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Conserved domains on  [gi|578802568|ref|XP_006711956|]
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EARP and GARP complex-interacting protein 1 isoform X3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-270 4.11e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 87.78  E-value: 4.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568  39 CVVWEPmgDGKKIISL-ADNHILLWDLQESSSQavlassASLEGKgQLKFTSGRWSPHHNctQVATA-NDTTLRGWDTRS 116
Cdd:cd00200   14 CVAFSP--DGKLLATGsGDGTIKVWDLETGELL------RTLKGH-TGPVRDVAASADGT--YLASGsSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568 117 MSQIYCIEnAHGQLVRDLDFNPNKQyYLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYNHShDQLVLTGSSDSR 196
Cdd:cd00200   83 GECVRTLT-GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGT 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578802568 197 VILSNMVSISsepfghlvddddisdqedhrseekskeplqdnVIATYEEHEDSVYAVDWSSADPWLFASlSYDG 270
Cdd:cd00200  159 IKLWDLRTGK--------------------------------CVATLTGHTGEVNSVAFSPDGEKLLSS-SSDG 199
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-270 4.11e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.78  E-value: 4.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568  39 CVVWEPmgDGKKIISL-ADNHILLWDLQESSSQavlassASLEGKgQLKFTSGRWSPHHNctQVATA-NDTTLRGWDTRS 116
Cdd:cd00200   14 CVAFSP--DGKLLATGsGDGTIKVWDLETGELL------RTLKGH-TGPVRDVAASADGT--YLASGsSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568 117 MSQIYCIEnAHGQLVRDLDFNPNKQyYLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYNHShDQLVLTGSSDSR 196
Cdd:cd00200   83 GECVRTLT-GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGT 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578802568 197 VILSNMVSISsepfghlvddddisdqedhrseekskeplqdnVIATYEEHEDSVYAVDWSSADPWLFASlSYDG 270
Cdd:cd00200  159 IKLWDLRTGK--------------------------------CVATLTGHTGEVNSVAFSPDGEKLLSS-SSDG 199
WD40 COG2319
WD40 repeat [General function prediction only];
39-272 1.16e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568  39 CVVWEPmgDGKKIISL-ADNHILLWDLQESSSQAVLASsaslegkGQLKFTSGRWSPhhNCTQVATA-NDTTLRGWDTRS 116
Cdd:COG2319  125 SVAFSP--DGKTLASGsADGTVRLWDLATGKLLRTLTG-------HSGAVTSVAFSP--DGKLLASGsDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568 117 MSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYnhSHD-QLVLTGSSDS 195
Cdd:COG2319  194 GKLLRTLT-GHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAF--SPDgRLLASGSADG 268

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578802568 196 RVILSNMVSissepfghlvddddisdqedhrseekskeplqDNVIATYEEHEDSVYAVDWsSADPWLFASLSYDGRL 272
Cdd:COG2319  269 TVRLWDLAT--------------------------------GELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGTV 312
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-157 4.18e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.18e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 578802568   125 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 157
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
125-157 1.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 578802568  125 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 157
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 104-181 1.57e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568 104 ANDTTLRGWDTR----SMSQI---YCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTL--EEHSHW 174
Cdd:PTZ00420  94 SEDLTIRVWEIPhndeSVKEIkdpQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINmpKKLSSL 173


                 ....*..
gi 578802568 175 VWNVRYN 181
Cdd:PTZ00420 174 KWNIKGN 180
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-270 4.11e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.78  E-value: 4.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568  39 CVVWEPmgDGKKIISL-ADNHILLWDLQESSSQavlassASLEGKgQLKFTSGRWSPHHNctQVATA-NDTTLRGWDTRS 116
Cdd:cd00200   14 CVAFSP--DGKLLATGsGDGTIKVWDLETGELL------RTLKGH-TGPVRDVAASADGT--YLASGsSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568 117 MSQIYCIEnAHGQLVRDLDFNPNKQyYLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYNHShDQLVLTGSSDSR 196
Cdd:cd00200   83 GECVRTLT-GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGT 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578802568 197 VILSNMVSISsepfghlvddddisdqedhrseekskeplqdnVIATYEEHEDSVYAVDWSSADPWLFASlSYDG 270
Cdd:cd00200  159 IKLWDLRTGK--------------------------------CVATLTGHTGEVNSVAFSPDGEKLLSS-SSDG 199
WD40 COG2319
WD40 repeat [General function prediction only];
39-272 1.16e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568  39 CVVWEPmgDGKKIISL-ADNHILLWDLQESSSQAVLASsaslegkGQLKFTSGRWSPhhNCTQVATA-NDTTLRGWDTRS 116
Cdd:COG2319  125 SVAFSP--DGKTLASGsADGTVRLWDLATGKLLRTLTG-------HSGAVTSVAFSP--DGKLLASGsDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568 117 MSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYnhSHD-QLVLTGSSDS 195
Cdd:COG2319  194 GKLLRTLT-GHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAF--SPDgRLLASGSADG 268

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578802568 196 RVILSNMVSissepfghlvddddisdqedhrseekskeplqDNVIATYEEHEDSVYAVDWsSADPWLFASLSYDGRL 272
Cdd:COG2319  269 TVRLWDLAT--------------------------------GELLRTLTGHSGGVNSVAF-SPDGKLLASGSDDGTV 312
WD40 COG2319
WD40 repeat [General function prediction only];
39-199 1.21e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 1.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568  39 CVVWEPmgDGKKIISL-ADNHILLWDLQESSSQAVLASSASlegkgqlKFTSGRWSPhhNCTQVATA-NDTTLRGWDTRS 116
Cdd:COG2319  251 SVAFSP--DGRLLASGsADGTVRLWDLATGELLRTLTGHSG-------GVNSVAFSP--DGKLLASGsDDGTVRLWDLAT 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568 117 MSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYnhSHD-QLVLTGSSDS 195
Cdd:COG2319  320 GKLLRTLT-GHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLAT-GELLRTLTGHTGAVTSVAF--SPDgRTLASGSADG 394


                 ....
gi 578802568 196 RVIL 199
Cdd:COG2319  395 TVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-199 1.51e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 1.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568  53 SLADNHILLWDLQESSSQAVLA------SSASLEGKGQlKFtsgrwsphhnctqVATANDTTLRGWDTRSMSQIYCIEnA 126
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTghtgevNSVAFSPDGE-KL-------------LSSSSDGTIKLWDLSTGKCLGTLR-G 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578802568 127 HGQLVRDLDFNPNKqYYLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYnHSHDQLVLTGSSDSRVIL 199
Cdd:cd00200  218 HENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 127-274 6.99e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 6.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568 127 HGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYnHSHDQLVLTGSSDSRVILSNMVSis 206
Cdd:cd00200    8 HTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLET-- 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578802568 207 sepfghlvddddisdqedhrseekskeplqDNVIATYEEHEDSVYAVDWSSADPWLFASlSYDGRLVI 274
Cdd:cd00200   83 ------------------------------GECVRTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKV 119
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-157 6.62e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 6.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568  32 TAH-GNMACVVWEPmgDGKKIISLA-DNHILLWDLQESssqavlASSASLEGKGQlKFTSGRWSPHHNcTQVATANDTTL 109
Cdd:cd00200  174 TGHtGEVNSVAFSP--DGEKLLSSSsDGTIKLWDLSTG------KCLGTLRGHEN-GVNSVAFSPDGY-LLASGSEDGTI 243

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 578802568 110 RGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 157
Cdd:cd00200  244 RVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
47-160 7.29e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 7.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568  47 DGKKIISL-ADNHILLWDLQESSSQAVLASSASlegkgqlKFTSGRWSPhhNCTQVATA-NDTTLRGWDTRSMSQIYCIE 124
Cdd:COG2319  299 DGKLLASGsDDGTVRLWDLATGKLLRTLTGHTG-------AVRSVAFSP--DGKTLASGsDDGTVRLWDLATGELLRTLT 369

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 578802568 125 nAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRN 160
Cdd:COG2319  370 -GHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
99-274 3.17e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 3.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568  99 TQVATANDTTLRGWDTRSMSQIYcIENAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNV 178
Cdd:COG2319   50 RLAAGAGDLTLLLLDAAAGALLA-TLLGHTAAVLSVAFSPDGRL-LASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSV 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568 179 RYnhSHD-QLVLTGSSDSRVILSNMVSissepfghlvddddisdqedhrseekskeplqDNVIATYEEHEDSVYAVDWSS 257
Cdd:COG2319  127 AF--SPDgKTLASGSADGTVRLWDLAT--------------------------------GKLLRTLTGHSGAVTSVAFSP 172

                        170
                 ....*....|....*..
gi 578802568 258 ADPWLfASLSYDGRLVI 274
Cdd:COG2319  173 DGKLL-ASGSDDGTVRL 188
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-157 4.18e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.18e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 578802568   125 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 157
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
125-157 1.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 578802568  125 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 157
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 104-181 1.57e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578802568 104 ANDTTLRGWDTR----SMSQI---YCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTL--EEHSHW 174
Cdd:PTZ00420  94 SEDLTIRVWEIPhndeSVKEIkdpQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINmpKKLSSL 173


                 ....*..
gi 578802568 175 VWNVRYN 181
Cdd:PTZ00420 174 KWNIKGN 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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