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Conserved domains on  [gi|2217351510|ref|XP_047271935|]
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solute carrier family 2, facilitated glucose transporter member 9 isoform X24 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 59-372 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17432:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 452  Bit Score: 530.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  59 ASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRK 138
Cdd:cd17432     1 ATLAAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 139 HTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQL 218
Cdd:cd17432    81 GTLLLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 219 LGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRS 298
Cdd:cd17432   161 LGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKG 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217351510 299 IRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSV 372
Cdd:cd17432   241 VGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCV 314
 
Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 59-372 0e+00

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 530.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  59 ASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRK 138
Cdd:cd17432     1 ATLAAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 139 HTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQL 218
Cdd:cd17432    81 GTLLLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 219 LGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRS 298
Cdd:cd17432   161 LGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKG 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217351510 299 IRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSV 372
Cdd:cd17432   241 VGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCV 314
Sugar_tr pfam00083
Sugar (and other) transporter;
57-372 2.51e-63

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 209.05  E-value: 2.51e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  57 LVASLAGafgssFLYGYNLSVVNAPTPYIKAFYNESWERRHGrpiDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLG 136
Cdd:pfam00083   3 LVAALGG-----FLFGYDTGVIGAFLTLIDFFKNFGLSKSVS---SLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 137 RKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTG 216
Cdd:pfam00083  75 RKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 217 QLLGLPELLGKEST-WPYLFGVIVVPAVVQLLSLPFLPDSPRYLLL-EKHNEARAVkaFQTFLGKADVSQEVEEVLAESR 294
Cdd:pfam00083 155 YIFGLGLNKTSNSDgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEkGRLEEAREV--LAKLRGVPDVDRELDEIKDSLE 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217351510 295 VQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKipYVTLSTGGIETLAAVFSV 372
Cdd:pfam00083 233 AGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSF--LVTIIVGVVNFVFTFIAI 308
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 57-372 5.29e-47

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 166.75  E-value: 5.29e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  57 LVASLAGafgssFLYGYNlsvvnapTPYIKAFYNE-SWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVL 135
Cdd:TIGR00879  31 LIAAIGG-----LMFGYD-------TGVIGGALALpAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRF 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 136 GRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFT 215
Cdd:TIGR00879  99 GRKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILV 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 216 GQLLGLPE-LLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYlLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESR 294
Cdd:TIGR00879 179 AYGFGSGKvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRW-LVGKGRVEEARKSLARLRGTSGEDKELLDELELID 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 295 VQRSI----RLVSVLELLR-APYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGG---IETL 366
Cdd:TIGR00879 258 IKRSIekrsVQPSWGSLFSsTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAvnfAFTF 337


                  ....*.
gi 2217351510 367 AAVFSV 372
Cdd:TIGR00879 338 VAIFLV 343
xylE PRK10077
D-xylose transporter XylE; Provisional
 57-347 3.19e-18

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 85.90  E-value: 3.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  57 LVASLAGafgssFLYGYNLSVVNAPTPYIKAFYNESwerrhgRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLG 136
Cdd:PRK10077   15 LVATLGG-----LLFGYDTAVISGTVESLNTVFVAP------QNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 137 RKHTL-LANNGFAISAalLMACSLQAGAFE----------MLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSL---G 202
Cdd:PRK10077   84 RRDSLkIAAVLFFISA--LGSAWPEFGFTSigpdntgyvpEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLvsfN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 203 QVTAIFICIGVF---TGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLeKHNEARAVKAFQTFLGK 279
Cdd:PRK10077  162 QFAIIFGQLVVYfvnYFIARSGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMS-RGKQEQAEGILRKIMGN 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 280 ADVSQEVEEVLA--ESRVQRSIRLVSvlellrapYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAG 347
Cdd:PRK10077  241 TLATQALQEIKHslDHGRKTGGKLLM--------FGVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLG 302
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 61-261 1.29e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 70.61  E-value: 1.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  61 LAGAFGSSFLYGYNLSVVNAPTPYIKAFYNeswerrhgrpidPDTLTLLWsvTVSIFAIGGLVGTLIVKMIGKVLGRKHT 140
Cdd:COG0477    16 LLALALGTFLEGLDFTIVNVALPSIAADLG------------ASSAQLGW--IVSAYLLGRAIGLLLFGRLGDRYGRKRV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 141 LLANNGFAISAALLMACslqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLG 220
Cdd:COG0477    82 LLIGLLLFGLASLLCGL---APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2217351510 221 LpeLLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLL 261
Cdd:COG0477   159 G--LLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLA 197
 
Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 59-372 0e+00

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 530.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  59 ASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRK 138
Cdd:cd17432     1 ATLAAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 139 HTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQL 218
Cdd:cd17432    81 GTLLLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 219 LGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRS 298
Cdd:cd17432   161 LGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKG 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217351510 299 IRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSV 372
Cdd:cd17432   241 VGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCV 314
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 68-372 4.19e-94

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 288.47  E-value: 4.19e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  68 SFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGF 147
Cdd:cd17431    10 SLQFGYNTGVINAPQKVIEEFYNKTLGDRYGEPISPETLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 148 AISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGK 227
Cdd:cd17431    90 AFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQIFGLEFILGT 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 228 ESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLEL 307
Cdd:cd17431   170 EELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESRQMMREKKVTILEL 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217351510 308 LRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKipYVTLSTGGIETLAAVFSV 372
Cdd:cd17431   250 FRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQPV--YATIGAGVVNTIFTVVSL 312
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 60-371 1.47e-91

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 281.84  E-value: 1.47e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  60 SLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKH 139
Cdd:cd17357     1 AVIVAFGGSFQFGYNIGVVNAPQEVFKEFINDTLVDRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 140 TLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLL 219
Cdd:cd17357    81 GLLISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 220 GLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLG-KADVSQEVEEVLAESRVQRS 298
Cdd:cd17357   161 GLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEEAEKSLKFLRGiEDDVDQELEEIKKESEQMGD 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217351510 299 IRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFS 371
Cdd:cd17357   241 QKQVSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVG 313
Sugar_tr pfam00083
Sugar (and other) transporter;
57-372 2.51e-63

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 209.05  E-value: 2.51e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  57 LVASLAGafgssFLYGYNLSVVNAPTPYIKAFYNESWERRHGrpiDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLG 136
Cdd:pfam00083   3 LVAALGG-----FLFGYDTGVIGAFLTLIDFFKNFGLSKSVS---SLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 137 RKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTG 216
Cdd:pfam00083  75 RKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 217 QLLGLPELLGKEST-WPYLFGVIVVPAVVQLLSLPFLPDSPRYLLL-EKHNEARAVkaFQTFLGKADVSQEVEEVLAESR 294
Cdd:pfam00083 155 YIFGLGLNKTSNSDgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEkGRLEEAREV--LAKLRGVPDVDRELDEIKDSLE 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217351510 295 VQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKipYVTLSTGGIETLAAVFSV 372
Cdd:pfam00083 233 AGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSF--LVTIIVGVVNFVFTFIAI 308
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 57-372 5.29e-47

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 166.75  E-value: 5.29e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  57 LVASLAGafgssFLYGYNlsvvnapTPYIKAFYNE-SWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVL 135
Cdd:TIGR00879  31 LIAAIGG-----LMFGYD-------TGVIGGALALpAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRF 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 136 GRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFT 215
Cdd:TIGR00879  99 GRKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILV 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 216 GQLLGLPE-LLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYlLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESR 294
Cdd:TIGR00879 179 AYGFGSGKvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRW-LVGKGRVEEARKSLARLRGTSGEDKELLDELELID 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 295 VQRSI----RLVSVLELLR-APYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGG---IETL 366
Cdd:TIGR00879 258 IKRSIekrsVQPSWGSLFSsTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAvnfAFTF 337


                  ....*.
gi 2217351510 367 AAVFSV 372
Cdd:TIGR00879 338 VAIFLV 343
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 110-348 1.12e-45

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 161.97  E-value: 1.12e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 110 WSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACslqAGAFEMLIVGRFIMGIDGGVALSVLPMYL 189
Cdd:cd17358    43 FSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAF---AKDVWMLYLGRFLAGFGGGAASVVVPVYI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 190 SEISPKEIRGSLGQVTAIFICIGVFTGQLLGLpeLLgkesTWPYLFGVIVVPAVVQLLSLPFLPDSPRYlLLEKHNEARA 269
Cdd:cd17358   120 AEIAPKNVRGALGSLNQLLVNIGILLGYVLGS--FL----PWRTLALIGAIPPVVFLILLFFIPESPRW-LAKKGREEEA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 270 VKAFQTFLGK-ADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGI 348
Cdd:cd17358   193 EKSLQFLRGKdADISKEAAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGS 272
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 58-260 4.45e-38

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 140.02  E-value: 4.45e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  58 VASLAGafgssFLYGYNLSVVNAPTPYIKAFYNESwerrhgrpidpdTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGR 137
Cdd:cd17315     1 VAALGG-----LLFGYDLGVINGALLYIAKDLGFG------------LSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGR 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 138 KHTLLANNGFAISAALLMAcslQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQ 217
Cdd:cd17315    64 RKSLLIAAVLYVIGALLSA---LAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAY 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2217351510 218 LLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLL 260
Cdd:cd17315   141 LLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLPESRALLV 183
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 69-372 1.14e-27

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 111.59  E-value: 1.14e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  69 FLYGYNLSVVNAPTPYIKAfyneswerrhgRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFA 148
Cdd:cd17360     7 FLFGYDTGVISGALLYIKD-----------DLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 149 ISAALLMACslqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPeLLGKE 228
Cdd:cd17360    76 TIGAIVMAA---APNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGA-FSYLP 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 229 STWPYLFGVIVVPAVVQLLSLPFLPDSPRYlllekhnearavkafqtflgkadvsqeveevlaesrvqrsirlvsvlell 308
Cdd:cd17360   152 GGWRWMLGLAAVPAVLQFIGLLFLPESPRW-------------------------------------------------- 181

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217351510 309 raPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAK----IPYVTLSTGGIETLAAVFSV 372
Cdd:cd17360   182 --PSTRRALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQnaiwLSLIVAGTNFIFTIVGMYLI 247
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 60-260 5.18e-25

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 104.57  E-value: 5.18e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  60 SLAGAFGSsFLYGYNLSVVNAPTPYIKAFYNESwerrhgrpidpdtlTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKH 139
Cdd:cd17359     3 SLVAALGG-LLFGYDTGVINGALPFLQTDFNLT--------------PFLEGLVVSSALLGAAIGALFAGRLADRFGRRK 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 140 TLLanngfaISAALLMACSLQAGAFE---MLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTG 216
Cdd:cd17359    68 TLL------ISAVLFFISALGSAFSPnftIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLA 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217351510 217 QLL------GLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLL 260
Cdd:cd17359   142 YIVnylianAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLV 191
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 58-256 9.83e-23

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 98.48  E-value: 9.83e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  58 VASLAGafgssFLYGYNLSV---VNAPTPYIKAFYNESWERRHGRPIDP------DTLTLLwsvtVSIFAIGGLVGTLIV 128
Cdd:cd17361     1 VAALGG-----LIFGYDIGIsggVTSMDPFLEKFFPSVYEKKKGASENNyckyddQLLQLF----TSSLYLAGLVASLLA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 129 KMIGKVLGRKHTLlanngFAISAALLMACSLQAGA--FEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTA 206
Cdd:cd17361    72 SYVTRKWGRKPSM-----LIGGVLFLVGAALNAAAqnIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQ 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217351510 207 IFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSP 256
Cdd:cd17361   147 LAITIGILIANLINYGTSKIKPNGWRLSLGLAAVPALILLLGSLFLPETP 196
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 115-348 1.62e-22

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 97.98  E-value: 1.62e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 115 SIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMAcslQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISP 194
Cdd:cd17434    48 SVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMG---SAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISH 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 195 KEIRGSLG---QVTAIFICIGVFTGQLLgLPellgkestWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLeKHNEARAVK 271
Cdd:cd17434   125 PGVRGALGacpQIMAVFGSLALYALGLL-LP--------WRWLAVAGEVPVVIMILLLCFMPNSPRFLIS-KGKDEKALK 194

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217351510 272 AFQTFLGK-ADVSQEVEEVlaESRVQRSIRLVSVLElLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGI 348
Cdd:cd17434   195 ALAWLRGPnTDYMTEFEQI--KDNIRKQSSRLSWAE-LKTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAV 269
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 118-346 2.99e-21

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 94.56  E-value: 2.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 118 AIGGLVGTLIVKMIGKVLGrkhTLLANNGFAISAALLMAcslqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEI 197
Cdd:cd17433    55 AAGGVLGGWIVDRAGRKLS---LMLCSVPFIAGFTVITA----AQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRV 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 198 RGSLGQVTAIFICIGVFTGQLLGLpellgkESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEaRAVKAFQtFL 277
Cdd:cd17433   128 RGTLGSCVQLMVVIGIMGAYLAGL------VLDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQ-EAMAALR-FL 199

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217351510 278 GKADVSQEVEEVLAESRVQRSIRLVSvLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKA 346
Cdd:cd17433   200 RGPDQGWEWECIGIEQSFHLEEQSFS-LALLKQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEA 267
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 56-260 1.15e-20

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 92.31  E-value: 1.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  56 LLVASLAGafgssFLYGYNlsvvnapTPYIKAFYNE-SWERRHGRPIDPDTLT-LLWSVTVSIFAIGGLVGTLIVKMIGK 133
Cdd:cd17356     3 CAFVSLGG-----FLFGYD-------TGSISGILNMkSFQKYFADNTGTYYPSsSRQGLIVSIVNLGSFFGALISSFLSD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 134 VLGRKHTLLANNGFAISAALLMACSLqaGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGV 213
Cdd:cd17356    71 RIGRKKSIQIGCVIYIIGAIIQVAAI--GKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGI 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2217351510 214 FTGQLL--GLpELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLL 260
Cdd:cd17356   149 LVAYCInyGT-HKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWLY 196
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 114-258 1.77e-18

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 85.87  E-value: 1.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 114 VSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACslqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEIS 193
Cdd:cd17362    45 VSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGL---APSYPVLLVGRLIYGVGIGLAMHAAPVYIAETS 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217351510 194 PKEIRGSLGQVTAIFICIGVFTGQLLGLPElLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRY 258
Cdd:cd17362   122 PSHIRGLLVSLKELFIVLGILLGYVSGYAF-ADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRW 185
xylE PRK10077
D-xylose transporter XylE; Provisional
 57-347 3.19e-18

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 85.90  E-value: 3.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  57 LVASLAGafgssFLYGYNLSVVNAPTPYIKAFYNESwerrhgRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLG 136
Cdd:PRK10077   15 LVATLGG-----LLFGYDTAVISGTVESLNTVFVAP------QNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 137 RKHTL-LANNGFAISAalLMACSLQAGAFE----------MLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSL---G 202
Cdd:PRK10077   84 RRDSLkIAAVLFFISA--LGSAWPEFGFTSigpdntgyvpEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLvsfN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 203 QVTAIFICIGVF---TGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLeKHNEARAVKAFQTFLGK 279
Cdd:PRK10077  162 QFAIIFGQLVVYfvnYFIARSGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMS-RGKQEQAEGILRKIMGN 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 280 ADVSQEVEEVLA--ESRVQRSIRLVSvlellrapYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAG 347
Cdd:PRK10077  241 TLATQALQEIKHslDHGRKTGGKLLM--------FGVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLG 302
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 112-258 1.10e-15

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 77.83  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 112 VTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACslqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSE 191
Cdd:cd17437    36 VLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGV---APNYPVLMVGRFVAGIGVGFALMIAPVYTAE 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217351510 192 ISPKEIRGSLGQVTAIFICIGVFTGQLL-----GLPELLGkestWPYLFGVIVVPAVVQLLSLPFLPDSPRY 258
Cdd:cd17437   113 VAPASSRGFLTSFPEIFINIGILLGYVSnyafsGLPLHVG----WRLMLGVGAVPSLFLAIGVLAMPESPRW 180
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 112-268 1.06e-14

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 74.83  E-value: 1.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 112 VTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLqagAFEMLIVGRFIMGIDGGVALSVLPMYLSE 191
Cdd:cd17435    40 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSV---SYTVLIVGRIAIGVSISLSSIATCVYIAE 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217351510 192 ISPKEIRGSLGQVTAIFICIGVFTGQLLGLPeLLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEAR 268
Cdd:cd17435   117 IAPQHRRGLLVSLNELMIVIGILLAYISNYA-FANVSNGWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMKDNMRAR 192
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 61-261 1.29e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 70.61  E-value: 1.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  61 LAGAFGSSFLYGYNLSVVNAPTPYIKAFYNeswerrhgrpidPDTLTLLWsvTVSIFAIGGLVGTLIVKMIGKVLGRKHT 140
Cdd:COG0477    16 LLALALGTFLEGLDFTIVNVALPSIAADLG------------ASSAQLGW--IVSAYLLGRAIGLLLFGRLGDRYGRKRV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 141 LLANNGFAISAALLMACslqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLG 220
Cdd:COG0477    82 LLIGLLLFGLASLLCGL---APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2217351510 221 LpeLLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLL 261
Cdd:COG0477   159 G--LLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLA 197
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
59-257 4.04e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 69.62  E-value: 4.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  59 ASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNeswerrhgrpIDPDTLTLLwsvtVSIFAIGGLVGTLIVKMIGKVLGRK 138
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALPLIAADLG----------ASPAQAGLV----VTAYLLGAALGAPLAGRLADRFGRR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 139 HTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQL 218
Cdd:COG2814    76 RVLLL--GLLLFALGSLLCAL-APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPL 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2217351510 219 LGLpeLLGKESTWPYLFGVIVVPAVVQL-LSLPFLPDSPR 257
Cdd:COG2814   153 LGG--LLADLFGWRWVFLVNAVLALLALlLLLRLLPESRP 190
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 113-257 1.66e-11

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 64.88  E-value: 1.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 113 TVSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEI 192
Cdd:cd17324    39 LVSAYALGYALGALLLGPLSDRIERRRLLLV--LLLLFILGNLLAAL-APSFALLLLARALAGLAHGGFWAIAAAYAADL 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217351510 193 SPKEIRgslGQVTAIFIcIGVFTGQLLGLP--ELLGKESTWPYLFGVI-VVPAVVQLLSLPFLPDSPR 257
Cdd:cd17324   116 VPPEKR---GRAIGLVF-SGLTLGLVLGRPlgGLLGQLLGWRAAFLAIaVLALLAALLLWRLLPSLPP 179
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 113-340 2.18e-11

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 65.04  E-value: 2.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 113 TVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGfaiSAALLMACSLQAGAFEMLIVGRFIMGI-DGGVALSVLPMYLsE 191
Cdd:TIGR00898 132 TQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTL---VTAVSGVLTAFSPNYTVFLVFRLLVGMgIGGIWVQAVVLNT-E 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 192 ISPKEIRGslgqVTAIFICIgVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEaRAVK 271
Cdd:TIGR00898 208 FLPKKQRA----IVGTLIQV-FFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIE-EALK 281

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217351510 272 AFQ---TFLGKAdVSQEV-----EEVLAESRVQRSIrlvsvLELLRAPYVRWQVVTVIvtmacyqlcglnAIWFYTN 340
Cdd:TIGR00898 282 ILQriaKINGKK-LPAEVlslslEKDLSSSKKQYSF-----LDLFRTPNLRKTTLCLM------------MLWFTTA 340
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 64-257 3.61e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 63.98  E-value: 3.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  64 AFGSSFLYGYNLSVVNAPTPYIKAFYNESwerrhgrpidpdtlTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLA 143
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLS--------------ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 144 NNGFAISAALLMACslqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPE 223
Cdd:cd06174    67 GLLLFALGALLFAF---APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL 143

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2217351510 224 LLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPR 257
Cdd:cd06174   144 ASSLGFGWRAVFLIAAALALLAAILLLLVVPDPP 177
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 108-257 7.46e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.73  E-value: 7.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 108 LLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMAcslQAGAFEMLIVGRFIMGIDGGVALSVLPM 187
Cdd:cd17325    31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA---FATSYWQLLLARFLQGLASAAVWPAAMA 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217351510 188 YLSEISPKEIRGS-LGQVTAIFIcIGVFTGQLLG--LPELLGKEstWPYLFgVIVVPAVVQLLSLPFLPDSPR 257
Cdd:cd17325   108 LIADIAPPEERGRaMGIFSSAIG-LGFLIGPLLGglLADALGYR--APFLV-CAALALLALVLALLLLPEPRP 176
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 116-267 8.25e-08

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 53.77  E-value: 8.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 116 IFAIGGLVGTLIVKMIGKVLGRKHTLLANngFAISAALLMACSLQAGaFEMLIVGRFIMGIDGGVALSVLPMYLSEISPK 195
Cdd:cd17438    42 IVYLGMMAGAFIWGGLADKLGRKRCLIIS--LAINASFAFLSSFVQG-YGAFLFCRLISGFGIGGSLPIVFAYFSEFLAR 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 196 EIRGSLGQVTAIFICIGVFTGQLLG---LPEL-----LGKE---STWPYLFGVIVVPAVVQLLSLPFLPDSPRYLL-LEK 263
Cdd:cd17438   119 EKRGEHLSWLCMFWMIGGLYASAMAwsiIPHYgwgfsMGTNyhfHSWRVFVIICALPCIASIIALKFMPESPRFLLeMGK 198


                  ....
gi 2217351510 264 HNEA 267
Cdd:cd17438   199 HDEA 202
MFS_1 pfam07690
Major Facilitator Superfamily;
114-276 8.89e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.19  E-value: 8.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 114 VSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLQAGaFEMLIVGRFIMGIDGGVALSVLPMYLSEIS 193
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLI--GLLLFALGLLLLLFASS-LWLLLVLRVLQGLGAGALFPAALALIADWF 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 194 PKEIRGSLGQVTAIFICIGVFTGQLLGLpeLLGKESTWPYLFGVIVVPAVVQLLSLpFLPDSPRYLLLEKHNEARAVKAF 273
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGG--LLASLFGWRAAFLILAILSLLAAVLL-LLPRPPPESKRPKPAEEARLSLI 191


                  ...
gi 2217351510 274 QTF 276
Cdd:pfam07690 192 VAW 194
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 114-282 1.00e-07

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 53.27  E-value: 1.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 114 VSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACslqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEIS 193
Cdd:cd17436    42 VSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTL---AGSFFWLVIGRAVVGFAISVSSMACCIYVSEMV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 194 PKEIRGSLGQVTAIFICIGVFTGQLLGLpELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKA- 272
Cdd:cd17436   119 TPHQRGLLVSLYEAGITVGILISYALNY-FFSNVLTGWRYMFGLAIIPAAIQFASILLLPKKPEVLNIKDNMRRRTLVGl 197

                         170
                  ....*....|....
gi 2217351510 273 ----FQTFLGKADV 282
Cdd:cd17436   198 glvlFQQFTGQPNV 211
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 61-247 2.06e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.22  E-value: 2.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  61 LAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESwerrhgrpidpdtLTLLWSVTV-SIFAIGGLVGTLIVKMIGKVLGRKH 139
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLG-------------LSLLQTGLLfAAGFLGRPIGALLFGYLGDRIGRKK 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 140 TLLANNGFAISAALLMACSlqaGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLL 219
Cdd:cd17316    68 ALILTLLLFGLATLLIGLL---PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALV 144

                         170       180       190
                  ....*....|....*....|....*....|
gi 2217351510 220 G--LPELLGKESTWPYLFGVIVVPAVVQLL 247
Cdd:cd17316   145 AslLIPLLSGDWGWRILFLIGALPALLALL 174
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 48-373 3.83e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 51.59  E-value: 3.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  48 RRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNeswerrhgrpIDPDTLTLLWSVTVSIFAIGGLVGTli 127
Cdd:TIGR00895   6 IRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWG----------LDPVQLGFLFSAGLIGMAFGALFFG-- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 128 vkMIGKVLGRKHTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAI 207
Cdd:TIGR00895  74 --PLADRIGRRRVLLW--SILLFSVFTLLCAL-ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFC 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 208 FICIGVFTGQLLGLPelLGKESTWPYLFGV-IVVPAVVQLLSLPFLPDSPRYLLLEKHNEARavkaFQTFLGKADVSQEV 286
Cdd:TIGR00895 149 GYPIGAAVGGFLAGW--LIPVFGWRSLFYVgGIAPLLLLLLLMRFLPESIDFLVSKRPETVR----RIVNAIAPQMQAEA 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 287 EEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTmacyqLCGLNAIWFYTNSifgkagippakIPYVTLSTGGIETL 366
Cdd:TIGR00895 223 QSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLY-----FMLLVGVYFLTNW-----------LPKLMVELGFSLSL 286


                  ....*..
gi 2217351510 367 AAVFSVA 373
Cdd:TIGR00895 287 AATGGAL 293
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 108-259 5.71e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 51.15  E-value: 5.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 108 LLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLannGFAISAALlmaCSLqAGAFEMLIVGRFIMGIDGGVALSVLPM 187
Cdd:cd17371    38 LLGTVTLAGGAIGGILGGILADRFGRVRVLVITIL---LFAVFTLL---CGF-AQNYWQLLILRALAGLGFGGEWAAGAA 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217351510 188 YLSEISPKEIRGSLGQVTAIFICIGVFTGQLLG--LPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYL 259
Cdd:cd17371   111 LMAEYVPARHRGKALGYVQSGWAVGWLLATLLAalLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQ 184
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 67-247 1.80e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 49.48  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  67 SSFLYGYNLSVVNAPTPYIkafyneswerrhGRPIDPDTLTLLWSVTVSIFAIGGLVgtLIVKMIGKVLGRKHTLLANNG 146
Cdd:cd17321     4 AVFLAALDVTIVNVALPTI------------ARDLGASPSQLQWVVNAYLLAFAALL--LLAGRLGDRFGRKRVFLIGLA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 147 FAISAALLMACslqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLG--LPEL 224
Cdd:cd17321    70 LFGLASLLCAL---APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGglLLEL 146

                         170       180
                  ....*....|....*....|...
gi 2217351510 225 LGkestWPYLFGVIVVPAVVQLL 247
Cdd:cd17321   147 FG----WRWIFLINVPIGLVALL 165
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
56-244 2.09e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.10  E-value: 2.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  56 LLVASLAGAFGSSFLYGYNLSVVnapTPYIKAFYNeswerrhgrpIDPDTLTLLwsvtVSIFAIGGLVGTLIVKMIGKVL 135
Cdd:COG2271    10 RILALLFLAYFLNYLDRSNLSVA---APPLQADLG----------LSAAQLGLL----ASAFFLGYALGQIPAGLLADRF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 136 GRKHTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFT 215
Cdd:COG2271    73 GRRRVLAI--GLLLWGLATLLFGF-ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGAL 149

                         170       180
                  ....*....|....*....|....*....
gi 2217351510 216 GQLLGLpeLLGKESTWPYLFGVIVVPAVV 244
Cdd:COG2271   150 APPLLG--WLLAAFGWRAAFLILGLPGLL 176
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
114-257 3.77e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 48.34  E-value: 3.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 114 VSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEIS 193
Cdd:COG2223   247 AALFALLGALGRPLGGWLSDRIGGRRVLLI--VFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIF 324

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217351510 194 PKEIRGS-LGQVTAIFICIGVFTGQLLGLpeLLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPR 257
Cdd:COG2223   325 PTKNAGAvYGLVGAAGGLGGFLGPLLFGA--LLDATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 109-253 4.47e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 48.34  E-value: 4.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 109 LWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIDGGVALSVLPMY 188
Cdd:cd17323    35 VANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLV--SLFIFVIFQIGCAL-APNIAMLIILRFLQGFFGSSPLAIGAGT 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217351510 189 LSEISPKEIRGSLGQVTAIFICIGVFTGQLLGlpELLGKESTWPYLFGVIV-VPAVVQLLSLPFLP 253
Cdd:cd17323   112 IADLFTPEERGKAMGVYSLGPLLGPALGPIIG--GFITQSLGWRWIFWFLAiISGFCLILIFLFLP 175
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
101-272 8.84e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.18  E-value: 8.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 101 IDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGkvlGRKHTLLAnngfAISAALLMACSLQAGAFEMLIVGRFIMGIDGGV 180
Cdd:COG2223    37 LSAAQLGLLFAIPVLVGALLRIPLGFLVDRFG---PRRVLLIG----LLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 181 ALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLpeLLGKESTWPYLFGVIVVP-AVVQLLSLPFLPDSPRYL 259
Cdd:COG2223   110 SFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP--LLIAAFGWRNAFLILGILlLVVAVLAWLFLRDPPAGA 187

                         170
                  ....*....|...
gi 2217351510 260 LLEKHNEARAVKA 272
Cdd:COG2223   188 AAAAKASLRDQLE 200
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 111-253 1.19e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 46.80  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 111 SVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSlqaGAFEMLIVGRFImgidggVALSVLPMYLS 190
Cdd:cd17317    28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFS---PSYELFLVLRFL------VGVTSAGIFTV 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217351510 191 ------EISPKEIRGSLGQVTAIFICIGVFtgqLLGLPELLgkESTWPYLFGVIVVPAVVQLLSLPFLP 253
Cdd:cd17317    99 gfvlgmEIVGPKYRSFVGILFGLFWALGYM---LLALLAYL--IRDWRWLQLAISLPGLLFLLLLWWLP 162
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
114-253 1.34e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.79  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 114 VSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEIS 193
Cdd:COG2271   222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAL-LPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217351510 194 PKEIRGS-LGQVTAIFICIGVFTGQLLGlpeLLGKESTWPYLFGVIVVPAVVQLLSLPFLP 253
Cdd:COG2271   301 PKKARGTaSGLVNTFGFLGGALGPLLVG---YLLDATGYQAAFLLLAALALLAALLALLLL 358
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 115-269 3.56e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 45.34  E-value: 3.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 115 SIFAIGGLVGTLIVKMIGKVLGRKHTLLAnngfaiSAALLMACSL---QAGAFEMLIVGRFIMGIDGGVALSVLPMYLSE 191
Cdd:PRK11551   57 SAGILGLLPGALLGGRLADRIGRKRILIV------SVALFGLFSLataQAWDFPSLLVARLLTGVGLGGALPNLIALTSE 130

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217351510 192 ISPKEIRGSLGQVTAIFICIGVFTGQLLGLpeLLGKESTWPYLFGV-IVVPAVVQLLSLPFLPDSPRYLLLEKHNEARA 269
Cdd:PRK11551  131 AVGPRLRGTAVSLMYCGVPFGGALASVIGV--LAAGDAAWRHIFYVgGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRA 207
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 108-261 3.73e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 45.26  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 108 LLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIdGGVALSVLPM 187
Cdd:cd17330    34 YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLL--SLAGSAVSYVLLGL-SRNLWLLFLARFLDGL-TGGNVSVAQA 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217351510 188 YLSEISPKEIRGS-LGQVTAIFICIGVFtGQLLG--LPELLGkeSTWPYLFgVIVVPAVVQLLSLPFLPDSPRYLLL 261
Cdd:cd17330   110 YIADITDEEERAKaFGIISAAFGLGFIL-GPALGgfLSTPYG--YALPFLV-AAALALLNLVLVLFFLPPLRRLLLV 182
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 115-267 4.36e-05

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 45.29  E-value: 4.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 115 SIFAIGGLVGTLIVKMIGKVLGRKHTLL----ANNGFAISAALLMAcslqagaFEMLIVGRFIMGIDGGVALSVLPMYLS 190
Cdd:cd17440    41 SIVYLGMMVGAFFWGGLADKVGRRQSLLicmsVNGFFAFLSSFVQG-------YGLFLFCRLLSGFGIGGAVPTVFSYFA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 191 EISPKEIRGSLGQVTAIFICIGVFTGQLL--------GLPELLGKE---STWPYLFGVIVVPAVVQLLSLPFLPDSPRYL 259
Cdd:cd17440   114 EVLAREKRGEHLSWLCMFWMIGGIYASAMawaiiphyGWSFSMGSAyqfHSWRVFVIVCALPCVSSVVALTFMPESPRFL 193


                  ....*....
gi 2217351510 260 L-LEKHNEA 267
Cdd:cd17440   194 LeVGKHDEA 202
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 115-267 4.71e-05

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 45.17  E-value: 4.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 115 SIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLQAGaFEMLIVGRFIMGIDGGVALSVLPMYLSEISP 194
Cdd:cd17363    41 LIVYLGMMVGAFVWGGLADKLGRKQCLLI--ALSVNGVFAFLSSFVQG-YGFFLFCRLLSGIGIGGSIPIVFSYFAEFLA 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 195 KEIRGSLGQVTAIFICIGVFTGQLLG---LPEL-----LGKE---STWPYLFGVIVVPAVVQLLSLPFLPDSPRYLL-LE 262
Cdd:cd17363   118 REKRGEHLSWLCMFWMIGGLYASAMAwaiIPHYgwgfsMGTAyqfHSWRVFVIVCALPSVASVVALTFMPESPRFLLeVG 197


                  ....*
gi 2217351510 263 KHNEA 267
Cdd:cd17363   198 KHDEA 202
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 115-267 6.10e-05

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 44.97  E-value: 6.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 115 SIFAIGGLVGTLIVKMIGKVLGRKHTLL----ANNGFAISAALLMAcslqagaFEMLIVGRFIMGIDGGVALSVLPMYLS 190
Cdd:TIGR01299 209 LIVYLGMMVGAFFWGGLADKLGRKQCLLiclsVNGFFAFFSSFVQG-------YGFFLFCRLLSGFGIGGAIPIVFSYFA 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 191 EISPKEIRGS-LGQVTAIFICIGVFTGQL-------LGLPELLGKE---STWPYLFGVIVVPAVVQLLSLPFLPDSPRYL 259
Cdd:TIGR01299 282 EFLAQEKRGEhLSWLCMFWMIGGIYAAAMawaiiphYGWSFQMGSAyqfHSWRVFVIVCAFPCVFAIGALTFMPESPRFF 361


                  ....*....
gi 2217351510 260 L-LEKHNEA 267
Cdd:TIGR01299 362 LeNGKHDEA 370
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 107-252 6.16e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.49  E-value: 6.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 107 TLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIDGGVALSVLP 186
Cdd:cd17325   234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI--GLLLSAVALLLLPL-ATSFWLLLLLLALLGLGLGLVFPATL 310

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217351510 187 MYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLG--LPELLGkestwpyLFGVIVVPAVVQLLSLPFL 252
Cdd:cd17325   311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGgfLYDAFG-------FATPFLAAAALLLLAAVLF 371
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 114-256 9.16e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.12  E-value: 9.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 114 VSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAIsAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEIS 193
Cdd:cd17489    37 VGLFTLAALLARPFAGRLLDRFGRKRLLLI--GLLI-FALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217351510 194 PKEIRGSLGQVTAIFICIGVFTGQLLGLpeLLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSP 256
Cdd:cd17489   114 PPSRRGEGIGYYGLATTLAMALGPALGL--FLYQHLGFAVLFIVAAVLALLALLLVFLVKDPP 174
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 114-244 1.08e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 43.74  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 114 VSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGrFIMGIDGGVALSVLPMYLSEIS 193
Cdd:cd17316   219 LLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLL-FILSFFVGGVWGALYAYLAELF 297

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217351510 194 PKEIRGS-LGQVTAIFICIGVFTGQLLGLP-ELLGKESTWPYLFGVIVVPAVV 244
Cdd:cd17316   298 PTEVRATgVGLSYNLGRLGGGGAPPLIALLlASTGGTGVPALILALLAIVALI 350
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
115-200 1.91e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.04  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 115 SIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISP 194
Cdd:COG2814   250 ALFGLGGVLGALLAGRLADRFGRRRLLLI--GLLLLALGLLLLAL-AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326


                  ....*.
gi 2217351510 195 KEIRGS 200
Cdd:COG2814   327 PEARGR 332
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 114-256 2.58e-04

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 42.77  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 114 VSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnngfaiSAALLM---ACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLS 190
Cdd:PRK10091   44 ISYYALGVVVGAPIIALFSSRYSLKHILLF------LVALCVignAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLS 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217351510 191 EISPKeirGSLGQVTAIFICiGVFTGQLLGLP--ELLGKESTWPYLFGVIVVPAVVQLLSL----PFLPDSP 256
Cdd:PRK10091  118 KIIKP---GKVTAAVAGMVS-GMTVANLLGIPlgTYLSQEFSWRYTFLLIAVFNIAVLASIyfwvPDIRDEA 185
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 141-253 3.08e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.56  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 141 LLANNGFAISAALlmaCSLqAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLG 220
Cdd:cd17503    65 LTALALFTLGSLL---CGL-APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLG 140

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2217351510 221 --LPELLGkestWPYLFGVIVVPAVVQLLSLPFLP 253
Cdd:cd17503   141 gwLTDNLS----WRWIFYINLPIGILALLLAPLLD 171
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 69-295 3.34e-04

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 42.41  E-value: 3.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  69 FLYGYNLSVVNAPTPYIKAFYnesWERRHGRPIDPDTLtllwsVTVSIFaIGGLVGTLIVKMIGKVLGRKHTL---LANN 145
Cdd:TIGR00887  26 FTDSYDLFCISLVTKMLGYVY---YHGKGPLPSSVSAA-----VNGSAS-IGTLAGQLFFGWLADKLGRKRVYgmeLIIM 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 146 GFAISAALLMACSLQAGAFEMLIVGRFIM--GIDGGVALSVLPMylSEISPKEIRGSL----------GQVTAIFICIGV 213
Cdd:TIGR00887  97 IIATVASGLSPGSSPKSVMATLCFWRFWLgvGIGGDYPLSAIIT--SEFATKKWRGAMmaavfamqgfGILAGAIVALIV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 214 ---FTGQLLGLPELLGKEST--------WPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADV 282
Cdd:TIGR00887 175 lagFKHSLEAAADEASCTGScvpavdymWRILIGFGAVPALLALYFRLTIPETPRYTADVAKDVEQAASDMSAVLQVKIE 254

                         250
                  ....*....|....*
gi 2217351510 283 SQ--EVEEVLAESRV 295
Cdd:TIGR00887 255 AEpdEVEKASTAVEV 269
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
61-244 3.40e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.15  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  61 LAGAFGSSFLYGYNLSVVNAPTPYIKAFYNeswerrhgrpIDPDTLTLLwsvtVSIFAIGGLVGTLIVKMIGKVLGRKHT 140
Cdd:COG0738    10 LIAIYLLFFLWGFATALWGPLIPALKDAFG----------LSDAQAGLL----LFAFFLGYLLASLPAGRLIDRFGYKRG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 141 LLANNGFAISAALLMAcslQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEiRGSLGQVTAIFICIGVFTGQLLG 220
Cdd:COG0738    76 LLLGLLLMALGLLLFA---LAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLG 151

                         170       180
                  ....*....|....*....|....*
gi 2217351510 221 -LPELLGKESTWPYLFGVIVVPAVV 244
Cdd:COG0738   152 gLLILLGLSLSWHLPYLILAVLLLL 176
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 113-258 3.48e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.18  E-value: 3.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 113 TVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMAcslQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEI 192
Cdd:cd17320    39 TLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCA---LASSIEQLLIARFLQGLGAAAGSVVARAIVRDL 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217351510 193 -SPKEIRGSLGQVTAIFiCIGVFTGQLLGlpELLGKESTWPYLFGVIVVPAVVQL-LSLPFLPDSPRY 258
Cdd:cd17320   116 ySGAELAKIFSLLMMIL-AIAPALAPLLG--GLLLLFFGWRAIFVFLALLGLLLLlLVLLFLPETLPE 180
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
109-252 4.08e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.20  E-value: 4.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 109 LWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMAcSLQAGAFEMLIVGRFIMGIDGGVALSVLPMY 188
Cdd:COG2211   265 LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF-FLGPGNLWLLLVLAALAGIGLGAILVLPWAM 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 189 LSEISPKEIRGSLGQVTAIFICI------------GVFTGQLLGL----PELLGKEST-WPYLFGVIVVPAVVQLLSLPF 251
Cdd:COG2211   344 LADVVDYDEWKTGRRREGLYFGIftfaiklgqalaGALAGLLLALfgyvAGAAQSPSAlTGIRLLFFLLPAVLLLLAALL 423


                  .
gi 2217351510 252 L 252
Cdd:COG2211   424 L 424
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 110-253 1.07e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 40.64  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 110 WSVTvsIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACslqAGAFEMLIVGRFImgidGGVALSVLPMYL 189
Cdd:cd17504    35 WVLT--AYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF---APNLPVLIAGRAL----QGIGGAVFPLAF 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 190 S----EISPKEIRGSLGQVTAIFiCIGVFTGQLLG--LPELLGkestWPYLFGVIVVPAVVQLLSLPFLP 253
Cdd:cd17504   106 AlvreEFPPERVPVAQGILSATF-GIGAGIGLPLGgwIVQHLG----WRWIFWTAAPVAVLLAALVPLID 170
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 115-256 1.10e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 40.65  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 115 SIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISP 194
Cdd:cd17365   213 LLLNIGGVIGSLLLGWLADRFGPKRVLAL--FFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYP 290

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217351510 195 KEIRGSlGQVTAIFIC-IGVFTGQLLGlPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSP 256
Cdd:cd17365   291 TEVRAT-GVGWALGVGrLGAILGPLLG-GLLLAAGLGPESVFLALAIPAALGALAVLLLRLRR 351
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 101-252 1.22e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 40.65  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 101 IDPDTLTLLWSVTVsifaIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIDGGV 180
Cdd:cd17365    31 LSPAQLGPVGSAAL----FGMAIGALLAGPLADRFGRKRVLLV--SVALFGLFTLLTAF-AQSVLQLALLRFLTGLGLGA 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217351510 181 ALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLP--ELLGkestWPYLFgviVVPAVVQLLSLPFL 252
Cdd:cd17365   104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAAliPAFG----WRSVF---LLGGVPPLILLPLL 170
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 111-213 1.31e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 40.36  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 111 SVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLS 190
Cdd:cd17371   248 AGYLVVTILGGFLGYLAGGFLADRIGRRNNFAL--FALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLT 325

                          90       100
                  ....*....|....*....|...
gi 2217351510 191 EISPKEIRGslgqvTAIFICIGV 213
Cdd:cd17371   326 ELFPTAVRA-----TAQGFCYNV 343
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 109-249 2.52e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 109 LWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIDGGVALSVLPMY 188
Cdd:cd06173   245 GYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLI--GALLLGLALLVLGL-SPSLWLLLAALFLLGLAGGLFNVPLNTL 321

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217351510 189 LSEISPKEIRgslGQVTAIFIcIGVFTGQLLGLPE--LLGKESTWPYLF---GVIVVPAVVQLLSL 249
Cdd:cd06173   322 LQLRVPDELR---GRVFSVYN-ALNSGAMPLGALLagLLADALGLSAVFllaGALLLLAALLLLLL 383
MFS_1 pfam07690
Major Facilitator Superfamily;
107-216 3.06e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.32  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 107 TLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLP 186
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313

                          90       100       110
                  ....*....|....*....|....*....|
gi 2217351510 187 MYLSEISPKEIRGSLGQVTAIFICIGVFTG 216
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 111-257 3.14e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.09  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 111 SVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIdGGVALSVLPMYL- 189
Cdd:cd17474    37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLP--GLLLFGIGGLLCGL-SDSFALLLAGRALQGI-GAAGLGPLALTLi 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217351510 190 SEISPKEIRGSLGQVTAIFICIGVFTGQLLGlpELLGkESTWPYLFGVIVVPAVVQLLSLPFLPDSPR 257
Cdd:cd17474   113 GDLFEGGERAKAMGLYEAALGLGIAVGPLLG--GLLA-AISWRYPFFLLAALIPVAFLAILFLLPEPK 177
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 69-233 8.89e-03

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 38.03  E-value: 8.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510  69 FLYGYNLSVVNAPTPYIKAFYneswerrhgrPIDPDTLTLLWSVTVSIFA-IGGLVGTLIVKMIGKVLGRKhtllanNGF 147
Cdd:cd17364     9 FTDAYDLFSISLVTKILGRLY----------YGGKGSLPSGVSGLVNAAAlVGTIIGQLFFGFLGDRFGRK------RVY 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 148 AISAALLMACS-LQAGAFE--------MLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQL 218
Cdd:cd17364    73 GVELIIMIIGTiLSALSPGstplgvmgWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAI 152

                         170
                  ....*....|....*
gi 2217351510 219 LGLPELLGKESTWPY 233
Cdd:cd17364   153 VTLILSAIFEHPLPA 167
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 107-249 9.59e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 37.54  E-value: 9.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217351510 107 TLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLAnnGFAISAALLMACSLqAGAFEMLIVGRFIMGIDGGVALSVLP 186
Cdd:cd17477    30 TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAA--GAAITAVSVLLLAL-TDSPWVWFLLRFVMGIGLAGLFVVSE 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217351510 187 MYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLpeLLGKESTWPYLFGVIVVPAVVQLLSL 249
Cdd:cd17477   107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA--LVGTAGALPFLIAAVLLLLALVPLLL 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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