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Conserved domains on  [gi|2217297813|ref|XP_047287473|]
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serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP2R3C cd21505
serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric ...
 56-280 1.97e-146

serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This subfamily includes protein phosphatase subunit G5PR (also known as serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, G4-1, G5pr, GDRM, SPGF36, or C14orf10) that is encoded by the PPP2R3C gene. It is involved in the control of the dynamic organization of the cortical cytoskeleton and plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. G5PR is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans, and thus is emerging as a potential therapeutic target for male infertility.


:

Pssm-ID: 410338 [Multi-domain]  Cd Length: 382  Bit Score: 415.43  E-value: 1.97e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297813  56 IPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCK 135
Cdd:cd21505     1 IPRFYFKKPSESSVLLQKLREEARARFLQRKSSELLDNDELQELWYLLLEHHVPPDSGEEERINYEDFLKVREEAGPKCR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297813 136 QFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFY 215
Cdd:cd21505    81 PFFTPSVFLKLLRDDPYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVDGDGFLTESDLENYILELIPTLPQLSGLEESFY 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217297813 216 SFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYG 280
Cdd:cd21505   161 SFYVCTAVRKFFFFLDPLRRGKIRIKDILASPFLDELLELRDEELSEELQESNWFSAPSALRVYG 225
 
Name Accession Description Interval E-value
PPP2R3C cd21505
serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric ...
 56-280 1.97e-146

serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This subfamily includes protein phosphatase subunit G5PR (also known as serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, G4-1, G5pr, GDRM, SPGF36, or C14orf10) that is encoded by the PPP2R3C gene. It is involved in the control of the dynamic organization of the cortical cytoskeleton and plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. G5PR is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans, and thus is emerging as a potential therapeutic target for male infertility.


Pssm-ID: 410338 [Multi-domain]  Cd Length: 382  Bit Score: 415.43  E-value: 1.97e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297813  56 IPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCK 135
Cdd:cd21505     1 IPRFYFKKPSESSVLLQKLREEARARFLQRKSSELLDNDELQELWYLLLEHHVPPDSGEEERINYEDFLKVREEAGPKCR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297813 136 QFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFY 215
Cdd:cd21505    81 PFFTPSVFLKLLRDDPYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVDGDGFLTESDLENYILELIPTLPQLSGLEESFY 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217297813 216 SFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYG 280
Cdd:cd21505   161 SFYVCTAVRKFFFFLDPLRRGKIRIKDILASPFLDELLELRDEELSEELQESNWFSAPSALRVYG 225
EF-hand_13 pfam17958
EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B ...
 184-258 3.12e-04

EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B subunits of PP2A.


Pssm-ID: 465586 [Multi-domain]  Cd Length: 90  Bit Score: 38.88  E-value: 3.12e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217297813 184 GQGYLRESDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDE 258
Cdd:pfam17958  14 GKNYLSREDFYPFVQDVVDTHPGLEFLREAeeFQDKYIQTVIARIFYVVNRSWSGKITLLELRKSDLLKAVRQLDEE 90
 
Name Accession Description Interval E-value
PPP2R3C cd21505
serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric ...
 56-280 1.97e-146

serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This subfamily includes protein phosphatase subunit G5PR (also known as serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, G4-1, G5pr, GDRM, SPGF36, or C14orf10) that is encoded by the PPP2R3C gene. It is involved in the control of the dynamic organization of the cortical cytoskeleton and plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. G5PR is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans, and thus is emerging as a potential therapeutic target for male infertility.


Pssm-ID: 410338 [Multi-domain]  Cd Length: 382  Bit Score: 415.43  E-value: 1.97e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297813  56 IPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCK 135
Cdd:cd21505     1 IPRFYFKKPSESSVLLQKLREEARARFLQRKSSELLDNDELQELWYLLLEHHVPPDSGEEERINYEDFLKVREEAGPKCR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297813 136 QFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFY 215
Cdd:cd21505    81 PFFTPSVFLKLLRDDPYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVDGDGFLTESDLENYILELIPTLPQLSGLEESFY 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217297813 216 SFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYG 280
Cdd:cd21505   161 SFYVCTAVRKFFFFLDPLRRGKIRIKDILASPFLDELLELRDEELSEELQESNWFSAPSALRVYG 225
PPP2R3 cd21339
serine/threonine protein phosphatase 2A regulatory subunit B"; Heterotrimeric serine/threonine ...
 171-280 2.38e-48

serine/threonine protein phosphatase 2A regulatory subunit B"; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This family includes PP2A regulatory B'' subunits alpha, beta and gamma, encoded by PPP2R3A, PPP2R3B and PPP2R3C, respectively. It also includes subunit delta encoded by PPP2R3D in mouse. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. Subunits alpha and beta contain two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


Pssm-ID: 410336  Cd Length: 259  Bit Score: 161.21  E-value: 2.38e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297813 171 HQTRIGLSLYDvAGQGYLRESDLENYILELIPTLPQLDGLEK--SFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSF 248
Cdd:cd21339     1 DATKFGLLLYD-PGCGYLRQEDFEPYLQDVVPTHPGLDFLKKapEFHSRYITTVIQRIFYFVNRSWSGKITIQEIRASSF 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2217297813 249 LDDLLELRDEELSKesQETNWFSAPSALRVYG 280
Cdd:cd21339    80 LQDLALLEEEEDIN--QETNWFSYEHFYVIYC 109
EF-hand_13 pfam17958
EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B ...
 184-258 3.12e-04

EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B subunits of PP2A.


Pssm-ID: 465586 [Multi-domain]  Cd Length: 90  Bit Score: 38.88  E-value: 3.12e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217297813 184 GQGYLRESDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDE 258
Cdd:pfam17958  14 GKNYLSREDFYPFVQDVVDTHPGLEFLREAeeFQDKYIQTVIARIFYVVNRSWSGKITLLELRKSDLLKAVRQLDEE 90
PPP2R3A cd21506
serine/threonine protein phosphatase 2A regulatory subunit B" subunit alpha; Heterotrimeric ...
 184-279 1.64e-03

serine/threonine protein phosphatase 2A regulatory subunit B" subunit alpha; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR130 (also known as protein phosphatase 2A regulatory subunit B'' subunit alpha, PR72, or PPP2R3) that is encoded by the PPP2R3A gene. PR130 and PR72 subunits are derived from the same gene through differential splicing; they harbor specific N-terminal domains of different lengths that are encoded by alternatively spliced exons and have identical C-termini. The common C-terminus contains a two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity. The PR130 subunit has been shown to interact with the LIM domain of lipoma-preferred partner (LPP) through a conserved Zn2+-finger-like motif in the N-terminus of PR130.


Pssm-ID: 410339  Cd Length: 284  Bit Score: 39.15  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297813 184 GQGYLRESDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEEls 261
Cdd:cd21506    23 NCSYLEQEDFIPLLQDIVDTHPGLTFLKDApeFHSRYITTVIQRIFYTVNRSWSGKITLTELRKSNFLQTLALLEEED-- 100

                          90
                  ....*....|....*...
gi 2217297813 262 KESQETNWFSAPSALRVY 279
Cdd:cd21506   101 DINQITDYFSYEHFYVIY 118
PPP2R3B cd21507
serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric ...
 177-271 5.17e-03

serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR70 (also known as protein phosphatase 2 regulatory subunit B'' subunit beta, PR48, NYREN8, PPP2R3L, or PPP2R3LY) that is encoded by the PPP2R3B gene. This substrate-recognizing subunit of PP2A has a two-domain elongated structure with two calcium EF-hands, each displaying different affinities to Ca2+. PPP2R3B/PR70 is a gonosomal melanoma tumor suppressor gene; PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing the cell division cycle 6 (CDC6)-chromatin licensing and DNA replication factor 1 (CDT1) interaction, which delays the firing of origins of DNA replication.


Pssm-ID: 410340  Cd Length: 355  Bit Score: 38.01  E-value: 5.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297813 177 LSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKS--FYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLE 254
Cdd:cd21507    90 VHLLMKPGCNYLVQEDFIPFLQDVVNTHPGLSFLKEAseFHSRYITTVIQRIFYTVNRSWSGRITCTELRRSSFLQNVAL 169

                          90
                  ....*....|....*..
gi 2217297813 255 LRDEElsKESQETNWFS 271
Cdd:cd21507   170 LEEEA--DINQLTEFFS 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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