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Conserved domains on  [gi|2462511927|ref|XP_054193896|]
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mesoderm induction early response protein 1 isoform X10 [Homo sapiens]

Protein Classification

ELM2 domain-containing protein( domain architecture ID 10477679)

ELM2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 272-321 2.57e-10

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


:

Pssm-ID: 460214  Cd Length: 53  Bit Score: 55.31  E-value: 2.57e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462511927 272 IMVGSMFQAEIPVgICRYKENEKVYENDDQ-LLWDPE-YLPEDKVIIFLKDA 321
Cdd:pfam01448   1 IRVGPRYQAEIPE-LLPPSEEEDRYEEEDElLVWDPNhNLPDRKLDEYLVVA 51
 
Name Accession Description Interval E-value
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 272-321 2.57e-10

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 55.31  E-value: 2.57e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462511927 272 IMVGSMFQAEIPVgICRYKENEKVYENDDQ-LLWDPE-YLPEDKVIIFLKDA 321
Cdd:pfam01448   1 IRVGPRYQAEIPE-LLPPSEEEDRYEEEDElLVWDPNhNLPDRKLDEYLVVA 51
 
Name Accession Description Interval E-value
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 272-321 2.57e-10

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 55.31  E-value: 2.57e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462511927 272 IMVGSMFQAEIPVgICRYKENEKVYENDDQ-LLWDPE-YLPEDKVIIFLKDA 321
Cdd:pfam01448   1 IRVGPRYQAEIPE-LLPPSEEEDRYEEEDElLVWDPNhNLPDRKLDEYLVVA 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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