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Conserved domains on  [gi|18677720|ref|NP_056441|]
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WD repeat and SOCS box-containing protein 1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-378 1.78e-66

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 217.47  E-value: 1.78e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  38 WTVAFAPDGSYFAWSQGHRTVKLvpWS----QCLQNFLLHGtknvtnssslrlprqnsdggqknkprehiidcgDIVWSL 113
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRL--WDlatgKLLRTLTGHS---------------------------------GAVTSV 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 114 AFGSSvpekqsrcvniewhrfrfGQdqlLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDK 193
Cdd:COG2319 169 AFSPD------------------GK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADG 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 194 TLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLAT 273
Cdd:COG2319 227 TVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 274 ASYDTRVYIWDPHNGDILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLS 352
Cdd:COG2319 306 GSDDGTVRLWDLATGKLLRTLtGH--------------TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371

                       330       340
                ....*....|....*....|....*...
gi 18677720 353 NG--LCCAFSTDGSVLAAGTHDGSVYFW 378
Cdd:COG2319 372 TGavTSVAFSPDGRTLASGSADGTVRLW 399
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 382-421 1.50e-23

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239715  Cd Length: 40  Bit Score: 92.18  E-value: 1.50e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 18677720 382 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 421
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-378 1.78e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 217.47  E-value: 1.78e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  38 WTVAFAPDGSYFAWSQGHRTVKLvpWS----QCLQNFLLHGtknvtnssslrlprqnsdggqknkprehiidcgDIVWSL 113
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRL--WDlatgKLLRTLTGHS---------------------------------GAVTSV 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 114 AFGSSvpekqsrcvniewhrfrfGQdqlLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDK 193
Cdd:COG2319 169 AFSPD------------------GK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADG 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 194 TLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLAT 273
Cdd:COG2319 227 TVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 274 ASYDTRVYIWDPHNGDILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLS 352
Cdd:COG2319 306 GSDDGTVRLWDLATGKLLRTLtGH--------------TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371

                       330       340
                ....*....|....*....|....*...
gi 18677720 353 NG--LCCAFSTDGSVLAAGTHDGSVYFW 378
Cdd:COG2319 372 TGavTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-388 4.60e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 186.77  E-value: 4.60e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLKDdGNMMKVLRGHQ 214
Cdd:cd00200  16 AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-GECVRTLTGHT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 215 NWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF 294
Cdd:cd00200  94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 295 -GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTH 371
Cdd:cd00200 174 tGH--------------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvNSVAFSPDGYLLASGSE 239

                       250
                ....*....|....*....
gi 18677720 372 DGSVYFW--ATPRQVPSLQ 388
Cdd:cd00200 240 DGTIRVWdlRTGECVQTLS 258
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 382-421 1.50e-23

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 92.18  E-value: 1.50e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 18677720 382 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 421
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 378-420 3.08e-15

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 69.25  E-value: 3.08e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 18677720    378 WATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
PTZ00421 PTZ00421
coronin; Provisional
 175-291 5.73e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.98  E-value: 5.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  175 DLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV------LRGHQNWVYSCAFSPDS-SMLCSVGASKAVFLWNMDKYT 247
Cdd:PTZ00421  80 DVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNIsdpivhLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGK 159

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 18677720  248 MIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDIL 291
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIV 203
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 383-417 6.95e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.01  E-value: 6.95e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18677720   383 QVPSLQHLCRMSIRRVMPT---QEVQELPIPSKLLEFL 417
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKrrlGAIDKLPLPPLLKDYL 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 249-284 1.23e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.23e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 18677720    249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
249-284 1.54e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.54e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 18677720   249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-378 1.78e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 217.47  E-value: 1.78e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  38 WTVAFAPDGSYFAWSQGHRTVKLvpWS----QCLQNFLLHGtknvtnssslrlprqnsdggqknkprehiidcgDIVWSL 113
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRL--WDlatgKLLRTLTGHS---------------------------------GAVTSV 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 114 AFGSSvpekqsrcvniewhrfrfGQdqlLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDK 193
Cdd:COG2319 169 AFSPD------------------GK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADG 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 194 TLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLAT 273
Cdd:COG2319 227 TVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 274 ASYDTRVYIWDPHNGDILMEF-GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLS 352
Cdd:COG2319 306 GSDDGTVRLWDLATGKLLRTLtGH--------------TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371

                       330       340
                ....*....|....*....|....*...
gi 18677720 353 NG--LCCAFSTDGSVLAAGTHDGSVYFW 378
Cdd:COG2319 372 TGavTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
38-388 1.94e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 217.09  E-value: 1.94e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  38 WTVAFAPDGSYFAWSQGHRTVKLvpWsqclqnfllhgtkNVTNSSSLRLPRQNSDGgqknkprehiidcgdiVWSLAFGS 117
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRL--W-------------DLATGLLLRTLTGHTGA----------------VRSVAFSP 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 118 svpekqsrcvniewhrfrfgqDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRV 197
Cdd:COG2319 131 ---------------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRL 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 198 WDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 277
Cdd:COG2319 189 WDL-ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 278 TRVYIWDPHNGDILMEFGHlfppptpifaggaNDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV--APLSNGL 355
Cdd:COG2319 268 GTVRLWDLATGELLRTLTG-------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTltGHTGAVR 334

                       330       340       350
                ....*....|....*....|....*....|....*
gi 18677720 356 CCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQ 388
Cdd:COG2319 335 SVAFSPDGKTLASGSDDGTVRLWdlATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-388 4.60e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 186.77  E-value: 4.60e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLKDdGNMMKVLRGHQ 214
Cdd:cd00200  16 AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-GECVRTLTGHT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 215 NWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF 294
Cdd:cd00200  94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 295 -GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTH 371
Cdd:cd00200 174 tGH--------------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvNSVAFSPDGYLLASGSE 239

                       250
                ....*....|....*....
gi 18677720 372 DGSVYFW--ATPRQVPSLQ 388
Cdd:cd00200 240 DGTIRVWdlRTGECVQTLS 258
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 166-378 1.46e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.73  E-value: 1.46e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 166 LVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLfppptpifaggandRWVRSVSFSHDGL 324
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGHT--------------DWVNSVAFSPDGT 148

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18677720 325 HVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 378
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTGKCVATLTGHTGevNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
38-287 1.06e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.77  E-value: 1.06e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  38 WTVAFAPDGSYFAWSQGHRTVKLvpWsqclqnfllhgtkNVTNSSSLRLPRQNSDGgqknkprehiidcgdiVWSLAFGS 117
Cdd:COG2319 208 RSVAFSPDGKLLASGSADGTVRL--W-------------DLATGKLLRTLTGHSGS----------------VRSVAFSP 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 118 svpekqsrcvniewhrfrfgqDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRV 197
Cdd:COG2319 257 ---------------------DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRL 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 198 WDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 277
Cdd:COG2319 315 WDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393

                       250
                ....*....|
gi 18677720 278 TRVYIWDPHN 287
Cdd:COG2319 394 GTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
135-389 1.65e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 1.65e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGsLILVSASRDKTLRVWDLkDDGNMMKVLRGHQ 214
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDG-ARLAAGAGDLTLLLLDA-AAGALLATLLGHT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 215 NWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF 294
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 295 -GHlfppptpifagganDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTH 371
Cdd:COG2319 159 tGH--------------SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGavRSVAFSPDGKLLASGSA 224

                       250       260
                ....*....|....*....|
gi 18677720 372 DGSVYFW--ATPRQVPSLQH 389
Cdd:COG2319 225 DGTVRLWdlATGKLLRTLTG 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-284 1.66e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.24  E-value: 1.66e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  38 WTVAFAPDGSYFAWSQGHRTVKLVPWS--QCLQNFLLHgTKNVtnsSSLRLprqnsdggqknKPREHII-----DCGDIV 110
Cdd:cd00200  55 RDVAASADGTYLASGSSDKTIRLWDLEtgECVRTLTGH-TSYV---SSVAF-----------SPDGRILssssrDKTIKV 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 111 WSLAFGSSVPEKQS-----RCVniewhrfRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLi 185
Cdd:cd00200 120 WDVETGKCLTTLRGhtdwvNSV-------AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK- 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 186 LVSASRDKTLRVWDLkDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFS 265
Cdd:cd00200 192 LLSSSSDGTIKLWDL-STGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                       250
                ....*....|....*....
gi 18677720 266 PDGALLATASYDTRVYIWD 284
Cdd:cd00200 271 PDGKRLASGSADGTIRIWD 289
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 382-421 1.50e-23

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 92.18  E-value: 1.50e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 18677720 382 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 421
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 382-420 3.72e-21

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 85.55  E-value: 3.72e-21
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 18677720 382 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 248-378 9.31e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 9.31e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 248 MIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GH-------LFPPPTPIFAGGANDR------- 312
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHtgpvrdvAASADGTYLASGSSDKtirlwdl 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 313 --------------WVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVY 376
Cdd:cd00200  81 etgecvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwvNSVAFSPDGTFVASSSQDGTIK 160


                ..
gi 18677720 377 FW 378
Cdd:cd00200 161 LW 162
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 378-420 3.08e-15

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 69.25  E-value: 3.08e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 18677720    378 WATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 383-420 1.43e-11

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 58.64  E-value: 1.43e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 18677720 383 QVPSLQHLCRMSIRRVM---PTQEVQELPIPSKLLEFLSYR 420
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 383-420 3.79e-10

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 54.52  E-value: 3.79e-10
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 18677720 383 QVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420
Cdd:cd03717   2 SVRSLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLKEY 39
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 382-420 6.39e-10

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 54.13  E-value: 6.39e-10
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 18677720 382 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420
Cdd:cd03745   1 RVLPSLRHLCRKALRHFLTTYQVLALPIPKKMKEFLTYR 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 385-420 5.36e-09

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 51.26  E-value: 5.36e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 18677720    385 PSLQHLCRMSIRRVMPTqeVQELPIPSKLLEFLSYR 420
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--IDKLPLPPRLKDYLLYY 34
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 382-420 5.45e-09

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 51.34  E-value: 5.45e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18677720 382 RQVPSLQHLCRMSIRRVMPTQ---EVQELPIPSKLLEFLSYR 420
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRrleLIKKLPLPPRLKDYLLYE 42
PTZ00421 PTZ00421
coronin; Provisional
 175-291 5.73e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.98  E-value: 5.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  175 DLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV------LRGHQNWVYSCAFSPDS-SMLCSVGASKAVFLWNMDKYT 247
Cdd:PTZ00421  80 DVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNIsdpivhLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGK 159

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 18677720  248 MIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDIL 291
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIV 203
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 383-417 6.95e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.01  E-value: 6.95e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18677720   383 QVPSLQHLCRMSIRRVMPT---QEVQELPIPSKLLEFL 417
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKrrlGAIDKLPLPPLLKDYL 38
PTZ00420 PTZ00420
coronin; Provisional
 163-333 6.94e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.57  E-value: 6.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  163 LLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMK-------VLRGHQNWVYSCAFSP-DSSMLCSVGA 234
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqcILKGHKKKISIIDWNPmNYYIMCSSGF 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  235 SKAVFLWNMD------KYTMIRKLEGHHHDVvacdfspDGALLATASYDTRVYIWDPHNGDILMEFghlfppptPIFAGG 308
Cdd:PTZ00420 147 DSFVNIWDIEnekrafQINMPKKLSSLKWNI-------KGNLLSGTCVGKHMHIIDPRKQEIASSF--------HIHDGG 211

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 18677720  309 AN------------DRWVRSVSFSHDGLHVASLADDK 333
Cdd:PTZ00420 212 KNtkniwidglggdDNYILSTGFSKNNMREMKLWDLK 248
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 385-420 8.17e-08

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 48.31  E-value: 8.17e-08
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 18677720 385 PSLQHLCRMSIRRVmpTQEVQELPIPSKLLEFLS-YR 420
Cdd:cd03736   4 PSLQHLCRITINKC--TRQIQELPLPTRLKDYLTeYT 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 249-284 1.23e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.23e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 18677720    249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
249-284 1.54e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.54e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 18677720   249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 382-419 5.15e-07

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 46.24  E-value: 5.15e-07
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 18677720 382 RQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSY 419
Cdd:cd03741   1 KNVQSLQHLCRFVIRKLVRRDHIPALPLPRRLIDYLRE 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 159-199 6.53e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 6.53e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 18677720    159 TGKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWD 199
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 203-242 1.07e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.07e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18677720    203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWN 242
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
142-288 2.36e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.54  E-value: 2.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 142 LLATGLNNGRIKIWDVYTGKLLlNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDdgnmMKVLR----GhqNWV 217
Cdd:COG3391  82 LYVANSGSGRVSVIDLATGKVV-ATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTAT----GKVVAtipvG--AGP 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 218 YSCAFSPDSSML--CSVGA---SKAVFLWNMDKYTMIRKLEGHHHdVVACDFSPDGALLATASYDT--------RVYIWD 284
Cdd:COG3391 155 HGIAVDPDGKRLyvANSGSntvSVIVSVIDTATGKVVATIPVGGG-PVGVAVSPDGRRLYVANRGSntsnggsnTVSVID 233


                ....
gi 18677720 285 PHNG 288
Cdd:COG3391 234 LATL 237
WD40 pfam00400
WD domain, G-beta repeat;
160-199 2.49e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.49e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 18677720   160 GKLLLNLVDHTEVVRDLTFAPDGSLiLVSASRDKTLRVWD 199
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
204-242 1.26e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18677720   204 GNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWN 242
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 383-417 2.51e-05

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 41.25  E-value: 2.51e-05
                        10        20        30
                ....*....|....*....|....*....|....*
gi 18677720 383 QVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFL 417
Cdd:cd03740   2 QVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYL 36
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 384-417 3.03e-05

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 41.10  E-value: 3.03e-05
                        10        20        30
                ....*....|....*....|....*....|....
gi 18677720 384 VPSLQHLCRMSIRRVmpTQEVQELPIPSKLLEFL 417
Cdd:cd03734   3 ARSLQHLCRLVINRL--VTDVDCLPLPRRMADYL 34
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 255-284 4.12e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.45  E-value: 4.12e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 18677720   255 HHHDVVAC-DFSPDGALLATASYDTRVYIWD 284
Cdd:pfam20426 122 QHKDVVSCvAVTSDGSILATGSYDTTVMVWE 152
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 149-284 5.63e-05

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 43.12  E-value: 5.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 149 NGRIKIWDVYTGKLLlNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
Cdd:COG0823  10 NSDIYVVDLDGGEPR-RLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKR 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18677720 229 L---CSVGASKAVFLWNMDKYTMIRKLEGHHHDVvacdFSPDGALLATASY---DTRVYIWD 284
Cdd:COG0823  89 LafvSRSDGRFDIYVLDLDGGAPRRLTDGPGSPS----WSPDGRRIVFSSDrggRPDLYVVD 146
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 123-284 7.34e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 7.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  123 QSRCVNIEWHRFRFGQdqllLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLkD 202
Cdd:PLN00181 532 RSKLSGICWNSYIKSQ----VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-N 606

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  203 DGNMMKVLRGHQNwVYSCAFSPDSSMLCSVG-ASKAVFLWNMDK-----YTMIrkleGHHHDVVACDFSpDGALLATASY 276
Cdd:PLN00181 607 QGVSIGTIKTKAN-ICCVQFPSESGRSLAFGsADHKVYYYDLRNpklplCTMI----GHSKTVSYVRFV-DSSTLVSSST 680


                 ....*...
gi 18677720  277 DTRVYIWD 284
Cdd:PLN00181 681 DNTLKLWD 688
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 386-420 1.89e-04

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 38.82  E-value: 1.89e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 18677720 386 SLQHLCRMSIRRVM---PTQEVQELPIPSKLLEFLSYR 420
Cdd:cd03718   5 PLMDLCRRRVRVALgrdRLEEIEQLPLPPSLKNYLLYQ 42
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 384-419 2.33e-04

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 38.62  E-value: 2.33e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18677720 384 VPSLQHLCRMSIRRVMPTQE------VQELPIPSKLLEFLSY 419
Cdd:cd03722   3 VPSLTHLCRLEIRSSLKSERlrsdsfICQLPLPRSLQDYLLY 44
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 380-417 2.37e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 38.58  E-value: 2.37e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 18677720 380 TPRqvpSLQHLCRMSIRRVMPTQ---EVQELPIPSKLLEFL 417
Cdd:cd03723   2 TPR---SLQHLCRCAIRKLLGSRchkLVPQLSLPTSLKNYL 39
PTZ00421 PTZ00421
coronin; Provisional
 143-255 3.42e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720  143 LATGLNNGRIKIWDVYTGKLLLNLVD-------HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLkDDGNMMKVLRGHQN 215
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEEGLTQNISDpivhlqgHTKKVGIVSFHPSAMNVLASAGADMVVNVWDV-ERGKAVEVIKCHSD 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 18677720  216 WVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 380-420 3.97e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 37.84  E-value: 3.97e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 18677720 380 TPRqvpSLQHLCRMSIRRVMPTQEVQ---ELPIPSKLLEFLSYR 420
Cdd:cd03729   2 TPL---SLQQLCRINLRKALGTRALEkiaKLNIPNRIIDYLSYN 42
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 386-420 2.10e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 36.35  E-value: 2.10e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 18677720 386 SLQHLCRMSIRRVMPTQEVQE------LPIPSKLLEFLSYR 420
Cdd:cd03731   5 PLKHLCRLKIRKLMGLQKLQQpssmkkLPLPPALKRYILYK 45
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 222-298 3.89e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 38.41  E-value: 3.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720   222 FSPDSSMLCSVG---ASKAVFLWNMDKYTMIRKLEghHHDVVACDFSPDGALLATAS------YDTRVYIWDpHNGDILM 292
Cdd:pfam08662 108 WSPFGRLVLLAGfgnLAGDIEFWDVVNKKKIATAE--ASNATLCEWSPDGRYFLTATtaprlrVDNGFKIWH-YNGALVY 184


                  ....*...
gi 18677720   293 E--FGHLF 298
Cdd:pfam08662 185 KydFDELY 192
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 309-338 8.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 8.18e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 18677720    309 ANDRWVRSVSFSHDGLHVASLADDKMVRFW 338
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 355-378 8.60e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.60e-03
                           10        20
                   ....*....|....*....|....
gi 18677720    355 LCCAFSTDGSVLAAGTHDGSVYFW 378
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLW 39
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 185-327 8.95e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 36.57  E-value: 8.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18677720 185 ILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSML--CSV-GASKAVFLWNMDKYTMIRKLEGHHHDvVA 261
Cdd:COG0823   1 LAFTLSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIafTSDrGGGPQIYVVDADGGEPRRLTFGGGYN-AS 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18677720 262 CDFSPDGALLATASYDT---RVYIWDPHNGDilmefghlfppPTPIFAGGAndrwvrSVSFSHDGLHVA 327
Cdd:COG0823  80 PSWSPDGKRLAFVSRSDgrfDIYVLDLDGGA-----------PRRLTDGPG------SPSWSPDGRRIV 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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