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Conserved domains on  [gi|2462555320|ref|XP_054172121|]
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microtubule-associated protein tau isoform X16 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 283-312 4.01e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 54.34  E-value: 4.01e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462555320 283 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 312
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 314-344 2.92e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.03  E-value: 2.92e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462555320 314 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 344
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 260-281 6.21e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 45.48  E-value: 6.21e-07
                          10        20
                  ....*....|....*....|..
gi 2462555320 260 DLKNVKSKIGSTENLKHQPGGG 281
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 46-270 1.55e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.47  E-value: 1.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555320   46 EEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPE 125
Cdd:PHA03307    46 DSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPAS 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555320  126 P-PSSPKHVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSG 204
Cdd:PHA03307   126 PpPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPR 205

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462555320  205 YSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGS 270
Cdd:PHA03307   206 PPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWE 271
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 283-312 4.01e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 54.34  E-value: 4.01e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462555320 283 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 312
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 314-344 2.92e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.03  E-value: 2.92e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462555320 314 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 344
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 260-281 6.21e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 45.48  E-value: 6.21e-07
                          10        20
                  ....*....|....*....|..
gi 2462555320 260 DLKNVKSKIGSTENLKHQPGGG 281
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 46-270 1.55e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.47  E-value: 1.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555320   46 EEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPE 125
Cdd:PHA03307    46 DSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPAS 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555320  126 P-PSSPKHVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSG 204
Cdd:PHA03307   126 PpPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPR 205

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462555320  205 YSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGS 270
Cdd:PHA03307   206 PPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWE 271
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 283-312 4.01e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 54.34  E-value: 4.01e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462555320 283 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 312
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 314-344 2.92e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.03  E-value: 2.92e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462555320 314 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 344
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 260-281 6.21e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 45.48  E-value: 6.21e-07
                          10        20
                  ....*....|....*....|..
gi 2462555320 260 DLKNVKSKIGSTENLKHQPGGG 281
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 46-270 1.55e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.47  E-value: 1.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555320   46 EEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPE 125
Cdd:PHA03307    46 DSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPAS 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555320  126 P-PSSPKHVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSG 204
Cdd:PHA03307   126 PpPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPR 205

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462555320  205 YSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGS 270
Cdd:PHA03307   206 PPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWE 271
PHA03378 PHA03378
EBNA-3B; Provisional
 101-259 4.02e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.75  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555320 101 LSPKHPTPGSSDPLIQPS---SPAVCPEPPSS----PKHVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPP-GQKG 172
Cdd:PHA03378  633 MRPLRMQPITFNVLVFPTphqPPQVEITPYKPtwtqIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPaAPPG 712

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555320 173 QANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKvAVVRTPPKSPSSAKSRLQ 252
Cdd:PHA03378  713 RAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGA-PTPQPPPQAPPAPQQRPR 791


                  ....*..
gi 2462555320 253 TAPVPMP 259
Cdd:PHA03378  792 GAPTPQP 798
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 102-248 2.86e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.06  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555320 102 SPKHPTPgssdpliqPSSPAVCPEPPSSPKHVSSVTSRTG-SSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIP 180
Cdd:PTZ00449  504 SDKHDEP--------PEGPEASGLPPKAPGDKEGEEGEHEdSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTL 575

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555320 181 AKTPPAPKTPPSSGEP--PKSGDR----SGYSSPGSPGTPGS-----------RSRTPSLPTPPTR--EPKKVAVVRTP- 240
Cdd:PTZ00449  576 SKKPEFPKDPKHPKDPeePKKPKRprsaQRPTRPKSPKLPELldipkspkrpeSPKSPKRPPPPQRpsSPERPEGPKIIk 655


                  ....*....
gi 2462555320 241 -PKSPSSAK 248
Cdd:PTZ00449  656 sPKPPKSPK 664
PHA03247 PHA03247
large tegument protein UL36; Provisional
 116-259 7.57e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 7.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555320  116 QPSSPAVCPEPPSSPKHVSSVTSrTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGE 195
Cdd:PHA03247  2675 QASSPPQRPRRRAARPTVGSLTS-LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG 2753

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462555320  196 PPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPtrePKKVAVVRTPPKSPSSAKSRLQTAPVPMP 259
Cdd:PHA03247  2754 PARPARPPTTAGPPAPAPPAAPAAGPPRRLTR---PAVASLSESRESLPSPWDPADPPAAVLAP 2814
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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