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Conserved domains on  [gi|190358750|sp|Q96HJ3|]
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RecName: Full=Coiled-coil domain-containing protein 34; AltName: Full=Renal carcinoma antigen NY-REN-41

Protein Classification

CCDC34 family protein( domain architecture ID 12159777)

CCDC34 family protein is a DUF4207 domain-containing protein similar to human coiled-coil domain-containing protein 34 (CCDC34)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 102-321 1.24e-38

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


:

Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 137.53  E-value: 1.24e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  102 DSEAKVASLRGMELQgcASTQVESENNQEEQKQVRLPESRLTPWEVWFIGKeKEERDRlqlkalEELNQQLEKRKEMEER 181
Cdd:pfam13904  16 EEESSKHRVPSLSLD--SSSQSSSLTYARKLEGLKLERQPLEAYENWLAAK-QRQRQK------ELQAQKEEREKEEQEA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  182 EKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEMEEKAAKEL---EKEYLQEKAKEKYQEWLKKKNAEECERKKKEKEKE 258
Cdd:pfam13904  87 ELRKRLAKEKYQEWLQRKARQQTKKREESHKQKAAESASKSLakpERKVSQEEAKEVLQEWERKKLEQQQRKREEEQREQ 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190358750  259 KQQQAEIQEKKEIAEKKFQEWLENAKHKPRPAAKSYGYANGKLTGfysgnsypEPAFYNPIPW 321
Cdd:pfam13904 167 LKKEEEEQERKQLAEKAWQKWMKNVKNKPKPVPLNQGFDSLRGTV--------SPIYINPIPW 221
 
Name Accession Description Interval E-value
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 102-321 1.24e-38

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 137.53  E-value: 1.24e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  102 DSEAKVASLRGMELQgcASTQVESENNQEEQKQVRLPESRLTPWEVWFIGKeKEERDRlqlkalEELNQQLEKRKEMEER 181
Cdd:pfam13904  16 EEESSKHRVPSLSLD--SSSQSSSLTYARKLEGLKLERQPLEAYENWLAAK-QRQRQK------ELQAQKEEREKEEQEA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  182 EKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEMEEKAAKEL---EKEYLQEKAKEKYQEWLKKKNAEECERKKKEKEKE 258
Cdd:pfam13904  87 ELRKRLAKEKYQEWLQRKARQQTKKREESHKQKAAESASKSLakpERKVSQEEAKEVLQEWERKKLEQQQRKREEEQREQ 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190358750  259 KQQQAEIQEKKEIAEKKFQEWLENAKHKPRPAAKSYGYANGKLTGfysgnsypEPAFYNPIPW 321
Cdd:pfam13904 167 LKKEEEEQERKQLAEKAWQKWMKNVKNKPKPVPLNQGFDSLRGTV--------SPIYINPIPW 221
PTZ00121 PTZ00121
MAEBL; Provisional
 152-293 2.78e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  152 KEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEMEEKAAKELEKeylQEK 231
Cdd:PTZ00121 1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKK---AAA 1415

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190358750  232 AKEKYQEWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKKfqewlENAKHKPRPAAKS 293
Cdd:PTZ00121 1416 AKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKA-----EEAKKKAEEAKKA 1472
 
Name Accession Description Interval E-value
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 102-321 1.24e-38

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 137.53  E-value: 1.24e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  102 DSEAKVASLRGMELQgcASTQVESENNQEEQKQVRLPESRLTPWEVWFIGKeKEERDRlqlkalEELNQQLEKRKEMEER 181
Cdd:pfam13904  16 EEESSKHRVPSLSLD--SSSQSSSLTYARKLEGLKLERQPLEAYENWLAAK-QRQRQK------ELQAQKEEREKEEQEA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  182 EKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEMEEKAAKEL---EKEYLQEKAKEKYQEWLKKKNAEECERKKKEKEKE 258
Cdd:pfam13904  87 ELRKRLAKEKYQEWLQRKARQQTKKREESHKQKAAESASKSLakpERKVSQEEAKEVLQEWERKKLEQQQRKREEEQREQ 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190358750  259 KQQQAEIQEKKEIAEKKFQEWLENAKHKPRPAAKSYGYANGKLTGfysgnsypEPAFYNPIPW 321
Cdd:pfam13904 167 LKKEEEEQERKQLAEKAWQKWMKNVKNKPKPVPLNQGFDSLRGTV--------SPIYINPIPW 221
PTZ00121 PTZ00121
MAEBL; Provisional
 152-293 2.78e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  152 KEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEMEEKAAKELEKeylQEK 231
Cdd:PTZ00121 1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKK---AAA 1415

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190358750  232 AKEKYQEWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKKfqewlENAKHKPRPAAKS 293
Cdd:PTZ00121 1416 AKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKA-----EEAKKKAEEAKKA 1472
PTZ00121 PTZ00121
MAEBL; Provisional
 106-278 3.63e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 3.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  106 KVASLRGMELQGCASTQVESENNQEEQKQVRLPESRLTPWEVWFIGKEKEERDRLQLKALEELNQqLEKRKEMEEREKRK 185
Cdd:PTZ00121 1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENK-IKAAEEAKKAEEDK 1674

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  186 IIAEEKHKEwvqkkNEQKRKEREQKINKEMEEKAAKELEKEYLQEKAK----EKYQEWLKKKNAEECERKKKEKEKEKQQ 261
Cdd:PTZ00121 1675 KKAEEAKKA-----EEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKaeelKKAEEENKIKAEEAKKEAEEDKKKAEEA 1749

                         170
                  ....*....|....*..
gi 190358750  262 QAEIQEKKEIAEKKFQE 278
Cdd:PTZ00121 1750 KKDEEEKKKIAHLKKEE 1766
PTZ00121 PTZ00121
MAEBL; Provisional
 152-292 3.99e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 3.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  152 KEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEEKHKEWVQKKNEQKRKEREQKinKEMEEKAAKELEKeylqeK 231
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAK--KAEEKKKADEAKK-----K 1310

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190358750  232 AKEKYQEWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKKFQEWLENAKHKPRPAAK 292
Cdd:PTZ00121 1311 AEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEK 1371
PTZ00121 PTZ00121
MAEBL; Provisional
 122-291 4.58e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  122 QVESENNQEEQKQVRLPESRLTPWEVWFIgKEKEERDRLQLKALEELNQ--QLEKRKEMEEREKRKIIAEEKHK-EWVQK 198
Cdd:PTZ00121 1244 KAEEERNNEEIRKFEEARMAHFARRQAAI-KAEEARKADELKKAEEKKKadEAKKAEEKKKADEAKKKAEEAKKaDEAKK 1322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  199 KNEQKRKEREQKINKEMEEKAAKELEKEYLQEKAKEKYQEWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKKFQE 278
Cdd:PTZ00121 1323 KAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEE 1402

                         170
                  ....*....|...
gi 190358750  279 WLENAKHKPRPAA 291
Cdd:PTZ00121 1403 DKKKADELKKAAA 1415
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 186-235 6.01e-04

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 41.40  E-value: 6.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 190358750  186 IIAEEKHKEWVQKKNEQKRKEREQKINKEMEEKAAKELEKEylQEKAKEK 235
Cdd:pfam07946 276 AAEEERAEEAQEKKEEAKKKEREEKLAKLSPEEQRKYEEKE--RKKEQRK 323
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 155-292 7.07e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 41.33  E-value: 7.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750 155 EERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEEKHKEwvqKKNEQKRKEREQKinKEMEEKAAKELEKEYLQEKAKE 234
Cdd:PRK09510  79 EQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKK---QAEEAAKQAALKQ--KQAEEAAAKAAAAAKAKAEAEA 153

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 190358750 235 KYQEWLKKKNAeecERKKKEKEKEKQQQAEIQEKKEIAEKKFQEWLENAKHKPRPAAK 292
Cdd:PRK09510 154 KRAAAAAKKAA---AEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAK 208
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 197-275 1.58e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 40.17  E-value: 1.58e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 190358750 197 QKKNEQKRKEREQKINKEMEEKAAKELEKeyLQEKAKEKYQEWLKKKNAeeceRKKKEKEKEKQQQAEIQEKKEIAEKK 275
Cdd:PRK09510  74 AKRAEEQRKKKEQQQAEELQQKQAAEQER--LKQLEKERLAAQEQKKQA----EEAAKQAALKQKQAEEAAAKAAAAAK 146
PTZ00121 PTZ00121
MAEBL; Provisional
 152-281 2.21e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  152 KEKEERDRLQLKALEELNQ----------QLEKRKEMEEREKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEMEE-KAA 220
Cdd:PTZ00121 1570 KKAEEDKNMALRKAEEAKKaeearieevmKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEkKKA 1649

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190358750  221 KELEKEylQEKAKEKYQEWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKKFQEWLE 281
Cdd:PTZ00121 1650 EELKKA--EEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELK 1708
PTZ00121 PTZ00121
MAEBL; Provisional
 152-290 3.26e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 3.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  152 KEKEERDRLQLkalEELNQQLEKRKEMEEREKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEMEEKAAKELEKEYLQEK 231
Cdd:PTZ00121 1363 EEKAEAAEKKK---EEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKK 1439

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  232 AKEKYQ-EWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKKFQEWLENAKHKPRPA 290
Cdd:PTZ00121 1440 AEEAKKaDEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKA 1499
PTZ00121 PTZ00121
MAEBL; Provisional
 119-278 3.91e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  119 ASTQVESENNQEEQKQVRLPESRLTPWEVWFIGKEKEERDRLQLKAlEELNQQLEKRKEMEEREKRKIIAEEKHKEwVQK 198
Cdd:PTZ00121 1355 AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKA-EEDKKKADELKKAAAAKKKADEAKKKAEE-KKK 1432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  199 KNEQKRKEREQKINKEMEEKAAKELEKEYLQEKAKE--KYQEWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKKF 276
Cdd:PTZ00121 1433 ADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEakKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKA 1512


                  ..
gi 190358750  277 QE 278
Cdd:PTZ00121 1513 DE 1514
PTZ00121 PTZ00121
MAEBL; Provisional
 152-288 6.45e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 6.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  152 KEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEE--KHKEWVQKKNEQKRKEREQKINKEMEEKAAKELEKEYLQ 229
Cdd:PTZ00121 1397 KKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEakKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAK 1476

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 190358750  230 EKAKEKYQEWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKKFQEWLENAKHKPR 288
Cdd:PTZ00121 1477 KKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKK 1535
PTZ00121 PTZ00121
MAEBL; Provisional
 188-288 8.95e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.20  E-value: 8.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190358750  188 AEEKHK-EWVQKKNEQKRKEREQKINKEMEEKAAKELEKEYLQEKAKEKYQEWLKKKNAEECERKKKEKEKEKQQQAEiq 266
Cdd:PTZ00121 1466 AEEAKKaDEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAE-- 1543

                          90       100
                  ....*....|....*....|..
gi 190358750  267 EKKEIAEKKFQEWLENAKHKPR 288
Cdd:PTZ00121 1544 EKKKADELKKAEELKKAEEKKK 1565
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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