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Conserved domains on  [gi|2462498640|ref|XP_054189141|]
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ADAMTS-like protein 3 isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 734-786 7.67e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.63  E-value: 7.67e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462498640 734 WHVGSWGPCSATCGVGIQTRDVYCLHP-GETPAPPEECRD-EKPHALQACNQFDC 786
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKgGGSIVPDSECSAqKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 449-506 8.65e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 60.93  E-value: 8.65e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462498640 449 WEHNPWTACSVSCGGGIQRRSFVCVEEsmHGEILQVEEWkCMYAPKPKVMQTCNLFDC 506
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSE-CSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 129-227 5.95e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 5.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498640 129 DFRAQQCSAYNDVQYQ-----GHYYEW---LPrYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRC------NTDSLDMC 194
Cdd:pfam19236   4 EFMSQQCARTDGQPLRsspggASFYHWgaaVP-HSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462498640 195 ISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTC 227
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 675-730 6.62e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 6.62e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498640 675 WEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMsQACNTEPC 730
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 78-124 9.55e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.12  E-value: 9.55e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462498640   78 WDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCP 124
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 790-846 1.06e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 1.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462498640 790 WHIEEWQQCSRTCGGGTQNRRVTCRQLltdGSFLNLSDELCQG-PKASSHKSCARTDC 846
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK---GGGSIVPDSECSAqKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 509-561 2.40e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 45.52  E-value: 2.40e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498640 509 WIAMEWSQCTVTCGRGLRYRVVLCI---NHRGEHVGGCNPQLKLHIKEECVIPiPC 561
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPDSECSAQKKPPETQSCNLK-PC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 597-652 4.70e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 41.67  E-value: 4.70e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498640 597 PEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEEcegPKLPTERPCLLEAC 652
Cdd:pfam19030   3 AGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQ---KKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 370-428 6.37e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 41.28  E-value: 6.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498640 370 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYChyypeNVKPKPKLKE-CSMDPC 428
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-----SAQKKPPETQsCNLKPC 55
 
Name Accession Description Interval E-value
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 734-786 7.67e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.63  E-value: 7.67e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462498640 734 WHVGSWGPCSATCGVGIQTRDVYCLHP-GETPAPPEECRD-EKPHALQACNQFDC 786
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKgGGSIVPDSECSAqKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 449-506 8.65e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 60.93  E-value: 8.65e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462498640 449 WEHNPWTACSVSCGGGIQRRSFVCVEEsmHGEILQVEEWkCMYAPKPKVMQTCNLFDC 506
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSE-CSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 129-227 5.95e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 5.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498640 129 DFRAQQCSAYNDVQYQ-----GHYYEW---LPrYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRC------NTDSLDMC 194
Cdd:pfam19236   4 EFMSQQCARTDGQPLRsspggASFYHWgaaVP-HSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462498640 195 ISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTC 227
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 675-730 6.62e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 6.62e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498640 675 WEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMsQACNTEPC 730
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 78-124 9.55e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.12  E-value: 9.55e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462498640   78 WDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCP 124
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 790-846 1.06e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 1.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462498640 790 WHIEEWQQCSRTCGGGTQNRRVTCRQLltdGSFLNLSDELCQG-PKASSHKSCARTDC 846
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK---GGGSIVPDSECSAqKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 509-561 2.40e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 45.52  E-value: 2.40e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498640 509 WIAMEWSQCTVTCGRGLRYRVVLCI---NHRGEHVGGCNPQLKLHIKEECVIPiPC 561
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPDSECSAQKKPPETQSCNLK-PC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 597-652 4.70e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 41.67  E-value: 4.70e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498640 597 PEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEEcegPKLPTERPCLLEAC 652
Cdd:pfam19030   3 AGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQ---KKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 734-787 4.86e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.80  E-value: 4.86e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462498640  734 WHVGSWGPCSATCGVGIQTRDVYCLHPGEtPAPPEECRDEKPHAlQACNQFDCP 787
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPP-QNGGGPCTGEDVET-RACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 370-428 6.37e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 41.28  E-value: 6.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498640 370 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYChyypeNVKPKPKLKE-CSMDPC 428
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-----SAQKKPPETQsCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 513-542 6.21e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 6.21e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462498640  513 EWSQCTVTCGRGLRYRVVLCINHRGEHVGG 542
Cdd:smart00209   6 EWSPCSVTCGGGVQTRTRSCCSPPPQNGGG 35
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 453-473 3.16e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 3.16e-03
                           10        20
                   ....*....|....*....|.
gi 2462498640  453 PWTACSVSCGGGIQRRSFVCV 473
Cdd:smart00209   6 EWSPCSVTCGGGVQTRTRSCC 26
TSP_1 pfam00090
Thrombospondin type 1 domain;
81-123 3.62e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.24  E-value: 3.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462498640  81 WGDWSDCSRTCGGGASYSLRRC----LTGRNCEGQNIRYKTCSNHDC 123
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTCkspfPGGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 598-618 4.92e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 4.92e-03
                           10        20
                   ....*....|....*....|.
gi 2462498640  598 EPWSACSTTCGPGVQVREVKC 618
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSC 25
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 790-847 5.22e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 5.22e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462498640  790 WHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFlnlsdELCQGPKASShKSCARTDCP 847
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGG-----GPCTGEDVET-RACNEQPCP 53
 
Name Accession Description Interval E-value
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 734-786 7.67e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 63.63  E-value: 7.67e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462498640 734 WHVGSWGPCSATCGVGIQTRDVYCLHP-GETPAPPEECRD-EKPHALQACNQFDC 786
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKgGGSIVPDSECSAqKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 449-506 8.65e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 60.93  E-value: 8.65e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462498640 449 WEHNPWTACSVSCGGGIQRRSFVCVEEsmHGEILQVEEWkCMYAPKPKVMQTCNLFDC 506
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSE-CSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 129-227 5.95e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 5.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498640 129 DFRAQQCSAYNDVQYQ-----GHYYEW---LPrYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRC------NTDSLDMC 194
Cdd:pfam19236   4 EFMSQQCARTDGQPLRsspggASFYHWgaaVP-HSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLSLC 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462498640 195 ISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTC 227
Cdd:pfam19236  83 VLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 675-730 6.62e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 6.62e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498640 675 WEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMsQACNTEPC 730
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 78-124 9.55e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.12  E-value: 9.55e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462498640   78 WDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCP 124
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 790-846 1.06e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.99  E-value: 1.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462498640 790 WHIEEWQQCSRTCGGGTQNRRVTCRQLltdGSFLNLSDELCQG-PKASSHKSCARTDC 846
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK---GGGSIVPDSECSAqKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 509-561 2.40e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 45.52  E-value: 2.40e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498640 509 WIAMEWSQCTVTCGRGLRYRVVLCI---NHRGEHVGGCNPQLKLHIKEECVIPiPC 561
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVqkgGGSIVPDSECSAQKKPPETQSCNLK-PC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 597-652 4.70e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 41.67  E-value: 4.70e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498640 597 PEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEEcegPKLPTERPCLLEAC 652
Cdd:pfam19030   3 AGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQ---KKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 734-787 4.86e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.80  E-value: 4.86e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462498640  734 WHVGSWGPCSATCGVGIQTRDVYCLHPGEtPAPPEECRDEKPHAlQACNQFDCP 787
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPP-QNGGGPCTGEDVET-RACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 370-428 6.37e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 41.28  E-value: 6.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462498640 370 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYChyypeNVKPKPKLKE-CSMDPC 428
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSEC-----SAQKKPPETQsCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 513-542 6.21e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 6.21e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462498640  513 EWSQCTVTCGRGLRYRVVLCINHRGEHVGG 542
Cdd:smart00209   6 EWSPCSVTCGGGVQTRTRSCCSPPPQNGGG 35
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 453-473 3.16e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 3.16e-03
                           10        20
                   ....*....|....*....|.
gi 2462498640  453 PWTACSVSCGGGIQRRSFVCV 473
Cdd:smart00209   6 EWSPCSVTCGGGVQTRTRSCC 26
TSP_1 pfam00090
Thrombospondin type 1 domain;
81-123 3.62e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.24  E-value: 3.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462498640  81 WGDWSDCSRTCGGGASYSLRRC----LTGRNCEGQNIRYKTCSNHDC 123
Cdd:pfam00090   3 WSPWSPCSVTCGKGIQVRQRTCkspfPGGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 598-618 4.92e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 4.92e-03
                           10        20
                   ....*....|....*....|.
gi 2462498640  598 EPWSACSTTCGPGVQVREVKC 618
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSC 25
TSP_1 pfam00090
Thrombospondin type 1 domain;
737-786 5.06e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.86  E-value: 5.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462498640 737 GSWGPCSATCGVGIQTRDVYCLHPgetPAPPEECRDEKpHALQACNQFDC 786
Cdd:pfam00090   4 SPWSPCSVTCGKGIQVRQRTCKSP---FPGGEPCTGDD-IETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 790-847 5.22e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 5.22e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462498640  790 WHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFlnlsdELCQGPKASShKSCARTDCP 847
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGG-----GPCTGEDVET-RACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 78-123 6.85e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.51  E-value: 6.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462498640  78 WDAwGDWSDCSRTCGGGASYSLRRCLT--------GRNCEGQN--IRYKTCSNHDC 123
Cdd:pfam19030   1 WVA-GPWGECSVTCGGGVQTRLVQCVQkgggsivpDSECSAQKkpPETQSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
794-828 8.20e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.09  E-value: 8.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462498640 794 EWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDE 828
Cdd:pfam00090   5 PWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDI 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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