membrane-associated phosphatidylinositol transfer protein 3 isoform X2 [Homo sapiens]
Protein Classification
DDHD family phospholipase( domain architecture ID 10502158)
DDHD family phospholipase similar to Homo sapiens phospholipase DDHD1 that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| DDHD | pfam02862 | DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that ... |
390-593 | 2.33e-45 | |||||
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family. : Pssm-ID: 460725 Cd Length: 241 Bit Score: 162.99 E-value: 2.33e-45
|
|||||||||
| HAD_like super family | cl21460 | Haloacid Dehalogenase-like Hydrolases; The haloacid dehalogenase (HAD) superfamily includes ... |
739-770 | 2.34e-04 | |||||
Haloacid Dehalogenase-like Hydrolases; The haloacid dehalogenase (HAD) superfamily includes carbon and phosphorus hydrolases such as 2-haloalkonoate dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, among others. These proteins catalyze nucleophilic substitution reactions at phosphorus or carbon centers, using a conserved Asp carboxylate in covalent catalysis. All members possess a conserve alpha/beta core domain, and many also possess a small cap domain, with varying folds and functions. The actual alignment was detected with superfamily member smart00775: Pssm-ID: 473868 Cd Length: 157 Bit Score: 42.26 E-value: 2.34e-04
|
|||||||||
| Name | Accession | Description | Interval | E-value | |||||
| DDHD | pfam02862 | DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that ... |
390-593 | 2.33e-45 | |||||
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family. Pssm-ID: 460725 Cd Length: 241 Bit Score: 162.99 E-value: 2.33e-45
|
|||||||||
| LNS2 | smart00775 | This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal ... |
739-770 | 2.34e-04 | |||||
This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; SMP2 is involved in plasmid maintenance and respiration. Lipin proteins are involved in adipose tissue development and insulin resistance. Pssm-ID: 197870 Cd Length: 157 Bit Score: 42.26 E-value: 2.34e-04
|
|||||||||
| Name | Accession | Description | Interval | E-value | |||||
| DDHD | pfam02862 | DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that ... |
390-593 | 2.33e-45 | |||||
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family. Pssm-ID: 460725 Cd Length: 241 Bit Score: 162.99 E-value: 2.33e-45
|
|||||||||
| LNS2 | smart00775 | This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal ... |
739-770 | 2.34e-04 | |||||
This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; SMP2 is involved in plasmid maintenance and respiration. Lipin proteins are involved in adipose tissue development and insulin resistance. Pssm-ID: 197870 Cd Length: 157 Bit Score: 42.26 E-value: 2.34e-04
|
|||||||||
| Blast search parameters | ||||
|
