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Conserved domains on  [gi|156037686|ref|XP_001586570|]
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hypothetical protein SS1G_12557 [Sclerotinia sclerotiorum 1980 UF-70]

Protein Classification

RPN7 and PINT domain-containing protein( domain architecture ID 10566213)

RPN7 and PINT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
 80-256 4.78e-60

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


:

Pssm-ID: 431387  Cd Length: 174  Bit Score: 192.40  E-value: 4.78e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156037686   80 DDQWIDATNKSNAAEAARLEAQLKGYKNNLIKESTRMGNEDLGKHYEATGQLALAFDAYSRMRQDISIPRHVIDVCKHII 159
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156037686  160 EVSIERKEYIAVLSNVQKMRGTSVGPyDDQDVKPFCHVAEGIAQMHAGQYAMAAQTFLQVPPGFagSYYTIVTANDVAVY 239
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKG-GDWERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTF--TSTELISYEDVAVY 157

                         170
                  ....*....|....*..
gi 156037686  240 GGLCALATIERNDLQKL 256
Cdd:pfam10602 158 GVLCALASLDRVDLKAK 174
PCI super family cl47662
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 271-319 5.87e-04

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


The actual alignment was detected with superfamily member pfam01399:

Pssm-ID: 460195  Cd Length: 105  Bit Score: 39.12  E-value: 5.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 156037686  271 PHIRRAIQAFVGSKYSTCLEILESYKADYLLDIHLQKHVDELYTRVRKM 319
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREH 49
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
 80-256 4.78e-60

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 192.40  E-value: 4.78e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156037686   80 DDQWIDATNKSNAAEAARLEAQLKGYKNNLIKESTRMGNEDLGKHYEATGQLALAFDAYSRMRQDISIPRHVIDVCKHII 159
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156037686  160 EVSIERKEYIAVLSNVQKMRGTSVGPyDDQDVKPFCHVAEGIAQMHAGQYAMAAQTFLQVPPGFagSYYTIVTANDVAVY 239
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKG-GDWERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTF--TSTELISYEDVAVY 157

                         170
                  ....*....|....*..
gi 156037686  240 GGLCALATIERNDLQKL 256
Cdd:pfam10602 158 GVLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 271-319 5.87e-04

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 39.12  E-value: 5.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 156037686  271 PHIRRAIQAFVGSKYSTCLEILESYKADYLLDIHLQKHVDELYTRVRKM 319
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREH 49
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
 80-256 4.78e-60

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 192.40  E-value: 4.78e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156037686   80 DDQWIDATNKSNAAEAARLEAQLKGYKNNLIKESTRMGNEDLGKHYEATGQLALAFDAYSRMRQDISIPRHVIDVCKHII 159
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156037686  160 EVSIERKEYIAVLSNVQKMRGTSVGPyDDQDVKPFCHVAEGIAQMHAGQYAMAAQTFLQVPPGFagSYYTIVTANDVAVY 239
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKG-GDWERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTF--TSTELISYEDVAVY 157

                         170
                  ....*....|....*..
gi 156037686  240 GGLCALATIERNDLQKL 256
Cdd:pfam10602 158 GVLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 271-319 5.87e-04

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 39.12  E-value: 5.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 156037686  271 PHIRRAIQAFVGSKYSTCLEILESYKADYLLDIHLQKHVDELYTRVRKM 319
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREH 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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