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Conserved domains on  [gi|1034638029|ref|XP_016863112|]
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apelin receptor early endogenous ligand isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Toddler cd20244
Apelin receptor early endogenous ligand, also called Toddler; Apelin receptor early endogenous ...
2-54 1.49e-20

Apelin receptor early endogenous ligand, also called Toddler; Apelin receptor early endogenous ligand, also called protein Elabela or protein Toddler, is an endogenous peptidic ligand of the G protein-coupled receptor APJ, also called apelin receptor (APLNR). The apelin/APJ axis contributes to maintaining homeostasis in normal and pathological hearts, and is also involved in heart development, including endoderm differentiation, heart morphogenesis and coronary vascular formation. Elabela/Toddler plays crucial roles in heart development and disease conditions, presumably at time points or at areas of the heart different from apelin. It is a potential therapeutic peptide, showing beneficial effects on body fluid homeostasis, cardiovascular health, and renal insufficiency, as well as potential benefits for metabolism and diabetes.


:

Pssm-ID: 380780  Cd Length: 53  Bit Score: 75.38  E-value: 1.49e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1034638029  2 RFQQFLFAFFIFIMSLLLISGQRPVNLTMRRKLRKHNCLQRRCMPLHSRVPFP 54
Cdd:cd20244    1 RFQNLLYLLLLLLMSLLLISGQRPDNLNLRRKYHRHNCPHRRCLPLHSRVPFP 53
 
Name Accession Description Interval E-value
Toddler cd20244
Apelin receptor early endogenous ligand, also called Toddler; Apelin receptor early endogenous ...
2-54 1.49e-20

Apelin receptor early endogenous ligand, also called Toddler; Apelin receptor early endogenous ligand, also called protein Elabela or protein Toddler, is an endogenous peptidic ligand of the G protein-coupled receptor APJ, also called apelin receptor (APLNR). The apelin/APJ axis contributes to maintaining homeostasis in normal and pathological hearts, and is also involved in heart development, including endoderm differentiation, heart morphogenesis and coronary vascular formation. Elabela/Toddler plays crucial roles in heart development and disease conditions, presumably at time points or at areas of the heart different from apelin. It is a potential therapeutic peptide, showing beneficial effects on body fluid homeostasis, cardiovascular health, and renal insufficiency, as well as potential benefits for metabolism and diabetes.


Pssm-ID: 380780  Cd Length: 53  Bit Score: 75.38  E-value: 1.49e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1034638029  2 RFQQFLFAFFIFIMSLLLISGQRPVNLTMRRKLRKHNCLQRRCMPLHSRVPFP 54
Cdd:cd20244    1 RFQNLLYLLLLLLMSLLLISGQRPDNLNLRRKYHRHNCPHRRCLPLHSRVPFP 53
 
Name Accession Description Interval E-value
Toddler cd20244
Apelin receptor early endogenous ligand, also called Toddler; Apelin receptor early endogenous ...
2-54 1.49e-20

Apelin receptor early endogenous ligand, also called Toddler; Apelin receptor early endogenous ligand, also called protein Elabela or protein Toddler, is an endogenous peptidic ligand of the G protein-coupled receptor APJ, also called apelin receptor (APLNR). The apelin/APJ axis contributes to maintaining homeostasis in normal and pathological hearts, and is also involved in heart development, including endoderm differentiation, heart morphogenesis and coronary vascular formation. Elabela/Toddler plays crucial roles in heart development and disease conditions, presumably at time points or at areas of the heart different from apelin. It is a potential therapeutic peptide, showing beneficial effects on body fluid homeostasis, cardiovascular health, and renal insufficiency, as well as potential benefits for metabolism and diabetes.


Pssm-ID: 380780  Cd Length: 53  Bit Score: 75.38  E-value: 1.49e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1034638029  2 RFQQFLFAFFIFIMSLLLISGQRPVNLTMRRKLRKHNCLQRRCMPLHSRVPFP 54
Cdd:cd20244    1 RFQNLLYLLLLLLMSLLLISGQRPDNLNLRRKYHRHNCPHRRCLPLHSRVPFP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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