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Conserved domains on  [gi|2462505117|ref|XP_054190611|]
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cystathionine gamma-lyase isoform X1 [Homo sapiens]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 1-189 6.94e-114

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member pfam01053:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 376  Bit Score: 329.96  E-value: 6.94e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:pfam01053 172 ASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGLKTLGLRMEQHQ 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:pfam01053 252 ENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLKLFSLAVSLGGVESLISH 331

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:pfam01053 332 PATMTHASIPPEEREAAGITDDLIRLSVG 360
 
Name Accession Description Interval E-value
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 1-189 6.94e-114

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 329.96  E-value: 6.94e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:pfam01053 172 ASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGLKTLGLRMEQHQ 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:pfam01053 252 ENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLKLFSLAVSLGGVESLISH 331

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:pfam01053 332 PATMTHASIPPEEREAAGITDDLIRLSVG 360
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 1-189 2.05e-110

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 320.69  E-value: 2.05e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:cd00614   165 ATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRMERHS 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:cd00614   245 ENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVESLVEH 324

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:cd00614   325 PASMTHSQLPPEERAAAGITPGLVRLSVG 353
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 1-189 3.93e-110

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 320.84  E-value: 3.93e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:COG0626   183 ATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSPFDAWLLLRGLKTLALRMERHC 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:COG0626   263 ENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAARRFLDALKLFTLAVSLGGVESLITH 342

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:COG0626   343 PATMTHRSLPPEERAALGITDGLVRLSVG 371
PRK07811 PRK07811
cystathionine gamma-synthase; Provisional
 2-189 1.85e-83

cystathionine gamma-synthase; Provisional


Pssm-ID: 236104 [Multi-domain]  Cd Length: 388  Bit Score: 252.64  E-value: 1.85e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK07811  187 SPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPFDAYLTLRGLKTLAVRMDRHSE 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELP 161
Cdd:PRK07811  267 NAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARDFCARTKVFTLAESLGGVESLIEHP 346

                         170       180
                  ....*....|....*....|....*...
gi 2462505117 162 AIMTHASVLKNDrdvLGISDTLIRLSVG 189
Cdd:PRK07811  347 SAMTHASTAGSQ---LEVPDDLVRLSVG 371
cysta_beta_ly_E TIGR01329
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...
 1-207 2.85e-61

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.


Pssm-ID: 273557 [Multi-domain]  Cd Length: 378  Bit Score: 195.82  E-value: 2.85e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:TIGR01329 171 MSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGIKTLAIRIEKQQ 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGcTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:TIGR01329 251 ENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKG-AGSVLSFETGSVALSKRLVEATKLFSITVSFGSVNSLISM 329

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAA 207
Cdd:TIGR01329 330 PCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
 
Name Accession Description Interval E-value
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 1-189 6.94e-114

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 329.96  E-value: 6.94e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:pfam01053 172 ASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGLKTLGLRMEQHQ 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:pfam01053 252 ENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLKLFSLAVSLGGVESLISH 331

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:pfam01053 332 PATMTHASIPPEEREAAGITDDLIRLSVG 360
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 1-189 2.05e-110

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 320.69  E-value: 2.05e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:cd00614   165 ATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRMERHS 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:cd00614   245 ENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVESLVEH 324

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:cd00614   325 PASMTHSQLPPEERAAAGITPGLVRLSVG 353
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 1-189 3.93e-110

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 320.84  E-value: 3.93e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:COG0626   183 ATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSPFDAWLLLRGLKTLALRMERHC 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:COG0626   263 ENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAARRFLDALKLFTLAVSLGGVESLITH 342

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:COG0626   343 PATMTHRSLPPEERAALGITDGLVRLSVG 371
PRK07811 PRK07811
cystathionine gamma-synthase; Provisional
 2-189 1.85e-83

cystathionine gamma-synthase; Provisional


Pssm-ID: 236104 [Multi-domain]  Cd Length: 388  Bit Score: 252.64  E-value: 1.85e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK07811  187 SPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPFDAYLTLRGLKTLAVRMDRHSE 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELP 161
Cdd:PRK07811  267 NAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARDFCARTKVFTLAESLGGVESLIEHP 346

                         170       180
                  ....*....|....*....|....*...
gi 2462505117 162 AIMTHASVLKNDrdvLGISDTLIRLSVG 189
Cdd:PRK07811  347 SAMTHASTAGSQ---LEVPDDLVRLSVG 371
PRK07671 PRK07671
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
1-189 6.25e-81

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;


Pssm-ID: 181076 [Multi-domain]  Cd Length: 377  Bit Score: 246.17  E-value: 6.25e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:PRK07671  174 MTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGLKTLGIRMEEHE 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIkGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:PRK07671  254 TNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVLERLQYFTLAESLGAVESLISI 332

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK07671  333 PSQMTHASIPADRRKELGITDGLIRISVG 361
PRK06176 PRK06176
cystathionine gamma-synthase;
2-189 1.56e-78

cystathionine gamma-synthase;


Pssm-ID: 180443 [Multi-domain]  Cd Length: 380  Bit Score: 240.18  E-value: 1.56e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK06176  175 TPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQK 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQhAEIFLKNLKLFTLAESLGGFESLAELP 161
Cdd:PRK06176  255 NALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSE-AVAFVESLKLFILGESLGGVESLVGIP 333

                         170       180
                  ....*....|....*....|....*...
gi 2462505117 162 AIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK06176  334 AFMTHACIPKEQREAAGIRDGLVRLSVG 361
PRK06234 PRK06234
methionine gamma-lyase; Provisional
 1-189 2.31e-70

methionine gamma-lyase; Provisional


Pssm-ID: 168478 [Multi-domain]  Cd Length: 400  Bit Score: 219.70  E-value: 2.31e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsVNCESLHNRLRF--LQNSLGAVPSPIDCYLCNRGLKTLHVRMEK 78
Cdd:PRK06234  191 CTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFV-VGKEEFINQVKLfgIKDMTGSVIGPFEAFLIIRGMKTLQIRMEK 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  79 HFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLA 158
Cdd:PRK06234  270 HCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGVEEGKVVMNNVKLATLAVSLGDAETLI 349

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2462505117 159 ELPAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK06234  350 QHPASMTHSPYTAEERKEAGISDGLVRLSVG 380
PRK08064 PRK08064
cystathionine beta-lyase MetC;
1-211 8.61e-65

cystathionine beta-lyase MetC;


Pssm-ID: 236146 [Multi-domain]  Cd Length: 390  Bit Score: 205.00  E-value: 8.61e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:PRK08064  178 LTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSS 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFyikgTLQHAEI---FLKNLKLFTLAESLGGFESL 157
Cdd:PRK08064  258 ETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSF----TLQSEEAvrqFVSHVKLPVFAVSLGAVESI 333

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462505117 158 AELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPS 211
Cdd:PRK08064  334 LSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALSYVEEPV 387
cysta_beta_ly_E TIGR01329
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...
 1-207 2.85e-61

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.


Pssm-ID: 273557 [Multi-domain]  Cd Length: 378  Bit Score: 195.82  E-value: 2.85e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:TIGR01329 171 MSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGIKTLAIRIEKQQ 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGcTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:TIGR01329 251 ENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKG-AGSVLSFETGSVALSKRLVEATKLFSITVSFGSVNSLISM 329

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAA 207
Cdd:TIGR01329 330 PCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
PRK07503 PRK07503
methionine gamma-lyase; Provisional
 2-210 4.04e-61

methionine gamma-lyase; Provisional


Pssm-ID: 181005 [Multi-domain]  Cd Length: 403  Bit Score: 196.18  E-value: 4.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsVNCESLHNRLRF--LQNSLGAVPSPIDCYLCNRGLKTLHVRMEKH 79
Cdd:PRK07503  191 TPYLQRPLELGADLVVHSATKYLGGHGDITAGLV-VGGKALADRIRLegLKDMTGAVMSPFDAFLLMRGLKTLALRMDRH 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  80 FKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAE 159
Cdd:PRK07503  270 CASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAGRRFMNALQLFARAVSLGDAESLAQ 349

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462505117 160 LPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPP 210
Cdd:PRK07503  350 HPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDACAVA 400
PRK08776 PRK08776
O-succinylhomoserine (thiol)-lyase;
1-189 1.81e-60

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181554 [Multi-domain]  Cd Length: 405  Bit Score: 194.44  E-value: 1.81e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:PRK08776  185 LSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGLRTLDARLRVHQ 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:PRK08776  265 ENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAESLGGVESLIAH 344

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK08776  345 PASMTHAAMTAEARAAAGISDGLLRLSVG 373
PRK06434 PRK06434
cystathionine gamma-lyase; Validated
 2-189 3.75e-60

cystathionine gamma-lyase; Validated


Pssm-ID: 102374 [Multi-domain]  Cd Length: 384  Bit Score: 192.81  E-value: 3.75e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK06434  187 SPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDPIQAYLALRGLKTLGLRMEKHNK 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLpshpqhELVKRQCTGCTGMVTFYIKgTLQHAEIFLKNLKLFTLAESLGGFESLAELP 161
Cdd:PRK06434  267 NGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELR-SMEDVHKFIRNLEIPMVAASLGGVESLITLP 339

                         170       180
                  ....*....|....*....|....*...
gi 2462505117 162 AIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK06434  340 VETSHSSLSPEERERLGISDNLVRFSIG 367
PLN02509 PLN02509
cystathionine beta-lyase
 1-189 6.36e-57

cystathionine beta-lyase


Pssm-ID: 178125 [Multi-domain]  Cd Length: 464  Bit Score: 186.77  E-value: 6.36e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:PLN02509  257 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQ 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGcTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:PLN02509  337 ENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKG-AGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISM 415

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PLN02509  416 PCFMSHASIPAEVREARGLTEDLVRISAG 444
PRK08861 PRK08861
O-succinylhomoserine (thiol)-lyase;
1-189 4.65e-56

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181567 [Multi-domain]  Cd Length: 388  Bit Score: 182.40  E-value: 4.65e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:PRK08861  178 LTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMTLRGIRTLGARMRVHE 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:PRK08861  258 ESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKALALFSLAESLGGVESLICH 337

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK08861  338 PASMTHRAMGEEALAEAGVSQQLLRLSVG 366
PRK07049 PRK07049
cystathionine gamma-synthase family protein;
3-189 1.10e-55

cystathionine gamma-synthase family protein;


Pssm-ID: 180809 [Multi-domain]  Cd Length: 427  Bit Score: 182.56  E-value: 1.10e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   3 PYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNcESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKN 82
Cdd:PRK07049  222 PVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAVLGR-KALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRN 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  83 GMAVAQFLESNPWVEKVIYPGL--PSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:PRK07049  301 ARAVAEFLRDHPKVEKLHYLPFldPDSAYGAVYKRQCTGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASH 380

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK07049  381 PASMTHSGVPADVRERIGVLESTIRLSIG 409
PRK08045 PRK08045
cystathionine gamma-synthase; Provisional
 1-189 1.59e-55

cystathionine gamma-synthase; Provisional


Pssm-ID: 169194 [Multi-domain]  Cd Length: 386  Bit Score: 181.25  E-value: 1.59e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:PRK08045  177 LSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQ 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:PRK08045  257 RNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISH 336

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK08045  337 AATMTHAGMAPEARAAAGISETLLRISTG 365
PRK08574 PRK08574
cystathionine gamma-synthase family protein;
2-189 3.28e-55

cystathionine gamma-synthase family protein;


Pssm-ID: 236298 [Multi-domain]  Cd Length: 385  Bit Score: 180.26  E-value: 3.28e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK08574  178 TPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAYLVLRGLKTLEVRFERQCR 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKR--QCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAE 159
Cdd:PRK08574  258 NAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRlfGKDLYGGVVSFRVKGGRDAVLKFLRSLKLIKPSPSLGGVESLAT 337

                         170       180       190
                  ....*....|....*....|....*....|
gi 2462505117 160 LPAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK08574  338 YPVKSAASPIPEEDRKALGITEDLVRLSVG 367
PRK06767 PRK06767
methionine gamma-lyase; Provisional
 2-189 1.96e-54

methionine gamma-lyase; Provisional


Pssm-ID: 180685 [Multi-domain]  Cd Length: 386  Bit Score: 178.11  E-value: 1.96e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK06767  187 SPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCD 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYpglpshPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELP 161
Cdd:PRK06767  267 NAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLIQHP 340

                         170       180
                  ....*....|....*....|....*...
gi 2462505117 162 AIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK06767  341 ATMTHAAIPAELRQEMGIYDNLIRLSVG 368
PRK08247 PRK08247
methionine biosynthesis PLP-dependent protein;
2-189 4.87e-54

methionine biosynthesis PLP-dependent protein;


Pssm-ID: 181320 [Multi-domain]  Cd Length: 366  Bit Score: 176.82  E-value: 4.87e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK08247  177 TPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRGMKTLALRMRQHEE 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLpshpqhelvkrqctgcTGMVTFyikgTLQHAE---IFLKNLKLFTLAESLGGFESLA 158
Cdd:PRK08247  257 NAKAIAAFLNEQPGVTDVLYPGR----------------GGMLSF----RLQDEEwvnPFLKSLKLITFAESLGGVESFI 316

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2462505117 159 ELPAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK08247  317 TYPATQTHADIPEEIRIANGVCNRLLRFSVG 347
MET17 COG2873
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ...
 2-189 4.44e-53

O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 442120 [Multi-domain]  Cd Length: 428  Bit Score: 175.60  E-value: 4.44e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsVNC------------------ESLHN----------------RLR 47
Cdd:COG2873   189 TPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVI-VDGgnfdwaangkfpeltepdPSYHGlvyteafgnaafitkaRVQ 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  48 FLQNsLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCT-GCTGMVTF 126
Cdd:COG2873   268 LLRD-LGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLPSHPYHELAQKYLPkGAGGVLTF 346

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462505117 127 YIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:COG2873   347 GLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPDLIRLSVG 409
PRK06460 PRK06460
hypothetical protein; Provisional
 2-189 2.12e-52

hypothetical protein; Provisional


Pssm-ID: 235807 [Multi-domain]  Cd Length: 376  Bit Score: 172.71  E-value: 2.12e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCEsLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK06460  171 TPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGK-LLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINR 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELP 161
Cdd:PRK06460  250 NAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLGGVNSVISHP 329

                         170       180
                  ....*....|....*....|....*...
gi 2462505117 162 AIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK06460  330 ATMSHRTLSLEERKIVGITDSLLRLSVG 357
PRK08249 PRK08249
cystathionine gamma-synthase family protein;
2-189 1.68e-51

cystathionine gamma-synthase family protein;


Pssm-ID: 236202 [Multi-domain]  Cd Length: 398  Bit Score: 171.08  E-value: 1.68e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVvMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK08249  190 TPINQNPLALGADLVIHSATKFLSGHADA-LGGVVCGSKELMEQVYHYREINGATMDPMSAYLILRGMKTLKLRVRQQQE 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELP 161
Cdd:PRK08249  269 SAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMDTVKRLLPKLRYAHRAANLGAVETIYGPA 348

                         170       180
                  ....*....|....*....|....*...
gi 2462505117 162 AIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK08249  349 RTTSHVENTLEERAALGIPEGLVRISVG 376
PRK08133 PRK08133
O-succinylhomoserine sulfhydrylase; Validated
 2-189 2.06e-51

O-succinylhomoserine sulfhydrylase; Validated


Pssm-ID: 181244 [Multi-domain]  Cd Length: 390  Bit Score: 170.57  E-value: 2.06e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQnSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK08133  187 TPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEVFGFLR-TAGPTLSPFNAWVFLKGLETLSLRMEAHSA 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELP 161
Cdd:PRK08133  266 NALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREAAWRVIDATRLISITANLGDTKTTITHP 345

                         170       180
                  ....*....|....*....|....*...
gi 2462505117 162 AIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK08133  346 ATTTHGRLSPEARAAAGITEGLIRVAVG 373
PRK07269 PRK07269
cystathionine gamma-synthase; Reviewed
 2-189 9.21e-51

cystathionine gamma-synthase; Reviewed


Pssm-ID: 235983  Cd Length: 364  Bit Score: 168.08  E-value: 9.21e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK07269  177 SPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGLKTLSLRMERSTA 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLpshpqhelvkrqctgcTGMVTFYI--KGTLQHaeiFLKNLKLFTLAESLGGFESLAE 159
Cdd:PRK07269  257 NAQEVVAFLKKSPAVKEVLYTGK----------------GGMISFKVadETRIPH---ILNSLKVFTFAESLGGVESLIT 317

                         170       180       190
                  ....*....|....*....|....*....|
gi 2462505117 160 LPAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK07269  318 YPTTQTHADIPAEVRHSYGLTDDLLRLSIG 347
O_suc_HS_sulf TIGR01325
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ...
 2-189 2.97e-49

O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 188131  Cd Length: 381  Bit Score: 164.63  E-value: 2.97e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:TIGR01325 180 TPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQNA 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTlQHAEIFLKNLKLFTLAESLGGFESLAELP 161
Cdd:TIGR01325 260 SALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCR-QAAFKVLDAMRLVDISNNLGDAKSTITHP 338

                         170       180
                  ....*....|....*....|....*...
gi 2462505117 162 AIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:TIGR01325 339 ATTTHRRMGPEERAAAGIGDGLVRLSVG 366
PRK05967 PRK05967
cystathionine beta-lyase; Provisional
 2-189 9.54e-45

cystathionine beta-lyase; Provisional


Pssm-ID: 235657 [Multi-domain]  Cd Length: 395  Bit Score: 153.43  E-value: 9.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNcESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK05967  190 TPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSAN-EKCWPQLLEAHGTLGLCAGPDDTYQILRGLRTMGIRLEHHRK 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTL----QHAEIFLKNLKLFTLAESLGGFESL 157
Cdd:PRK05967  269 SALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGPekgkAKAHAFLDALEIFGLGYSWGGYESL 348

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462505117 158 AeLPAIMTHASVLKNDRDvlgisDTLIRLSVG 189
Cdd:PRK05967  349 A-LHVKLGDRTVAKAPYA-----GPVIRLQIG 374
PRK07504 PRK07504
O-succinylhomoserine sulfhydrylase; Reviewed
 2-207 6.31e-42

O-succinylhomoserine sulfhydrylase; Reviewed


Pssm-ID: 168979 [Multi-domain]  Cd Length: 398  Bit Score: 146.05  E-value: 6.31e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLV-SVNC---ESLHNRLRFLQNSLgavpSPIDCYLCNRGLKTLHVRME 77
Cdd:PRK07504  191 TPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVlSDKAwieEHLQDYFRHTGPSL----SPFNAWTLLKGLETLPVRVR 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  78 KHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESL 157
Cdd:PRK07504  267 QQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSL 346

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462505117 158 AELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAA 207
Cdd:PRK07504  347 ITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALKKV 396
PRK07582 PRK07582
cystathionine gamma-lyase; Validated
 1-189 3.56e-41

cystathionine gamma-lyase; Validated


Pssm-ID: 236061  Cd Length: 366  Bit Score: 143.21  E-value: 3.56e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   1 MSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:PRK07582  172 ATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFARQC 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIkGTLQHAEIFLKNLKLFTLAESLGGFESLAEL 160
Cdd:PRK07582  252 ANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFEL-ADAAAAERFVAASRLVVAATSFGGVHTSADR 330

                         170       180
                  ....*....|....*....|....*....
gi 2462505117 161 PAIMTHAsvlkndrdvlgISDTLIRLSVG 189
Cdd:PRK07582  331 RARWGDA-----------VPEGFVRLSCG 348
cysta_beta_ly_B TIGR01324
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ...
 2-189 2.52e-39

cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 130391 [Multi-domain]  Cd Length: 377  Bit Score: 138.86  E-value: 2.52e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVnCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:TIGR01324 176 AGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVA-NARTWDQLREHSYLMGQMVDADDAYTTLRGLRTLGVRLKQHQE 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHA-EIFLKNLKLFTLAESLGGFESLAeL 160
Cdd:TIGR01324 255 SSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQKQvHAFLDHLQLFGLGYSWGGYESLA-L 333

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2462505117 161 P--AIMTHASVLKNDrdvlgISDTLIRLSVG 189
Cdd:TIGR01324 334 CnqPELGHRPNIKRN-----LEGPLIRVHIG 359
PRK09028 PRK09028
cystathionine beta-lyase; Provisional
 2-189 8.07e-39

cystathionine beta-lyase; Provisional


Pssm-ID: 181615 [Multi-domain]  Cd Length: 394  Bit Score: 137.56  E-value: 8.07e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNcESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK09028  187 SPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATAN-EKHWDQLREHSYLMGQCTSPDDVYLAMRGLRTLGVRLAQHEK 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIK-GTLQHAEIFLKNLKLFTLAESLGGFESLael 160
Cdd:PRK09028  266 NALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKqGDPKAVTALVEGMQHFKMGFSWGGFESL--- 342

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2462505117 161 paIMTHASVlKNDRDVL--GISDTLIRLSVG 189
Cdd:PRK09028  343 --ILGVFGI-NKLRTATnwDFSKPLIRLHIG 370
PRK08248 PRK08248
homocysteine synthase;
2-207 2.27e-38

homocysteine synthase;


Pssm-ID: 236201 [Multi-domain]  Cd Length: 431  Bit Score: 137.28  E-value: 2.27e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVS--------------------------VNCESL-------HNRLRF 48
Cdd:PRK08248  190 SPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVdsgkfdwkgsgkfpgltepdpsyhglVYTDAVgeaayitKARVQL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  49 LQNsLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQC-TGCTGMVTFY 127
Cdd:PRK08248  270 LRD-LGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSHPSYELAKKYLpKGQGAILTFG 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117 128 IKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAA 207
Cdd:PRK08248  349 IKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRLSVGTEAIDDILDDLRQAIRQS 428
PRK07050 PRK07050
cystathionine beta-lyase; Provisional
 4-189 6.23e-38

cystathionine beta-lyase; Provisional


Pssm-ID: 180810 [Multi-domain]  Cd Length: 394  Bit Score: 135.24  E-value: 6.23e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   4 YFqRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNG 83
Cdd:PRK07050  194 AF-KPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSA 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  84 MAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGM--VTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAeLP 161
Cdd:PRK07050  273 LEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLfsVVFDERYSPAQVDAFVEALELFAIGWSWGGACSLA-MP 351

                         170       180
                  ....*....|....*....|....*...
gi 2462505117 162 AIMTHASVLKNDRDvlgisDTLIRLSVG 189
Cdd:PRK07050  352 YDVASMRTAKWPHR-----GTLVRLYIG 374
PRK05968 PRK05968
hypothetical protein; Provisional
 2-207 7.40e-38

hypothetical protein; Provisional


Pssm-ID: 168320 [Multi-domain]  Cd Length: 389  Bit Score: 135.21  E-value: 7.40e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsVNCESLHNRLRFLQNS-LGAVPSPIDCYLCNRGLKTLHVRMEKHF 80
Cdd:PRK05968  188 SPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVV-AGSKEHIARINAEAYPyLGAKLSPFEAWLLLRGLRTLPLRMKAHE 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  81 KNGMAVAQFLESNPWVEKVIYPGLPSHPQHELvkrqcTGCTGMVTFYIKGTLQHAEiFLKNLKLFTLAESLGGFESLAeL 160
Cdd:PRK05968  267 ASALEIARRLKAHPVVERVCHPALANHPPAGL-----SGTSGLFSFIFREGIDVRA-FADALKLFRLGVSWGGHESLV-V 339

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2462505117 161 PA-IMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAA 207
Cdd:PRK05968  340 PAeVVLQQKAQPNSAARFGVSPRSVRLHVGLEGTEALWADLEQALAAA 387
PRK07810 PRK07810
O-succinylhomoserine sulfhydrylase; Provisional
 2-189 9.20e-38

O-succinylhomoserine sulfhydrylase; Provisional


Pssm-ID: 236103 [Multi-domain]  Cd Length: 403  Bit Score: 135.25  E-value: 9.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFK 81
Cdd:PRK07810  196 TPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSNA 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  82 NGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTL----QHAEIFLKNLKLFTLAESLGGFESL 157
Cdd:PRK07810  276 SALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDAPEdaakKRAFEVLDKLRVIDISNNLGDAKSL 355

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462505117 158 AELPAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK07810  356 ITHPATTTHRAMGPEGRAAIGLGDGVVRLSVG 387
PRK08134 PRK08134
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 2-207 1.56e-37

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 236159  Cd Length: 433  Bit Score: 134.87  E-value: 1.56e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLV----------SVNCESL-------HNR------------LRFLQNS 52
Cdd:PRK08134  190 TPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLvdggrfdweaSGKFPELtepyagfHGMvfaeestvaaflLRARREG 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  53 L---GAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQC-TGCTGMVTFYI 128
Cdd:PRK08134  270 LrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDHALAKRLLpRGAGSVFSFDL 349

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462505117 129 KGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAA 207
Cdd:PRK08134  350 KGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLSIGLEDADDLIDDLKRALKAA 428
PRK08114 PRK08114
cystathionine beta-lyase; Provisional
 7-189 5.80e-36

cystathionine beta-lyase; Provisional


Pssm-ID: 181231 [Multi-domain]  Cd Length: 395  Bit Score: 130.21  E-value: 5.80e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   7 RPLALGADISMYSATKYMNGHSDVVMGLVSVNcESLHNRLRflQNS--LGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGM 84
Cdd:PRK08114  195 KALDFGIDISIQAGTKYLVGHSDAMIGTAVAN-ARCWEQLR--ENSylMGQMVDADTAYMTSRGLRTLGVRLRQHEESSL 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  85 AVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEI--FLKNLKLFTLAESLGGFESL----- 157
Cdd:PRK08114  272 KVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKKKLTDEQLanYLDNFSLFSMAYSWGGFESLilanq 351

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462505117 158 -AELPAIMTHASVlkndrdvlGISDTLIRLSVG 189
Cdd:PRK08114  352 pEEIAAIRPAGEV--------DFTGTLIRLHIG 376
PRK06084 PRK06084
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
2-207 7.01e-35

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;


Pssm-ID: 180392 [Multi-domain]  Cd Length: 425  Bit Score: 127.71  E-value: 7.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLV------------------SVNCESLHN--------------RLRFL 49
Cdd:PRK06084  184 TPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVvdsgkfpwaehkerfallNTPDPSYHGvtyteafgpaafigRCRVV 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  50 Q-NSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGC-TGMVTFY 127
Cdd:PRK06084  264 PlRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHPEHELARRYMGGKpASILSFG 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117 128 IKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVlkNDRDVL--GISDTLIRLSVGLEDEEDLLEDLDQALK 205
Cdd:PRK06084  344 IKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQL--NDEELEkaGVSRDMVRLSIGIEHIDDIIADLAQALD 421


                  ..
gi 2462505117 206 AA 207
Cdd:PRK06084  422 AS 423
PRK07812 PRK07812
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 2-189 2.45e-34

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 236105  Cd Length: 436  Bit Score: 126.40  E-value: 2.45e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLV----------------SVNCESLHN---------------RLRFLQ 50
Cdd:PRK07812  196 TPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIvdggtfdwtqgrfpgfTTPDPSYHGvvfaelgppayalkaRVQLLR 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  51 NsLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTG-MVTFYIK 129
Cdd:PRK07812  276 D-LGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPWYERAKRLAPKGTGaVLSFELA 354

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117 130 GTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK07812  355 GGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAVG 414
PRK05994 PRK05994
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 2-207 1.82e-30

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 180344 [Multi-domain]  Cd Length: 427  Bit Score: 115.97  E-value: 1.82e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsVNC---------------------------ESLHN-------RLR 47
Cdd:PRK05994  189 SPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGII-VDGgtfdwsksgkypmlseprpeyhglvlhETFGNfafaiaaRVL 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  48 FLQNsLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMV-TF 126
Cdd:PRK05994  268 GLRD-LGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDDPYHALAQKYSPKGAGAVfTF 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117 127 YIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKA 206
Cdd:PRK05994  347 GLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLSIGIEDVDDIIADLEQALAK 426


                  .
gi 2462505117 207 A 207
Cdd:PRK05994  427 A 427
PRK05939 PRK05939
cystathionine gamma-synthase family protein;
2-207 2.01e-28

cystathionine gamma-synthase family protein;


Pssm-ID: 235650 [Multi-domain]  Cd Length: 397  Bit Score: 110.16  E-value: 2.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVS----------VNCESLHNR---------------LRflqnSLGAV 56
Cdd:PRK05939  172 SPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTdtglfdwsayPNIFPAYRKgdpqqwgltqirkkgLR----DMGAT 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  57 PSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAE 136
Cdd:PRK05939  248 LSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGIDCFD 327

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462505117 137 iFLKNLKLFTLAESLGGFESLAeLPAIMT-HASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAA 207
Cdd:PRK05939  328 -FLNRLKLVIKATHLGDTRTLV-IPVAPTiYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
PRK06702 PRK06702
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
2-189 2.05e-28

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;


Pssm-ID: 102505 [Multi-domain]  Cd Length: 432  Bit Score: 110.53  E-value: 2.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVS---------------VNCESLHNRLRFLQN--------------- 51
Cdd:PRK06702  188 TPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypelVEPDPSYHGVSYVQNfgaaayivkarvqll 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  52 -SLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCT-GCTGMVTFYIK 129
Cdd:PRK06702  268 rDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYLKkGASGVLTFGIK 347

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117 130 GTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK06702  348 GGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVG 407
PRK05613 PRK05613
O-acetylhomoserine/O-acetylserine sulfhydrylase;
7-189 6.72e-26

O-acetylhomoserine/O-acetylserine sulfhydrylase;


Pssm-ID: 168128 [Multi-domain]  Cd Length: 437  Bit Score: 103.80  E-value: 6.72e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   7 RPLALGADISMYSATKYMNGHSDVVMGLVS--------------------VNCESLHNRLRF---------------LQN 51
Cdd:PRK05613  201 RPLELGADVVVASLTKFYTGNGSGLGGVLIdggkfdwtverdgkpvfpyfVTPDPAYHGLKYadlgapafglkaragLLR 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  52 SLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMV-TFYIKG 130
Cdd:PRK05613  281 DTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLKDSPWYATKEKLGLKYTGSVlSFDIKG 360

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462505117 131 TLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PRK05613  361 GKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQATVRLSVG 419
PLN02242 PLN02242
methionine gamma-lyase
 2-189 1.07e-22

methionine gamma-lyase


Pssm-ID: 215134  Cd Length: 418  Bit Score: 94.45  E-value: 1.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117   2 SPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsvnC--ESLHNRLRFLQNS----LGAVPSPIDCYLCNRGLKTLHVR 75
Cdd:PLN02242  203 APMVLSPARLGADVVVHSISKFISGGADIIAGAV---CgpAELVNSMMDLHHGalmlLGPTMNPKVAFELSERLPHLSLR 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462505117  76 MEKHFKNGMAVAQFLESNPWveKVIYPGLPSHPQHELVKRQ---CTGCTGMVTFYIkGTLQHAEIFLKNLKLFT----LA 148
Cdd:PLN02242  280 MKEHCRRAMEYAKRMKELGL--KVIYPGLEDHPQHALLKSMankGYGFGGLLCLDM-DTEERANRLMRYLQNSTqfgfMA 356

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462505117 149 ESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 189
Cdd:PLN02242  357 VSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVG 397
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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