENEELLNGHASD 150
Cdd:PHA03307   173 ALPLSSPEETA--RAPSSPPAepppSTPPAAASPRPPRRSSPISASASSpapapgRSAADDAGASSSDSSSSESSGCGWG 250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  151 SENEDVGKHPASDSEIEELQKSPASDSETEDAL--KPQISDSESEEPPRHQASDSEnEEPPKPRMSDSESEELPKPQVSD 228
Cdd:PHA03307   251 PENECPLPRPAPITLPTRIWEASGWNGPSSRPGpaSSSSSPRERSPSPSPSSPGSG-PAPSSPRASSSSSSSRESSSSST 329

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  229 SESEEPPRHQASDS--ENEELPKPRiSDSESEDPPRHQASDSENEELPKPRISDSESEdpPRNQASDSENEELPKPRVSD 306
Cdd:PHA03307   330 SSSSESSRGAAVSPgpSPSRSPSPS-RPPPPADPSSPRKRPRPSRAPSSPAASAGRPT--RRRARAAVAGRARRRDATGR 406

                          330
                   ....*....|....*....
gi 2462575019  307 SESEGPQKGPASDSETEDA 325
Cdd:PHA03307   407 FPAGRPRPSPLDAGAASGA 425
PHA03247 PHA03247
large tegument protein UL36; Provisional
 170-350 1.12e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  170 QKSPASDSETEDALKPQISDSESEEPPRHQASDSE---NEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQA--SDSEN 244
Cdd:PHA03247  2864 RRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFalpPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPprPQPPL 2943

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  245 EELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDP-PRNQASDSENEELPKPRVSDSES-----EGPQKGPAS 318
Cdd:PHA03247  2944 APTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSrEAPASSTPPLTGHSLSRVSSWASslalhEETDPPPVS 3023

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2462575019  319 DSETEDASRHKQkpESDDDSDRENKGEDTEMQ 350
Cdd:PHA03247  3024 LKQTLWPPDDTE--DSDADSLFDSDSERSDLE 3053
PHA03169 PHA03169
hypothetical protein; Provisional
 153-339 1.70e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 41.49  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 153 NEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESE 232
Cdd:PHA03169   49 PAPTTSGPQVRAVAEQGHRQTESDTETAEESRHGEKEERGQGGPSGSGSESVGSPTPSPSGSAEELASGLSPENTSGSSP 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 233 EpprhqaSDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGP 312
Cdd:PHA03169  129 E------SPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTSSP 202

                         170       180
                  ....*....|....*....|....*..
gi 2462575019 313 QKGPASDSETEDASRHKQKPESDDDSD 339
Cdd:PHA03169  203 PPQSPPDEPGEPQSPTPQQAPSPNTQQ 229
PRK08581 PRK08581
amidase domain-containing protein;
13-231 2.06e-03

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 41.31  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  13 PPEEDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKghhvtDSENDEPLNLNASDSESeel 92
Cdd:PRK08581  110 KNKYDDNYSLTTLIQNLFNLNSDISDYEQPRNSEKSTNDSNKNSDSSIKNDTDTQ-----SSKQDKADNQKAPSSNN--- 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  93 hrQKDSDSESEERAEPPASDSENedvnqhGSDSESEETRKLPGSDSENEEllnghASDSENEDVGKHPASDSEIEE---L 169
Cdd:PRK08581  182 --TKPSTSNKQPNSPKPTQPNQS------NSQPASDDTANQKSSSKDNQS-----MSDSALDSILDQYSEDAKKTQkdyA 248

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462575019 170 QKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELpkPQVSDSES 231
Cdd:PRK08581  249 SQSKKDKTETSNTKNPQLPTQDELKHKSKPAQSFENDVNQSNTRSTSLFETG--PSLSNNDD 308
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 6-251 2.16e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 41.52  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019    6 PRGSDQDPPEEDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDrEDGLPKGHHVTDSENDEPLNLNAS 85
Cdd:TIGR00927  669 QEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEA-EGTEDEGEIETGEEGEEVEDEGEG 747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   86 DSESEELHRQKDSDSESEERAEPPASDSENEDVN--QHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASD 163
Cdd:TIGR00927  748 EAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGeiQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTE 827

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  164 SEIEELQKSPASDSETEDALKPQISDSESEEpprhQASDSENEEPPKPRMSDSESEElpkpqvsdsESEEPPRHQASDSE 243
Cdd:TIGR00927  828 VKDETGEQELNAENQGEAKQDEKGVDGGGGS----DGGDSEEEEEEEEEEEEEEEEE---------EEEEEEEEENEEPL 894


                   ....*...
gi 2462575019  244 NEELPKPR 251
Cdd:TIGR00927  895 SLEWPETR 902
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 72-293 2.26e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.57  E-value: 2.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019   72 TDSENDEPLNLNASDSESEELHRQKDSDSESeerAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNghASDS 151
Cdd:PTZ00108  1186 ADKSKKASVVGNSKRVDSDEKRKLDDKPDNK---KSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSED--NDEF 1260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  152 ENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEepPKPRMSDSESEELPKPQVSDSES 231
Cdd:PTZ00108  1261 SSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKKRLE--GSLAALKKKKKSEKKTARKKKSK 1338

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462575019  232 EEPPRHQASDSENEELPKPRISDSESEDpprhqasDSENEELpkpriSDSESEDPPRNQASD 293
Cdd:PTZ00108  1339 TRVKQASASQSSRLLRRPRKKKSDSSSE-------DDDDSEV-----DDSEDEDDEDDEDDD 1388
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 193-348 2.71e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 40.73  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 193 EEPPRHQASDSENEEPPKPrmsdsESEELPKPQVSDSESEEPPRHQASDSENE---ELPKPRISDSESEDPPRHQASDSE 269
Cdd:PRK13108  280 EAPGALRGSEYVVDEALER-----EPAELAAAAVASAASAVGPVGPGEPNQPDdvaEAVKAEVAEVTDEVAAESVVQVAD 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 270 NEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDS-ESEGPQKGPASDSETEDASR----HKQKPESDDDSDRENKG 344
Cdd:PRK13108  355 RDGESTPAVEETSEADIEREQPGDLAGQAPAAHQVDAEaASAAPEEPAALASEAHDETEpevpEKAAPIPDPAKPDELAV 434


                  ....
gi 2462575019 345 EDTE 348
Cdd:PRK13108  435 AGPG 438
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 79-293 4.55e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 40.46  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  79 PLNLNASDS----ESEELHRQKDSDSESEERAEPP----ASDSENEDVNQHGSDSESEETRKL-PGSDSENEELLNGHAS 149
Cdd:PRK08691  360 PLAAASCDAnaviENTELQSPSAQTAEKETAAKKPqprpEAETAQTPVQTASAAAMPSEGKTAgPVSNQENNDVPPWEDA 439

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019 150 DSENEDV-GKHPASDSEIE---ELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQ 225
Cdd:PRK08691  440 PDEAQTAaGTAQTSAKSIQtasEAETPPENQVSKNKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEAPAEPFYG 519

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462575019 226 VSDSESEEPPRhqasdsENEELPKPrisDSESEDPPRHQASDSENEELPKpRISDSESEDPPRNQASD 293
Cdd:PRK08691  520 YGFPDNDCPPE------DGAEIPPP---DWEHAAPADTAGGGADEEAEAG-GIGGNNTPSAPPPEFST 577
PTZ00482 PTZ00482
membrane-attack complex/perforin (MACPF) Superfamily; Provisional
 10-181 7.75e-03

membrane-attack complex/perforin (MACPF) Superfamily; Provisional


Pssm-ID: 240433 [Multi-domain]  Cd Length: 844  Bit Score: 39.85  E-value: 7.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  10 DQDPpeeDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREdglpkghhvtDSENDEPLNlNASDSES 89
Cdd:PTZ00482   87 DDDD---DDEFDFLYEDDEDDAGNATSGESSTDDDSLLELPDRDEDADTQANN----------DQTNDFDQD-DSSNSQT 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  90 EELHRQKDSDSESEERAEPPASDSENE-DVNQHGSDSESEETRKLPGSDSENEELLNghaSDSENEDVGkhpASDSEIEE 168
Cdd:PTZ00482  153 DQGLKQSVNLSSAEKLIEEKKGQTENTfKFYNFGNDGEEAAAKDGGKSKSSDPGPLN---DSDGQGDDG---DPESAEED 226

                         170
                  ....*....|...
gi 2462575019 169 LQKSPASDSETED 181
Cdd:PTZ00482  227 KAASNTRAAYTKA 239
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 168-382 7.87e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 39.64  E-value: 7.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  168 ELQKSPASDSETED--ALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESEElpkpqVSDSESEEPPRHQASDSENE 245
Cdd:PTZ00108  1168 KLRKPKLKKKEKKKkkSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSG-----SDQEDDEEQKTKPKKSSVKR 1242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575019  246 ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSesedPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDA 325
Cdd:PTZ00108  1243 LKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRV----SAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKKRLEGSL 1318

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462575019  326 SRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDS 382
Cdd:PTZ00108  1319 AALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDD 1375
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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