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Conserved domains on  [gi|767908874|ref|XP_011507671|]
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protein crumbs homolog 1 isoform X6 [Homo sapiens]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2-130 5.75e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.62  E-value: 5.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874    2 ALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKCIAKAPTP 79
Cdd:pfam02210   8 GLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSLPPGESLL 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767908874   80 LESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 130
Cdd:pfam02210  88 LNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 224-341 2.13e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.08  E-value: 2.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874  224 VRTLQPSGLLLALENSTYQYIRVWLERGRLAML--TPNSPKLVV--KFVLNDGNVHLISLKIKPYKIELYQSSQNLGFIS 299
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRydLGSGPESLLssGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767908874  300 ASTWK--IEKGDVIYIGGLP--DKQETELNGGFFKGCIQDVRLNNQ 341
Cdd:pfam02210  81 PPGESllLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 461-586 8.13e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.16  E-value: 8.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874  461 FRTRDANVIILHAE-KEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQMEVDNE 539
Cdd:pfam02210   1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSG-KNLNDGQWHSVRVERNG-----NTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767908874  540 TpfVTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGGI 586
Cdd:pfam02210  75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 627-656 3.44e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 3.44e-07
                         10        20        30
                 ....*....|....*....|....*....|
gi 767908874 627 NPCLHGGNCEDIYSSYHCSCPLGWSGKHCE 656
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 778-814 4.75e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 4.75e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767908874 778 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 814
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 658-693 1.33e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.33e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767908874 658 NIDECFS-NPC-IHGNCSDRVAAYHCTCEPGYTGVNCE 693
Cdd:cd00054    1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 695-730 2.87e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.87e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767908874 695 DIDNCQS-HQCANGATCISHTNGYSCLCFGNFTGKFC 730
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 157-188 4.38e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 4.38e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 767908874 157 CESQ-PCQSRGRCINLWLSYQCDCHRPYEGPNC 188
Cdd:cd00054    5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 370-404 8.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 8.05e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767908874 370 NSCKS-NPCHNGGVCHSRWDDFSCSCPALTSGKACE 404
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2-130 5.75e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.62  E-value: 5.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874    2 ALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKCIAKAPTP 79
Cdd:pfam02210   8 GLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSLPPGESLL 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767908874   80 LESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 130
Cdd:pfam02210  88 LNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 224-341 2.13e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.08  E-value: 2.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874  224 VRTLQPSGLLLALENSTYQYIRVWLERGRLAML--TPNSPKLVV--KFVLNDGNVHLISLKIKPYKIELYQSSQNLGFIS 299
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRydLGSGPESLLssGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767908874  300 ASTWK--IEKGDVIYIGGLP--DKQETELNGGFFKGCIQDVRLNNQ 341
Cdd:pfam02210  81 PPGESllLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 461-586 8.13e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.16  E-value: 8.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874  461 FRTRDANVIILHAE-KEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQMEVDNE 539
Cdd:pfam02210   1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSG-KNLNDGQWHSVRVERNG-----NTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767908874  540 TpfVTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGGI 586
Cdd:pfam02210  75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 433-583 6.51e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 78.61  E-value: 6.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874 433 AVFNGQSGqILFRSNGNITRElTNITFGFRTRDANVIILHAEKEP--EFLNISIQDSRLFFQLQSGNSfyMLSLTSLQSV 510
Cdd:cd00110    2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874 511 NDGTWHEVTLSMtdplsQTSRWQMEVDNEtPFVTSTIATGSLnFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEI 583
Cdd:cd00110   78 NDGQWHSVSVER-----NGRSVTLSVDGE-RVVESGSPGGSA-LLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 201-339 2.37e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.07  E-value: 2.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874 201 DSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRLAM---LTPNSPKLVVKFVLNDGNVHL 276
Cdd:cd00110    5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLrydLGSGSLVLSSKTPLNDGQWHS 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767908874 277 ISLKIKPYKIELY--QSSQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLN 339
Cdd:cd00110   85 VSVERNGRSVTLSvdGERVVESGSPGGSALLNLDGPLYLGGLPEdlKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
456-585 2.15e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 73.53  E-value: 2.15e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874   456 NITFGFRTRDANVIILHA--EKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQ 533
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDP-TPLNDGQWHRVAVERNG-----RSVT 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767908874   534 MEVDNETPfvTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGG 585
Cdd:smart00282  75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
219-341 1.36e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.44  E-value: 1.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874   219 SLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRL-AMLTPNSPKLVVK---FVLNDGNVHLISLKIKPYKIELY--QS 291
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLvLRYDLGSGPARLTsdpTPLNDGQWHRVAVERNGRSVTLSvdGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767908874   292 SQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLNNQ 341
Cdd:smart00282  81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2-130 4.68e-11

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 61.67  E-value: 4.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874   2 ALLLF--RSNRDVFVKLELLSGYIHLSiqVNNQSKVLLFISHNT-SDGEWHFVEVIfAEAVTLTLIDDSCK--EKCIAKA 76
Cdd:cd00110   35 GLLLYagSQNGGDFLALELEDGRLVLR--YDLGSGSLVLSSKTPlNDGQWHSVSVE-RNGRSVTLSVDGERvvESGSPGG 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767908874  77 PTPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSFVGCLQDIKID 130
Cdd:cd00110  112 SALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
2-130 6.22e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.12  E-value: 6.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874     2 ALLLF--RSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIfAEAVTLTLIDDSCKEKcIAKAP-- 77
Cdd:smart00282  13 GLLLYagSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVE-RNGRSVTLSVDGGNRV-SGESPgg 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767908874    78 -TPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSFVGCLQDIKID 130
Cdd:smart00282  91 lTILNLDGPL------YLGGLPEDLKLPPL--------PVTPGFRGCIRNLKVN 130
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 627-656 3.44e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 3.44e-07
                         10        20        30
                 ....*....|....*....|....*....|
gi 767908874 627 NPCLHGGNCEDIYSSYHCSCPLGWSGKHCE 656
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 778-814 4.75e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 4.75e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767908874 778 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 814
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 624-654 1.02e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.84  E-value: 1.02e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767908874  624 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKH 654
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 658-693 1.33e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.33e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767908874 658 NIDECFS-NPC-IHGNCSDRVAAYHCTCEPGYTGVNCE 693
Cdd:cd00054    1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
778-814 1.02e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.02e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767908874   778 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAF-AGERCE 814
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
627-656 2.19e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.19e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767908874   627 NPCLHGGNCEDIYSSYHCSCPLGWS-GKHCE 656
Cdd:smart00179   9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 695-730 2.87e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.87e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767908874 695 DIDNCQS-HQCANGATCISHTNGYSCLCFGNFTGKFC 730
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 157-188 4.38e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 4.38e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 767908874 157 CESQ-PCQSRGRCINLWLSYQCDCHRPYEGPNC 188
Cdd:cd00054    5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
658-693 6.58e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 6.58e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767908874   658 NIDECFS-NPCIHG-NCSDRVAAYHCTCEPGYT-GVNCE 693
Cdd:smart00179   1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 370-404 8.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 8.05e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767908874 370 NSCKS-NPCHNGGVCHSRWDDFSCSCPALTSGKACE 404
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 157-187 2.99e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 2.99e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767908874  157 CESQPCQSRGRCINLWLSYQCDCHRPYEGPN 187
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 372-401 4.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 4.70e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 767908874  372 CKSNPCHNGGVCHSRWDDFSCSCPALTSGK 401
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
370-404 1.03e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767908874   370 NSCKS-NPCHNGGVCHSRWDDFSCSCPA-LTSGKACE 404
Cdd:smart00179   3 DECASgNPCQNGGTCVNTVGSYRCECPPgYTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 662-691 1.47e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.47e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767908874  662 CFSNPCIH-GNCSDRVAAYHCTCEPGYTGVN 691
Cdd:pfam00008   1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
695-730 1.71e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 1.71e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767908874   695 DIDNCQS-HQCANGATCISHTNGYSCLCFGNFT-GKFC 730
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 782-812 2.55e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767908874  782 CASDPCVNGGLCQDLLNKFQCLCDVAFAGER 812
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
157-188 3.37e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767908874   157 CES-QPCQSRGRCINLWLSYQCDCHRPYE-GPNC 188
Cdd:smart00179   5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2-130 5.75e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.62  E-value: 5.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874    2 ALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKCIAKAPTP 79
Cdd:pfam02210   8 GLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSLPPGESLL 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767908874   80 LESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 130
Cdd:pfam02210  88 LNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 224-341 2.13e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.08  E-value: 2.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874  224 VRTLQPSGLLLALENSTYQYIRVWLERGRLAML--TPNSPKLVV--KFVLNDGNVHLISLKIKPYKIELYQSSQNLGFIS 299
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRydLGSGPESLLssGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767908874  300 ASTWK--IEKGDVIYIGGLP--DKQETELNGGFFKGCIQDVRLNNQ 341
Cdd:pfam02210  81 PPGESllLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 461-586 8.13e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.16  E-value: 8.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874  461 FRTRDANVIILHAE-KEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQMEVDNE 539
Cdd:pfam02210   1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSG-KNLNDGQWHSVRVERNG-----NTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767908874  540 TpfVTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGGI 586
Cdd:pfam02210  75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 433-583 6.51e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 78.61  E-value: 6.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874 433 AVFNGQSGqILFRSNGNITRElTNITFGFRTRDANVIILHAEKEP--EFLNISIQDSRLFFQLQSGNSfyMLSLTSLQSV 510
Cdd:cd00110    2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874 511 NDGTWHEVTLSMtdplsQTSRWQMEVDNEtPFVTSTIATGSLnFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEI 583
Cdd:cd00110   78 NDGQWHSVSVER-----NGRSVTLSVDGE-RVVESGSPGGSA-LLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 201-339 2.37e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.07  E-value: 2.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874 201 DSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRLAM---LTPNSPKLVVKFVLNDGNVHL 276
Cdd:cd00110    5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLrydLGSGSLVLSSKTPLNDGQWHS 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767908874 277 ISLKIKPYKIELY--QSSQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLN 339
Cdd:cd00110   85 VSVERNGRSVTLSvdGERVVESGSPGGSALLNLDGPLYLGGLPEdlKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
456-585 2.15e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 73.53  E-value: 2.15e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874   456 NITFGFRTRDANVIILHA--EKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQ 533
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDP-TPLNDGQWHRVAVERNG-----RSVT 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767908874   534 MEVDNETPfvTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGG 585
Cdd:smart00282  75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_1 pfam00054
Laminin G domain;
461-585 4.78e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 66.96  E-value: 4.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874  461 FRTRDANVIILHAEK--EPEFLNISIQDSRLFFQLQSGNSfyMLSLTSLQSVNDGTWHEVTLSMTdplsqTSRWQMEVDN 538
Cdd:pfam00054   1 FRTTEPSGLLLYNGTqtERDFLALELRDGRLEVSYDLGSG--AAVVRSGDKLNDGKWHSVELERN-----GRSGTLSVDG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767908874  539 ETPFVTSTiATGSLNFLKDNTDIYVG--------DRAIDNIKGLQGCLSTIEIGG 585
Cdd:pfam00054  74 EARPTGES-PLGATTDLDVDGPLYVGglpslgvkKRRLAISPSFDGCIRDVIVNG 127
LamG smart00282
Laminin G domain;
219-341 1.36e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.44  E-value: 1.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874   219 SLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRL-AMLTPNSPKLVVK---FVLNDGNVHLISLKIKPYKIELY--QS 291
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLvLRYDLGSGPARLTsdpTPLNDGQWHRVAVERNGRSVTLSvdGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767908874   292 SQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLNNQ 341
Cdd:smart00282  81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2-130 4.68e-11

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 61.67  E-value: 4.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874   2 ALLLF--RSNRDVFVKLELLSGYIHLSiqVNNQSKVLLFISHNT-SDGEWHFVEVIfAEAVTLTLIDDSCK--EKCIAKA 76
Cdd:cd00110   35 GLLLYagSQNGGDFLALELEDGRLVLR--YDLGSGSLVLSSKTPlNDGQWHSVSVE-RNGRSVTLSVDGERvvESGSPGG 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767908874  77 PTPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSFVGCLQDIKID 130
Cdd:cd00110  112 SALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
2-130 6.22e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.12  E-value: 6.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874     2 ALLLF--RSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIfAEAVTLTLIDDSCKEKcIAKAP-- 77
Cdd:smart00282  13 GLLLYagSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVE-RNGRSVTLSVDGGNRV-SGESPgg 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767908874    78 -TPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSFVGCLQDIKID 130
Cdd:smart00282  91 lTILNLDGPL------YLGGLPEDLKLPPL--------PVTPGFRGCIRNLKVN 130
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 627-656 3.44e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 3.44e-07
                         10        20        30
                 ....*....|....*....|....*....|
gi 767908874 627 NPCLHGGNCEDIYSSYHCSCPLGWSGKHCE 656
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 778-814 4.75e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 4.75e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767908874 778 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 814
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
9-130 7.70e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 49.24  E-value: 7.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874    9 NRDVFVKLELLSGYIHLSIQVNNQsKVLLFISHNTSDGEWHFVEVifaEAVT--LTLIDDSCKEKCIAkapTPLESDQSI 86
Cdd:pfam00054  17 TERDFLALELRDGRLEVSYDLGSG-AAVVRSGDKLNDGKWHSVEL---ERNGrsGTLSVDGEARPTGE---SPLGATTDL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767908874   87 CAFQNSFLGGLPvgmtSNGVALLNFynmPSTPSFVGCLQDIKID 130
Cdd:pfam00054  90 DVDGPLYVGGLP----SLGVKKRRL---AISPSFDGCIRDVIVN 126
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 624-654 1.02e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.84  E-value: 1.02e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767908874  624 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKH 654
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 658-693 1.33e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.33e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767908874 658 NIDECFS-NPC-IHGNCSDRVAAYHCTCEPGYTGVNCE 693
Cdd:cd00054    1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
224-344 5.10e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 5.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908874  224 VRTLQPSGLLLALENSTY-QYIRVWLERGRLAMLTPNSPKLVV---KFVLNDGNVHLISLKIKPYKIELY---------- 289
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTErDFLALELRDGRLEVSYDLGSGAAVvrsGDKLNDGKWHSVELERNGRSGTLSvdgearptge 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767908874  290 QSSQNLGFISASTwkiekgdVIYIGGLPDKQETEL---NGGFFKGCIQDVRLNNQNLE 344
Cdd:pfam00054  81 SPLGATTDLDVDG-------PLYVGGLPSLGVKKRrlaISPSFDGCIRDVIVNGKPLD 131
EGF_CA smart00179
Calcium-binding EGF-like domain;
778-814 1.02e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.02e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767908874   778 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAF-AGERCE 814
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
627-656 2.19e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.19e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767908874   627 NPCLHGGNCEDIYSSYHCSCPLGWS-GKHCE 656
Cdd:smart00179   9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 695-730 2.87e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.87e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767908874 695 DIDNCQS-HQCANGATCISHTNGYSCLCFGNFTGKFC 730
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 157-188 4.38e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 4.38e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 767908874 157 CESQ-PCQSRGRCINLWLSYQCDCHRPYEGPNC 188
Cdd:cd00054    5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
658-693 6.58e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 6.58e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767908874   658 NIDECFS-NPCIHG-NCSDRVAAYHCTCEPGYT-GVNCE 693
Cdd:smart00179   1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 370-404 8.05e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 8.05e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767908874 370 NSCKS-NPCHNGGVCHSRWDDFSCSCPALTSGKACE 404
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 625-656 1.35e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.77  E-value: 1.35e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 767908874 625 NSNPCLHGGNCEDIYSSYHCSCPLGWSG-KHCE 656
Cdd:cd00053    4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 157-187 2.99e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 2.99e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767908874  157 CESQPCQSRGRCINLWLSYQCDCHRPYEGPN 187
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 372-401 4.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 4.70e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 767908874  372 CKSNPCHNGGVCHSRWDDFSCSCPALTSGK 401
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
370-404 1.03e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767908874   370 NSCKS-NPCHNGGVCHSRWDDFSCSCPA-LTSGKACE 404
Cdd:smart00179   3 DECASgNPCQNGGTCVNTVGSYRCECPPgYTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 662-691 1.47e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.47e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767908874  662 CFSNPCIH-GNCSDRVAAYHCTCEPGYTGVN 691
Cdd:pfam00008   1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
695-730 1.71e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 1.71e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767908874   695 DIDNCQS-HQCANGATCISHTNGYSCLCFGNFT-GKFC 730
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 782-812 2.55e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767908874  782 CASDPCVNGGLCQDLLNKFQCLCDVAFAGER 812
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
157-188 3.37e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767908874   157 CES-QPCQSRGRCINLWLSYQCDCHRPYE-GPNC 188
Cdd:smart00179   5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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