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Conserved domains on  [gi|2217396515|ref|XP_047298592|]
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mediator of RNA polymerase II transcription subunit 14 isoform X1 [Homo sapiens]

Protein Classification

mediator of RNA polymerase II transcription subunit 14( domain architecture ID 10554477)

mediator of RNA polymerase II transcription subunit 14 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Gene Ontology:  GO:0003712|GO:0016592
PubMed:  29209056

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med14 pfam08638
Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects ...
 104-272 2.08e-65

Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.


:

Pssm-ID: 462543  Cd Length: 192  Bit Score: 219.68  E-value: 2.08e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515  104 VNILP--RKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDaLVHA 181
Cdd:pfam08638   23 IETLPntSESDVEKKRRLLDFAQRTRQQFIKLLVLVKWSRKAEDVSKLIDLLAFLRQQNMAFEDAADALKNMKRS-LVNA 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515  182 RLPSFAIPYAIDVLTTGSYPRLPTCIRDkIIPPDPITKIEKQATLHQLNQILRHRLVTTD-LPPQLANLTVANGRVKFRV 260
Cdd:pfam08638  102 RLPNPDLPTALEVLSTGRYPRLPTLIYD-IIPPPPLTPKEILKTLRDLNTLLSIRLNLHEkIPPQFRNYTIADGRVTFTV 180

                          170
                   ....*....|..
gi 2217396515  261 EGEFEATLTVMG 272
Cdd:pfam08638  181 PGEFEVDLTIAG 192
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1049-1223 1.13e-10

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 66.48  E-value: 1.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1049 TSGAYPLT-SPPTSYHSTVNQSPSMmhtqspgnlhaaSSPSGALRAPSPASFVPTPPPSShgisigPGASFASPhgTLDP 1127
Cdd:pfam05109  482 TSGASPVTpSPSPRDNGTESKAPDM------------TSPTSAVTTPTPNATSPTPAVTT------PTPNATSP--TLGK 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1128 SSPYTMVSPSGRAGNWPgSPQVSGPSPAARMPGMSPANPS--LHSPVPDASH------SPRAGTSSQTM-PTNMPPPRKL 1198
Cdd:pfam05109  542 TSPTSAVTTPTPNATSP-TPAVTTPTPNATIPTLGKTSPTsaVTTPTPNATSptvgetSPQANTTNHTLgGTSSTPVVTS 620

                          170       180
                   ....*....|....*....|....*....
gi 2217396515 1199 PQRSWAASIPT----ILTHSALNILLLPS 1223
Cdd:pfam05109  621 PPKNATSAVTTgqhnITSSSTSSMSLRPS 649
 
Name Accession Description Interval E-value
Med14 pfam08638
Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects ...
 104-272 2.08e-65

Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.


Pssm-ID: 462543  Cd Length: 192  Bit Score: 219.68  E-value: 2.08e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515  104 VNILP--RKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDaLVHA 181
Cdd:pfam08638   23 IETLPntSESDVEKKRRLLDFAQRTRQQFIKLLVLVKWSRKAEDVSKLIDLLAFLRQQNMAFEDAADALKNMKRS-LVNA 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515  182 RLPSFAIPYAIDVLTTGSYPRLPTCIRDkIIPPDPITKIEKQATLHQLNQILRHRLVTTD-LPPQLANLTVANGRVKFRV 260
Cdd:pfam08638  102 RLPNPDLPTALEVLSTGRYPRLPTLIYD-IIPPPPLTPKEILKTLRDLNTLLSIRLNLHEkIPPQFRNYTIADGRVTFTV 180

                          170
                   ....*....|..
gi 2217396515  261 EGEFEATLTVMG 272
Cdd:pfam08638  181 PGEFEVDLTIAG 192
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1049-1223 1.13e-10

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 66.48  E-value: 1.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1049 TSGAYPLT-SPPTSYHSTVNQSPSMmhtqspgnlhaaSSPSGALRAPSPASFVPTPPPSShgisigPGASFASPhgTLDP 1127
Cdd:pfam05109  482 TSGASPVTpSPSPRDNGTESKAPDM------------TSPTSAVTTPTPNATSPTPAVTT------PTPNATSP--TLGK 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1128 SSPYTMVSPSGRAGNWPgSPQVSGPSPAARMPGMSPANPS--LHSPVPDASH------SPRAGTSSQTM-PTNMPPPRKL 1198
Cdd:pfam05109  542 TSPTSAVTTPTPNATSP-TPAVTTPTPNATIPTLGKTSPTsaVTTPTPNATSptvgetSPQANTTNHTLgGTSSTPVVTS 620

                          170       180
                   ....*....|....*....|....*....
gi 2217396515 1199 PQRSWAASIPT----ILTHSALNILLLPS 1223
Cdd:pfam05109  621 PPKNATSAVTTgqhnITSSSTSSMSLRPS 649
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1006-1230 2.88e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.56  E-value: 2.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1006 DARRRSVNEDDNP-PSPIGGDMM-DSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHA 1083
Cdd:PHA03307   206 PPRRSSPISASASsPAPAPGRSAaDDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPA 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1084 ASSPSGALRAPSPASFVP----TPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQvSGPSPAArmP 1159
Cdd:PHA03307   286 SSSSSPRERSPSPSPSSPgsgpAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS-RPPPPAD--P 362

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217396515 1160 GMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPP--PRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVP 1230
Cdd:PHA03307   363 SSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRarRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTP 435
 
Name Accession Description Interval E-value
Med14 pfam08638
Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects ...
 104-272 2.08e-65

Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.


Pssm-ID: 462543  Cd Length: 192  Bit Score: 219.68  E-value: 2.08e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515  104 VNILP--RKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDaLVHA 181
Cdd:pfam08638   23 IETLPntSESDVEKKRRLLDFAQRTRQQFIKLLVLVKWSRKAEDVSKLIDLLAFLRQQNMAFEDAADALKNMKRS-LVNA 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515  182 RLPSFAIPYAIDVLTTGSYPRLPTCIRDkIIPPDPITKIEKQATLHQLNQILRHRLVTTD-LPPQLANLTVANGRVKFRV 260
Cdd:pfam08638  102 RLPNPDLPTALEVLSTGRYPRLPTLIYD-IIPPPPLTPKEILKTLRDLNTLLSIRLNLHEkIPPQFRNYTIADGRVTFTV 180

                          170
                   ....*....|..
gi 2217396515  261 EGEFEATLTVMG 272
Cdd:pfam08638  181 PGEFEVDLTIAG 192
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1049-1223 1.13e-10

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 66.48  E-value: 1.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1049 TSGAYPLT-SPPTSYHSTVNQSPSMmhtqspgnlhaaSSPSGALRAPSPASFVPTPPPSShgisigPGASFASPhgTLDP 1127
Cdd:pfam05109  482 TSGASPVTpSPSPRDNGTESKAPDM------------TSPTSAVTTPTPNATSPTPAVTT------PTPNATSP--TLGK 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1128 SSPYTMVSPSGRAGNWPgSPQVSGPSPAARMPGMSPANPS--LHSPVPDASH------SPRAGTSSQTM-PTNMPPPRKL 1198
Cdd:pfam05109  542 TSPTSAVTTPTPNATSP-TPAVTTPTPNATIPTLGKTSPTsaVTTPTPNATSptvgetSPQANTTNHTLgGTSSTPVVTS 620

                          170       180
                   ....*....|....*....|....*....
gi 2217396515 1199 PQRSWAASIPT----ILTHSALNILLLPS 1223
Cdd:pfam05109  621 PPKNATSAVTTgqhnITSSSTSSMSLRPS 649
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1048-1224 9.52e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.08  E-value: 9.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1048 GTSGAYPLTSPPTSY-----------HSTVNQSPSMmHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHG-ISIGPG 1115
Cdd:pfam03154  202 SAPSVPPQGSPATSQppnqtqstaapHTLIQQTPTL-HPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGqMPPMPH 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1116 ASFASPHGTLDPSSPYTMVSPSGRA-GNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHS-PRAGTSsqtMPTNMP 1193
Cdd:pfam03154  281 SLQTGPSHMQHPVPPQPFPLTPQSSqSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPlPPAPLS---MPHIKP 357

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2217396515 1194 PPRK-LPQrswaasIPTILTHSALNILLLPSP 1224
Cdd:pfam03154  358 PPTTpIPQ------LPNPQSHKHPPHLSGPSP 383
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1006-1230 2.88e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.56  E-value: 2.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1006 DARRRSVNEDDNP-PSPIGGDMM-DSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHA 1083
Cdd:PHA03307   206 PPRRSSPISASASsPAPAPGRSAaDDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPA 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1084 ASSPSGALRAPSPASFVP----TPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQvSGPSPAArmP 1159
Cdd:PHA03307   286 SSSSSPRERSPSPSPSSPgsgpAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS-RPPPPAD--P 362

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217396515 1160 GMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPP--PRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVP 1230
Cdd:PHA03307   363 SSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRarRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTP 435
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1048-1231 3.56e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 3.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1048 GTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPS--PASFVPTPP---PSSHGISIGPGASFASPH 1122
Cdd:PHA03247  2774 APAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAasPAGPLPPPTsaqPTAPPPPPGPPPPSLPLG 2853

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1123 GTLDPSSPYTMVSPSGRAGNWPGS-----------PQVSGPSPAARMPGMSPANPslhsPVPDASHSPRAGTSSQTMPTN 1191
Cdd:PHA03247  2854 GSVAPGGDVRRRPPSRSPAAKPAAparppvrrlarPAVSRSTESFALPPDQPERP----PQPQAPPPPQPQPQPPPPPQP 2929

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2217396515 1192 MPPPRKlPQRSWAASIPTILTHSALNIL-LLPSPTPG-LVPG 1231
Cdd:PHA03247  2930 QPPPPP-PPRPQPPLAPTTDPAGAGEPSgAVPQPWLGaLVPG 2970
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1056-1224 1.10e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 53.38  E-value: 1.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1056 TSPPTSYHSTV-NQSPSMMHTQSPGNLHAASSPSGALRAPSpASFVPT--PPPSSHGISIGPG-ASFASPHGTLDPSSPY 1131
Cdd:pfam05109  410 TNATTTTHKVIfSKAPESTTTSPTLNTTGFAAPNTTTGLPS-STHVPTnlTAPASTGPTVSTAdVTSPTPAGTTSGASPV 488

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1132 TmVSPSGR-AGNWPGSPQ-------VSGPSPAARMPgmspaNPSLHSPVPDAShSPRAGTSSQTMPTNMPPPR------K 1197
Cdd:pfam05109  489 T-PSPSPRdNGTESKAPDmtsptsaVTTPTPNATSP-----TPAVTTPTPNAT-SPTLGKTSPTSAVTTPTPNatsptpA 561

                          170       180
                   ....*....|....*....|....*..
gi 2217396515 1198 LPQRSWAASIPTILTHSALNILLLPSP 1224
Cdd:pfam05109  562 VTTPTPNATIPTLGKTSPTSAVTTPTP 588
PHA03378 PHA03378
EBNA-3B; Provisional
 1054-1235 1.11e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 50.07  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1054 PLTSPPTSYHSTVNQS------PSMMHTQSPGNLHAASSP---SGALRAPSPASFVPTPPPSSHGISIGPgASFASPHGT 1124
Cdd:PHA03378   576 PLTSPTTSQLASSAPSyaqtpwPVPHPSQTPEPPTTQSHIpetSAPRQWPMPLRPIPMRPLRMQPITFNV-LVFPTPHQP 654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1125 ldPSSPYTMVSPS-GRAGNWPGSPQVSGPSpAARMPGMSPAN----PSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLP 1199
Cdd:PHA03378   655 --PQVEITPYKPTwTQIGHIPYQPSPTGAN-TMLPIQWAPGTmqppPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAP 731

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2217396515 1200 ---QRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGS 1235
Cdd:PHA03378   732 graRPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAA 770
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1049-1233 1.34e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.17  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1049 TSGAYPLTSPPTSY----HSTVNQSPSMMhtqSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGT 1124
Cdd:PHA03307    15 AEGGEFFPRPPATPgdaaDDLLSGSQGQL---VSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWS 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1125 LDPSSPYTMvsPSGRAGNWPGSPQVSGPSPAArmpgmSPANPsLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA 1204
Cdd:PHA03307    92 LSTLAPASP--AREGSPTPPGPSSPDPPPPTP-----PPASP-PPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163

                          170       180
                   ....*....|....*....|....*....
gi 2217396515 1205 ASIPTILtHSALNILLLPSPTPGLVPGLA 1233
Cdd:PHA03307   164 SDAASSR-QAALPLSSPEETARAPSSPPA 191
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 1070-1196 1.44e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 49.68  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1070 PSMMHTQSPGNLHAASSPSGALRAPSPAS--FVPTPPPSSHGISIGPGASFASPhGTLDPSSPYTMVSPSGRAgNW---P 1144
Cdd:PRK14959   363 PRLMPVESLRPSGGGASAPSGSAAEGPASggAATIPTPGTQGPQGTAPAAGMTP-SSAAPATPAPSAAPSPRV-PWddaP 440

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217396515 1145 GSPQVSG--PSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPR 1196
Cdd:PRK14959   441 PAPPRSGipPRPAPRMPEASPVPGAPDSVASASDAPPTLGDPSDTAEHTPSGPR 494
PHA03378 PHA03378
EBNA-3B; Provisional
 1053-1199 1.58e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.68  E-value: 1.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1053 YPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGA--LRAPSPASFVPTPPPSSHGISIGP--GASFASPHGTLDPS 1128
Cdd:PHA03378   653 QPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWApgTMQPPPRAPTPMRPPAAPPGRAQRpaAATGRARPPAAAPG 732

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217396515 1129 SPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSP-ANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLP 1199
Cdd:PHA03378   733 RARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPaAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGP 804
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1087-1233 4.12e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1087 PSGALRAPSPASfvpTPPPSSHGISigPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANP 1166
Cdd:PHA03247  2604 DRGDPRGPAPPS---PLPPDTHAPD--PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217396515 1167 SLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLA 1233
Cdd:PHA03247  2679 PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP 2745
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 1064-1201 4.83e-05

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 45.41  E-value: 4.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1064 STVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPsshgisigPGASFASPH--GTLDPSSPYTMVSPSGRAG 1141
Cdd:pfam15240   28 SPSLISEEEGQSQQGGQGPQGPPPGGFPPQPPASDDPPGPPP--------PGGPQQPPPqgGKQKPQGPPPQGGPRPPPG 99

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1142 NWPGSPQVSGPSPAARMPgmsPANPslHSPVPDASHSPRAGTSSQTMPTnmPPPRKlPQR 1201
Cdd:pfam15240  100 KPQGPPPQGGNQQQGPPP---PGKP--QGPPPQGGGPPPQGGNQQGPPP--PPPGN-PQG 151
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1083-1208 8.70e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.29  E-value: 8.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1083 AASSPSGALRAPSPASfvpTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMS 1162
Cdd:PRK07764   616 AAPAAPAAPAAPAPAG---AAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAA 692

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2217396515 1163 PANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKL--PQRSWAASIP 1208
Cdd:PRK07764   693 PAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGAsaPSPAADDPVP 740
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1056-1199 8.73e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.18  E-value: 8.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1056 TSPPTSYHSTVNQSPSmmhtqspgnlhAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVS 1135
Cdd:PRK12323   372 AGPATAAAAPVAQPAP-----------AAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQAS 440

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217396515 1136 PSGRAG-NWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQtmPTNMPPPRKLP 1199
Cdd:PRK12323   441 ARGPGGaPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPA--DDDPPPWEELP 503
Gag_spuma pfam03276
Spumavirus gag protein;
1069-1246 9.94e-05

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 47.05  E-value: 9.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1069 SPSMMHTQSPGNLHA-----ASSPSGALRAPSPASFVPTPP--PSSHGISIGPGASFAsphgtlDPSSPYTMVSPSGRAG 1141
Cdd:pfam03276  179 SPGAQGGIPPGASFSglpslPAIGGIHLPAIPGIHARAPPGniARSLGDDIMPSLGDA------GMPQPRFAFHPGNPFA 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1142 NWPGSPqvsgPSPAAR-MPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKL-------PQRSwAASIPTILTH 1213
Cdd:pfam03276  253 EAEGHP----FAEAEGeRPRDIPRAPRIDAPSAPAIPAIQPIAPPMIPPIGAPIPIPHgasipgeHIRN-PREEPIRLGR 327

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2217396515 1214 SALNIL-LLPSPTPGLVPGLAGSYLCSPLERFLG 1246
Cdd:pfam03276  328 EAPAIDgRFAPAIDDLFCRIINALLCGIIGALLG 361
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 989-1231 1.18e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 1.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515  989 PAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPI---GGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPT----- 1060
Cdd:PHA03307     3 NAPDLYDLIEAAAEGGEFFPRPPATPGDAADDLLsgsQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTeapan 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1061 ------SYHSTVNQSPSMMHTQSPGNlHAASSPSGALRAPSPAsfvpTPPPSSHGISIGPGASFASPHGTLDPSSPYTMV 1134
Cdd:PHA03307    83 esrstpTWSLSTLAPASPAREGSPTP-PGPSSPDPPPPTPPPA----SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1135 S----PSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPR-------KLPQRSW 1203
Cdd:PHA03307   158 SpaavASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPApgrsaadDAGASSS 237

                          250       260       270
                   ....*....|....*....|....*....|
gi 2217396515 1204 --AASIPTILTHSALNILLLPSPTPGLVPG 1231
Cdd:PHA03307   238 dsSSSESSGCGWGPENECPLPRPAPITLPT 267
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1082-1208 1.26e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 1.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1082 HAASSPSGALRAPSPASFVPTP--PPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMP 1159
Cdd:PHA03307   165 DAASSRQAALPLSSPEETARAPssPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSES 244

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2217396515 1160 GMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSwAASIP 1208
Cdd:PHA03307   245 SGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASS-SSSPR 292
PHA03379 PHA03379
EBNA-3A; Provisional
 1054-1230 1.65e-04

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 46.20  E-value: 1.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1054 PLTSPPTSYHSTVNQSPSMMHTQSPGnlhaasSPSGALRAP---SPASFVPTPPPSSHGISIGPGASFASPHGTLDPSS- 1129
Cdd:PHA03379   533 PVPVPTVALERPVCPAPPLIAMQGPG------ETSGIVRVRerwRPAPWTPNPPRSPSQMSVRDRLARLRAEAQPYQASv 606

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1130 -----PYTMVSPS--------GRAGNWPGSP--QVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTnmpP 1194
Cdd:PHA03379   607 evqppQLTQVSPQqpmeyplePEQQMFPGSPfsQVADVMRAGGVPAMQPQYFDLPLQQPISQGAPLAPLRASMGPV---P 683

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2217396515 1195 PRKLPQRSW---AASIPTILTHSALNILLLPSPTPGLVP 1230
Cdd:PHA03379   684 PVPATQPQYfdiPLTEPINQGASAAHFLPQQPMEGPLVP 722
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1083-1234 1.85e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 1.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1083 AASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPS--SPYTMVSPSGRAGNWPGSPQVSGPSPAARMPG 1160
Cdd:PRK07764   605 SSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPehHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPA 684

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217396515 1161 MSPANPSLHSPVPDAS--HSPRAGTSSQTMPTNMPPPRKLPQRSWAASiptilTHSALNILLLPSPTPGLVPGLAG 1234
Cdd:PRK07764   685 PAPAAPAAPAGAAPAQpaPAPAATPPAGQADDPAAQPPQAAQGASAPS-----PAADDPVPLPPEPDDPPDPAGAP 755
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1052-1233 3.35e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1052 AYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGA-----------LRAPSPASFVPTPPPSSHGISIGPGASFAS 1120
Cdd:PHA03247  2621 THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrprrarrlGRAAQASSPPQRPRRRAARPTVGSLTSLAD 2700

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1121 PHGT-LDPSSPYTMVSPSGRAGNWPGSPQVSGPS-PAARMPGMSPANPSLhsPVPDASHSPRAGTSSQTMPTN-----MP 1193
Cdd:PHA03247  2701 PPPPpPTPEPAPHALVSATPLPPGPAAARQASPAlPAAPAPPAVPAGPAT--PGGPARPARPPTTAGPPAPAPpaapaAG 2778

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2217396515 1194 PPRKLPQrswAASIPTILTHSALNILLLPSPTPGLVPGLA 1233
Cdd:PHA03247  2779 PPRRLTR---PAVASLSESRESLPSPWDPADPPAAVLAPA 2815
PHA03292 PHA03292
envelope glycoprotein I; Provisional
 1052-1197 5.87e-04

envelope glycoprotein I; Provisional


Pssm-ID: 177577  Cd Length: 413  Bit Score: 44.18  E-value: 5.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1052 AYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGAlrapspASFVPTPPPSSHGISIGP-------GASFASPHGT 1124
Cdd:PHA03292   178 TTARPEPAAGYVATPTPRYLNAVTTSTYSRSMSSQPAGA------ATATPTPTLDTGLTTVAPpnetvvtGETALLCHWF 251

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217396515 1125 LDPSSPYTM-VSPSGRAGNWPGSPQVSGPSPAARMPgmspanpslhSPVPDASHSPRAGTSSQTMPTNMPPPRK 1197
Cdd:PHA03292   252 QPSTRVPTLyLHLLGTTGNLTEDVLLTEDSEILRTP----------PPDPSSSRSPGAGDDFKQTNSTSPKRRN 315
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1074-1196 1.28e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1074 HTQSPGNLHAASSPSGalraPSPASFVPTPPPSshgisigPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPS 1153
Cdd:PHA03307   810 DAASRTASKRKSRSHT----PDGGSESSGPARP-------PGAAARPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPE 878

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2217396515 1154 PAARMPGMSP---ANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPR 1196
Cdd:PHA03307   879 PRARPGAAAPpkaAAAAPPAGAPAPRPRPAPRVKLGPMPPGGPDPR 924
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 1057-1196 1.82e-03

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 42.46  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1057 SPPTSYHSTVNQSPSMMHTQSPGNLHAAS---SPSGALRAPSPASFVPTPPPSSH-------GISIGPGASFASPHGTLD 1126
Cdd:pfam13254  163 SPKPKAQPSQPAQPAWMKELNKIRQSRASvdlGRPNSFKEVTPVGLMRSPAPGGHskspsvsGISADSSPTKEEPSEEAD 242

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217396515 1127 PSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANP-SLHSPVPDASHSPRAGTSSQTMPTNMPPPR 1196
Cdd:pfam13254  243 TLSTDKEQSPAPTSASEPPPKTKELPKDSEEPAAPSKSAEaSTEKKEPDTESSPETSSEKSAPSLLSPVSK 313
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1042-1230 1.83e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1042 PFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNlhAASSPSGALRAPSPASfvPTPPPSShgisigpgASFASP 1121
Cdd:PHA03247  2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA--GPATPGGPARPARPPT--TAGPPAP--------APPAAP 2775

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1122 HGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAArMPGMSPANPSLHSPvpdASHSPRAGTSSQTMPTNMPPP------ 1195
Cdd:PHA03247  2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA-VLAPAAALPPAASP---AGPLPPPTSAQPTAPPPPPGPpppslp 2851

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2217396515 1196 ------------RKLPQRSwAASIPTILTHSALNILLLPSPTPGLVP 1230
Cdd:PHA03247  2852 lggsvapggdvrRRPPSRS-PAAKPAAPARPPVRRLARPAVSRSTES 2897
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 1083-1208 2.73e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 41.86  E-value: 2.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1083 AASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLdPSSPYTMVSPSGRAGNWPgSPQVSGPSPAARMPGMS 1162
Cdd:PTZ00436   225 AAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKA-AAPPAKAAAPPAKAAAPP-AKAAAPPAKAAAAPAKA 302

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2217396515 1163 PANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIP 1208
Cdd:PTZ00436   303 AAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1083-1300 2.96e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 2.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1083 AASSPSGALRAPSPASFVPTPPPSSHgisIGPGASFASPHGTLDPSSPYTMVSPSgragnwPGSPQVSGPSPAARMPGMS 1162
Cdd:PRK14951   373 AAPAEKKTPARPEAAAPAAAPVAQAA---AAPAPAAAPAAAASAPAAPPAAAPPA------PVAAPAAAAPAAAPAAAPA 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1163 PANPSLHSPVPDASH--SPRAGTSSQTMPTNMPPPRKLPQRSwAASIPTILT---HSALNILLLPSPTPGLVPGLAgsyl 1237
Cdd:PRK14951   444 AVALAPAPPAQAAPEtvAIPVRVAPEPAVASAAPAPAAAPAA-ARLTPTEEGdvwHATVQQLAAAEAITALARELA---- 518

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217396515 1238 csplerfLGSVIMRR---HLQRIIQQETLQLINSNEpgvimfktdalKCRVALSPKTNQTLQLKVT 1300
Cdd:PRK14951   519 -------LQSELVARdgdQWLLRVERESLNQPGARE-----------RLRAALEAALGHAVRLEVE 566
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 1064-1237 4.48e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.39  E-value: 4.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1064 STVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMvspsgragnW 1143
Cdd:PRK07994   362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQR---------A 432

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1144 PGSPQVSGPSPAARmPGMSPANPSLHsPVPDASHSPRAgtsSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPS 1223
Cdd:PRK07994   433 QGATKAKKSEPAAA-SRARPVNSALE-RLASVRPAPSA---LEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHE 507

                          170
                   ....*....|....
gi 2217396515 1224 PTPGLVPGLAGSYL 1237
Cdd:PRK07994   508 KTPELAAKLAAEAI 521
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 1070-1179 8.28e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 40.76  E-value: 8.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1070 PSMMHTQSP---GNLHAASSPSGALRAPSPAsfVPTP-PPSSHGISIGPGASFASPHgtLDPSSpytmvspsgragnwpg 1145
Cdd:pfam09606  370 PGMMSSPSPvpgQQVRQVTPNQFMRQSPQPS--VPSPqGPGSQPPQSHPGGMIPSPA--LIPSP---------------- 429

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2217396515 1146 SPQVSGPSPAARMPGMSPANPSLHSPVPDASHSP 1179
Cdd:pfam09606  430 SPQMSQQPAQQRTIGQDSPGGSLNTPGQSAVNSP 463
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1041-1226 9.50e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 9.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1041 QPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSP--GNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGAS- 1117
Cdd:PHA03247  2738 APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPaaGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAa 2817

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217396515 1118 ---FASPHGTLDPSSPYTMVSPSGRAGNWP------GSPQVSGP---SPAARMPGMSPANPslhsPVPDASHSPRAGTSS 1185
Cdd:PHA03247  2818 lppAASPAGPLPPPTSAQPTAPPPPPGPPPpslplgGSVAPGGDvrrRPPSRSPAAKPAAP----ARPPVRRLARPAVSR 2893

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2217396515 1186 QTMPTNMPPPRKLPQRSWAASIPTiLTHSALNILLLPSPTP 1226
Cdd:PHA03247  2894 STESFALPPDQPERPPQPQAPPPP-QPQPQPPPPPQPQPPP 2933
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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