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Conserved domains on  [gi|2217310928|ref|XP_047291649|]
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clustered mitochondria protein homolog isoform X3 [Homo sapiens]

Protein Classification

CLU and CLU-central domain-containing protein( domain architecture ID 12171920)

protein containing domains CLU_N, CLU, CLU-central, and TPR_12

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLU pfam13236
Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found ...
 356-576 2.16e-112

Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport although the exact function of the domain is unknown. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure.


:

Pssm-ID: 463814  Cd Length: 225  Bit Score: 351.47  E-value: 2.16e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  356 DWNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVIDGNVMAINPSEETKMQMFIWNNIFFSLGFDVRDH 435
Cdd:pfam13236    1 DWNEEFQSLRELPRETLQERLLRERLLSKLASDFVEAATKGAKAIIDGNVLPLNPKEPPGGHKYLYNNIFFSFAVDVRGT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  436 YKDFGGDVAAYVAPTNDLNGVRTYNAVDVEGLYTLGTVVVDYRGYRVTAQSIIPGILERDQEQ----SVIYGSIDFGKTV 511
Cdd:pfam13236   81 YPSLGGDEAARKAAGKDLKGVKALNRLDIPGLHTLLTAIVDYRGYRLIAQSILPGILSRDEETiekdTIVYGSSDGGKTV 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217310928  512 VSHPRYLELLERTSRPLKILRHQVLNDRDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNF 576
Cdd:pfam13236  161 HSDEEFHELLKKIAKALNLKPHKVGDADGKPVELYGSADIKGIKGTDGRYYVLDLARLFPPDVNF 225
eIF3_p135 pfam12807
Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a ...
 768-949 5.77e-74

Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.


:

Pssm-ID: 463717  Cd Length: 168  Bit Score: 242.86  E-value: 5.77e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  768 VLPVDGATLAEVMRQRGINMRYLGKVLELVLRSPARHQLDHVFKIGIGELITRSAKHIFKTYLQGVELSGLSAAISHFLN 847
Cdd:pfam12807    2 SFPMDGQSLTEALHKRGINMRYLGKIAKKLSKSPNKARLEHLKRLCVQEMIARAAKHILRKYLRGVPPPLLSAAVSHFLN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  848 CFLSSYPNPVAHLPADELVSkkrnkrrknrPPGAADNTAWAVMTPQELWKNICQEAKNYFDFDLECETVDQavetyGLQK 927
Cdd:pfam12807   82 CLLGSSLNPKPTAEIDELLK----------GLYKKKNRAWAKLTPESLWEEIEQEVKSRFRYELPEDWVDS-----GLQK 146

                          170       180
                   ....*....|....*....|..
gi 2217310928  928 ITLLREISLKTGIQVLLKEYSF 949
Cdd:pfam12807  147 ISLLREICLKTGIQLLAREYNF 168
CLU_N pfam15044
Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, ...
 66-139 2.97e-16

Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organizms. The function of this domain is not known. It family is found in association with pfam13236.


:

Pssm-ID: 464466  Cd Length: 79  Bit Score: 74.61  E-value: 2.97e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217310928   66 PQEMVQEIHQVLMDREDTCHRTCFSL-HLDGN--VLDHFSELRSV--EGLQEGSVLRVVEEPYTVREARIHVRHVRDLL 139
Cdd:pfam15044    1 KSETVQDLRQVLSELPATKYLTNYHLeYQNGNgeRLNEFVTLSEIieELDVDELKLQLKEKPYTEREALEHVLRFREFI 79
FxSxx_TPR super family cl48889
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1000-1185 1.03e-11

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


The actual alignment was detected with superfamily member NF040586:

Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 69.56  E-value: 1.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1000 ELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALYCFASSQL 1079
Cdd:NF040586   499 ELDEETLERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRY 578

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1080 STALSLLYRA-RYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHG---PKALKVALSHhlvAR 1155
Cdd:NF040586   579 AEALDLLEEAlERYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGpdhPDTLAAALSL---AN 655

                          170       180       190
                   ....*....|....*....|....*....|
gi 2217310928 1156 VYESKAEFRSALQHEKEGYTIYKTQLGEDH 1185
Cdd:NF040586   656 DLRALGDADEARELAREVLDRYRRVLGEDH 685
 
Name Accession Description Interval E-value
CLU pfam13236
Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found ...
 356-576 2.16e-112

Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport although the exact function of the domain is unknown. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure.


Pssm-ID: 463814  Cd Length: 225  Bit Score: 351.47  E-value: 2.16e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  356 DWNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVIDGNVMAINPSEETKMQMFIWNNIFFSLGFDVRDH 435
Cdd:pfam13236    1 DWNEEFQSLRELPRETLQERLLRERLLSKLASDFVEAATKGAKAIIDGNVLPLNPKEPPGGHKYLYNNIFFSFAVDVRGT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  436 YKDFGGDVAAYVAPTNDLNGVRTYNAVDVEGLYTLGTVVVDYRGYRVTAQSIIPGILERDQEQ----SVIYGSIDFGKTV 511
Cdd:pfam13236   81 YPSLGGDEAARKAAGKDLKGVKALNRLDIPGLHTLLTAIVDYRGYRLIAQSILPGILSRDEETiekdTIVYGSSDGGKTV 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217310928  512 VSHPRYLELLERTSRPLKILRHQVLNDRDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNF 576
Cdd:pfam13236  161 HSDEEFHELLKKIAKALNLKPHKVGDADGKPVELYGSADIKGIKGTDGRYYVLDLARLFPPDVNF 225
eIF3_p135 pfam12807
Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a ...
 768-949 5.77e-74

Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.


Pssm-ID: 463717  Cd Length: 168  Bit Score: 242.86  E-value: 5.77e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  768 VLPVDGATLAEVMRQRGINMRYLGKVLELVLRSPARHQLDHVFKIGIGELITRSAKHIFKTYLQGVELSGLSAAISHFLN 847
Cdd:pfam12807    2 SFPMDGQSLTEALHKRGINMRYLGKIAKKLSKSPNKARLEHLKRLCVQEMIARAAKHILRKYLRGVPPPLLSAAVSHFLN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  848 CFLSSYPNPVAHLPADELVSkkrnkrrknrPPGAADNTAWAVMTPQELWKNICQEAKNYFDFDLECETVDQavetyGLQK 927
Cdd:pfam12807   82 CLLGSSLNPKPTAEIDELLK----------GLYKKKNRAWAKLTPESLWEEIEQEVKSRFRYELPEDWVDS-----GLQK 146

                          170       180
                   ....*....|....*....|..
gi 2217310928  928 ITLLREISLKTGIQVLLKEYSF 949
Cdd:pfam12807  147 ISLLREICLKTGIQLLAREYNF 168
CLU-central cd15466
An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the ...
 770-949 2.04e-61

An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the mitochondrial CLU proteins have been shown to result in clustered mitochondria. CLU proteins include Saccharomyces cerevisiae clustered mitochondria protein (Clu1p, alias translation initiation factor 31/TIF31p), Dictyostelium discoideum clustered mitochondria protein homolog (CluA), Caenorhabditis elegans clustered mitochondria protein homolog (CLUH/ Protein KIAA0664), Drosophila clueless (alias clustered mitochondria protein homolog), Arabidopsis clustered mitochondria protein (CLU, alias friendly mitochondria protein/FMT), and human clustered mitochondria protein homolog (CLUH). Dictyostelium CluA is involved in mitochondrial dynamics and is necessary for both, mitochondrial fission and fusion. Drosophila clueless is essential for cytoplasmic localization and function of cellular mitochondria. The Drosophila clu gene interacts genetically with parkin (park, the Drosophila ortholog of a human gene responsible for many familial cases of Parkinson's disease). Arabidopsis CLU/FMT is required for correct mitochondrial distribution and morphology. The specific role CLU proteins play in mitochondrial processes in not yet known. In an early study, S. cerevisiae Clu1/TIF31p was reported as sometimes being associated with the elF3 translation initiation factor. The authors noted, however, that its tentative assignment as a subunit of elf3 was uncertain, and to date there has been no direct evidence for a role of this protein in translation.


Pssm-ID: 271318  Cd Length: 159  Bit Score: 206.82  E-value: 2.04e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  770 PVDGATLAEVMRQRGINMRYLGKVLELVlrsPARHQLDHVFKIGIGELITRSAKHIFKTYLQGVELSGLSAAISHFLNCF 849
Cdd:cd15466      1 PIDGASLTELLHRRGINMRYLGKVAELI---SKLPKLPHLKRLLLTEMVARAAKHILRAYLRSVPLAELSAAVAHFLNCL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  850 LSSYPNPVAHLPADELVSkkrnkrrknrppgAADNTAWAVMTPQELWKNICQEAKNYFDFDLECETVDQavetyGLQKIT 929
Cdd:cd15466     78 LGSSSNPAPSAEIDEELK-------------PAADTSWASLTPSFLWKEIKKEVKKRFRYDLPEESLDE-----GLRKLS 139

                          170       180
                   ....*....|....*....|
gi 2217310928  930 LLREISLKTGIQVLLKEYSF 949
Cdd:cd15466    140 LLRELCLKVGIQLLARDYDF 159
CLU_N pfam15044
Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, ...
 66-139 2.97e-16

Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organizms. The function of this domain is not known. It family is found in association with pfam13236.


Pssm-ID: 464466  Cd Length: 79  Bit Score: 74.61  E-value: 2.97e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217310928   66 PQEMVQEIHQVLMDREDTCHRTCFSL-HLDGN--VLDHFSELRSV--EGLQEGSVLRVVEEPYTVREARIHVRHVRDLL 139
Cdd:pfam15044    1 KSETVQDLRQVLSELPATKYLTNYHLeYQNGNgeRLNEFVTLSEIieELDVDELKLQLKEKPYTEREALEHVLRFREFI 79
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1000-1185 1.03e-11

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 69.56  E-value: 1.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1000 ELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALYCFASSQL 1079
Cdd:NF040586   499 ELDEETLERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRY 578

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1080 STALSLLYRA-RYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHG---PKALKVALSHhlvAR 1155
Cdd:NF040586   579 AEALDLLEEAlERYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGpdhPDTLAAALSL---AN 655

                          170       180       190
                   ....*....|....*....|....*....|
gi 2217310928 1156 VYESKAEFRSALQHEKEGYTIYKTQLGEDH 1185
Cdd:NF040586   656 DLRALGDADEARELAREVLDRYRRVLGEDH 685
TPR_12 pfam13424
Tetratricopeptide repeat;
1103-1178 1.86e-10

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 58.17  E-value: 1.86e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217310928 1103 EMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALSHHLVARVYESKAEFRSALQHEKEGYTIYK 1178
Cdd:pfam13424    1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 991-1188 1.45e-07

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 56.08  E-value: 1.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  991 QQGFLKEGCELINEALNLF--NNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMH 1068
Cdd:NF040586   446 SLGRYEEARELDEDTLERQrrVLGLGEDHPHTLMTAGGLGADLRALGRFREALELDEETLERHRRVFGEDHPRTLRAANN 525

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1069 LALYCFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHG----PKAL 1144
Cdd:NF040586   526 LAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVLGgpdhPDTL 605

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2217310928 1145 KVALSHHLVARvyesKA-EFRSALQHEKEGYTIYKTQLGEDHEKT 1188
Cdd:NF040586   606 RAAKSLAVALR----RAgRLEEALELAEDTYERYRRRFGPDHPDT 646
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 993-1102 3.99e-06

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 51.46  E-value: 3.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  993 GFLKEGCELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALY 1072
Cdd:NF040586   619 GRLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLGEDHPFTLACRNNLAVL 698

                           90       100       110
                   ....*....|....*....|....*....|
gi 2217310928 1073 CFASSQLSTALSLLYRARYLMLLVFGEDHP 1102
Cdd:NF040586   699 LRALGDPEEARELAEAALEGLRERLGPDHP 728
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1023-1214 3.23e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.92  E-value: 3.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1023 CLRLLARLHYIMGDYAEALSNQQKAVLMservmgteHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLmllvfgedHP 1102
Cdd:COG0457     10 AYNNLGLAYRRLGRYEEAIEDYEKALEL--------DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL--------DP 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1103 EMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYhgPKAL-KVALSHHLVARVYESKAEFRSALQHEKEGYTIYKTqL 1181
Cdd:COG0457     74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDD--AEALyNLGLALLELGRYDEAIEAYERALELDPDDADALYN-L 150

                          170       180       190
                   ....*....|....*....|....*....|...
gi 2217310928 1182 GEDHEKTKESSEYLKCLTQQAVALQRTMNEIYR 1214
Cdd:COG0457    151 GIALEKLGRYEEALELLEKLEAAALAALLAAAL 183
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 993-1133 4.88e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 47.99  E-value: 4.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  993 GFLKEGCELINEALNLFNNVY-GAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLAL 1071
Cdd:NF040586   576 GRYAEALDLLEEALERYREVLgGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHPDTLAAALSLAN 655

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217310928 1072 YCFASSQLSTALSLLYRA--RYLmlLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALA 1133
Cdd:NF040586   656 DLRALGDADEARELAREVldRYR--RVLGEDHPFTLACRNNLAVLLRALGDPEEARELAEAALE 717
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 950-1185 6.56e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 47.61  E-value: 6.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  950 DSRHKPAFTEedvlnifpVVKHVNPkaSDAFHffqSGQAKVQQ------------GFLKEGCELINEALNLFNNVYGAMH 1017
Cdd:NF040586   364 DPRNWPRYAE--------LWPHLEP--SGALE---SDDPEVRRllldqvrylylrGDYESARDLAERALERWRERLGPDD 430

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1018 VETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVM--GTEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLMLL 1095
Cdd:NF040586   431 RQTLRLRFHLANALRSLGRYEEARELDEDTLERQRRVLglGEDHPHTLMTAGGLGADLRALGRFREALELDEETLERHRR 510

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1096 VFGEDHPE--MALldNNIGLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALSHHLVARVYESKAEFRSALQHEKEG 1173
Cdd:NF040586   511 VFGEDHPRtlRAA--NNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEA 588

                          250
                   ....*....|...
gi 2217310928 1174 YTIYKTQL-GEDH 1185
Cdd:NF040586   589 LERYREVLgGPDH 601
 
Name Accession Description Interval E-value
CLU pfam13236
Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found ...
 356-576 2.16e-112

Clustered mitochondria; The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport although the exact function of the domain is unknown. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure.


Pssm-ID: 463814  Cd Length: 225  Bit Score: 351.47  E-value: 2.16e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  356 DWNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVIDGNVMAINPSEETKMQMFIWNNIFFSLGFDVRDH 435
Cdd:pfam13236    1 DWNEEFQSLRELPRETLQERLLRERLLSKLASDFVEAATKGAKAIIDGNVLPLNPKEPPGGHKYLYNNIFFSFAVDVRGT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  436 YKDFGGDVAAYVAPTNDLNGVRTYNAVDVEGLYTLGTVVVDYRGYRVTAQSIIPGILERDQEQ----SVIYGSIDFGKTV 511
Cdd:pfam13236   81 YPSLGGDEAARKAAGKDLKGVKALNRLDIPGLHTLLTAIVDYRGYRLIAQSILPGILSRDEETiekdTIVYGSSDGGKTV 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217310928  512 VSHPRYLELLERTSRPLKILRHQVLNDRDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNF 576
Cdd:pfam13236  161 HSDEEFHELLKKIAKALNLKPHKVGDADGKPVELYGSADIKGIKGTDGRYYVLDLARLFPPDVNF 225
eIF3_p135 pfam12807
Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a ...
 768-949 5.77e-74

Translation initiation factor eIF3 subunit 135; Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation.


Pssm-ID: 463717  Cd Length: 168  Bit Score: 242.86  E-value: 5.77e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  768 VLPVDGATLAEVMRQRGINMRYLGKVLELVLRSPARHQLDHVFKIGIGELITRSAKHIFKTYLQGVELSGLSAAISHFLN 847
Cdd:pfam12807    2 SFPMDGQSLTEALHKRGINMRYLGKIAKKLSKSPNKARLEHLKRLCVQEMIARAAKHILRKYLRGVPPPLLSAAVSHFLN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  848 CFLSSYPNPVAHLPADELVSkkrnkrrknrPPGAADNTAWAVMTPQELWKNICQEAKNYFDFDLECETVDQavetyGLQK 927
Cdd:pfam12807   82 CLLGSSLNPKPTAEIDELLK----------GLYKKKNRAWAKLTPESLWEEIEQEVKSRFRYELPEDWVDS-----GLQK 146

                          170       180
                   ....*....|....*....|..
gi 2217310928  928 ITLLREISLKTGIQVLLKEYSF 949
Cdd:pfam12807  147 ISLLREICLKTGIQLLAREYNF 168
CLU-central cd15466
An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the ...
 770-949 2.04e-61

An uncharacterized central domain of CLU mitochondrial proteins; Mutations in the mitochondrial CLU proteins have been shown to result in clustered mitochondria. CLU proteins include Saccharomyces cerevisiae clustered mitochondria protein (Clu1p, alias translation initiation factor 31/TIF31p), Dictyostelium discoideum clustered mitochondria protein homolog (CluA), Caenorhabditis elegans clustered mitochondria protein homolog (CLUH/ Protein KIAA0664), Drosophila clueless (alias clustered mitochondria protein homolog), Arabidopsis clustered mitochondria protein (CLU, alias friendly mitochondria protein/FMT), and human clustered mitochondria protein homolog (CLUH). Dictyostelium CluA is involved in mitochondrial dynamics and is necessary for both, mitochondrial fission and fusion. Drosophila clueless is essential for cytoplasmic localization and function of cellular mitochondria. The Drosophila clu gene interacts genetically with parkin (park, the Drosophila ortholog of a human gene responsible for many familial cases of Parkinson's disease). Arabidopsis CLU/FMT is required for correct mitochondrial distribution and morphology. The specific role CLU proteins play in mitochondrial processes in not yet known. In an early study, S. cerevisiae Clu1/TIF31p was reported as sometimes being associated with the elF3 translation initiation factor. The authors noted, however, that its tentative assignment as a subunit of elf3 was uncertain, and to date there has been no direct evidence for a role of this protein in translation.


Pssm-ID: 271318  Cd Length: 159  Bit Score: 206.82  E-value: 2.04e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  770 PVDGATLAEVMRQRGINMRYLGKVLELVlrsPARHQLDHVFKIGIGELITRSAKHIFKTYLQGVELSGLSAAISHFLNCF 849
Cdd:cd15466      1 PIDGASLTELLHRRGINMRYLGKVAELI---SKLPKLPHLKRLLLTEMVARAAKHILRAYLRSVPLAELSAAVAHFLNCL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  850 LSSYPNPVAHLPADELVSkkrnkrrknrppgAADNTAWAVMTPQELWKNICQEAKNYFDFDLECETVDQavetyGLQKIT 929
Cdd:cd15466     78 LGSSSNPAPSAEIDEELK-------------PAADTSWASLTPSFLWKEIKKEVKKRFRYDLPEESLDE-----GLRKLS 139

                          170       180
                   ....*....|....*....|
gi 2217310928  930 LLREISLKTGIQVLLKEYSF 949
Cdd:cd15466    140 LLRELCLKVGIQLLARDYDF 159
CLU_N pfam15044
Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, ...
 66-139 2.97e-16

Mitochondrial function, CLU-N-term; CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organizms. The function of this domain is not known. It family is found in association with pfam13236.


Pssm-ID: 464466  Cd Length: 79  Bit Score: 74.61  E-value: 2.97e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217310928   66 PQEMVQEIHQVLMDREDTCHRTCFSL-HLDGN--VLDHFSELRSV--EGLQEGSVLRVVEEPYTVREARIHVRHVRDLL 139
Cdd:pfam15044    1 KSETVQDLRQVLSELPATKYLTNYHLeYQNGNgeRLNEFVTLSEIieELDVDELKLQLKEKPYTEREALEHVLRFREFI 79
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 1000-1185 1.03e-11

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 69.56  E-value: 1.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1000 ELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALYCFASSQL 1079
Cdd:NF040586   499 ELDEETLERHRRVFGEDHPRTLRAANNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRY 578

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1080 STALSLLYRA-RYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHG---PKALKVALSHhlvAR 1155
Cdd:NF040586   579 AEALDLLEEAlERYREVLGGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGpdhPDTLAAALSL---AN 655

                          170       180       190
                   ....*....|....*....|....*....|
gi 2217310928 1156 VYESKAEFRSALQHEKEGYTIYKTQLGEDH 1185
Cdd:NF040586   656 DLRALGDADEARELAREVLDRYRRVLGEDH 685
TPR_12 pfam13424
Tetratricopeptide repeat;
1103-1178 1.86e-10

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 58.17  E-value: 1.86e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217310928 1103 EMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALSHHLVARVYESKAEFRSALQHEKEGYTIYK 1178
Cdd:pfam13424    1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
TPR_12 pfam13424
Tetratricopeptide repeat;
986-1048 1.32e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 52.77  E-value: 1.32e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217310928  986 GQAKVQQGFLKEGCELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAV 1048
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERAL 72
TPR_12 pfam13424
Tetratricopeptide repeat;
1024-1089 1.93e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 52.39  E-value: 1.93e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217310928 1024 LRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALYCFASSQLSTALSLLYRA 1089
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERA 71
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 991-1188 1.45e-07

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 56.08  E-value: 1.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  991 QQGFLKEGCELINEALNLF--NNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMH 1068
Cdd:NF040586   446 SLGRYEEARELDEDTLERQrrVLGLGEDHPHTLMTAGGLGADLRALGRFREALELDEETLERHRRVFGEDHPRTLRAANN 525

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1069 LALYCFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHG----PKAL 1144
Cdd:NF040586   526 LAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEALERYREVLGgpdhPDTL 605

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2217310928 1145 KVALSHHLVARvyesKA-EFRSALQHEKEGYTIYKTQLGEDHEKT 1188
Cdd:NF040586   606 RAAKSLAVALR----RAgRLEEALELAEDTYERYRRRFGPDHPDT 646
TPR_10 pfam13374
Tetratricopeptide repeat;
1020-1061 1.18e-06

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 46.34  E-value: 1.18e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2217310928 1020 TCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPN 1061
Cdd:pfam13374    1 TASSLNNLANALRAQGRYDEAEELLEEALAIRERVLGPDHPD 42
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 993-1102 3.99e-06

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 51.46  E-value: 3.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  993 GFLKEGCELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALY 1072
Cdd:NF040586   619 GRLEEALELAEDTYERYRRRFGPDHPDTLAAALSLANDLRALGDADEARELAREVLDRYRRVLGEDHPFTLACRNNLAVL 698

                           90       100       110
                   ....*....|....*....|....*....|
gi 2217310928 1073 CFASSQLSTALSLLYRARYLMLLVFGEDHP 1102
Cdd:NF040586   699 LRALGDPEEARELAEAALEGLRERLGPDHP 728
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1023-1214 3.23e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.92  E-value: 3.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1023 CLRLLARLHYIMGDYAEALSNQQKAVLMservmgteHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLmllvfgedHP 1102
Cdd:COG0457     10 AYNNLGLAYRRLGRYEEAIEDYEKALEL--------DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL--------DP 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1103 EMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYhgPKAL-KVALSHHLVARVYESKAEFRSALQHEKEGYTIYKTqL 1181
Cdd:COG0457     74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDD--AEALyNLGLALLELGRYDEAIEAYERALELDPDDADALYN-L 150

                          170       180       190
                   ....*....|....*....|....*....|...
gi 2217310928 1182 GEDHEKTKESSEYLKCLTQQAVALQRTMNEIYR 1214
Cdd:COG0457    151 GIALEKLGRYEEALELLEKLEAAALAALLAAAL 183
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
986-1169 3.90e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.54  E-value: 3.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  986 GQAKVQQGFLKEGCELINEALNLFNNVYGAmhvetcacLRLLARLHYIMGDYAEALSNQQKAVLMservmgteHPNTIQE 1065
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDDAEA--------LYNLGLAYLRLGRYEEALADYEQALEL--------DPDDAEA 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1066 YMHLALYCFASSQLSTALSLLYRARYLmllvfgedHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYhgpkalk 1145
Cdd:COG0457     79 LNNLGLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDD------- 143

                          170       180
                   ....*....|....*....|....
gi 2217310928 1146 vALSHHLVARVYESKAEFRSALQH 1169
Cdd:COG0457    144 -ADALYNLGIALEKLGRYEEALEL 166
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 993-1133 4.88e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 47.99  E-value: 4.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  993 GFLKEGCELINEALNLFNNVY-GAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLAL 1071
Cdd:NF040586   576 GRYAEALDLLEEALERYREVLgGPDHPDTLRAAKSLAVALRRAGRLEEALELAEDTYERYRRRFGPDHPDTLAAALSLAN 655

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217310928 1072 YCFASSQLSTALSLLYRA--RYLmlLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALA 1133
Cdd:NF040586   656 DLRALGDADEARELAREVldRYR--RVLGEDHPFTLACRNNLAVLLRALGDPEEARELAEAALE 717
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 974-1170 5.24e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.68  E-value: 5.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  974 PKASDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAmhvetcacLRLLARLHYIMGDYAEALSNQQKAVLMser 1053
Cdd:COG3914     73 ALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEA--------LFNLGNLLLALGRLEEALAALRRALAL--- 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1054 vmgteHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLmllvfgedHPEMALLDNNIGLVLHGVMEYDLSLRFLENALA 1133
Cdd:COG3914    142 -----NPDFAEAYLNLGEALRRLGRLEEAIAALRRALEL--------DPDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 2217310928 1134 VStkyhgPKALKvALSHHLVARVYESKAEFRSALQHE 1170
Cdd:COG3914    209 LD-----PDNAD-AHSNLLFALRQACDWEVYDRFEEL 239
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 950-1185 6.56e-05

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 47.61  E-value: 6.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  950 DSRHKPAFTEedvlnifpVVKHVNPkaSDAFHffqSGQAKVQQ------------GFLKEGCELINEALNLFNNVYGAMH 1017
Cdd:NF040586   364 DPRNWPRYAE--------LWPHLEP--SGALE---SDDPEVRRllldqvrylylrGDYESARDLAERALERWRERLGPDD 430

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1018 VETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVM--GTEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLMLL 1095
Cdd:NF040586   431 RQTLRLRFHLANALRSLGRYEEARELDEDTLERQRRVLglGEDHPHTLMTAGGLGADLRALGRFREALELDEETLERHRR 510

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928 1096 VFGEDHPE--MALldNNIGLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALSHHLVARVYESKAEFRSALQHEKEG 1173
Cdd:NF040586   511 VFGEDHPRtlRAA--NNLAVSLRLLGDYREALELDREVLRRRRRVLGPDHPRTLLSANNLARDLRELGRYAEALDLLEEA 588

                          250
                   ....*....|...
gi 2217310928 1174 YTIYKTQL-GEDH 1185
Cdd:NF040586   589 LERYREVLgGPDH 601
TPR_12 pfam13424
Tetratricopeptide repeat;
1066-1137 1.64e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.22  E-value: 1.64e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217310928 1066 YMHLALYCFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTK 1137
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 976-1133 2.11e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 2.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217310928  976 ASDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAmhvetcacLRLLARLHYIMGDYAEALSNQQKAVLMservm 1055
Cdd:COG4783      1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEA--------FALLGEILLQLGDLDEAIVLLHEALEL----- 67

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217310928 1056 gteHPNTIQEYMHLALYCFASSQLSTALSLLYRARylmllvfgEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALA 1133
Cdd:COG4783     68 ---DPDEPEARLNLGLALLKAGDYDEALALLEKAL--------KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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