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Conserved domains on  [gi|2462554933|ref|XP_054171930|]
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forkhead box protein K2 isoform X1 [Homo sapiens]

Protein Classification

forkhead box protein K2( domain architecture ID 17784357)

forkhead box protein K2 (FOXK2) is a transcriptional regulator involved in several signaling pathways, including the mammalian target of rapamycin, WNT, and AKT signaling pathways which regulate cell proliferation and death by influencing the expression of important genes through the transcription repressor FOXK2

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700|GO:0046872
PubMed:  27965437|10473770|33303287|12297093|15719167|20097901|10518219|11069759
SCOP:  4000182|4002605

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FHA_FOXK2 cd22723
forkhead associated (FHA) domain found in forkhead box protein K2 (FOXK2) and similar proteins; ...
 35-157 9.42e-71

forkhead associated (FHA) domain found in forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, also called cellular transcription factor ILF-1, or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to HIV-1 long terminal repeat. FOXK2 may be involved in both positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FHA domain is a small phosphopeptide recognition module.


:

Pssm-ID: 438775 [Multi-domain]  Cd Length: 111  Bit Score: 223.63  E-value: 9.42e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  35 WAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPpgggghggaapelPPAQPRPDAGGDFYLR 114
Cdd:cd22723     2 PAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTA-------------GEDGGDGGGGGDFYLR 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462554933 115 CLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTAL 157
Cdd:cd22723    69 CLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTAL 111
FH_FOXK2 cd20055
Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, ...
 256-353 9.11e-67

Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


:

Pssm-ID: 410829 [Multi-domain]  Cd Length: 98  Bit Score: 212.75  E-value: 9.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 256 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 335
Cdd:cd20055     1 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 80

                          90
                  ....*....|....*...
gi 2462554933 336 PASESKLIEQAFRKRRPR 353
Cdd:cd20055    81 PASESKLIEQAFRKRRPR 98
COG5025 super family cl34870
Transcription factor of the Forkhead/HNF3 family [Transcription];
180-577 2.51e-24

Transcription factor of the Forkhead/HNF3 family [Transcription];


The actual alignment was detected with superfamily member COG5025:

Pssm-ID: 227358 [Multi-domain]  Cd Length: 610  Bit Score: 107.59  E-value: 2.51e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 180 SPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRgagSSGYKVGRVMPSD---LNLMADNSQPENEKEASGgdspKDD 256
Cdd:COG5025   263 SSGEENISRINNSSQIDSPTPNYRMSSIDSSVNPSR---LANNKDEGRKGSKsspVPKDAAPPSTLSDLSADV----NRT 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 257 SKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDP 336
Cdd:COG5025   336 SKPAFSYANSITQAILSSPSGKMTLSEIYSWISSNLPYYRHKPTAWQNSIRHNLSLNKSFEKVPRSASQPGKGCFWKIDY 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 337 ASesklIEQAFRKRRPRgvpcfrtplgplsSRSApaspnhagVLSAHSsgAQTPESLSREgSPAPLEPEPGAAQPKLAVI 416
Cdd:COG5025   416 SY----IYEKESKRNPR-------------SPKK--------SPSAHS--VHQKLSLHVN-DLYQSPATSDIASSSSQVN 467

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 417 QEARFAQSAPGSPLSSQPVLITvQRQLPQAIKPVTYTVAtpvttstsqppvvqtvhvvhqipAVSVTSVAglapANTYTV 496
Cdd:COG5025   468 SQPEFISTQIHSSKGVSNVDLT-EQDSQKEASKGNFLDD-----------------------SGSLSPNT----NEINSF 519

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 497 SGQAVVTPAAVLAPPKAEAQENGDHREVKVKVEPIPAIGHATLGTASRIIQTAQTTPVQTvTIVQQAPLGQHQLPIKTVT 576
Cdd:COG5025   520 SLNTTDSQQKQSPSHNAPTNNSLNEMASKNSNSQTQASNSNENVAAVKAILDASAQMEKP-YDLSQAATPTKATESASVR 598


                  .
gi 2462554933 577 Q 577
Cdd:COG5025   599 Q 599
 
Name Accession Description Interval E-value
FHA_FOXK2 cd22723
forkhead associated (FHA) domain found in forkhead box protein K2 (FOXK2) and similar proteins; ...
 35-157 9.42e-71

forkhead associated (FHA) domain found in forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, also called cellular transcription factor ILF-1, or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to HIV-1 long terminal repeat. FOXK2 may be involved in both positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438775 [Multi-domain]  Cd Length: 111  Bit Score: 223.63  E-value: 9.42e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  35 WAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPpgggghggaapelPPAQPRPDAGGDFYLR 114
Cdd:cd22723     2 PAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTA-------------GEDGGDGGGGGDFYLR 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462554933 115 CLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTAL 157
Cdd:cd22723    69 CLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTAL 111
FH_FOXK2 cd20055
Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, ...
 256-353 9.11e-67

Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410829 [Multi-domain]  Cd Length: 98  Bit Score: 212.75  E-value: 9.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 256 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 335
Cdd:cd20055     1 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 80

                          90
                  ....*....|....*...
gi 2462554933 336 PASESKLIEQAFRKRRPR 353
Cdd:cd20055    81 PASESKLIEQAFRKRRPR 98
Forkhead pfam00250
Forkhead domain;
258-343 9.23e-52

Forkhead domain;


Pssm-ID: 459732  Cd Length: 86  Bit Score: 172.66  E-value: 9.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:pfam00250   1 KPPYSYAALIAMAILSSPEKKLTLSEIYEWISENFPYYRTADKGWQNSIRHNLSLNKCFVKVPRPKDEPGKGSYWTIDPE 80


                  ....*.
gi 2462554933 338 SESKLI 343
Cdd:pfam00250  81 YEEMFE 86
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
 258-344 8.63e-45

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 153.93  E-value: 8.63e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:smart00339   1 KPPYSYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRAGWQNSIRHNLSLNDCFVKVPREGDRPGKGSYWTLDPA 80


                   ....*..
gi 2462554933  338 SESKLIE 344
Cdd:smart00339  81 AENMFEN 87
COG5025 COG5025
Transcription factor of the Forkhead/HNF3 family [Transcription];
180-577 2.51e-24

Transcription factor of the Forkhead/HNF3 family [Transcription];


Pssm-ID: 227358 [Multi-domain]  Cd Length: 610  Bit Score: 107.59  E-value: 2.51e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 180 SPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRgagSSGYKVGRVMPSD---LNLMADNSQPENEKEASGgdspKDD 256
Cdd:COG5025   263 SSGEENISRINNSSQIDSPTPNYRMSSIDSSVNPSR---LANNKDEGRKGSKsspVPKDAAPPSTLSDLSADV----NRT 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 257 SKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDP 336
Cdd:COG5025   336 SKPAFSYANSITQAILSSPSGKMTLSEIYSWISSNLPYYRHKPTAWQNSIRHNLSLNKSFEKVPRSASQPGKGCFWKIDY 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 337 ASesklIEQAFRKRRPRgvpcfrtplgplsSRSApaspnhagVLSAHSsgAQTPESLSREgSPAPLEPEPGAAQPKLAVI 416
Cdd:COG5025   416 SY----IYEKESKRNPR-------------SPKK--------SPSAHS--VHQKLSLHVN-DLYQSPATSDIASSSSQVN 467

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 417 QEARFAQSAPGSPLSSQPVLITvQRQLPQAIKPVTYTVAtpvttstsqppvvqtvhvvhqipAVSVTSVAglapANTYTV 496
Cdd:COG5025   468 SQPEFISTQIHSSKGVSNVDLT-EQDSQKEASKGNFLDD-----------------------SGSLSPNT----NEINSF 519

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 497 SGQAVVTPAAVLAPPKAEAQENGDHREVKVKVEPIPAIGHATLGTASRIIQTAQTTPVQTvTIVQQAPLGQHQLPIKTVT 576
Cdd:COG5025   520 SLNTTDSQQKQSPSHNAPTNNSLNEMASKNSNSQTQASNSNENVAAVKAILDASAQMEKP-YDLSQAATPTKATESASVR 598


                  .
gi 2462554933 577 Q 577
Cdd:COG5025   599 Q 599
COG5025 COG5025
Transcription factor of the Forkhead/HNF3 family [Transcription];
258-342 1.74e-16

Transcription factor of the Forkhead/HNF3 family [Transcription];


Pssm-ID: 227358 [Multi-domain]  Cd Length: 610  Bit Score: 82.94  E-value: 1.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:COG5025    86 VPPYSYATGRGLAILNSPDKPLTLSKIYTWIHNTFFYYAKVVSRWQNSIRHNLSLNDAFIKIEGRNGAKVKGHFWSIGPG 165


                  ....*
gi 2462554933 338 SESKL 342
Cdd:COG5025   166 HETQF 170
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 54-128 8.52e-07

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 46.02  E-value: 8.52e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462554933   54 VTIGRNSSQGSVDVSmghSSFISRRHLEIftppgggghggaapelppaqpRPDAGGDFYLRCLG-KNGVFVDGVFQ 128
Cdd:smart00240   1 VTIGRSSEDCDIQLD---GPSISRRHAVI---------------------VYDGGGRFYLIDLGsTNGTFVNGKRI 52
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 54-138 3.94e-06

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 44.49  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  54 VTIGRNSSQgsvDVSMGHSSfISRRHLEIftppgggghggaapelppaqpRPDAGGDFYLRCLG-KNGVFVDGvfQRRGA 132
Cdd:pfam00498   1 VTIGRSPDC---DIVLDDPS-VSRRHAEI---------------------RYDGGGRFYLEDLGsTNGTFVNG--QRLGP 53


                  ....*.
gi 2462554933 133 PPLQLP 138
Cdd:pfam00498  54 EPVRLK 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 350-511 7.60e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 7.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  350 RRPRGVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPA----PLEPEP-----GAAQPKLAVIQEAR 420
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPttagPPAPAPpaapaAGPPRRLTRPAVAS 2790

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  421 FAQSAPGSPLSSQPVLITVQRQLPQAIKPVTYTVATPVTTSTSQPPVVQTVHVVHQIPAVSVT-SVAGLAPANTYTVSGQ 499
Cdd:PHA03247  2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgSVAPGGDVRRRPPSRS 2870

                          170
                   ....*....|..
gi 2462554933  500 AVVTPAAVLAPP 511
Cdd:PHA03247  2871 PAAKPAAPARPP 2882
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
46-126 6.55e-04

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 39.17  E-value: 6.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  46 EYLMKKRSVTIGRNSSqgsVDVSMGHSSfISRRHLEIFTPpgggghggaapelppaqprpdaGGDFYLRCLG-KNGVFVD 124
Cdd:COG1716    15 RFPLDGGPLTIGRAPD---NDIVLDDPT-VSRRHARIRRD----------------------GGGWVLEDLGsTNGTFVN 68


                  ..
gi 2462554933 125 GV 126
Cdd:COG1716    69 GQ 70
 
Name Accession Description Interval E-value
FHA_FOXK2 cd22723
forkhead associated (FHA) domain found in forkhead box protein K2 (FOXK2) and similar proteins; ...
 35-157 9.42e-71

forkhead associated (FHA) domain found in forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, also called cellular transcription factor ILF-1, or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to HIV-1 long terminal repeat. FOXK2 may be involved in both positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438775 [Multi-domain]  Cd Length: 111  Bit Score: 223.63  E-value: 9.42e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  35 WAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPpgggghggaapelPPAQPRPDAGGDFYLR 114
Cdd:cd22723     2 PAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTA-------------GEDGGDGGGGGDFYLR 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462554933 115 CLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTAL 157
Cdd:cd22723    69 CLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTAL 111
FH_FOXK2 cd20055
Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, ...
 256-353 9.11e-67

Forkhead (FH) domain found in Forkhead box protein K2 (FOXK2) and similar proteins; FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410829 [Multi-domain]  Cd Length: 98  Bit Score: 212.75  E-value: 9.11e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 256 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 335
Cdd:cd20055     1 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 80

                          90
                  ....*....|....*...
gi 2462554933 336 PASESKLIEQAFRKRRPR 353
Cdd:cd20055    81 PASESKLIEQAFRKRRPR 98
FH_FOXK cd20026
Forkhead (FH) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily ...
 258-335 2.89e-59

Forkhead (FH) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410800 [Multi-domain]  Cd Length: 78  Bit Score: 192.24  E-value: 2.89e-59
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 335
Cdd:cd20026     1 KPPYSYAQLIVQAISSAPDKQLTLSGIYAYITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 78
FH_FOXK1 cd20054
Forkhead (FH) domain found in Forkhead box protein K1 (FOXK1) and similar proteins; FOXK1, ...
 256-355 1.01e-58

Forkhead (FH) domain found in Forkhead box protein K1 (FOXK1) and similar proteins; FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410828 [Multi-domain]  Cd Length: 101  Bit Score: 191.58  E-value: 1.01e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 256 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 335
Cdd:cd20054     1 ESKPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 80

                          90       100
                  ....*....|....*....|
gi 2462554933 336 PASESKLIEQAFRKRRPRGV 355
Cdd:cd20054    81 PASEAKLVEQAFRKRRQRGV 100
FHA_FOXK cd22688
forkhead associated (FHA) domain found in the Forkhead box protein K (FOXK) subfamily; The ...
 35-155 2.35e-58

forkhead associated (FHA) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two-winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The Forkhead (FH) domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438740 [Multi-domain]  Cd Length: 100  Bit Score: 190.56  E-value: 2.35e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  35 WAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPpgggghggaapelppaqprpdaGGDFYLR 114
Cdd:cd22688     2 AAIARLEGREFEYLMRKSRVVIGRNSSRGPVDVNMGHSSFISRKHLEIFYE----------------------GGRFFLL 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462554933 115 CLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFT 155
Cdd:cd22688    60 CNGKNGIFVDGVFQRRGAPPLQLPKTCVFRFPSTNIKIVFE 100
Forkhead pfam00250
Forkhead domain;
258-343 9.23e-52

Forkhead domain;


Pssm-ID: 459732  Cd Length: 86  Bit Score: 172.66  E-value: 9.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:pfam00250   1 KPPYSYAALIAMAILSSPEKKLTLSEIYEWISENFPYYRTADKGWQNSIRHNLSLNKCFVKVPRPKDEPGKGSYWTIDPE 80


                  ....*.
gi 2462554933 338 SESKLI 343
Cdd:pfam00250  81 YEEMFE 86
FHA_FOXK1 cd22722
forkhead associated (FHA) domain found in forkhead box protein K1 (FOXK1) and similar proteins; ...
 36-157 3.44e-49

forkhead associated (FHA) domain found in forkhead box protein K1 (FOXK1) and similar proteins; FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of the myoglobin gene. It positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438774  Cd Length: 103  Bit Score: 166.22  E-value: 3.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  36 AVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPpgggghggaapelppaQPRpdaggdFYLRC 115
Cdd:cd22722     3 ALARLEGRDFEFLMRQPTVTIGRNSSQGSVDVNMGHSSFISRRHLQLSFQ----------------EPH------FYLRC 60

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462554933 116 LGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTAL 157
Cdd:cd22722    61 LGKNGVFVDGAFQRRGAPPLQLPRQCTFRFPSTVIKIQFTSL 102
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
 258-344 8.63e-45

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 153.93  E-value: 8.63e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:smart00339   1 KPPYSYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRAGWQNSIRHNLSLNDCFVKVPREGDRPGKGSYWTLDPA 80


                   ....*..
gi 2462554933  338 SESKLIE 344
Cdd:smart00339  81 AENMFEN 87
FH_FOX cd00059
Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar ...
 259-333 4.95e-43

Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins; The FOX family comprises diverse tissue- and cell type-specific transcription factors with an evolutionary conserved "Forkhead (FH)" or "winged helix" DNA-binding domain. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. The structure of the FH domain contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. They participate in a variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Their expression can be regulated by multiple factors, and they can act as co-activators and/or transcriptional repressors. Fifty FOX-encoding genes in humans have been categorized into 19 subfamilies based on protein sequence homology (FOXA to FOXS).


Pssm-ID: 410788 [Multi-domain]  Cd Length: 75  Bit Score: 148.44  E-value: 4.95e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462554933 259 PPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWR 333
Cdd:cd00059     1 PPYSYAALIALAILSSPDKRLTLSEIYKWIEDNFPYYRTATKGWKNSIRHNLSLNKCFVKVPREPSDPGKGSYWT 75
FH_FOXJ2-like cd20024
Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins; The ...
 258-334 1.14e-42

Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins; The FOXJ2-like subfamily includes two winged helix transcription factors, FOXJ2 and FOXJ3. FOXJ2, also called Forkhead homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410798 [Multi-domain]  Cd Length: 77  Bit Score: 147.89  E-value: 1.14e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRI 334
Cdd:cd20024     1 KPPYSYATLITFAINSSPKKKMTLSEIYTWICENFPYYREAGTGWKNSIRHNLSLNKCFKKVPRSKDDPGKGSYWTL 77
FH_FOXJ1 cd20023
Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins; FOXJ1, ...
 258-336 5.29e-40

Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins; FOXJ1, also called Forkhead-related protein FKHL13 or hepatocyte nuclear factor 3 Forkhead homolog 4 (HFH-4), acts as a transcription factor specifically required for the formation of motile cilia. It acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. FOXJ1 binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). It activates the transcription of a variety of ciliary proteins in the developing brain and lung. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410797 [Multi-domain]  Cd Length: 79  Bit Score: 140.63  E-value: 5.29e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDP 336
Cdd:cd20023     1 KPPYSYATLICMAMQASKKTKITLSAIYKWITDNFMYYRVADPTWQNSIRHNLSLNKCFIKVPRSKDEPGKGGFWRIDP 79
FH_FOXG cd20021
Forkhead (FH) domain found in the Forkhead box protein G (FOXG) subfamily; The FOXG subfamily ...
 258-336 4.05e-38

Forkhead (FH) domain found in the Forkhead box protein G (FOXG) subfamily; The FOXG subfamily includes a winged helix transcription factor FOXG1, which is also called brain factor 1 (BF-1), brain factor 2 (BF-2), Forkhead box protein G1A, Forkhead box protein G1B, Forkhead box protein G1C, Forkhead-related protein FKHL1, Forkhead-related protein FKHL2, or Forkhead-related protein FKHL3. FOXG1 acts as a transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. It is repetitively used in the sequential events of telencephalic development to control multi-steps of brain circuit formation ranging from cell cycle control to neuronal differentiation in a clade- and species-specific manner. Individuals with mutations in FOXG1 harbor "FOXG1-related encephalopathy", characterized by two clinical phenotypes/syndromes including microcephaly, developmental delay, severe cognitive disabilities, early-onset dyskinesia and hyperkinetic movements, stereotypies, epilepsy, and cerebral malformation for those with deletions or intragenic mutations of FOXG1. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410795 [Multi-domain]  Cd Length: 79  Bit Score: 135.39  E-value: 4.05e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDP 336
Cdd:cd20021     1 KPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDP 79
FH_FOXL1 cd20027
Forkhead (FH) domain found in Forkhead box protein L1 (FOXL1) and similar proteins; FOXL1, ...
 258-353 8.99e-38

Forkhead (FH) domain found in Forkhead box protein L1 (FOXL1) and similar proteins; FOXL1, also called Forkhead-related protein FKHL11 or Forkhead-related transcription factor 7 (FREAC-7), acts as a transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. It may play a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410801  Cd Length: 98  Bit Score: 134.94  E-value: 8.99e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:cd20027     3 KPPYSYIALIAMAIKSAPDQKVTLNGIYQFIMDRFPYYHDNKQGWQNSIRHNLSLNDCFVKVPREKGRPGKGNYWTLDPD 82

                          90
                  ....*....|....*.
gi 2462554933 338 SESKLIEQAFRKRRPR 353
Cdd:cd20027    83 CEEMFENGNYRRRKRR 98
FH_FOXQ2-like cd20035
Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is ...
 258-354 1.34e-36

Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is the neurogenic ectoderm specification transcription factor that controls aboral development in cnidarians and anterior identity in bilaterians. It plays essential roles in epidermal development and central brain patterning. The foxQ2 gene is absent in placental mammals. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410809 [Multi-domain]  Cd Length: 95  Bit Score: 131.59  E-value: 1.34e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSqeEPGKGSFWRIDPA 337
Cdd:cd20035     1 KPSHSYVALIAKAILSSPEKKLVLSDIYQYIEENYPYFKSRGSSWKNSVRHNLSLNECFVKAGRA--ENGKGNYWTIHPA 78

                          90
                  ....*....|....*..
gi 2462554933 338 SESKLIEQAFRKRRPRG 354
Cdd:cd20035    79 CLEDFEKGDFRRRRARR 95
FH_FOXE cd20019
Forkhead (FH) domain found in the Forkhead box protein E (FOXE) subfamily; The FOXE subfamily ...
 258-351 2.06e-36

Forkhead (FH) domain found in the Forkhead box protein E (FOXE) subfamily; The FOXE subfamily includes two winged helix transcription factors, FOXE1 (also known as FOXE2) and FOXE3. FOXE1, also called Forkhead-related protein FKHL15, HFKH4, HNF-3/fork head-like protein 5 (HFKL5), or thyroid transcription factor 2 (TTF-2), is a transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. FOXE3, also called Forkhead-related protein FKHL12 or Forkhead-related transcription factor 8 (FREAC-8), is a transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis, and the cell cycle. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410793  Cd Length: 94  Bit Score: 131.08  E-value: 2.06e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:cd20019     1 KPPYSYIALIAMAIANSPERKLTLGGIYKFIMERFPFYRDNSKKWQNSIRHNLTLNDCFVKIPREPGRPGKGNYWTLDPA 80

                          90
                  ....*....|....
gi 2462554933 338 SESKLIEQAFRKRR 351
Cdd:cd20019    81 AEDMFDNGSFLRRR 94
FH_FOXL2 cd20028
Forkhead (FH) domain found in Forkhead box protein L2 (FOXL2) and similar proteins; FOXL2 is a ...
 258-339 1.08e-35

Forkhead (FH) domain found in Forkhead box protein L2 (FOXL2) and similar proteins; FOXL2 is a transcriptional regulator that is essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Mutations in the FOXL2 gene cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II, a rare genetic disorder. In BPES type I, a complex eyelid malformation is associated with premature ovarian failure (POF), whereas in BPES type II, the eyelid defect occurs as an isolated entity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410802 [Multi-domain]  Cd Length: 89  Bit Score: 129.10  E-value: 1.08e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:cd20028     1 KPPYSYVALIAMAIRESPEKRLTLSGIYQYIIAKFPYYEKNKKGWQNSIRHNLSLNECFVKVPREGGGERKGNYWTLDPA 80


                  ..
gi 2462554933 338 SE 339
Cdd:cd20028    81 CE 82
FH_FOXC1 cd20044
Forkhead (FH) domain found in Forkhead box protein C1 (FOXC1) and similar proteins; FOXC1, ...
 253-338 1.23e-34

Forkhead (FH) domain found in Forkhead box protein C1 (FOXC1) and similar proteins; FOXC1, also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3 (FREAC-3), is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410818  Cd Length: 93  Bit Score: 126.35  E-value: 1.23e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 253 PKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFW 332
Cdd:cd20044     1 PKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMERFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYW 80


                  ....*.
gi 2462554933 333 RIDPAS 338
Cdd:cd20044    81 TLDPDS 86
FH_FOXJ3 cd20052
Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins; FOXJ3 is a ...
 257-335 1.28e-34

Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins; FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. Polymorphisms in the FOXJ3 gene may be associated with the development of rheumatoid arthritis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410826 [Multi-domain]  Cd Length: 79  Bit Score: 125.91  E-value: 1.28e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462554933 257 SKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 335
Cdd:cd20052     1 GKPPYSYANLITFAINSSPKKKMTLSEIYQWICDNFPYYREAGNGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAID 79
FH_FOXC cd20017
Forkhead (FH) domain found in the Forkhead box protein C (FOXC) subfamily; The FOXC subfamily ...
 258-332 2.25e-33

Forkhead (FH) domain found in the Forkhead box protein C (FOXC) subfamily; The FOXC subfamily includes two winged helix transcription factors, FOXC1 (also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3) and FOXC2 (also called Forkhead-related protein FKHL14, or Mesenchyme fork head protein 1). FOXC1 is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. FOXC2 acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410791 [Multi-domain]  Cd Length: 77  Bit Score: 122.36  E-value: 2.25e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFW 332
Cdd:cd20017     1 KPPYSYIALIAMAIQNAPDKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYW 75
FH_FOXI cd20025
Forkhead (FH) domain found in the Forkhead box protein I (FOXI) subfamily; The FOXI subfamily ...
 259-335 5.66e-33

Forkhead (FH) domain found in the Forkhead box protein I (FOXI) subfamily; The FOXI subfamily includes three human winged helix transcription factors, FOXI1-3, Xenopus laevis FoxI1c, and similar proteins. FOXI1 acts as a transcriptional activator required for the development of normal hearing, sense of balance, and kidney function. FOXI2 may act as a transcriptional activator that plays a possible role in controlling cellular identity. Loss of function mutations in the FOXI2 gene may contribute to ectodermal dysplasia. FOXI3 plays a critical role in the development of the inner ear and jaw. It is a regulator of ectodermal development. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410799 [Multi-domain]  Cd Length: 77  Bit Score: 121.10  E-value: 5.66e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462554933 259 PPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 335
Cdd:cd20025     1 PPYSYSALIAMAIQSAPEKKLTLSQIYQYVAENFPFYKRSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLD 77
FH_FOXC2 cd20045
Forkhead (FH) domain found in Forkhead box protein C2 (FOXC2) and similar proteins; FOXC2, ...
 258-338 3.55e-32

Forkhead (FH) domain found in Forkhead box protein C2 (FOXC2) and similar proteins; FOXC2, also called Forkhead-related protein FKHL14, Mesenchyme fork head protein 1 (MFH-1 protein), or transcription factor FKH-14, acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410819  Cd Length: 90  Bit Score: 119.42  E-value: 3.55e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:cd20045     3 KPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPD 82


                  .
gi 2462554933 338 S 338
Cdd:cd20045    83 S 83
FH_FOXI1 cd20053
Forkhead (FH) domain found in Forkhead box protein I1 (FOXI1) and similar proteins; FOXI1 is ...
 258-353 6.91e-32

Forkhead (FH) domain found in Forkhead box protein I1 (FOXI1) and similar proteins; FOXI1 is also called Forkhead-related protein FKHL10, Forkhead-related transcription factor 6 (FREAC-6), Hepatocyte nuclear factor 3 Forkhead homolog 3 (HFH-3), or HNF-3/fork-head homolog 3. It is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney, and epididymis, and is required for the development of normal hearing, sense of balance, and kidney function. Its epididymal expression is required for male fertility. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410827  Cd Length: 100  Bit Score: 119.05  E-value: 6.91e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:cd20053     4 RPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPN 83

                          90
                  ....*....|....*.
gi 2462554933 338 SESKLIEQAFRKRRPR 353
Cdd:cd20053    84 CEKMFDNGNFRRKRKR 99
FH_FOXD4-like cd20048
Forkhead (FH) domain found in Forkhead box protein D4 (FOXD4) and similar proteins; FOXD4, ...
 258-353 9.59e-32

Forkhead (FH) domain found in Forkhead box protein D4 (FOXD4) and similar proteins; FOXD4, also called Forkhead-related protein FKHL9, Forkhead-related transcription factor 5 (FREAC-5), or myeloid factor-alpha, is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410822  Cd Length: 96  Bit Score: 118.45  E-value: 9.59e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:cd20048     1 KPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLSLNDCFVKIPREPGHPGKGNYWSLDPA 80

                          90
                  ....*....|....*.
gi 2462554933 338 SESKLIEQAFRKRRPR 353
Cdd:cd20048    81 SQDMFDNGSFLRRRKR 96
FH_FOXJ2 cd20051
Forkhead (FH) domain found in Forkhead box protein J2 (FOXJ2) and similar proteins; FOXJ2, ...
 258-335 1.04e-31

Forkhead (FH) domain found in Forkhead box protein J2 (FOXJ2) and similar proteins; FOXJ2, also called Fork head homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. It is specifically expressed in meiotic spermatocytes in adult mouse testes and appears to promote meiotic progression during spermatogenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410825 [Multi-domain]  Cd Length: 82  Bit Score: 117.79  E-value: 1.04e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 335
Cdd:cd20051     2 KPPYSYATLITYAINSSPAKKMTLSEIYRWICDNFPYYRNAGVGWKNSIRHNLSLNKCFRKVPRPRDDPGKGSYWMID 79
FH_FOXS1 cd20037
Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1); FOXS1, also called ...
 257-353 1.29e-31

Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1); FOXS1, also called Forkhead-like 18 protein or Forkhead-related transcription factor 10 (FREAC-10), is a transcriptional repressor that suppresses transcription from the FASLG, FOXO3, and FOXO4 promoters. It may have a role in the organization of the testicular vasculature. It has also been implicated in energy turnover, motor function, and body weight. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410811  Cd Length: 100  Bit Score: 118.19  E-value: 1.29e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 257 SKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDP 336
Cdd:cd20037     1 TKPPYSYIALIAMAIQSSPGQRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDP 80

                          90
                  ....*....|....*..
gi 2462554933 337 ASESKLIEQAFRKRRPR 353
Cdd:cd20037    81 DCHDMFEHGSFLRRRRR 97
FH_FOXD3 cd20047
Forkhead (FH) domain found in Forkhead box protein D3 (FOXD3) and similar proteins; FOXD3, ...
 258-353 2.73e-30

Forkhead (FH) domain found in Forkhead box protein D3 (FOXD3) and similar proteins; FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410821  Cd Length: 97  Bit Score: 114.43  E-value: 2.73e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:cd20047     2 KPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQ 81

                          90
                  ....*....|....*.
gi 2462554933 338 SESKLIEQAFRKRRPR 353
Cdd:cd20047    82 SEDMFDNGSFLRRRKR 97
FH_FOXF1 cd20049
Forkhead (FH) domain found in Forkhead box protein F1 (FOXF1) and similar proteins; FOXF1, ...
 259-354 2.98e-30

Forkhead (FH) domain found in Forkhead box protein F1 (FOXF1) and similar proteins; FOXF1, also called Forkhead-related activator 1 (FREAC-1), Forkhead-related protein FKHL5, or Forkhead-related transcription factor 1, is a probable transcription activator for a number of lung-specific genes. FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins (ACD/MPV) suggest its involvement in ACD/MPV and lung organogenesis. The role of FOXF1 in cancer is conflicting; its loss in some cancers suggests a tumor suppressive function, but its abundance in others is associated with protumorigenic and metastatic traits. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410823  Cd Length: 99  Bit Score: 114.39  E-value: 2.98e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 259 PPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPAS 338
Cdd:cd20049     1 PPYSYIALIVMAIQSSPTKRLTLSEIYQFLQSRFPFFRGSYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPAS 80

                          90
                  ....*....|....*.
gi 2462554933 339 ESKLIEQAFRkRRPRG 354
Cdd:cd20049    81 EFMFEEGSFR-RRPRG 95
FH_FOXF cd20020
Forkhead (FH) domain found in the Forkhead box protein F (FOXF) subfamily; The FOXF subfamily ...
 259-336 2.68e-29

Forkhead (FH) domain found in the Forkhead box protein F (FOXF) subfamily; The FOXF subfamily includes two winged helix transcription factors, FOXF1 and FOXF2, both of which are probable transcription activators for a number of lung-specific genes. FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins (ACD/MPV) suggest its involvement in ACD/MPV and lung organogenesis. FOXF2 is involved in programming organogenesis and regulating epithelial-to-mesenchymal transition (EMT) and cell proliferation. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410794  Cd Length: 78  Bit Score: 110.67  E-value: 2.68e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462554933 259 PPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDP 336
Cdd:cd20020     1 PPYSYIALIVMAIQASPTKRLTLSEIYQFLQQRFPFFRGPYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDP 78
FH_FOXF2 cd20050
Forkhead (FH) domain found in Forkhead box protein F2 (FOXF2) and similar proteins; FOXF2, ...
 259-350 3.83e-29

Forkhead (FH) domain found in Forkhead box protein F2 (FOXF2) and similar proteins; FOXF2, also called Forkhead-related activator 2 (FREAC-2), Forkhead-related protein FKHL6, or Forkhead-related transcription factor 2, is a probable transcription activator for a number of lung-specific genes. It is involved in programming organogenesis and regulating epithelial-to-mesenchymal transition (EMT) and cell proliferation. FOXF2 dysregulation is critical for tumorigenesis of various tissue types. Its expression correlates with good prognosis in patients with early non-invasive stages of breast cancer, but with poor prognosis in advanced breast cancer. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410824  Cd Length: 93  Bit Score: 110.94  E-value: 3.83e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 259 PPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPAS 338
Cdd:cd20050     1 PPYSYIALIVMAIQSSPSKKLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPAS 80

                          90
                  ....*....|..
gi 2462554933 339 ESKLIEQAFRKR 350
Cdd:cd20050    81 EFMFEEGSFRRR 92
FH_FOXB cd20016
Forkhead (FH) domain found in the Forkhead box protein B (FOXB) subfamily; The FOXB subfamily ...
 258-336 8.17e-29

Forkhead (FH) domain found in the Forkhead box protein B (FOXB) subfamily; The FOXB subfamily includes two winged helix transcription factors, FOXB1 (also called transcription factor FKH-5) and FOXB2 (also called transcription factor FKH-4). FOXB1 controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. FOXB2 may act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410790 [Multi-domain]  Cd Length: 79  Bit Score: 109.52  E-value: 8.17e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDP 336
Cdd:cd20016     1 KPPYSYISLTAMAIQSSPEKMLPLSDIYKFIMDRFPYYRKNTQRWQNSLRHNLSFNDCFIKIPRRPDRPGKGSYWALHP 79
FH_FOXA cd20015
Forkhead (FH) domain found in the Forkhead box protein A (FOXA) subfamily; The FOXA subfamily ...
 258-353 1.28e-28

Forkhead (FH) domain found in the Forkhead box protein A (FOXA) subfamily; The FOXA subfamily includes three winged helix transcription factors, FOXA1 (also called hepatocyte nuclear factor 3-alpha or transcription factor 3A), FOXA2 (also called hepatocyte nuclear factor 3-beta or transcription factor 3B), and FOXA3 (also called hepatocyte nuclear factor 3-gamma or transcription factor 3G). FOXA1 is essential for epithelial lineage differentiation and has been found to be upregulated in numerous cancers. FOXA2 controls cell differentiation. It is a key transcriptional regulator that maintains airway mucus homeostasis and may also have an important role in bone metabolism. FOXA3 acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. This subfamily also includes Xenopus tropicalis FOXA4, Drosophila melanogaster protein fork head (dFKH), and similar proteins. FOXA4 is only present in amphibians, where it is required for the correct regionalization and maintenance of the central nervous system. dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410789 [Multi-domain]  Cd Length: 97  Bit Score: 109.64  E-value: 1.28e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:cd20015     1 KPPYSYISLITMAIQQSPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVPRSPDKPGKGSYWTLHPD 80

                          90
                  ....*....|....*.
gi 2462554933 338 SESKLIEQAFRKRRPR 353
Cdd:cd20015    81 SGNMFENGCYLRRQKR 96
FH_FOXN2-like cd20031
Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2) and similar proteins; The ...
 258-334 3.82e-28

Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2) and similar proteins; The FOXN2-like group includes two FOXN subfamily winged helix transcription factors, FOXN2 and FOXN3. FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN3, also called checkpoint suppressor 1, acts as a transcriptional repressor that may be involved in DNA damage-inducible cell cycle arrests (checkpoints). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410805 [Multi-domain]  Cd Length: 76  Bit Score: 107.44  E-value: 3.82e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEpGKGSFWRI 334
Cdd:cd20031     1 KPPYSFSCLIFMAIESSPEKALPVKDIYSWIEKHFPYYRNAPSGWKNSIRHNLSLNKCFKKVEKEKNK-GKGSLWCV 76
FH_dFKH cd20041
Forkhead (FH) domain found in Drosophila melanogaster protein fork head (dFKH) and similar ...
 258-353 8.90e-28

Forkhead (FH) domain found in Drosophila melanogaster protein fork head (dFKH) and similar proteins; dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410815 [Multi-domain]  Cd Length: 98  Bit Score: 107.36  E-value: 8.90e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:cd20041     1 KPPYSYISLITMAIQNSPNKMVTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKVPRTPDKPGKGSFWTLHPD 80

                          90
                  ....*....|....*.
gi 2462554933 338 SESKLIEQAFRKRRPR 353
Cdd:cd20041    81 SGNMFENGCYLRRQKR 96
FH_FOXD1_D2-like cd20046
Forkhead (FH) domain found in Forkhead box proteins FOXD1, FOXD2 and similar proteins; FOXD1, ...
 258-353 1.68e-27

Forkhead (FH) domain found in Forkhead box proteins FOXD1, FOXD2 and similar proteins; FOXD1, also called Forkhead-related protein FKHL8, or Forkhead-related transcription factor 4 (FREAC-4), is involved in transcriptional activation of Placental Growth Factor (PGF) and the complement component (C3) genes. It plays an important role in early embryonic development and organogenesis, and functions as an oncogene in several cancers. FOXD2, also called Forkhead-related protein FKHL17, or Forkhead-related transcription factor 9 (FREAC-9), is a probable transcription factor involved in embryogenesis and somatogenesis. It has been found that long noncoding RNA FOXD2 adjacent opposite strand RNA1 (lncRNA FOXD2-AS1) expression is upregulated in various human malignancies, including gastric, lung, bladder, colorectal, nasopharyngeal, esophageal, hepatocellular, thyroid and skin cancer. It is a promising candidate as a new biomarker and therapeutic target for cancer diagnosis/prognostication due to high tissue specificity and elevated efficiency. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410820  Cd Length: 99  Bit Score: 106.32  E-value: 1.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:cd20046     1 KPPYSYIALITMAILQSPKKRLTLSEICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPE 80

                          90
                  ....*....|....*.
gi 2462554933 338 SESKLIEQAFRKRRPR 353
Cdd:cd20046    81 SADMFDNGSFLRRRKR 96
FH_FOXA2 cd20039
Forkhead (FH) domain found in Forkhead box protein A2 (FOXA2) and similar proteins; FOXA2, ...
 257-353 5.24e-27

Forkhead (FH) domain found in Forkhead box protein A2 (FOXA2) and similar proteins; FOXA2, also called hepatocyte nuclear factor 3-beta (HNF-3-beta or HNF-3B) or transcription factor 3B (TCF-3B), acts as a core transcription factor that controls cell differentiation. It is a key transcriptional regulator that maintains airway mucus homeostasis. It may also have an important role in bone metabolism. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410813 [Multi-domain]  Cd Length: 104  Bit Score: 105.19  E-value: 5.24e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 257 SKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDP 336
Cdd:cd20039     4 AKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHP 83

                          90
                  ....*....|....*..
gi 2462554933 337 ASESKLIEQAFRKRRPR 353
Cdd:cd20039    84 DSGNMFENGCYLRRQKR 100
FH_FOXA3 cd20040
Forkhead (FH) domain found in Forkhead box protein A3 (FOXA3) and similar proteins; FOXA3, ...
 257-353 1.06e-26

Forkhead (FH) domain found in Forkhead box protein A3 (FOXA3) and similar proteins; FOXA3, also called hepatocyte nuclear factor 3-gamma (HNF-3-gamma or HNF-3G), fork head-related protein FKH H3, or transcription factor 3G (TCF-3G), acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410814 [Multi-domain]  Cd Length: 102  Bit Score: 104.42  E-value: 1.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 257 SKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDP 336
Cdd:cd20040     2 AKPPYSYISLITMAIQQAPSKMLTLNEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHP 81

                          90
                  ....*....|....*..
gi 2462554933 337 ASESKLIEQAFRKRRPR 353
Cdd:cd20040    82 NSGNMFENGCYLRRQKR 98
FH_FOXD cd20018
Forkhead (FH) domain found in the Forkhead box protein D (FOXD) subfamily; The FOXD subfamily ...
 258-335 1.50e-26

Forkhead (FH) domain found in the Forkhead box protein D (FOXD) subfamily; The FOXD subfamily includes four winged helix transcription factors, FOXD1-4. FOXD1, also called Forkhead-related protein FKHL8 or Forkhead-related transcription factor 4 (FREAC-4), is involved in transcriptional activation of Placental Growth Factor (PGF) and the complement component (C3) genes. It plays an important role in early embryonic development and organogenesis, and functions as an oncogene in several cancers. FOXD2, also called Forkhead-related protein FKHL17 or Forkhead-related transcription factor 9 (FREAC-9), is a probable transcription factor involved in embryogenesis and somatogenesis. FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. FOXD4, also called Forkhead-related protein FKHL9 or Forkhead-related transcription factor 5 (FREAC-5), is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410792 [Multi-domain]  Cd Length: 78  Bit Score: 103.03  E-value: 1.50e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 335
Cdd:cd20018     1 KPPYSYIALITMAILQSPQKKLTLSGICEFIMNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLD 78
FH_FOXO cd20032
Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily; The FOXO subfamily ...
 262-335 4.18e-26

Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily; The FOXO subfamily includes several winged helix transcription factors: FOXO1, FOXO3, FOXO4 and FOXO6. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members. FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis, and prognosis. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410806 [Multi-domain]  Cd Length: 80  Bit Score: 101.99  E-value: 4.18e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462554933 262 SYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRT-----ADKGWQNSIRHNLSLNRYFIKVPrsQEEPGKGSFWRID 335
Cdd:cd20032     4 SYADLITKAIESSPDKRLTLQQIYDWMVRNVPYFKDkgdsnSSAGWKNSIRHNLSLHSRFVRVQ--NEGTGKSSWWTLN 80
FH_FOXA1 cd20038
Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, ...
 257-353 4.32e-26

Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, also called hepatocyte nuclear factor 3-alpha (HNF-3-alpha or HNF-3A) or transcription factor 3A (TCF-3A), acts as a transcription factor that is essential for epithelial lineage differentiation. It has been found to be upregulated in numerous cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410812 [Multi-domain]  Cd Length: 112  Bit Score: 102.90  E-value: 4.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 257 SKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDP 336
Cdd:cd20038    13 AKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHP 92

                          90
                  ....*....|....*..
gi 2462554933 337 ASESKLIEQAFRKRRPR 353
Cdd:cd20038    93 DSGNMFENGCYLRRQKR 109
FH_FOXB1 cd20042
Forkhead (FH) domain found in Forkhead box protein B1 (FOXB1) and similar proteins; FOXB1, ...
 256-336 6.25e-26

Forkhead (FH) domain found in Forkhead box protein B1 (FOXB1) and similar proteins; FOXB1, also called transcription factor FKH-5, is a winged helix transcription factor that controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410816 [Multi-domain]  Cd Length: 92  Bit Score: 101.75  E-value: 6.25e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 256 DSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 335
Cdd:cd20042     4 DQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKGSFWALH 83


                  .
gi 2462554933 336 P 336
Cdd:cd20042    84 P 84
FH_FOXB2 cd20043
Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins; FOXB2, ...
 250-353 6.36e-26

Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins; FOXB2, also called transcription factor FKH-4, may act as a transcription factor. It may also act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410817 [Multi-domain]  Cd Length: 110  Bit Score: 102.45  E-value: 6.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 250 GDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKG 329
Cdd:cd20043     5 GKNSYSDQKPPYSYISLTAMAIQSSQEKMLPLSDIYKFIMDRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKG 84

                          90       100
                  ....*....|....*....|....
gi 2462554933 330 SFWRIDPASESKLIEQAFRKRRPR 353
Cdd:cd20043    85 SFWALHPDCGDMFENGSFLRRRKR 108
FH_FOXM cd20029
Forkhead (FH) domain found in the Forkhead box protein M (FOXM) subfamily; The FOXM subfamily ...
 258-336 3.70e-25

Forkhead (FH) domain found in the Forkhead box protein M (FOXM) subfamily; The FOXM subfamily includes a winged helix transcription factor, FOXM1, which is also called Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 Forkhead homolog 11 (HFH-11), HNF-3/fork-head homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, transcription factor Trident, or Winged-helix factor from INS-1 cells. FOXM1 acts as a transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. It plays a role in the control of cell proliferation. It is also involved in DNA break repair, participating in the DNA damage checkpoint response. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410803 [Multi-domain]  Cd Length: 77  Bit Score: 99.04  E-value: 3.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYR-TADKGWQNSIRHNLSLNRYFIkvpRSQEEPGKGSFWRIDP 336
Cdd:cd20029     1 RPPYSYMALIQFAINSTEDKRMTLKEIYTWIEDHFPYFKhTAKPGWKNSIRHNLSLHDIFV---RETSANGKGSFWTLRP 77
FH_FOXQ1-like cd20034
Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, ...
 258-335 1.76e-24

Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, also called HNF-3/Forkhead-like protein 1 (HFH-1), or hepatocyte nuclear factor 3 Forkhead homolog 1, plays a role in hair follicle differentiation. It has also been reported to promote epithelial differentiation, inhibit smooth muscle differentiation, activate T cells and autoimmunity, and control mucin gene expression and granule content in stomach surface mucous cells. FOXQ1 is significantly associated with the pathogenesis of various tumor types including gastric, breast, colorectal, pancreatic, bladder and ovarian cancer, and glioma. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410808 [Multi-domain]  Cd Length: 79  Bit Score: 97.11  E-value: 1.76e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEP-GKGSFWRID 335
Cdd:cd20034     1 KPPYSYIALIAMAIRDSPSGRLTLAEINEYLMKKFPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDPSRPwGKDNYWTIN 79
FH_FOXP cd20033
Forkhead (FH) domain found in the Forkhead box protein P (FOXP) subfamily; The FOXP subfamily ...
 258-335 2.02e-24

Forkhead (FH) domain found in the Forkhead box protein P (FOXP) subfamily; The FOXP subfamily includes four winged helix transcription factors, FOXP1-4. They are involved in the development of the central nervous system. Mutations in FOXP1, also called Mac-1-regulated Forkhead (MFH), leads to developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. FOXP2, also called CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal and cardiovascular tissues. FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410807 [Multi-domain]  Cd Length: 73  Bit Score: 96.74  E-value: 2.02e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVprsqeEPGKGSFWRID 335
Cdd:cd20033     1 RPPFTYASLIRQAILESPNKQLTLNEIYNWFQKTFAYFRRNAATWKNAVRHNLSLHKCFVRV-----ENVKGAVWTVD 73
FH_FOXH cd20022
Forkhead (FH) domain found in the Forkhead box protein H (FOXH) subfamily; The FOXH subfamily ...
 258-335 2.15e-24

Forkhead (FH) domain found in the Forkhead box protein H (FOXH) subfamily; The FOXH subfamily includes a winged helix transcription factor, FOXH1, which is also called Forkhead activin signal transducer 1 (Fast-1), or Forkhead activin signal transducer 2 (Fast-2). FOXH1 acts as a transcriptional activator that recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. It is required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. FOXH1 forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410796 [Multi-domain]  Cd Length: 79  Bit Score: 97.05  E-value: 2.15e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEP-GKGSFWRID 335
Cdd:cd20022     1 KPPYSYLAMIALAIQNSPEKRLTLSEIIKALSTMFPFFKGEYKGWKDSVRHNLSSNDCFVKVLKDPGKPqAKGNYWTVD 79
COG5025 COG5025
Transcription factor of the Forkhead/HNF3 family [Transcription];
180-577 2.51e-24

Transcription factor of the Forkhead/HNF3 family [Transcription];


Pssm-ID: 227358 [Multi-domain]  Cd Length: 610  Bit Score: 107.59  E-value: 2.51e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 180 SPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRgagSSGYKVGRVMPSD---LNLMADNSQPENEKEASGgdspKDD 256
Cdd:COG5025   263 SSGEENISRINNSSQIDSPTPNYRMSSIDSSVNPSR---LANNKDEGRKGSKsspVPKDAAPPSTLSDLSADV----NRT 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 257 SKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDP 336
Cdd:COG5025   336 SKPAFSYANSITQAILSSPSGKMTLSEIYSWISSNLPYYRHKPTAWQNSIRHNLSLNKSFEKVPRSASQPGKGCFWKIDY 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 337 ASesklIEQAFRKRRPRgvpcfrtplgplsSRSApaspnhagVLSAHSsgAQTPESLSREgSPAPLEPEPGAAQPKLAVI 416
Cdd:COG5025   416 SY----IYEKESKRNPR-------------SPKK--------SPSAHS--VHQKLSLHVN-DLYQSPATSDIASSSSQVN 467

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 417 QEARFAQSAPGSPLSSQPVLITvQRQLPQAIKPVTYTVAtpvttstsqppvvqtvhvvhqipAVSVTSVAglapANTYTV 496
Cdd:COG5025   468 SQPEFISTQIHSSKGVSNVDLT-EQDSQKEASKGNFLDD-----------------------SGSLSPNT----NEINSF 519

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 497 SGQAVVTPAAVLAPPKAEAQENGDHREVKVKVEPIPAIGHATLGTASRIIQTAQTTPVQTvTIVQQAPLGQHQLPIKTVT 576
Cdd:COG5025   520 SLNTTDSQQKQSPSHNAPTNNSLNEMASKNSNSQTQASNSNENVAAVKAILDASAQMEKP-YDLSQAATPTKATESASVR 598


                  .
gi 2462554933 577 Q 577
Cdd:COG5025   599 Q 599
FH_FOXN3 cd20059
Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3); FOXN3, also called checkpoint ...
 258-344 2.94e-24

Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3); FOXN3, also called checkpoint suppressor 1 (CHES1), acts as a transcriptional repressor that may be involved in DNA damage-inducible cell cycle arrests (checkpoints). It displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. Alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. FOXN3 also regulates hepatic glucose utilization/metabolism by regulating gluconeogenic substrate selection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410833 [Multi-domain]  Cd Length: 90  Bit Score: 96.85  E-value: 2.94e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEP-GKGSFWRIDP 336
Cdd:cd20059     1 KPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKEKGQSiGKGSLWCIDP 80


                  ....*...
gi 2462554933 337 ASESKLIE 344
Cdd:cd20059    81 EYRPNLLQ 88
FH_FOXN2 cd20058
Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2); FOXN2, also called human T-cell ...
 257-336 1.68e-23

Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2); FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN2 has also been found to be down-regulated in breast cancer, where it regulates migration, invasion, and epithelial-mesenchymal transition. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410832 [Multi-domain]  Cd Length: 82  Bit Score: 94.71  E-value: 1.68e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 257 SKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQ-EEPGKGSFWRID 335
Cdd:cd20058     1 SKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILEHFPYFSTAPTGWKNSVRHNLSLNKCFRKVERSHgKVNGKGSLWCVD 80


                  .
gi 2462554933 336 P 336
Cdd:cd20058    81 P 81
FH_FOXP1 cd20064
Forkhead (FH) domain found in Forkhead box protein P1 (FOXP1); FOXP1, also called ...
 258-353 4.16e-23

Forkhead (FH) domain found in Forkhead box protein P1 (FOXP1); FOXP1, also called Mac-1-regulated Forkhead (MFH), is a transcription factor that is widely expressed and has a broad range of functions. It has been shown to have a role in cardiac, lung, and lymphocyte development. Deregulation of FOXP1 is an important contributor to the pathogenesis of diffuse large B-cell lymphoma (DLBCL), suggesting it may function as an oncogene. Loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting that FOXP1 may function as a tumor suppressor in some tissues. Haploinsufficiency of the FOXP1 gene leads to a neurodevelopmental disorder termed FOXP1 syndrome, characterized by developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410838 [Multi-domain]  Cd Length: 87  Bit Score: 93.65  E-value: 4.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVprsqeEPGKGSFWRIDpa 337
Cdd:cd20064     4 RPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRV-----ENVKGAVWTVD-- 76

                          90
                  ....*....|....*.
gi 2462554933 338 seskliEQAFRKRRPR 353
Cdd:cd20064    77 ------EIEFQKRRPQ 86
FH_FOXP2 cd20065
Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2); FOXP2, also called CAG repeat ...
 258-351 1.12e-22

Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2); FOXP2, also called CAG repeat protein 44, or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal, and cardiovascular tissues. An arginine-to-histidine missense mutation (R553H) in the FOXP2 Forkhead domain has been linked to a severe speech and language disorder. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410839 [Multi-domain]  Cd Length: 82  Bit Score: 92.06  E-value: 1.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVprsqeEPGKGSFWRIDpa 337
Cdd:cd20065     2 RPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRV-----ENVKGAVWTVD-- 74

                          90
                  ....*....|....
gi 2462554933 338 seskliEQAFRKRR 351
Cdd:cd20065    75 ------EVEYQKRR 82
FH_FOXN1-like cd20030
Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1) and similar proteins; The ...
 258-336 2.52e-22

Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1) and similar proteins; The FOXN1-like group includes two FOXN subfamily winged helix transcription factors, FOXN1 and FOXN4. FOXN1, also called winged helix transcription factor nude, acts as a transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs), both in the prenatal and postnatal thymus. FOXN4 acts as a transcription factor essential for neural and some non-neural tissue development, such as retina and lung, respectively. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410804 [Multi-domain]  Cd Length: 81  Bit Score: 90.96  E-value: 2.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKV--PRSQEEPGKGSFWRID 335
Cdd:cd20030     1 KPAYSYSCLIAMALKNSRTGCLPVSEIYSFMCENFPYFKTAPDGWKNSVRHNLSLNKCFEKIerPDGNGSSRKGCLWALN 80


                  .
gi 2462554933 336 P 336
Cdd:cd20030    81 P 81
FH_FOXP4 cd20067
Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins; FOXP4, ...
 258-352 1.09e-20

Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins; FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is not required for T cell development, but is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410841 [Multi-domain]  Cd Length: 87  Bit Score: 86.71  E-value: 1.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVprsqeEPGKGSFWRIDpa 337
Cdd:cd20067     1 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRV-----ENVKGAVWTVD-- 73

                          90
                  ....*....|....*
gi 2462554933 338 seskliEQAFRKRRP 352
Cdd:cd20067    74 ------ELEYQKRRP 82
FH_FOXO4 cd20062
Forkhead (FH) domain found in Forkhead box protein O4 (FOXO4) and similar proteins; FOXO4, ...
 262-336 1.19e-20

Forkhead (FH) domain found in Forkhead box protein O4 (FOXO4) and similar proteins; FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.


Pssm-ID: 410836 [Multi-domain]  Cd Length: 86  Bit Score: 86.68  E-value: 1.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 262 SYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYR-----TADKGWQNSIRHNLSLNRYFIKVprSQEEPGKGSFWRIDP 336
Cdd:cd20062     8 SYAELISQAIESSPEKRLTLAQIYEWMVKSVPYFKdkgdsNSSAGWKNSIRHNLSLHSKFIKV--HNEATGKSSWWMLNP 85
FH_FOXP3 cd20066
Forkhead (FH) domain found in Forkhead box protein P3 (FOXP3) and similar proteins; FOXP3, ...
 258-351 3.31e-20

Forkhead (FH) domain found in Forkhead box protein P3 (FOXP3) and similar proteins; FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg), which are required for maintaining self-tolerance. It may also have intrinsic regulatory function in conventional T (Tconv) cells. A deletion of the Forkhead domain arising from a frame-shift mutation in mouse FOXP3 is linked to the autoimmune disorder scurfy, and a similar congenital disease in humans is known as IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410840 [Multi-domain]  Cd Length: 81  Bit Score: 85.01  E-value: 3.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVprsqeEPGKGSFWRIDpa 337
Cdd:cd20066     1 RPPFTYASLIRWAILESPEKQLTLNEIYHWFTRMFAFFRNNTATWKNAVRHNLSLHKCFVRV-----ENEKGAVWTVD-- 73

                          90
                  ....*....|....
gi 2462554933 338 seskliEQAFRKRR 351
Cdd:cd20066    74 ------ELEFQRRR 81
FH_FOXO3 cd20061
Forkhead (FH) domain found in Forkhead box protein O3 (FOXO3); FOXO3, also called AF6q21 ...
 262-336 1.02e-18

Forkhead (FH) domain found in Forkhead box protein O3 (FOXO3); FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.


Pssm-ID: 410835 [Multi-domain]  Cd Length: 83  Bit Score: 80.87  E-value: 1.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 262 SYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYR-----TADKGWQNSIRHNLSLNRYFIKVprSQEEPGKGSFWRIDP 336
Cdd:cd20061     5 SYADLITRAIESSPDKRLTLSQIYDWMVRCVPYFKdkgdsNSSAGWKNSIRHNLSLHSRFIRV--QNEGTGKSSWWMINP 82
FH_FOXN1 cd20056
Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1); FOXN1, also called winged helix ...
 258-351 2.24e-18

Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1); FOXN1, also called winged helix transcription factor nude, acts as a transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs), both in the prenatal and postnatal thymus. It is also an important factor in controlling the skin wound healing process, as it actively participates in re-epithelialization and is responsible for scar formation. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410830 [Multi-domain]  Cd Length: 97  Bit Score: 80.53  E-value: 2.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVP-RSQEEPGKGSFWRIDP 336
Cdd:cd20056     2 KPIYSYSILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVEnKSGSSSRKGCLWALNP 81

                          90
                  ....*....|....*
gi 2462554933 337 ASESKLIEQAFRKRR 351
Cdd:cd20056    82 AKIDKMQEELQKWKR 96
FH_FOXR cd20036
Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily; The FOXR subfamily ...
 258-336 5.63e-18

Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily; The FOXR subfamily includes two winged helix transcription factors, FOXR1-2. FOXR1, also called Forkhead box protein N5 (FOXN5), is required for proper cell division and survival possibly via the p21 and mTOR pathways. FOXR2, also called Forkhead box protein N6 (FOXN6), is an important player in a wide range of cellular processes such as proliferation, migration, differentiation, and apoptosis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410810 [Multi-domain]  Cd Length: 87  Bit Score: 78.89  E-value: 5.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPG--KGSFWRID 335
Cdd:cd20036     3 KPPLSYPNLIALALRNSETGSLNVQEIYDFIRFHFPFFRTAPDGWKNSVRHNLSFSDSFEKVPTSVSGYGgrRSCLWKLT 82


                  .
gi 2462554933 336 P 336
Cdd:cd20036    83 P 83
FH_FOXO6 cd20063
Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins; FOXO6 acts ...
 262-336 1.11e-17

Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins; FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis and prognosis. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.


Pssm-ID: 410837 [Multi-domain]  Cd Length: 88  Bit Score: 78.17  E-value: 1.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 262 SYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYR-----TADKGWQNSIRHNLSLNRYFIKVprSQEEPGKGSFWRIDP 336
Cdd:cd20063     4 SYADLITKAIESSPDKRLTLSQIYDWMVRYVPYFKdkgdsNSSAGWKNSIRHNLSLHTRFIRV--QNEGTGKSSWWMLNP 81
FHA_FKH1-like cd22701
forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 ...
 36-138 1.57e-17

forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 (FKH1), 2 (FKH2) and similar proteins; This family includes FKH1 and FKH2, as well as pre-rRNA-processing protein FHL1. FKH1 and FKH2 are forkhead transcription factors that regulate the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle. The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20, as well as SWI5 and ACE2. FKH1 and FKH2 are involved in HMRa silencing. They associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing. Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation. They also function in controlling yeast cell morphology by preventing pseudohyphal growth and act as rate-limiting replication origin activators via their interaction with the origin recognition complex (ORC). FHL1 is a forkhead protein that controls the pre-rRNA processing machinery in conjunction with IFH1. It might act as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator. This family also includes AtFHA1 and AtFHA2, which may play a role in the control of plant organ development. AtFHA2 is specifically involved in the regulation of stamen development. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438753 [Multi-domain]  Cd Length: 106  Bit Score: 78.44  E-value: 1.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  36 AVARLEGREFEYLMKKRSVTIGRNSS------QGSVDVSMGHSSFISRRHLEIFTppgggghggaapelppaqprpDAG- 108
Cdd:cd22701     1 AYAKLDGDDFTYYVQKLEVVLGRNSKnssstaADSVDIDLGPSKKISRRHARIFY---------------------DFTt 59

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462554933 109 GDFYLRCLGKNGVFVDGVFQRRGAPPLQLP 138
Cdd:cd22701    60 QCFELSVLGRNGVKVDGILVKPGSPPVPLR 89
FH_FOXN4 cd20057
Forkhead (FH) domain found in Forkhead box protein N4 (FOXN4); FOXN4 acts as a transcription ...
 253-351 6.62e-17

Forkhead (FH) domain found in Forkhead box protein N4 (FOXN4); FOXN4 acts as a transcription factor essential for neural and some non-neural tissue development, such as retina and lung, respectively. During development of the central nervous system, FOXN4 is required in specifying the amacrine and horizontal cell fates from multipotent retinal progenitors, while suppressing alternative photoreceptor cell fates. In non-neural tissues, it plays an essential role in specifying the atrioventricular canal and is indirectly required for patterning the distal airway during lung development. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410831 [Multi-domain]  Cd Length: 106  Bit Score: 76.67  E-value: 6.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 253 PKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVP-RSQEEPGKGSF 331
Cdd:cd20057     1 PKHYPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVEnKMSGSSRKGCL 80

                          90       100
                  ....*....|....*....|
gi 2462554933 332 WRIDPASESKLIEQAFRKRR 351
Cdd:cd20057    81 WALNPAKIDKMEEEMQKWKR 100
FH_FOXO1 cd20060
Forkhead (FH) domain found in Forkhead box protein O1 (FOXO1); FOXO1, also called Forkhead box ...
 262-336 1.30e-16

Forkhead (FH) domain found in Forkhead box protein O1 (FOXO1); FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. It binds to the insulin response element (IRE) with the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with the consensus sequence 5'-TT[G/A]TTTAC-3'. The FH domain is a winged helix DNA-binding domain.


Pssm-ID: 410834 [Multi-domain]  Cd Length: 99  Bit Score: 75.65  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 262 SYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYR-----TADKGWQNSIRHNLSLNRYFIKVprSQEEPGKGSFWRIDP 336
Cdd:cd20060    14 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdsNSSAGWKNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLNP 91
COG5025 COG5025
Transcription factor of the Forkhead/HNF3 family [Transcription];
258-342 1.74e-16

Transcription factor of the Forkhead/HNF3 family [Transcription];


Pssm-ID: 227358 [Multi-domain]  Cd Length: 610  Bit Score: 82.94  E-value: 1.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933 258 KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPA 337
Cdd:COG5025    86 VPPYSYATGRGLAILNSPDKPLTLSKIYTWIHNTFFYYAKVVSRWQNSIRHNLSLNDAFIKIEGRNGAKVKGHFWSIGPG 165


                  ....*
gi 2462554933 338 SESKL 342
Cdd:COG5025   166 HETQF 170
FHA_MCRS1 cd22687
forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; ...
 36-145 5.20e-11

forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; MCRS1, also called 58 kDa microspherule protein (MSP58), cell cycle-regulated factor p78, or INO80 complex subunit J, is a nuclear RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal ribonucleoparticles (mRNPs) from neurons. It is a cell-cycle-dependent protein that acts as an inhibitor of TERT telomerase activity. It associates with LPTS/PinX1 and reduces the telomere length. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex, MCRS1 may be involved in acetylation of nucleosomal histone H4 on several lysine residues. MCRS1 is also a putative regulatory component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication, and probably DNA repair. MCRS1 contains an FHA domain at its C-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438739 [Multi-domain]  Cd Length: 105  Bit Score: 59.87  E-value: 5.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  36 AVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSM---GHSSFISRRHLEIftppgggghggaapelppaQPRPDagGDFY 112
Cdd:cd22687     5 ALAVLRGRLVRYLMRSREVTIGRSTKDNQVDIDLsleGPAWKISRRQAVI-------------------KLKND--GDFY 63

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462554933 113 LRCLGKNGVFVDGV----FQRRGAPPLQLPRVCTFRF 145
Cdd:cd22687    64 IKNEGKRPIYVNGKpvptGEKAILNNNSLIEIGGLRF 100
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 54-128 8.52e-07

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 46.02  E-value: 8.52e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462554933   54 VTIGRNSSQGSVDVSmghSSFISRRHLEIftppgggghggaapelppaqpRPDAGGDFYLRCLG-KNGVFVDGVFQ 128
Cdd:smart00240   1 VTIGRSSEDCDIQLD---GPSISRRHAVI---------------------VYDGGGRFYLIDLGsTNGTFVNGKRI 52
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 54-138 3.94e-06

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 44.49  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  54 VTIGRNSSQgsvDVSMGHSSfISRRHLEIftppgggghggaapelppaqpRPDAGGDFYLRCLG-KNGVFVDGvfQRRGA 132
Cdd:pfam00498   1 VTIGRSPDC---DIVLDDPS-VSRRHAEI---------------------RYDGGGRFYLEDLGsTNGTFVNG--QRLGP 53


                  ....*.
gi 2462554933 133 PPLQLP 138
Cdd:pfam00498  54 EPVRLK 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 350-511 7.60e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 7.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  350 RRPRGVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPA----PLEPEP-----GAAQPKLAVIQEAR 420
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPttagPPAPAPpaapaAGPPRRLTRPAVAS 2790

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  421 FAQSAPGSPLSSQPVLITVQRQLPQAIKPVTYTVATPVTTSTSQPPVVQTVHVVHQIPAVSVT-SVAGLAPANTYTVSGQ 499
Cdd:PHA03247  2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgSVAPGGDVRRRPPSRS 2870

                          170
                   ....*....|..
gi 2462554933  500 AVVTPAAVLAPP 511
Cdd:PHA03247  2871 PAAKPAAPARPP 2882
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 41-152 1.71e-05

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 43.42  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  41 EGREFEYLMKKRSVTIGRNSSQgsvDVSMGHSSfISRRHLEIFTPpgggghggaapelppaqprpdaGGDFYLRCLG-KN 119
Cdd:cd00060     8 DGGGREFPLTKGVVTIGRSPDC---DIVLDDPS-VSRRHARIEVD----------------------GGGVYLEDLGsTN 61

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462554933 120 GVFVDGvfqRRGAPPLQLPRVCTFRFPSTNIKI 152
Cdd:cd00060    62 GTFVNG---KRITPPVPLQDGDVIRLGDTTFRF 91
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
46-126 6.55e-04

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 39.17  E-value: 6.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554933  46 EYLMKKRSVTIGRNSSqgsVDVSMGHSSfISRRHLEIFTPpgggghggaapelppaqprpdaGGDFYLRCLG-KNGVFVD 124
Cdd:COG1716    15 RFPLDGGPLTIGRAPD---NDIVLDDPT-VSRRHARIRRD----------------------GGGWVLEDLGsTNGTFVN 68


                  ..
gi 2462554933 125 GV 126
Cdd:COG1716    69 GQ 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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