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Conserved domains on  [gi|2462513324|ref|XP_054194575|]
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tumor necrosis factor ligand superfamily member 4 isoform X1 [Homo sapiens]

Protein Classification

TNF domain-containing protein( domain architecture ID 10641272)

TNF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
 170-279 4.42e-28

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


:

Pssm-ID: 214557  Cd Length: 125  Bit Score: 104.35  E-value: 4.42e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513324  170 GFILTSQKED--EIMKVQNNSVIINCDGFYLISLKGYF--------SQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASL 239
Cdd:smart00207   2 SWESDRGLASllSGMELQNGELVVPRDGLYYIYSQVYFrgqgcngkSVELSLSLHLRKPSYPLPLLLLEAARSSCWSASS 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2462513324  240 TYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGE--FCVL 279
Cdd:smart00207  82 AWKDSVYLGGLFPLTAGDRLSVNVTEPSLVDLAPGAtfFGAF 123
 
Name Accession Description Interval E-value
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
 170-279 4.42e-28

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 104.35  E-value: 4.42e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513324  170 GFILTSQKED--EIMKVQNNSVIINCDGFYLISLKGYF--------SQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASL 239
Cdd:smart00207   2 SWESDRGLASllSGMELQNGELVVPRDGLYYIYSQVYFrgqgcngkSVELSLSLHLRKPSYPLPLLLLEAARSSCWSASS 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2462513324  240 TYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGE--FCVL 279
Cdd:smart00207  82 AWKDSVYLGGLFPLTAGDRLSVNVTEPSLVDLAPGAtfFGAF 123
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 153-279 1.79e-20

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 84.70  E-value: 1.79e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513324 153 PRIQSIKVQFTEYKKEKGFILTS----QKEdeIMKVQNNSVIINCDGFYLISLKGYFSQ------EVNISLHYQKD--EE 220
Cdd:cd00184     1 PAAHLIGTNSSSGGTGLSWESDDgrafLSG--GLELQNGELVVPQDGLYYIYSQVYFRGqccstlSVSHVLQLRTDsyPE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462513324 221 PLFQLKKVRSVNSLMvaSLTYKDKVYLNVTTDNTSLDDFHVN--GGELILIHQNPGEFCVL 279
Cdd:cd00184    79 PILLLKGIRSVCSSV--SEGWYNSVYLGGLFQLRAGDRLSVNvsAPALLDLSQGTTFFGAF 137
 
Name Accession Description Interval E-value
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
 170-279 4.42e-28

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 104.35  E-value: 4.42e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513324  170 GFILTSQKED--EIMKVQNNSVIINCDGFYLISLKGYF--------SQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASL 239
Cdd:smart00207   2 SWESDRGLASllSGMELQNGELVVPRDGLYYIYSQVYFrgqgcngkSVELSLSLHLRKPSYPLPLLLLEAARSSCWSASS 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2462513324  240 TYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGE--FCVL 279
Cdd:smart00207  82 AWKDSVYLGGLFPLTAGDRLSVNVTEPSLVDLAPGAtfFGAF 123
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 153-279 1.79e-20

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 84.70  E-value: 1.79e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513324 153 PRIQSIKVQFTEYKKEKGFILTS----QKEdeIMKVQNNSVIINCDGFYLISLKGYFSQ------EVNISLHYQKD--EE 220
Cdd:cd00184     1 PAAHLIGTNSSSGGTGLSWESDDgrafLSG--GLELQNGELVVPQDGLYYIYSQVYFRGqccstlSVSHVLQLRTDsyPE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462513324 221 PLFQLKKVRSVNSLMvaSLTYKDKVYLNVTTDNTSLDDFHVN--GGELILIHQNPGEFCVL 279
Cdd:cd00184    79 PILLLKGIRSVCSSV--SEGWYNSVYLGGLFQLRAGDRLSVNvsAPALLDLSQGTTFFGAF 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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