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Conserved domains on  [gi|1034664448|ref|XP_016869970|]
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FERM and PDZ domain-containing protein 1 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FERM_F1_FRMPD1 cd17168
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ ...
 70-159 1.70e-57

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 1 (FRMPD1); FRMPD1, also termed FERM domain-containing protein 2, is an activator of G-protein signaling 3 (AGS3)-binding protein that regulates the subcellular location of AGS3 and its interaction with G-proteins. It also binds to the tetratricopeptide repeat (TPR) motif-containing adaptor protein LGN. FRMPD1 contains a PDZ domain and a FERM domain. The FERM domain is made up of three sub-domains, F1, F2, and F3. The family corresponds to the F1 sub-domain of the FERM domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N).


:

Pssm-ID: 340688  Cd Length: 90  Bit Score: 193.16  E-value: 1.70e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448   70 MPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHEEELIQQVVEREESHDYRC 149
Cdd:cd17168      1 MPNVLKVYLENGQTKAFKFESNTTVKDIILTLKEKLSIRSIEHFALVLEEQYSISKLYLLHEEELIEQVVEKRESHDYRC 80

                           90
                   ....*....|
gi 1034664448  150 LFRVCFVPKD 159
Cdd:cd17168     81 LFRVCFVPKD 90
FERM_C_FRMPD1_FRMPD3_FRMPD4 cd13183
FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4); The ...
 288-392 3.62e-55

FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4); The function of FRMPD1, FRMPD3, and FRMPD4 is unknown at present. These proteins contain an N-terminal PDZ (post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) domain and a C-terminal FERM domain. PDZ (also known as DHR (Dlg homologous region) or GLGF (glycine-leucine-glycine-phenylalanine) domains) help anchor transmembrane proteins to the cytoskeleton and hold together signaling complexes. PDZ domains bind to a short region of the C-terminus of other specific proteins. The FERM domain is composed of three subdomains: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3), which form a clover leaf fold. The C-lobe/F3 within the FERM domain is part of the PH domain family. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases (PTPs) , the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites.


:

Pssm-ID: 270004  Cd Length: 105  Bit Score: 186.83  E-value: 3.62e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  288 GGRIFNATLMLQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESN 367
Cdd:cd13183      1 GGRSFQATLMLQDRESEVTLLVGPRYGISHVINHKLNLLALLAEFSHISRIELLRESDKVSRVELHIHDVKPITLLMESP 80

                           90       100
                   ....*....|....*....|....*
gi 1034664448  368 SAKDLACLIAGYYRLLVDPVTSIFL 392
Cdd:cd13183     81 DAKDLACLIAGYYRLLVDPRRSIFS 105
B41 smart00295
Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in ...
 73-292 2.87e-35

Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.


:

Pssm-ID: 214604 [Multi-domain]  Cd Length: 201  Bit Score: 133.57  E-value: 2.87e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448    73 VLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHEEELIQQVVEREEshdYRCLFR 152
Cdd:smart00295    1 VLKVYLLDGTTLEFEVDSSTTAEELLETVCRKLGIRESEYFGLQFEDPDEDLRHWLDPAKTLLDQDVKSEP---LTLYFR 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448   153 VCFVPKDPLDlLKEDPVAFEYLYLQSCSDVLQERFavemKCS--SALRLAALHIQeriyACAQPQKISLKYIEKDWGIEN 230
Cdd:smart00295   78 VKFYPPDPNQ-LKEDPTRLNLLYLQVRNDILEGRL----PCPeeEALLLAALALQ----AEFGDYDEELHDLRGELSLKR 148

                           170       180       190       200       210       220
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034664448   231 FISPTLLRNMKGKDIKKAI-SFHMK-RNQnlleprqkqliSAAQLRLNYLQILGELKTYGGRIF 292
Cdd:smart00295  149 FLPKQLLDSRKLKEWRERIvELHKElIGL-----------SPEEAKLKYLELARKLPTYGVELF 201
LGNbd_FRMPD1 cd21942
LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1; ...
 792-829 1.02e-12

LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1; FERM and PDZ domain-containing protein 1 (FRMPD1), also called FERM domain-containing protein 2 (FRMD2), stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. It also acts as a regulatory binding partner of Activator of G-protein Signaling 3 (AGS3). This model corresponds to a conserved region in FRMPD1 that binds to tetratricopeptide (TPR) repeats present in the N-terminal domain of adaptor protein LGN. LGN plays a crucial role in mitotic spindle orientation and cell polarization via interaction with multiple targets including FRMPD1.


:

Pssm-ID: 409273  Cd Length: 38  Bit Score: 63.52  E-value: 1.02e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1034664448  792 ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRV 829
Cdd:cd21942      1 SFGQLKSQRPTKNKNLSSELMEMEPDTMETKSVTDSVV 38
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 446-718 2.02e-04

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  446 KEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGYRTSGSSESMDALE-EDDLDTCSSSRSTFFHFGSP 524
Cdd:PHA03307   119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSsPEETARAPSSPPAEPPPSTP 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  525 GLAESidsDSQEERSGIETSGFLCL--LDLAQRANPQCQKTEFSESAALETFGWAPE-------LSTVRLDPRLYEGSHA 595
Cdd:PHA03307   199 PAAAS---PRPPRRSSPISASASSPapAPGRSAADDAGASSSDSSSSESSGCGWGPEnecplprPAPITLPTRIWEASGW 275

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  596 DYY-SLCSSVSPASYLSDSSESTASRQGGAPPAwgqqgwteAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADklTPPGP 674
Cdd:PHA03307   276 NGPsSRPGPASSSSSPRERSPSPSPSSPGSGPA--------PSSPRASSSSSSSRESSSSSTSSSSESSRGAA--VSPGP 345

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1034664448  675 PSG--PRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGG 718
Cdd:PHA03307   346 SPSrsPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRAR 391
 
Name Accession Description Interval E-value
FERM_F1_FRMPD1 cd17168
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ ...
 70-159 1.70e-57

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 1 (FRMPD1); FRMPD1, also termed FERM domain-containing protein 2, is an activator of G-protein signaling 3 (AGS3)-binding protein that regulates the subcellular location of AGS3 and its interaction with G-proteins. It also binds to the tetratricopeptide repeat (TPR) motif-containing adaptor protein LGN. FRMPD1 contains a PDZ domain and a FERM domain. The FERM domain is made up of three sub-domains, F1, F2, and F3. The family corresponds to the F1 sub-domain of the FERM domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N).


Pssm-ID: 340688  Cd Length: 90  Bit Score: 193.16  E-value: 1.70e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448   70 MPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHEEELIQQVVEREESHDYRC 149
Cdd:cd17168      1 MPNVLKVYLENGQTKAFKFESNTTVKDIILTLKEKLSIRSIEHFALVLEEQYSISKLYLLHEEELIEQVVEKRESHDYRC 80

                           90
                   ....*....|
gi 1034664448  150 LFRVCFVPKD 159
Cdd:cd17168     81 LFRVCFVPKD 90
FERM_C_FRMPD1_FRMPD3_FRMPD4 cd13183
FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4); The ...
 288-392 3.62e-55

FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4); The function of FRMPD1, FRMPD3, and FRMPD4 is unknown at present. These proteins contain an N-terminal PDZ (post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) domain and a C-terminal FERM domain. PDZ (also known as DHR (Dlg homologous region) or GLGF (glycine-leucine-glycine-phenylalanine) domains) help anchor transmembrane proteins to the cytoskeleton and hold together signaling complexes. PDZ domains bind to a short region of the C-terminus of other specific proteins. The FERM domain is composed of three subdomains: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3), which form a clover leaf fold. The C-lobe/F3 within the FERM domain is part of the PH domain family. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases (PTPs) , the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites.


Pssm-ID: 270004  Cd Length: 105  Bit Score: 186.83  E-value: 3.62e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  288 GGRIFNATLMLQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESN 367
Cdd:cd13183      1 GGRSFQATLMLQDRESEVTLLVGPRYGISHVINHKLNLLALLAEFSHISRIELLRESDKVSRVELHIHDVKPITLLMESP 80

                           90       100
                   ....*....|....*....|....*
gi 1034664448  368 SAKDLACLIAGYYRLLVDPVTSIFL 392
Cdd:cd13183     81 DAKDLACLIAGYYRLLVDPRRSIFS 105
B41 smart00295
Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in ...
 73-292 2.87e-35

Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.


Pssm-ID: 214604 [Multi-domain]  Cd Length: 201  Bit Score: 133.57  E-value: 2.87e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448    73 VLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHEEELIQQVVEREEshdYRCLFR 152
Cdd:smart00295    1 VLKVYLLDGTTLEFEVDSSTTAEELLETVCRKLGIRESEYFGLQFEDPDEDLRHWLDPAKTLLDQDVKSEP---LTLYFR 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448   153 VCFVPKDPLDlLKEDPVAFEYLYLQSCSDVLQERFavemKCS--SALRLAALHIQeriyACAQPQKISLKYIEKDWGIEN 230
Cdd:smart00295   78 VKFYPPDPNQ-LKEDPTRLNLLYLQVRNDILEGRL----PCPeeEALLLAALALQ----AEFGDYDEELHDLRGELSLKR 148

                           170       180       190       200       210       220
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034664448   231 FISPTLLRNMKGKDIKKAI-SFHMK-RNQnlleprqkqliSAAQLRLNYLQILGELKTYGGRIF 292
Cdd:smart00295  149 FLPKQLLDSRKLKEWRERIvELHKElIGL-----------SPEEAKLKYLELARKLPTYGVELF 201
FERM_M pfam00373
FERM central domain; This domain is the central structural domain of the FERM domain.
 160-292 4.50e-25

FERM central domain; This domain is the central structural domain of the FERM domain.


Pssm-ID: 459788 [Multi-domain]  Cd Length: 117  Bit Score: 101.19  E-value: 4.50e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  160 PLDLLKEDPVAFEYLYLQSCSDVLQERFAVEmkCSSALRLAALHIQERIYACAQPQKISlkyieKDWGIENFISPTLLRN 239
Cdd:pfam00373    1 DLELLLQDEVTRHLLYLQAKDDILEGRLPCS--EEEALLLAALQLQAEFGDYQPSSHTS-----EYLSLESFLPKQLLRK 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034664448  240 MKGKDIKKAISFHMKRNQNLleprqkqliSAAQLRLNYLQILGELKTYGGRIF 292
Cdd:pfam00373   74 MKSKELEKRVLEAHKNLRGL---------SAEEAKLKYLQIAQSLPTYGVEFF 117
LGNbd_FRMPD1 cd21942
LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1; ...
 792-829 1.02e-12

LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1; FERM and PDZ domain-containing protein 1 (FRMPD1), also called FERM domain-containing protein 2 (FRMD2), stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. It also acts as a regulatory binding partner of Activator of G-protein Signaling 3 (AGS3). This model corresponds to a conserved region in FRMPD1 that binds to tetratricopeptide (TPR) repeats present in the N-terminal domain of adaptor protein LGN. LGN plays a crucial role in mitotic spindle orientation and cell polarization via interaction with multiple targets including FRMPD1.


Pssm-ID: 409273  Cd Length: 38  Bit Score: 63.52  E-value: 1.02e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1034664448  792 ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRV 829
Cdd:cd21942      1 SFGQLKSQRPTKNKNLSSELMEMEPDTMETKSVTDSVV 38
FERM_B-lobe cd14473
FERM domain B-lobe; The FERM domain has a cloverleaf tripart structure (FERM_N, FERM_M, FERM_C ...
 170-284 9.50e-12

FERM domain B-lobe; The FERM domain has a cloverleaf tripart structure (FERM_N, FERM_M, FERM_C/N, alpha-, and C-lobe/A-lobe, B-lobe, C-lobe/F1, F2, F3). The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases, the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains and consequently is capable of binding to both peptides and phospholipids at different sites.


Pssm-ID: 271216  Cd Length: 99  Bit Score: 62.65  E-value: 9.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  170 AFEYLYLQSCSDVLQERFAVemKCSSALRLAALHIQeRIYACAQPQKISLKYIekdwGIENFISPTLLRNMKGKDIKKAI 249
Cdd:cd14473      1 TRYLLYLQVKRDILEGRLPC--SEETAALLAALALQ-AEYGDYDPSEHKPKYL----SLKRFLPKQLLKQRKPEEWEKRI 73

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1034664448  250 SFHMKRNQNLleprqkqliSAAQLRLNYLQILGEL 284
Cdd:cd14473     74 VELHKKLRGL---------SPAEAKLKYLKIARKL 99
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 446-718 2.02e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  446 KEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGYRTSGSSESMDALE-EDDLDTCSSSRSTFFHFGSP 524
Cdd:PHA03307   119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSsPEETARAPSSPPAEPPPSTP 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  525 GLAESidsDSQEERSGIETSGFLCL--LDLAQRANPQCQKTEFSESAALETFGWAPE-------LSTVRLDPRLYEGSHA 595
Cdd:PHA03307   199 PAAAS---PRPPRRSSPISASASSPapAPGRSAADDAGASSSDSSSSESSGCGWGPEnecplprPAPITLPTRIWEASGW 275

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  596 DYY-SLCSSVSPASYLSDSSESTASRQGGAPPAwgqqgwteAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADklTPPGP 674
Cdd:PHA03307   276 NGPsSRPGPASSSSSPRERSPSPSPSSPGSGPA--------PSSPRASSSSSSSRESSSSSTSSSSESSRGAA--VSPGP 345

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1034664448  675 PSG--PRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGG 718
Cdd:PHA03307   346 SPSrsPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRAR 391
 
Name Accession Description Interval E-value
FERM_F1_FRMPD1 cd17168
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ ...
 70-159 1.70e-57

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 1 (FRMPD1); FRMPD1, also termed FERM domain-containing protein 2, is an activator of G-protein signaling 3 (AGS3)-binding protein that regulates the subcellular location of AGS3 and its interaction with G-proteins. It also binds to the tetratricopeptide repeat (TPR) motif-containing adaptor protein LGN. FRMPD1 contains a PDZ domain and a FERM domain. The FERM domain is made up of three sub-domains, F1, F2, and F3. The family corresponds to the F1 sub-domain of the FERM domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N).


Pssm-ID: 340688  Cd Length: 90  Bit Score: 193.16  E-value: 1.70e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448   70 MPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHEEELIQQVVEREESHDYRC 149
Cdd:cd17168      1 MPNVLKVYLENGQTKAFKFESNTTVKDIILTLKEKLSIRSIEHFALVLEEQYSISKLYLLHEEELIEQVVEKRESHDYRC 80

                           90
                   ....*....|
gi 1034664448  150 LFRVCFVPKD 159
Cdd:cd17168     81 LFRVCFVPKD 90
FERM_C_FRMPD1_FRMPD3_FRMPD4 cd13183
FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4); The ...
 288-392 3.62e-55

FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4); The function of FRMPD1, FRMPD3, and FRMPD4 is unknown at present. These proteins contain an N-terminal PDZ (post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) domain and a C-terminal FERM domain. PDZ (also known as DHR (Dlg homologous region) or GLGF (glycine-leucine-glycine-phenylalanine) domains) help anchor transmembrane proteins to the cytoskeleton and hold together signaling complexes. PDZ domains bind to a short region of the C-terminus of other specific proteins. The FERM domain is composed of three subdomains: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3), which form a clover leaf fold. The C-lobe/F3 within the FERM domain is part of the PH domain family. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases (PTPs) , the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites.


Pssm-ID: 270004  Cd Length: 105  Bit Score: 186.83  E-value: 3.62e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  288 GGRIFNATLMLQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESN 367
Cdd:cd13183      1 GGRSFQATLMLQDRESEVTLLVGPRYGISHVINHKLNLLALLAEFSHISRIELLRESDKVSRVELHIHDVKPITLLMESP 80

                           90       100
                   ....*....|....*....|....*
gi 1034664448  368 SAKDLACLIAGYYRLLVDPVTSIFL 392
Cdd:cd13183     81 DAKDLACLIAGYYRLLVDPRRSIFS 105
FERM_F1_FRMPD1_like cd17088
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ ...
 70-157 7.63e-45

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing proteins FRMPD1, FRMPD3, FRMPD4, and similar proteins; This family includes FERM and PDZ domain-containing proteins FRMPD1, FRMPD3, and FRMPD4, which all contain a PDZ domain and a FERM domain. The FERM domain is made up of three sub-domains, F1, F2, and F3. This family corresponds to the F1 sub-domain of the FERM domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N). FRMPD1, also termed FERM domain-containing protein 2, is an activator of G-protein signaling 3 (AGS3)-binding protein that regulates the subcellular location of AGS3 and its interaction with G-proteins. FRMPD4, also termed PDZ domain-containing protein 10, or PSD-95-interacting regulator of spine morphogenesis (Preso), is a multiscaffolding protein that modulates both Homer1 and post-synaptic density protein 95 activity. Both FRMPD1 and FRMPD4 can associate with the tetratricopeptide repeat (TPR) motif-containing adaptor protein LGN. The biological role of FRMPD3 remains unclear.


Pssm-ID: 340608  Cd Length: 90  Bit Score: 156.67  E-value: 7.63e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448   70 MPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQ--YSISRLHLLHEEELIQQVVEREESHDY 147
Cdd:cd17088      1 MPNVLKVYLENGQTKSFKYDQSTTVKDVLLSLQEKLGIKSMEHFSLVLEYVksPRTNKLSLLQPDESLAQVAARPGSHHL 80

                           90
                   ....*....|
gi 1034664448  148 RCLFRVCFVP 157
Cdd:cd17088     81 RCLFRISFVP 90
FERM_F1_FRMPD4 cd17170
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ ...
 70-160 5.44e-37

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 4 (FRMPD4); FRMPD4, also termed PDZ domain-containing protein 10, or PSD-95-interacting regulator of spine morphogenesis (Preso), is a multiscaffolding protein that modulates both Homer1 and postsynaptic density protein 95 activity. It can associate with the tetratricopeptide repeat (TPR) motif-containing adaptor protein LGN. Moreover, FRMPD4 is asymmetrically distributed in the cytosol and nuclei of neural stem/progenitor cells in the adult brain, suggesting a significant role in cell differentiation via association with cell polarity machinery. FRMPD4 contains a WW domain, a PDZ domain, and a FERM domain. The FERM domain is made up of three sub-domains, F1, F2, and F3. This family corresponds to the F1 sub-domain of the FERM domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N).


Pssm-ID: 340690  Cd Length: 94  Bit Score: 134.41  E-value: 5.44e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448   70 MPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQY--SISRLHLLHEEELIQQVVEREESHDY 147
Cdd:cd17170      2 MPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKCIEHFSLMLEQRTegSGTKLLLLHEQETLTQVTQRPGSHKM 81

                           90
                   ....*....|...
gi 1034664448  148 RCLFRVCFVPKDP 160
Cdd:cd17170     82 RCLFRISFVPKDP 94
B41 smart00295
Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in ...
 73-292 2.87e-35

Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.


Pssm-ID: 214604 [Multi-domain]  Cd Length: 201  Bit Score: 133.57  E-value: 2.87e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448    73 VLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHEEELIQQVVEREEshdYRCLFR 152
Cdd:smart00295    1 VLKVYLLDGTTLEFEVDSSTTAEELLETVCRKLGIRESEYFGLQFEDPDEDLRHWLDPAKTLLDQDVKSEP---LTLYFR 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448   153 VCFVPKDPLDlLKEDPVAFEYLYLQSCSDVLQERFavemKCS--SALRLAALHIQeriyACAQPQKISLKYIEKDWGIEN 230
Cdd:smart00295   78 VKFYPPDPNQ-LKEDPTRLNLLYLQVRNDILEGRL----PCPeeEALLLAALALQ----AEFGDYDEELHDLRGELSLKR 148

                           170       180       190       200       210       220
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034664448   231 FISPTLLRNMKGKDIKKAI-SFHMK-RNQnlleprqkqliSAAQLRLNYLQILGELKTYGGRIF 292
Cdd:smart00295  149 FLPKQLLDSRKLKEWRERIvELHKElIGL-----------SPEEAKLKYLELARKLPTYGVELF 201
FERM_F1_FRMPD3 cd17169
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ ...
 70-160 5.70e-31

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3); FRMPD3 is an uncharacterized FERM and PDZ domain-containing protein. The FERM domain is made up of three sub-domains, F1, F2, and F3. The family corresponds to the F1 sub-domain of the FERM domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N).


Pssm-ID: 340689  Cd Length: 93  Bit Score: 117.23  E-value: 5.70e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448   70 MPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALE----EQYsiSRLHLLHEEELIQQVVEREESH 145
Cdd:cd17169      1 IPNVLKVFLENGQIKSFTFDGRTTVKDVMLTLQDRLSLRHIEHFALVLEyggpEQN--HKFLLLQDKQPLAHVVQRTHYQ 78

                           90
                   ....*....|....*
gi 1034664448  146 DYRCLFRVCFVPKDP 160
Cdd:cd17169     79 GMKCLFRICFFPKDP 93
FERM_M pfam00373
FERM central domain; This domain is the central structural domain of the FERM domain.
 160-292 4.50e-25

FERM central domain; This domain is the central structural domain of the FERM domain.


Pssm-ID: 459788 [Multi-domain]  Cd Length: 117  Bit Score: 101.19  E-value: 4.50e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  160 PLDLLKEDPVAFEYLYLQSCSDVLQERFAVEmkCSSALRLAALHIQERIYACAQPQKISlkyieKDWGIENFISPTLLRN 239
Cdd:pfam00373    1 DLELLLQDEVTRHLLYLQAKDDILEGRLPCS--EEEALLLAALQLQAEFGDYQPSSHTS-----EYLSLESFLPKQLLRK 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034664448  240 MKGKDIKKAISFHMKRNQNLleprqkqliSAAQLRLNYLQILGELKTYGGRIF 292
Cdd:pfam00373   74 MKSKELEKRVLEAHKNLRGL---------SAEEAKLKYLQIAQSLPTYGVEFF 117
LGNbd_FRMPD1 cd21942
LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1; ...
 792-829 1.02e-12

LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1; FERM and PDZ domain-containing protein 1 (FRMPD1), also called FERM domain-containing protein 2 (FRMD2), stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. It also acts as a regulatory binding partner of Activator of G-protein Signaling 3 (AGS3). This model corresponds to a conserved region in FRMPD1 that binds to tetratricopeptide (TPR) repeats present in the N-terminal domain of adaptor protein LGN. LGN plays a crucial role in mitotic spindle orientation and cell polarization via interaction with multiple targets including FRMPD1.


Pssm-ID: 409273  Cd Length: 38  Bit Score: 63.52  E-value: 1.02e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1034664448  792 ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRV 829
Cdd:cd21942      1 SFGQLKSQRPTKNKNLSSELMEMEPDTMETKSVTDSVV 38
FERM_F0_F1 cd01765
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain and F1 sub-domain, found ...
 73-155 1.71e-12

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain and F1 sub-domain, found in FERM (Four.1/Ezrin/Radixin/Moesin) family proteins; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain is present at the N-terminus of a large and diverse group of proteins that mediate linkage of the cytoskeleton to the plasma membrane. FERM-containing proteins are ubiquitous components of the cytocortex and are involved in cell transport, cell structure and signaling functions. The FERM domain is made up of three sub-domains, F1, F2, and F3. The family corresponds to the F1 sub-domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N), which is structurally similar to ubiquitin.


Pssm-ID: 340464  Cd Length: 80  Bit Score: 64.15  E-value: 1.71e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448   73 VLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSIsrLHLLHEEELIQQVVEReeSHDYRCLFR 152
Cdd:cd01765      2 SCRVRLLDGTELTLEVSKKATGQELFDKVCEKLNLLEKDYFGLFYEDNDGQ--KHWLDLDKKISKQLKR--SGPYQFYFR 77


                   ...
gi 1034664448  153 VCF 155
Cdd:cd01765     78 VKF 80
FERM_B-lobe cd14473
FERM domain B-lobe; The FERM domain has a cloverleaf tripart structure (FERM_N, FERM_M, FERM_C ...
 170-284 9.50e-12

FERM domain B-lobe; The FERM domain has a cloverleaf tripart structure (FERM_N, FERM_M, FERM_C/N, alpha-, and C-lobe/A-lobe, B-lobe, C-lobe/F1, F2, F3). The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases, the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains and consequently is capable of binding to both peptides and phospholipids at different sites.


Pssm-ID: 271216  Cd Length: 99  Bit Score: 62.65  E-value: 9.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  170 AFEYLYLQSCSDVLQERFAVemKCSSALRLAALHIQeRIYACAQPQKISLKYIekdwGIENFISPTLLRNMKGKDIKKAI 249
Cdd:cd14473      1 TRYLLYLQVKRDILEGRLPC--SEETAALLAALALQ-AEYGDYDPSEHKPKYL----SLKRFLPKQLLKQRKPEEWEKRI 73

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1034664448  250 SFHMKRNQNLleprqkqliSAAQLRLNYLQILGEL 284
Cdd:cd14473     74 VELHKKLRGL---------SPAEAKLKYLKIARKL 99
LGNbd_FRMPD1_D4-like cd21928
LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing proteins ...
 793-828 3.14e-10

LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing proteins FRMPD1, FRMPD4, and similar proteins; The family includes FRMPD1, FRMPD4, and similar proteins. FRMPD1, also called FERM domain-containing protein 2 (FRMD2), stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. It also acts as a regulatory binding partner of Activator of G-protein Signaling 3 (AGS3). FRMPD4, also called PDZ domain-containing protein 10 (PDZD10), PDZK10, or PSD-95-interacting regulator of spine morphogenesis (Preso), is a novel PSD-95-interacting FERM and PDZ domain-containing protein that regulates dendritic spine morphogenesis. It acts as a positive regulator of dendritic spine morphogenesis and density. It is required for the maintenance of excitatory synaptic transmission. It binds phosphatidylinositol 4,5-bisphosphate. This model corresponds to a conserved region in FRMPD1 and FRMPD4 that binds to tetratricopeptide (TPR) repeats present in the N-terminal domain of adaptor protein LGN. LGN plays a crucial role in mitotic spindle orientation and cell polarization via interaction with multiple targets including FRMPD1 and FRMPD4.


Pssm-ID: 409272  Cd Length: 37  Bit Score: 56.48  E-value: 3.14e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1034664448  793 LGLLAPLRETKSTNPASR-VMEMEPETMETKSVIDSR 828
Cdd:cd21928      1 LGEDAPLGLQASGDRSSYsLMEMEPETMETKSVTDSV 37
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 446-718 2.02e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  446 KEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGYRTSGSSESMDALE-EDDLDTCSSSRSTFFHFGSP 524
Cdd:PHA03307   119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSsPEETARAPSSPPAEPPPSTP 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  525 GLAESidsDSQEERSGIETSGFLCL--LDLAQRANPQCQKTEFSESAALETFGWAPE-------LSTVRLDPRLYEGSHA 595
Cdd:PHA03307   199 PAAAS---PRPPRRSSPISASASSPapAPGRSAADDAGASSSDSSSSESSGCGWGPEnecplprPAPITLPTRIWEASGW 275

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034664448  596 DYY-SLCSSVSPASYLSDSSESTASRQGGAPPAwgqqgwteAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADklTPPGP 674
Cdd:PHA03307   276 NGPsSRPGPASSSSSPRERSPSPSPSSPGSGPA--------PSSPRASSSSSSSRESSSSSTSSSSESSRGAA--VSPGP 345

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1034664448  675 PSG--PRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGG 718
Cdd:PHA03307   346 SPSrsPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRAR 391
LGNbd_FRMPD4 cd21943
LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 4; ...
 812-826 4.90e-04

LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 4; FRMPD4, also called PDZ domain-containing protein 10 (PDZD10), PDZK10, or PSD-95-interacting regulator of spine morphogenesis (Preso), is a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. It acts as a positive regulator of dendritic spine morphogenesis and density. It is required for the maintenance of excitatory synaptic transmission. It binds phosphatidylinositol 4,5-bisphosphate. FRMPD4 contains WW, PDZ and FERM domains in the N-terminal region. This model corresponds to a conserved region in the C-terminal region of FRMPD4 that binds to tetratricopeptide (TPR) repeats present in the N-terminal domain of adaptor protein LGN. LGN plays a crucial role in mitotic spindle orientation and cell polarization via interaction with multiple targets including FRMPD4.


Pssm-ID: 409274  Cd Length: 49  Bit Score: 39.40  E-value: 4.90e-04
                           10
                   ....*....|....*
gi 1034664448  812 MEMEPETMETKSVID 826
Cdd:cd21943     21 IEMEPETMETKSLTD 35
FERM_F1_DdMyo7_like cd17208
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Dictyostelium ...
 71-133 3.77e-03

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Dictyostelium discoideum Myosin-VIIa (DdMyo7) and similar proteins; DdMyo7, also termed Myosin-I heavy chain, or class VII unconventional myosin, or M7, plays a role in adhesion in Dictyostelium where it is a component of a complex of proteins that serve to link membrane receptors to the underlying actin cytoskeleton. It interacts with talinA, an actin-binding protein with a known role in cell-substrate adhesion. DdMyo7 is required for phagocytosis. It is also essential for the extension of filopodia, plasma membrane protrusions filled with parallel bundles of F-actin. Members in this family contain a myosin motor domain, two MyTH4 domains, two FERM (Band 4.1, ezrin, radixin, moesin) domains, and two Pleckstrin homology (PH) domains. Some family members contain an extra SH3 domain. Each FERM domain is made up of three sub-domains, F1, F2, and F3. This family corresponds to the F1 sub-domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N).


Pssm-ID: 340728  Cd Length: 98  Bit Score: 38.39  E-value: 3.77e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034664448   71 PNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEyFALALEEQYS-ISRlhLLHEEE 133
Cdd:cd17208      3 PIVARFYFLDGQFKALEFDSAATAAEVLEQLKQKIGLRSTA-DGFALYEVFGgIER--AILPEE 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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