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Conserved domains on  [gi|2217269770|ref|XP_047282888|]
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leucine-rich repeat-containing G-protein coupled receptor 6 isoform X10 [Homo sapiens]

Protein Classification

LRR and 7tmA_LGR6 domain-containing protein( domain architecture ID 11469450)

LRR and 7tmA_LGR6 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 399-671 3.73e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


:

Pssm-ID: 320484  Cd Length: 276  Bit Score: 478.90  E-value: 3.73e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 399 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 478
Cdd:cd15362     1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 479 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 558
Cdd:cd15362    80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 559 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 638
Cdd:cd15362   160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2217269770 639 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd15362   240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-294 3.15e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  46 LRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNqlggipaEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGF 125
Cdd:COG4886    71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 126 HNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVGrSAFQYLPKLHTLSLNGAmDIQEFPD-LKGTTSLEILTLTRAGIRLL 204
Cdd:COG4886   144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN-QITDLPEpLGNLTNLEELDLSGNQLTDL 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 205 PSGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIgaDTFSQLSSLQALDLTDNQLTTLPLAGLGGLMH 284
Cdd:COG4886   221 PEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLG 297

                         250
                  ....*....|
gi 2217269770 285 LKLKGNLALS 294
Cdd:COG4886   298 LNSLLLLLLL 307
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 399-671 3.73e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 478.90  E-value: 3.73e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 399 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 478
Cdd:cd15362     1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 479 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 558
Cdd:cd15362    80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 559 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 638
Cdd:cd15362   160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2217269770 639 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd15362   240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-294 3.15e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  46 LRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNqlggipaEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGF 125
Cdd:COG4886    71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 126 HNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVGrSAFQYLPKLHTLSLNGAmDIQEFPD-LKGTTSLEILTLTRAGIRLL 204
Cdd:COG4886   144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN-QITDLPEpLGNLTNLEELDLSGNQLTDL 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 205 PSGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIgaDTFSQLSSLQALDLTDNQLTTLPLAGLGGLMH 284
Cdd:COG4886   221 PEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLG 297

                         250
                  ....*....|
gi 2217269770 285 LKLKGNLALS 294
Cdd:COG4886   298 LNSLLLLLLL 307
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-297 4.36e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 82.97  E-value: 4.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEaLWELPSLQSLDLNYNK 106
Cdd:PLN00113  290 DLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPV-ALTSLPRLQVLQLWSNKFsGEIPKN-LGKHNNLTVLDLSTNN 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 107 LQ-------------------------EFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA 161
Cdd:PLN00113  368 LTgeipeglcssgnlfklilfsnslegEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSR 447

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 162 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELPS-LHRCQKLE 238
Cdd:PLN00113  448 KWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKL-GSLSELMQLKLSENKLSgEIPDeLSSCKKLV 526

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217269770 239 EIGLQHNRIWEIGADTFSQLSSLQALDLTDNQLTTLPLAGLGG--------LMHLKLKGNLALSQAF 297
Cdd:PLN00113  527 SLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNveslvqvnISHNHLHGSLPSTGAF 593
LRR_8 pfam13855
Leucine rich repeat;
49-107 3.82e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.25  E-value: 3.82e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217269770  49 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKL 107
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 167-310 1.07e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.19  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 167 KLHTLSLNGaMDIQEFPDLKGTTSLEILTLTRAGIRLLPSgmCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR 246
Cdd:cd21340     3 RITHLYLND-KNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 247 IWEI-GADTFSQLS---------------------------SLQALDLTDNQLTTL-PLAGLGGLMHLKLKGNL-----A 292
Cdd:cd21340    80 ISVVeGLENLTNLEelhienqrlppgekltfdprslaalsnSLRVLNISGNNIDSLePLAPLRNLEQLDASNNQisdleE 159

                         170
                  ....*....|....*...
gi 2217269770 293 LSQAFSkdSFPKLRILEV 310
Cdd:cd21340   160 LLDLLS--SWPSLRELDL 175
LRR smart00370
Leucine-rich repeats, outliers;
46-69 6.23e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.23e-03
                           10        20
                   ....*....|....*....|....
gi 2217269770   46 LRFLEELRLSGNHLSHIPGQAFSG 69
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 399-671 3.73e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 478.90  E-value: 3.73e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 399 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 478
Cdd:cd15362     1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 479 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 558
Cdd:cd15362    80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 559 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 638
Cdd:cd15362   160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2217269770 639 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd15362   240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
 399-671 2.53e-147

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 433.13  E-value: 2.53e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 399 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPlPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 478
Cdd:cd15138     1 WMIRLTVWFIFLLALFCNLLVILTVFASCTSL-PPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 479 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 558
Cdd:cd15138    80 CKVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 559 PpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 638
Cdd:cd15138   160 T--GEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLI 237

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2217269770 639 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd15138   238 SISPEIMKSVLLVVFPLPACLNPLLYVLFNPHF 270
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 399-671 1.27e-96

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 302.15  E-value: 1.27e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 399 WGIRLAVWAIVLLSVLCNGLVLLTVFAGgPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 478
Cdd:cd15363     1 WLIRIGVWTIAVLALVCNALVTATVFRS-PLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 479 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 558
Cdd:cd15363    80 CQITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPL- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 559 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 638
Cdd:cd15363   159 -PFGEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLT 237

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2217269770 639 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd15363   238 FISPEVIKFILLVIVPLPACLNPLLYILFNPHF 270
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 399-671 2.24e-76

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 248.62  E-value: 2.24e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 399 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGpVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 478
Cdd:cd15361     1 WMIRLTVWFIFLVALFFNLLVILTTFASC-TSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 479 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 558
Cdd:cd15361    80 CKVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPF- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 559 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 638
Cdd:cd15361   159 -PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 237

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2217269770 639 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd15361   238 SISPEIMKSVTLIFFPLPACLNPVLYVFFNPKF 270
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
 399-671 2.25e-39

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 147.39  E-value: 2.25e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 399 WGIRLAVWAIVLLSVLCNGLVLLTVF----AGGPVPlppvKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWE 474
Cdd:cd14980     1 ISLRIFIWIIGILALIGNILVIIWHIsskkKKKKVP----KLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 475 TGLGCRATGFLAVLGSEASVLLLTLAAVQ----CSVSVSCVRAYGKSP--------SLGSVRAGVLGCLalaglaaalpl 542
Cdd:cd14980    77 RSPPCLLACFLVSLSSLMSVLMMLLITLDryicIVYPFSNKRLSYKSAkiililgwLFSIIFAAIPILY----------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 543 aSVGE------YGASPLCLPYAPpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-----WDCAMVRH 611
Cdd:cd14980   146 -SINQpgdnrlYGYSSICMPSNV--SNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSARrssskRDKRIAIR 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 612 VAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd14980   223 LALILITDLICWLPYYIVIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTF 282
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
 399-671 2.48e-36

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 138.12  E-value: 2.48e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 399 WGIRLAVWAIVLLSVLCNG---LVLLTVFAGGPVPlppvKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWET 475
Cdd:cd15136     1 WWLRIGVWFVFLLALVGNIivlLVLLTSRTKLTVP----RFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 476 GLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCL 555
Cdd:cd15136    77 GAGCKTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 556 PYAppEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW-DCAMVRHVAWLIFADGLLYCPVAFLSFASM 634
Cdd:cd15136   157 PFE--TETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSnDTRIAKRMALLVFTDFLCWAPIAFFGLTAA 234

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2217269770 635 LGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd15136   235 FGLPLISVSNAKILLVFFYPLNSCANPFLYAIFTKQF 271
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-294 3.15e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.83  E-value: 3.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  46 LRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNqlggipaEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGF 125
Cdd:COG4886    71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 126 HNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVGrSAFQYLPKLHTLSLNGAmDIQEFPD-LKGTTSLEILTLTRAGIRLL 204
Cdd:COG4886   144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN-QITDLPEpLGNLTNLEELDLSGNQLTDL 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 205 PSGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIgaDTFSQLSSLQALDLTDNQLTTLPLAGLGGLMH 284
Cdd:COG4886   221 PEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLG 297

                         250
                  ....*....|
gi 2217269770 285 LKLKGNLALS 294
Cdd:COG4886   298 LNSLLLLLLL 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-282 1.57e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 119.27  E-value: 1.57e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  29 DLSMNNLTELqPGLFHHLRFLEELRLSGNHLSHIPgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLDLNYNKLQ 108
Cdd:COG4886   119 DLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQIT 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 109 EFPVAIRTLGRLQELGFHNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVgrSAFQYLPKLHTLSLNGaMDIQEFPDLKGT 188
Cdd:COG4886   196 DLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSN-NQLTDLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 189 TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLTD 268
Cdd:COG4886   272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250
                  ....*....|....
gi 2217269770 269 NQLTTLPLAGLGGL 282
Cdd:COG4886   352 LLLLLNLLSLLLTL 365
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
 401-671 3.10e-26

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 109.22  E-value: 3.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 401 IRLAVWAIVLLSVLCNGLVLLTVFAGGpVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 480
Cdd:cd15964     3 LRIVVWFVNLLAILGNVFVLLILLTSH-YKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 481 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 560
Cdd:cd15964    82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 561 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEA-VWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 639
Cdd:cd15964   162 --TPLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYKSgDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPL 239

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2217269770 640 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd15964   240 ITVSNSKILLVLFYPLNSCANPFLYAIFTKAF 271
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
 401-671 3.24e-23

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 100.32  E-value: 3.24e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 401 IRLAVWAIVLLSVLCNgLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 480
Cdd:cd15360     3 LRVLIWFINILAITGN-IVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGCA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 481 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 560
Cdd:cd15360    82 AAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 561 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 639
Cdd:cd15360   162 --SPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFvSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPL 239

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2217269770 640 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd15360   240 ITVSKSKILLVLFYPINSCANPFLYAIFTKTF 271
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
 401-671 1.86e-21

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 94.93  E-value: 1.86e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 401 IRLAVWAIVLLSVLCNGLVLLtVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 480
Cdd:cd15359     3 LRVLIWFINILAIAGNLIVLF-VLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 481 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 560
Cdd:cd15359    82 TAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 561 EGQPAAlgFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-WDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 639
Cdd:cd15359   162 TLLSQA--YILLILVLNVIAFLVICACYIKIYLAVQNPELVAKnKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPL 239

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2217269770 640 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd15359   240 ITVTNSKILLVLFYPINSCANPFLYAIFTKAF 271
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 401-671 1.30e-19

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 89.95  E-value: 1.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 401 IRLAVWAIVLLSVLCNGLVL---LTVFAGGPVPLppvkFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL 477
Cdd:cd15137     3 LRVFIWVVGIIALLGNLFVLiwrLKYKEENKVHS----FLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 478 GCRATGFLAVLGSEASVLLLTLAAVQ---CSVS-VSCVRAygKSPSLGSVRAGVLGCLALAGLAAALPLASVGE-YGASP 552
Cdd:cd15137    79 LCTFAGFLATLSSEVSVLILTLITLDrfiCIVFpFSGRRL--GLRRAIIVLACIWLIGLLLAVLPLLPWDYFGNfYGRSG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 553 LCLPYAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLPR-----GDFEAVWDCAMVRHVAWLIFADGLLYCPV 626
Cdd:cd15137   157 VCLPLHITDERPAGWEYSVFVFLgLNFLAFVFILLSYIAMFISIRRtrkaaASRKSKRDMAVAKRFFLIVLTDFLCWIPI 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2217269770 627 AFLSFASMLGlFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 671
Cdd:cd15137   237 IVIGILALSG-VPIPGEVYAWVAVFVLPINSALNPILYTLSTPKF 280
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-297 4.36e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 82.97  E-value: 4.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEaLWELPSLQSLDLNYNK 106
Cdd:PLN00113  290 DLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPV-ALTSLPRLQVLQLWSNKFsGEIPKN-LGKHNNLTVLDLSTNN 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 107 LQ-------------------------EFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA 161
Cdd:PLN00113  368 LTgeipeglcssgnlfklilfsnslegEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSR 447

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 162 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELPS-LHRCQKLE 238
Cdd:PLN00113  448 KWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKL-GSLSELMQLKLSENKLSgEIPDeLSSCKKLV 526

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217269770 239 EIGLQHNRIWEIGADTFSQLSSLQALDLTDNQLTTLPLAGLGG--------LMHLKLKGNLALSQAF 297
Cdd:PLN00113  527 SLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNveslvqvnISHNHLHGSLPSTGAF 593
LRR_8 pfam13855
Leucine rich repeat;
49-107 3.82e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.25  E-value: 3.82e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217269770  49 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKL 107
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 167-310 1.07e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.19  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 167 KLHTLSLNGaMDIQEFPDLKGTTSLEILTLTRAGIRLLPSgmCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR 246
Cdd:cd21340     3 RITHLYLND-KNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 247 IWEI-GADTFSQLS---------------------------SLQALDLTDNQLTTL-PLAGLGGLMHLKLKGNL-----A 292
Cdd:cd21340    80 ISVVeGLENLTNLEelhienqrlppgekltfdprslaalsnSLRVLNISGNNIDSLePLAPLRNLEQLDASNNQisdleE 159

                         170
                  ....*....|....*...
gi 2217269770 293 LSQAFSkdSFPKLRILEV 310
Cdd:cd21340   160 LLDLLS--SWPSLRELDL 175
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 30-275 3.35e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 3.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  30 LSMN--NLTELqpGLFHHLRFLEELRLSGNHLSHIPGqaFSGLYSLKILMLQNNQLGGIpaEALWELPSLQSLDLNYNKl 107
Cdd:cd21340     7 LYLNdkNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 108 qefpvaIRTLGRLQELgfhnnnikaipekafmgnPLLQTIHFyDNpiqfvgrsafQYLPKlhtlslngamdiqefpdlkg 187
Cdd:cd21340    80 ------ISVVEGLENL------------------TNLEELHI-EN----------QRLPP-------------------- 104

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 188 TTSLEILTLTRAGIRllpsgmcqqlPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIG--ADTFSQLSSLQALD 265
Cdd:cd21340   105 GEKLTFDPRSLAALS----------NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELD 174

                         250
                  ....*....|
gi 2217269770 266 LTDNQLTTLP 275
Cdd:cd21340   175 LTGNPVCKKP 184
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
 444-671 1.11e-10

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 63.27  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 444 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV----SCVRAyGKSPS 519
Cdd:cd15966    45 ADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQCRIIGFLAMLSTEVSVLLLTYLTLEKYLVIvfpfSNIRP-GKCQT 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 520 LgSVRAGVLGCLALAGLAAALPLASVGE-YGASPLCLP-YAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLP 596
Cdd:cd15966   124 L-IILISIWLVGFIIAVIPFWNEDFFGNyYGKNGVCFPlHSDQTEKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQ 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 597 RGDFEAV-------WDCAMVRHVAWLIFADGLLYCPVAFLsfaSMLGLFPV-TPEAVKS-VLLVVLPLPACLNPLLYLLF 667
Cdd:cd15966   203 KTGLQTTevrshihRDVAVANRFFFIVFSDAICWIPIFLL---KILSLFQVeIPGTITSwIVIFILPINSALNPILYTLT 279


                  ....
gi 2217269770 668 NPHF 671
Cdd:cd15966   280 TSFF 283
LRR_8 pfam13855
Leucine rich repeat;
29-83 5.03e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 5.03e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217269770  29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 83
Cdd:pfam13855   7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-272 5.72e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 5.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  29 DLSMNNLTELQPGLFhhLRFLEELRLSGNHLS-------------------------HIPGqAFSGLYSLKILMLQNNQL 83
Cdd:PLN00113  124 NLSNNNFTGSIPRGS--IPNLETLDLSNNMLSgeipndigsfsslkvldlggnvlvgKIPN-SLTNLTSLEFLTLASNQL 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  84 -GGIPAE-----------------------ALWELPSLQSLDLNYNKLQ-EFPVAIRTLGRLQELGFHNNNIKA-IPEKA 137
Cdd:PLN00113  201 vGQIPRElgqmkslkwiylgynnlsgeipyEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGpIPPSI 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 138 FMGNPL-----------------------LQTIHFYDNpiQFVGR--SAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSL 191
Cdd:PLN00113  281 FSLQKLisldlsdnslsgeipelviqlqnLEILHLFSN--NFTGKipVALTSLPRLQVLQLWSNKFSGEIPkNLGKHNNL 358

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 192 EILTLTRAGIR-LLPSGMCQQlPRLRVLELSHNQIE-ELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLTD 268
Cdd:PLN00113  359 TVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSNSLEgEIPkSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISN 437


                  ....
gi 2217269770 269 NQLT 272
Cdd:PLN00113  438 NNLQ 441
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
8-275 7.90e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.41  E-value: 7.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770   8 RSARAGQNLSRAGSARRgaPRDLSMNNLTEL---QPGLFHHLRFLEE----LRLSGNHLSHIPgQAFSGlySLKILMLQN 80
Cdd:PRK15370  155 KEAPAKEAANREEAVQR--MRDCLKNNKTELrlkILGLTTIPACIPEqittLILDNNELKSLP-ENLQG--NIKTLYANS 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  81 NQLGGIPAEalweLP-SLQSLDLNYNKLQEFPVaiRTLGRLQELGFHNNNIKAIPEKAFMGnplLQTIHFYDNPIQ---- 155
Cdd:PRK15370  230 NQLTSIPAT----LPdTIQEMELSINRITELPE--RLPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRtlpa 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 156 ---------FVGRSAFQYLPKlhTLSLNgamdiqefpdlkgttsLEILTLTRAGIRLLPSGMCqqlPRLRVLELSHNQIE 226
Cdd:PRK15370  301 hlpsgithlNVQSNSLTALPE--TLPPG----------------LKTLEAGENALTSLPASLP---PELQVLDVSKNQIT 359

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2217269770 227 ELPSLHRcQKLEEIGLQHNRIWEIGADTFSQLSSLQAldlTDNQLTTLP 275
Cdd:PRK15370  360 VLPETLP-PTITTLDVSRNALTNLPENLPAALQIMQA---SRNNLVRLP 404
LRR_8 pfam13855
Leucine rich repeat;
235-291 1.58e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.58e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 235 QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLTDNQLTTLP---LAGLGGLMHLKLKGNL 291
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNR 60
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 29-253 1.65e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.06  E-value: 1.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  29 DLSMNNLTELQ-PGLF---HHLRFLEELRLSGNHLSHIP------GQAFSGLYSLKILMLQNNQLGGIPA---EALWELP 95
Cdd:cd00116    29 RLEGNTLGEEAaKALAsalRPQPSLKELCLSLNETGRIPrglqslLQGLTKGCGLQELDLSDNALGPDGCgvlESLLRSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  96 SLQSLDLNYNKLQEFPVAI--RTLG----RLQELGFHNNNIKAIP----EKAFMGNPLLQTIHFYDNPIQFVG-RSAFQY 164
Cdd:cd00116   109 SLQELKLNNNGLGDRGLRLlaKGLKdlppALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGiRALAEG 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 165 LP---KLHTLSLN-------GAMDIQE-FPDLKgttSLEILTL-----TRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 228
Cdd:cd00116   189 LKancNLEVLDLNnngltdeGASALAEtLASLK---SLEVLNLgdnnlTDAGAAALASALLSPNISLLTLSLSCNDITDD 265

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2217269770 229 PSLHRCQ------KLEEIGLQHNRIWEIGAD 253
Cdd:cd00116   266 GAKDLAEvlaekeSLLELDLRGNKFGEEGAQ 296
LRR_8 pfam13855
Leucine rich repeat;
213-271 6.04e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 6.04e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217269770 213 PRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLTDNQL 271
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-272 1.26e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.71  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPgQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQ 108
Cdd:PLN00113  219 LGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIP-SSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 109 -EFPVAIRTLGRLQELG-FHNNNIKAIPEkAFMGNPLLQTIHFYDN------PIQFVGRSAFQYLpKLHTLSLNG----- 175
Cdd:PLN00113  298 gEIPELVIQLQNLEILHlFSNNFTGKIPV-ALTSLPRLQVLQLWSNkfsgeiPKNLGKHNNLTVL-DLSTNNLTGeipeg 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 176 ---------------AMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMCQ-----------------------QLPRLR 216
Cdd:PLN00113  376 lcssgnlfklilfsnSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKlplvyfldisnnnlqgrinsrkwDMPSLQ 455

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217269770 217 VLELSHNQIE-ELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLTDNQLT 272
Cdd:PLN00113  456 MLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS 512
LRR_8 pfam13855
Leucine rich repeat;
72-130 1.08e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.08e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  72 SLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNI 130
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 29-272 2.78e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 53.64  E-value: 2.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  29 DLSMNNLTELQPGLFHHLRFLEEL-------------RLSGNHLSHIPGQAFSGLY-----SLKILMLQNNQLGGIPAEA 90
Cdd:COG5238   120 RRIMAKTLEDSLILYLALPRRINLiqvlkdplggnavHLLGLAARLGLLAAISMAKalqnnSVETVYLGCNQIGDEGIEE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  91 LWEL----PSLQSLDLNYNK-----LQEFPVAIRTLGRLQELGFHNNNIK-----AIPEkAFMGNPLLQTIHFYDNPIQF 156
Cdd:COG5238   200 LAEAltqnTTVTTLWLKRNPigdegAEILAEALKGNKSLTTLDLSNNQIGdegviALAE-ALKNNTTVETLYLSGNQIGA 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 157 VG----RSAFQYLPKLHTLSLN-------GAMDIQEfpDLKGTTSLEILTLTRAGIRllPSGM------CQQLPRLRVLE 219
Cdd:COG5238   279 EGaialAKALQGNTTLTSLDLSvnrigdeGAIALAE--GLQGNKTLHTLNLAYNGIG--AQGAialakaLQENTTLHSLD 354

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217269770 220 LSHNQI-----EEL-PSLHRCQKLEEIGLQHNRIWEIGADTF---SQLSSLQALDLTDNQLT 272
Cdd:COG5238   355 LSDNQIgdegaIALaKYLEGNTTLRELNLGKNNIGKQGAEALidaLQTNRLHTLILDGNLIG 416
LRR_8 pfam13855
Leucine rich repeat;
119-175 5.53e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 5.53e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217269770 119 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 175
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
 444-666 6.00e-07

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 51.79  E-value: 6.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 444 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQ---CSV-SVSCVRAyGKSPS 519
Cdd:cd15965    45 ADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQCQLVGSLAILSTEVSVLLLTYLTLEkyiCIVyPFRCLTP-GKCRT 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 520 LGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY--APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR 597
Cdd:cd15965   124 ITILILIWIIGFIIAFIPLSNKEFFRNYYGTNGVCFPLhsEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQ 203

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217269770 598 GDFEAVW-------DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLfpVTPEAVKS-VLLVVLPLPACLNPLLYLL 666
Cdd:cd15965   204 TAIMATEisnhikkEMTLAKRFFFIVFTDALCWIPIFILKLLSLLQV--EIPGTISSwVVIFILPINSALNPILYTL 278
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 88-279 8.66e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 8.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  88 AEALWELPSLQSLDLNYNKLQE------------FPVAIRTLGRLQELGFHNNNIKAIPEkAFMGNPLLQTIHFYDNPIQ 155
Cdd:cd00116    16 TELLPKLLCLQVLRLEGNTLGEeaakalasalrpQPSLKELCLSLNETGRIPRGLQSLLQ-GLTKGCGLQELDLSDNALG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 156 FVGRSAFQYL---PKLHTLSLN--------GAMDIQEFPDLKgtTSLEILTLTRagiRLLPSGMCQQL-------PRLRV 217
Cdd:cd00116    95 PDGCGVLESLlrsSSLQELKLNnnglgdrgLRLLAKGLKDLP--PALEKLVLGR---NRLEGASCEALakalranRDLKE 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217269770 218 LELSHNQIEE------LPSLHRCQKLEEIGLQHNRIWEIG----ADTFSQLSSLQALDLTDNQLTTLPLAGL 279
Cdd:cd00116   170 LNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDAGAAAL 241
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-310 4.15e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 4.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGQAFSGLYSLKILMLQNNQL-GGIPAEAlweLPSLQSLDLNYNK 106
Cdd:PLN00113   75 DLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGS---IPNLETLDLSNNM 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 107 LQ-EFPVAIRTLGRLQELGFHNNNIKA-IPekAFMGN-PLLQTIHFYDNpiQFVGRSAFQyLPKLHTLSLngamDIQEFP 183
Cdd:PLN00113  152 LSgEIPNDIGSFSSLKVLDLGGNVLVGkIP--NSLTNlTSLEFLTLASN--QLVGQIPRE-LGQMKSLKW----IYLGYN 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 184 DLKGTTSLEIltltragirllpsgmcQQLPRLRVLELSHNQI--EELPSLHRCQKLEEIGLQHNRIW-EIGADTFSqLSS 260
Cdd:PLN00113  223 NLSGEIPYEI----------------GGLTSLNHLDLVYNNLtgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQK 285

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217269770 261 LQALDLTDNQLTtlplaglGGLMHLKLK-GNLALSQAFSKD----------SFPKLRILEV 310
Cdd:PLN00113  286 LISLDLSDNSLS-------GEIPELVIQlQNLEILHLFSNNftgkipvaltSLPRLQVLQL 339
LRR_8 pfam13855
Leucine rich repeat;
95-154 6.36e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 6.36e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217269770  95 PSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 213-245 2.12e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.23  E-value: 2.12e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2217269770 213 PRLRVLELSHNQIEELPSLHRCQKLEEIGLQHN 245
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 29-81 6.54e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 6.54e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217269770  29 DLSMNNLTELQPglFHHLRFLEELRLSGNHLSHIP--GQAFSGLYSLKILMLQNN 81
Cdd:cd21340   126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
215-318 2.17e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 215 LRVLELSHNQIEELPSlHRCQKLEEIGLQHNRIWEIgADTFSQlsSLQALDLTDNQLTTLPLAGLGGLMHLKLKGNlalS 294
Cdd:PRK15370  243 IQEMELSINRITELPE-RLPSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---S 315

                          90       100
                  ....*....|....*....|....*.
gi 2217269770 295 QAFSKDSFP-KLRILEV-PYAYQCCP 318
Cdd:PRK15370  316 LTALPETLPpGLKTLEAgENALTSLP 341
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 407-668 3.08e-04

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 43.43  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 407 AIVLLSVLCNGLVLLTVFAGgPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQfseygarWETGLGCRATGFLA 486
Cdd:cd00637     7 LIFVVGLVGNLLVILVILRN-RRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRW-------WFGDALCKLLGFLQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 487 VLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAA 566
Cdd:cd00637    79 SVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 567 LGFTVALVMMNSF-CFLVVAGAYIKLYCDL-------------PRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFA 632
Cdd:cd00637   159 KAYTIFLFVLLFLlPLLVIIVCYVRIFRKLrrhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2217269770 633 SMLGLFPV-TPEAVKSVLLVVLPLPACLNPLLYLLFN 668
Cdd:cd00637   239 DVFGPDPSpLPRILYFLALLLAYLNSAINPIIYAFFN 275
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 73-286 1.35e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  73 LKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQ-EFPVAIRTLG-RLQELGFHNNNikaipekafmgnpllqtihfy 150
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNN--------------------- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 151 dnpiqFVGRSAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ-IEEL 228
Cdd:PLN00113  130 -----FTGSIPRGSIPNLETLDLSNNMLSGEIPnDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQlVGQI 204

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217269770 229 PS-LHRCQKLEEIGLQHNRI-----WEIGadtfsQLSSLQALDLTDNQLTTLPLAGLGGLMHLK 286
Cdd:PLN00113  205 PReLGQMKSLKWIYLGYNNLsgeipYEIG-----GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQ 263
LRR_8 pfam13855
Leucine rich repeat;
142-225 1.36e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 142 PLLQTIHFYDNPIQFVGRSAFQYLPklhtlslngamdiqefpdlkgttSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 221
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-----------------------NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 2217269770 222 HNQI 225
Cdd:pfam13855  58 GNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 72-107 1.37e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217269770  72 SLKILMLQNNQLGGIPAeaLWELPSLQSLDLNYNKL 107
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
PLN03150 PLN03150
hypothetical protein; Provisional
 48-153 1.41e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  48 FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL-GGIPAeALWELPSLQSLDLNYNKLQ-EFPVAIRTLGRLQELGF 125
Cdd:PLN03150  419 FIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIrGNIPP-SLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNL 497

                          90       100
                  ....*....|....*....|....*....
gi 2217269770 126 HNNNIKAIPEKAFMGNPLLQTI-HFYDNP 153
Cdd:PLN03150  498 NGNSLSGRVPAALGGRLLHRASfNFTDNA 526
PLN03150 PLN03150
hypothetical protein; Provisional
 30-114 1.48e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770  30 LSMNN--LTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKL 107
Cdd:PLN03150  423 LGLDNqgLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                  ....*...
gi 2217269770 108 Q-EFPVAI 114
Cdd:PLN03150  503 SgRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 166-282 1.91e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 166 PKLHTLSlnGAmDIQeFPDLKGTTSLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELP-SLHRCQKLEEIGL 242
Cdd:PLN03150  399 PQQHPWS--GA-DCQ-FDSTKGKWFIDGLGLDNQGLRgFIPNDI-SKLRHLQSINLSGNSIRgNIPpSLGSITSLEVLDL 473

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2217269770 243 QHNRIWEIGADTFSQLSSLQALDLTDNQLTTLPLAGLGGL 282
Cdd:PLN03150  474 SYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513
LRR_9 pfam14580
Leucine-rich repeat;
218-309 1.98e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.75  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217269770 218 LELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLTDNQLTTL----PLAGLGGLMHLKLKGNLAL 293
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELgdldPLASLKKLTFLSLLRNPVT 126

                          90       100
                  ....*....|....*....|
gi 2217269770 294 SQ----AFSKDSFPKLRILE 309
Cdd:pfam14580 127 NKphyrLYVIYKVPQLRLLD 146
LRR smart00370
Leucine-rich repeats, outliers;
46-69 6.23e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.23e-03
                           10        20
                   ....*....|....*....|....
gi 2217269770   46 LRFLEELRLSGNHLSHIPGQAFSG 69
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
46-69 6.23e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.23e-03
                           10        20
                   ....*....|....*....|....
gi 2217269770   46 LRFLEELRLSGNHLSHIPGQAFSG 69
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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