S-methyl-5-thioribose-1-phosphate isomerase catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) and methylthioribulose-1-phosphate (MTRu-1-P)
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part ...
4-317
6.88e-172
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family]
:
Pssm-ID: 273112 [Multi-domain] Cd Length: 335 Bit Score: 479.83 E-value: 6.88e-172
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part ...
4-317
6.88e-172
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 273112 [Multi-domain] Cd Length: 335 Bit Score: 479.83 E-value: 6.88e-172
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a ...
1-317
8.01e-130
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit [Amino acid transport and metabolism];
Pssm-ID: 439952 Cd Length: 343 Bit Score: 373.61 E-value: 8.01e-130
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ...
44-317
1.08e-70
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.
Pssm-ID: 395798 [Multi-domain] Cd Length: 281 Bit Score: 221.01 E-value: 1.08e-70
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part ...
4-317
6.88e-172
S-methyl-5-thioribose-1-phosphate isomerase; The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 273112 [Multi-domain] Cd Length: 335 Bit Score: 479.83 E-value: 6.88e-172
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a ...
1-317
8.01e-130
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit [Amino acid transport and metabolism];
Pssm-ID: 439952 Cd Length: 343 Bit Score: 373.61 E-value: 8.01e-130
eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes ...
33-314
2.89e-97
eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes half of a superfamily, where the other half consists of eukaryotic translation initiation factor 2B (eIF-2B) subunits alpha, beta, and delta. It is unclear whether the eIF-2B_rel set is monophyletic, or whether they are all more closely related to each other than to any eIF-2B subunit because the eIF-2B clade is highly derived. Members of this branch of the family are all uncharacterized with respect to function and are found in the Archaea, Bacteria, and Eukarya, although a number are described as putative translation intiation factor components. Proteins found by eIF-2B_rel include at least three clades, including a set of uncharacterized eukaryotic proteins, a set found in some but not all Archaea, and a set universal so far among the Archaea and closely related to several uncharacterized bacterial proteins. [Unknown function, General]
Pssm-ID: 273119 [Multi-domain] Cd Length: 303 Bit Score: 289.34 E-value: 2.89e-97
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ...
44-317
1.08e-70
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.
Pssm-ID: 395798 [Multi-domain] Cd Length: 281 Bit Score: 221.01 E-value: 1.08e-70
Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ...
38-318
1.76e-44
Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family is part of the Pathway/BioSystem: Translation factors
Pssm-ID: 440797 [Multi-domain] Cd Length: 304 Bit Score: 153.85 E-value: 1.76e-44
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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